Weight Loss by Multidisciplinary Intervention Improves Endothelial and Sexual Function in Obese Fertile Women

Journal of Sexual Medicine

Volumn 10, Issue 4, 2013, Pages 1024-1033

  Aversa, Antonio ^a   Bruzziches, Roberto ^a   Francomano, Davide ^a   Greco, Emanuela A ^a   Violi, Francesco ^b   Lenzi, Andrea ^a   Donini, Lorenzo M ^a  

^a Food Science and Endocrinology Section ^*  (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Body Composition; Female Obesity; Insulin Resistance; Nutritional Rehabilitation; Overweight; Physical Exercise; Sexual Life

Indexed keywords

ADULT; ANTHROPOMETRIC PARAMETERS; AROUSAL; ARTICLE; BODY COMPOSITION; BODY MASS; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; EXERCISE; FAT MASS; FEMALE; FERTILE PERIOD; FOLLOW UP; HUMAN; HYPEREMIA; INSULIN RESISTANCE; LIFESTYLE MODIFICATION; LOW CALORY DIET; LUBRICATION; MAJOR CLINICAL STUDY; OBESITY; OUTPATIENT DEPARTMENT; PREMENOPAUSE; PRIORITY JOURNAL; SATISFACTION; SEXUAL BEHAVIOR; SEXUAL DYSFUNCTION; SEXUAL FUNCTION; TREATMENT DURATION; WEIGHT REDUCTION;

EID: 84875681044     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/jsm.12069     Document Type: Article

References (44)

