메뉴 건너뛰기




Volumn 377, Issue 1-2, 2013, Pages 97-106

Docosahexaenoic acid and eicosapentaenoic acid reduce C-reactive protein expression and STAT3 activation in IL-6-treated HepG2 cells

Author keywords

C reactive protein; HepG2 cells; IL 6; n 3 PUFAs; STAT3

Indexed keywords

C REACTIVE PROTEIN; CCAAT ENHANCER BINDING PROTEIN BETA; CCAAT ENHANCER BINDING PROTEIN DELTA; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; INTERLEUKIN 6; MESSENGER RNA; SMALL INTERFERING RNA; STAT3 PROTEIN;

EID: 84875673591     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1574-1     Document Type: Article
Times cited : (16)

References (45)
  • 1
    • 79961054708 scopus 로고    scopus 로고
    • Omega-3 fatty acids and cardiovascular disease: Effects on risk factors, molecular pathways, and clinical events
    • 22051327 10.1016/j.jacc.2011.06.063 1:CAS:528:DC%2BC3MXhs1eju7zE
    • Mozaffarian D, Wu JHY (2011) Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. J Am Coll Cardiol 58:2047-2067
    • (2011) J Am Coll Cardiol , vol.58 , pp. 2047-2067
    • Mozaffarian, D.1    Wu, J.H.Y.2
  • 2
    • 79959484739 scopus 로고    scopus 로고
    • N-3 fatty acids in cardiovascular disease
    • 21696310 10.1056/NEJMra1008153
    • De Caterina R (2011) n-3 fatty acids in cardiovascular disease. N Engl J Med 364:2439-2450
    • (2011) N Engl J Med , vol.364 , pp. 2439-2450
    • De Caterina, R.1
  • 3
    • 84857708439 scopus 로고    scopus 로고
    • Marine n-3 fatty acids for cardiovascular risk reduction and disease control in rheumatoid arthritis: "kill two birds with one stone"?
    • 22364137 10.2174/138161212799504722 1:CAS:528:DC%2BC38XntV2gtLs%3D
    • Rontoyanni VG, Sfikakis PP, Kitas GD, Protogerou AD (2012) Marine n-3 fatty acids for cardiovascular risk reduction and disease control in rheumatoid arthritis: "kill two birds with one stone"? Curr Pharm Des 18:1531-1542
    • (2012) Curr Pharm des , vol.18 , pp. 1531-1542
    • Rontoyanni, V.G.1    Sfikakis, P.P.2    Kitas, G.D.3    Protogerou, A.D.4
  • 4
    • 77955920757 scopus 로고    scopus 로고
    • Dietary conjugated linoleic acid and n-3 polyunsaturated fatty acids in inflammatory bowel disease
    • 20508519 10.1097/MCO.0b013e32833b648e 1:CAS:528:DC%2BC3cXpvFOjt78%3D
    • Bassaganya-Riera J, Hontecillas R (2010) Dietary conjugated linoleic acid and n-3 polyunsaturated fatty acids in inflammatory bowel disease. Curr Opin Clin Nutr Metab Care 13:569-573
    • (2010) Curr Opin Clin Nutr Metab Care , vol.13 , pp. 569-573
    • Bassaganya-Riera, J.1    Hontecillas, R.2
  • 5
    • 84858243360 scopus 로고    scopus 로고
    • Mechanisms of action of (n-3) fatty acids
    • 22279140 10.3945/jn.111.155259 1:CAS:528:DC%2BC38XjsV2it74%3D
    • Calder PC (2012) Mechanisms of action of (n-3) fatty acids. J Nutr 142:592S-5929S
    • (2012) J Nutr , vol.142
    • Calder, P.C.1
  • 6
    • 77955842717 scopus 로고    scopus 로고
    • Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids
    • 20382009 10.1016/j.jnutbio.2009.12.004 1:CAS:528:DC%2BC3cXhtVKgsb%2FF
    • Adkins Y, Kelley DS (2010) Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids. J Nutr Biochem 21:781-792
    • (2010) J Nutr Biochem , vol.21 , pp. 781-792
    • Adkins, Y.1    Kelley, D.S.2
  • 7
    • 10344239447 scopus 로고    scopus 로고