1. Esposito K, Giugliano D. Obesity, the metabolic syndrome, and sexual dysfunction. Int J Impot Res 2005;17:391-398.
2. Kirchengast S, Hartmann B, Gruber D, Huber J. Decreased sexual interest and its relationship to body build in postmenopausal women. Maturitas 1996;23:63-71.
3. Brody S. Slimness is associated with greater intercourse and lesser masturbation frequency. J Sex Marital Ther 2004;30:251-261.
4. Lemarche B. Abdominal obesity and its metabolic complications: Implication for the risk of ischaemic heart disease. Coron Artery Dis 1998;9:473-481.
5. Jang Y, Lincoff M, Plow EF, Topol EJ. Cell adhesion molecules in coronary artery diseases. J Am Coll Cardiol 1994;24:1591-1601.
6. Ridker PM. Novel risk factors and markers for coronary disease. Adv Intern Med 2000;45:391-418.
7. Yudkin JS, Stehouwer CDA, Emeis JJ, Coppack SW. C-reactive protein in healthy subjects: Associations with obesity, insulinresistance, and endothelial dysfunction: A potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 1999;19:972-978.
8. Kolotkin RL, Zunker C, Østbye T. Sexual functioning and obesity: A review. Obesity (Silver Spring). 2012;20:2325-2333.
9. Miner M, Esposito K, Guay A, Montorsi P, Goldstein I. Cardiometabolic risk and female sexual health: The Princeton III summary. J Sex Med 2012;9:641-651.
10. Christensen BS, Grønbaek M, Pedersen BV, Graugaard C, Frisch M. Associations of unhealthy lifestyle factors with sexual inactivity and sexual dysfunctions in Denmark. J Sex Med 2011;8:1903-1916.
11. Edwards WM, Coleman E. Defining sexual health: A descriptive overview. Arch Sex Behav 2004;33:189-195.
12. Lue T, Basson R, Rosen R, Giuliano F, Khoury S, Montorsi F. Sexual medicine. Sexual dysfunction in men and women. 2nd International Consultation on Sexual Dysfunction. Paris: Health Publication; 2004.
13. Frank E, Anderson C, Rubinstein D. Frequency of sexual dysfunction in normal couples. N Engl J Med 1978;299:111-115.
14. Laumann EO, Paik A, Rosen RC. Sexual dysfunction in the United States: Prevalence and predictors. JAMA 1999;281:537-544.
15. Laumann EO, Nicolosi A, Glasser DB, Paik A, Gingell C, Moreira E, Wang T; GSSAB Investigators' Group. Sexual problems amomg women and men aged 40-80 y: Prevalence and correlates identified in the Global Study of Sexual Attitudes and Behaviors. Int J Impot Res 2005;17:39-57.
16. Larsen SH, Wagner G, Heitmann BL. Sexual function and obesity. Int J Obes (Lond) 2007;31:1189-1198.
17. Borges R, Temido P, Sousa L, Azinhais P, Conceiçaõ P, Pereira B, Leão R, Retroz E, Brandão A, Cristo L, Sobral F. Metabolic syndrome sexual (dys)function. J Sex Med 2009;6:2958-2975.
18. Traish A, Guay AT, Spark RF, Alarie P, Altman A, Aversa A, Buvat J, Caruso S, Goodman N, Graziottin A, Guay A, Jannini EA, Kingsberg S, Miner M, Martinez L, Munarriz R, Nappi R, Nachtigall L, Parish S, Perelman M, Petak S, Schwenkhagen A, Shabsigh R, Simon J, Spark R, Thacker H, Traish AM, Whipple B. Are the endocrine society's clinical practice guidelines on androgen therapy in women misguided? A commentary. J Sex Med 2007;4:1223-1234.
19. Miller WC, Wallace JP, Eggert KE. Predicting max HR and the HR-VO2 relationship for exercise prescription in obesity. Med Sci Sports Exerc 1993;25:1077-1081.
20. American Diabetes Association. Standards of medical care in diabetes-2011. Diabetes Care 2011;34:S11-61.
21. Rosen R, Brown C, Heiman J, Leiblum S, Meston C, Shabsigh R, Ferguson D, D'Agostino R Jr. The Female Sexual Function Index (FSFI): A ultidimensional self-report instrument for the assessment of female sexual function. J Sex Marital Ther 2000;26:191-208.
22. Meston CM. Validation of the Female Sexual Function Index (FSFI) in women with female orgasmic disorder and in women with hypoactive sexual desire disorder. J Sex Marital Ther 2003;29:39-46.
23. Isidori AM, Pozza C, Esposito K, Giugliano D, Morano S, Vignozzi L, Corona G, Lenzi A, Jannini EA. Development and validation of a 6-item version of the female sexual function index (FSFI) as a diagnostic tool for female sexual dysfunction. J Sex Med 2010;7:1139-1146.
24. Prior BM, Cureton KJ, Modlesky CM, Evans EM, Sloniger MA, Saunders M, Lewis RD. In-vivo validation of whole body composition estimates from dual-energy X-ray absorptiometry. J Appl Physiol 1997;83:623-630.