    • C-reactive protein
    • 15337754 10.1074/jbc.R400025200 1:CAS:528:DC%2BD2cXpslGqtrw%3D
    • Black S, Kushner I, Samols D (2004) C-reactive protein. J Biol Chem 279:48487-48490
    • (2004) J Biol Chem , vol.279 , pp. 48487-48490
    • Black, S.1    Kushner, I.2    Samols, D.3
  • 9
    • 77956398698 scopus 로고    scopus 로고
    • C-reactive protein is a mediator of cardiovascular disease
    • 20685682 10.1093/eurheartj/ehq238 1:CAS:528:DC%2BC3cXhtFaitrbL
    • Bisoendial RJ, Boekholdt SM, Vergeer M, Stroes ES, Kastelein JJ (2010) C-reactive protein is a mediator of cardiovascular disease. Eur Heart J 31:2087-2091
    • (2010) Eur Heart J , vol.31 , pp. 2087-2091
    • Bisoendial, R.J.1    Boekholdt, S.M.2    Vergeer, M.3    Stroes, E.S.4    Kastelein, J.J.5
  • 10
    • 70349742564 scopus 로고    scopus 로고
    • C-reactive protein as a risk factor for coronary heart disease: A systematic review and meta-analyses for the U.S. Preventive Services Task Force
    • 19805771
    • Buckley DI, Fu R, Freeman M, Rogers K, Helfand M (2009) C-reactive protein as a risk factor for coronary heart disease: a systematic review and meta-analyses for the U.S. Preventive Services Task Force. Ann Intern Med 151:483-495
    • (2009) Ann Intern Med , vol.151 , pp. 483-495
    • Buckley, D.I.1    Fu, R.2    Freeman, M.3    Rogers, K.4    Helfand, M.5
  • 11
    • 79955901873 scopus 로고    scopus 로고
    • The role of C-reactive protein as a risk predictor of coronary atherosclerosis: Implications from the JUPITER trial
    • 21274757 10.1007/s11883-011-0164-5 1:CAS:528:DC%2BC3MXjs1Cru70%3D
    • Abd TT, Eapen DJ, Bajpai A, Goyal A, Dollar A, Sperling L (2011) The role of C-reactive protein as a risk predictor of coronary atherosclerosis: implications from the JUPITER trial. Curr Atheroscler Rep 13:154-161
    • (2011) Curr Atheroscler Rep , vol.13 , pp. 154-161
    • Abd, T.T.1    Eapen, D.J.2    Bajpai, A.3    Goyal, A.4    Dollar, A.5    Sperling, L.6
  • 12
    • 1042301971 scopus 로고    scopus 로고
    • C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice
    • 14744975 10.1161/01.CIR.0000114526.50618.24 1:CAS:528: DC%2BD2cXos1emtQ%3D%3D
    • Paul A, Ko KW, Li L, Yechoor V, McCrory MA, Szalai AJ, Chan L (2004) C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. Circulation 109:647-655
    • (2004) Circulation , vol.109 , pp. 647-655
    • Paul, A.1    Ko, K.W.2    Li, L.3    Yechoor, V.4    McCrory, M.A.5    Szalai, A.J.6    Chan, L.7
  • 13
    • 0042744797 scopus 로고    scopus 로고
    • C-reactive protein: A critical update
    • 12813013 1:CAS:528:DC%2BD3sXkvV2ktb0%3D
    • Pepys MB, Hirschfield GM (2003) C-reactive protein: a critical update. J Clin Invest 111:1805-1812
    • (2003) J Clin Invest , vol.111 , pp. 1805-1812
    • Pepys, M.B.1    Hirschfield, G.M.2
  • 15
    • 43249090355 scopus 로고    scopus 로고
    • High omega-3 fat intake improves insulin sensitivity and reduces CRP and IL6, but does not affect other endocrine axes in healthy older adults
    • 18348080 10.1055/s-2008-1046759 1:CAS:528:DC%2BD1cXlsFenurg%3D
    • Tsitouras PD, Gucciardo F, Salbe AD, Heward C, Harman SM (2008) High omega-3 fat intake improves insulin sensitivity and reduces CRP and IL6, but does not affect other endocrine axes in healthy older adults. Horm Metab Res 40:199-205