25. Mariani S, Fiore D, Barbaro G, Basciani S, Saponara M, D'Arcangelo E, Ulisse S, Moretti C, Fabbri A, Gnessi L. Association of epicardial fat thickness with the severity of obstructive sleep apnea in obese patients. Int J Cardiol 2012 Jun 20. [Epub ahead of print] doi: 10.1016/j.ijcard.2012.06.011.
26. Bonetti PO, Pumper GM, Higano ST, Holmes DR Jr, Kuvin JT, Lerman A. Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia. J Am Coll Cardiol 2004;44:2137-2141.
27. Aversa A, Francomano D, Bruzziches R, Pili M, Natali M, Spera G, Lenzi A. The application of digital pulse amplitude tonometry to the diagnostic investigation of endothelial dysfunction in men with erectile dysfunction. Andrologia 2011;43:9-15.
28. Merhi ZO. Bariatric surgery and subsequent sexual function. Fertil Steril 2007;87:710-711.
29. Veronelli A, Mauri C, Zecchini B, Peca MG, Turri O, Valitutti MT, Asta C, Pontiroli AE. Sexual dysfunction is frequent in premenopausal women with diabetes, obesity, and hypothyroidism, and correlates with markers of increased cardiovascular risk. A preliminary report. J Sex Med 2009;6:1561-1568.
30. Martelli V, Valisella S, Moscatiello S, Matteucci C, Lantadilla C, Costantino A, Pelusi G, Marchesini G, Meriggiola MC. Prevalence of sexual dysfunction among postmenopausal women with and without metabolic syndrome. J Sex Med 2012;9:434-441.
31. Esposito K, Giugliano F, Ciotola M, De Sio M, D'Armiento M, Giugliano D. Obesity and sexual dysfunction, male and female. Int J Impot Res 2008;20:358-365.
32. Ribeiro MC, Nakamura MU, Scanavino Mde T, Torloni MR, Mattar R. Female sexual function and gestational diabetes. J Sex Med 2012;9:786-792.
33. Yaylali GF, Tekekoglu S, Akin F. Sexual dysfunction in obese and overweight women. Int J Impot Res 2010;22:220-226.
34. Castellini G, Mannucci E, Mazzei C, Lo Sauro C, Faravelli C, Rotella CM, Maggi M, Ricca V. Sexual function in obese women with and without binge eating disorder. J Sex Med 2010;7:3969-3978.
35. Turcato E, Zamboni M, De Pergola G, Armellini F, Zivelonghi A, Bergamo-Andreis IA, Giorgino R, Bosello O. Interrelationships between weight loss, body fat distribution and sex hormones in pre- and postmenopausal obese women. J Intern Med 1997;241:363-372.
36. Shifren JL. The role of androgens in female sexual dysfunction. Mayo Clin Proc 2004;79(suppl 4):S19-24.
37. Aversa A, Bruzziches R, Francomano D, Natali M, Gareri P, Spera G. Endothelial dysfunction and erectile dysfunction in the aging man. Int J Urol 2010;17:38-47.
38. Fujii N, Tsuchihashi K, Sasao H, Eguchi M, Miurakami H, Hase M, Higashiura K, Yuda S, Hashimoto A, Miura T, Ura N, Shimamoto K. Insulin resistance functionally limits endothelium-dependent coronary vasodilation in nondiabetic patients. Heart Vessels 2008;23:9-15.
39. Arikan S, Akay H, Bahceci M, Tuzcu A, Gokalp D. The evaluation of endothelial function with flow-mediated dilatation and carotid intima media thickness in young non-obese polycystic ovary syndrome patients; existence of insulin resistance alone may not represent an adequate condition for deterioration of endothelial function. Fertil Steril 2009;91:450-455.
40. Carmina E, Orio F, Palomba S, Longo RA, Cascella T, Colao A, Lombardi G, Rini GB, Lobo RA. Endothelial dysfunction in PCOS: Role of obesity and adipose hormones. Am J Med 2006;119:356.e1-3566.
41. Brook RD, Bard RL, Glazewski L, Kehrer C, Bodary PF, Eitzman DL, Rajagopalan S. Effect of short-term weight loss on the metabolic syndrome and conduit vascular endothelial function in overweight adults. Am J Cardiol 2004;93:1012-1016.
42. Ziccardi P, Nappo F, Giugliano G, Esposito K, Marfella R, Cioffi M, D'Andrea F, Molinari AM, Giugliano D. Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year. Circulation 2002;105:804-809.
43. McCoy RG, Irving BA, Soop M, Srinivasan M, Tatpati L, Chow L, Weymiller AJ, Carter RE, Nair KS. Effect of insulin sensitizer therapy on atherothrombotic and inflammatory profiles associated with insulin resistance. Mayo Clin Proc 2012;87:561-570.
44. Graziottin A, Leiblum SR. Biological and psychosocial pathophysiology of female sexual dysfunction during the menopausal transition. J Sex Med 2005;2(suppl 3):133-145.