    • (2008) Horm Metab Res , vol.40 , pp. 199-205
    • Tsitouras, P.D.1    Gucciardo, F.2    Salbe, A.D.3    Heward, C.4    Harman, S.M.5
  • 16
    • 70249129428 scopus 로고    scopus 로고
    • An inverse relationship between plasma n-3 fatty acids and C-reactive protein in healthy individuals
    • 19352379 10.1038/ejcn.2009.20 1:CAS:528:DC%2BD1MXhtVKku7%2FF
    • Micallef MA, Munro IA, Garg ML (2009) An inverse relationship between plasma n-3 fatty acids and C-reactive protein in healthy individuals. Eur J Clin Nutr 63:1154-1156
    • (2009) Eur J Clin Nutr , vol.63 , pp. 1154-1156
    • Micallef, M.A.1    Munro, I.A.2    Garg, M.L.3
  • 17
    • 67650876215 scopus 로고    scopus 로고
    • Inverse association of erythrocyte n-3 fatty acid levels with inflammatory biomarkers in patients with stable coronary artery disease: The Heart and Soul Study
    • 19185299 10.1016/j.atherosclerosis.2008.12.013 1:CAS:528: DC%2BD1MXptVelsbg%3D
    • Farzaneh-Far R, Harris WS, Garg S, Na B, Whooley MA (2009) Inverse association of erythrocyte n-3 fatty acid levels with inflammatory biomarkers in patients with stable coronary artery disease: the Heart and Soul Study. Atherosclerosis 205:538-543
    • (2009) Atherosclerosis , vol.205 , pp. 538-543
    • Farzaneh-Far, R.1    Harris, W.S.2    Garg, S.3    Na, B.4    Whooley, M.A.5
  • 18
    • 65249144656 scopus 로고    scopus 로고
    • Associations of dietary long-chain n-3 polyunsaturated fatty acids and fish with biomarkers of inflammation and endothelial activation (from the Multi-Ethnic Study of Atherosclerosis MESA)
    • 19406265 10.1016/j.amjcard.2009.01.016 1:CAS:528:DC%2BD1MXlsVKjsbs%3D
    • He K, Liu K, Daviglus ML, Jenny NS, Mayer-Davis E, Jiang R, Steffen L, Siscovick D, Tsai M, Herrington D (2009) Associations of dietary long-chain n-3 polyunsaturated fatty acids and fish with biomarkers of inflammation and endothelial activation (from the Multi-Ethnic Study of Atherosclerosis MESA). Am J Cardiol 103:1238-1243
    • (2009) Am J Cardiol , vol.103 , pp. 1238-1243
    • He, K.1    Liu, K.2    Daviglus, M.L.3    Jenny, N.S.4    Mayer-Davis, E.5    Jiang, R.6    Steffen, L.7    Siscovick, D.8    Tsai, M.9    Herrington, D.10
  • 19
    • 62749187788 scopus 로고    scopus 로고
    • DHA supplementation decreases serum C-reactive protein and other markers of inflammation in hypertriglyceridemic men
    • 19158225 10.3945/jn.108.100354 1:CAS:528:DC%2BD1MXjsFKitbg%3D
    • Kelley DS, Siegel D, Fedor DM, Adkins Y, Mackey BE (2009) DHA supplementation decreases serum C-reactive protein and other markers of inflammation in hypertriglyceridemic men. J Nutr 139:495-501
    • (2009) J Nutr , vol.139 , pp. 495-501
    • Kelley, D.S.1    Siegel, D.2    Fedor, D.M.3    Adkins, Y.4    MacKey, B.E.5
  • 20
    • 0025228036 scopus 로고
    • Acute-phase response of human hepatocytes: Regulation of acute-phase protein synthesis by interleukin-6
    • 1699862 10.1002/hep.1840120517 1:CAS:528:DyaK3MXktVOlsA%3D%3D
    • Castell JV, Gomez-Lechion MJ, David M, Fabra R, Trullenque R, Heinrich PC (1990) Acute-phase response of human hepatocytes: regulation of acute-phase protein synthesis by interleukin-6. Hepatology 12:1179-1186
    • (1990) Hepatology , vol.12 , pp. 1179-1186
    • Castell, J.V.1    Gomez-Lechion, M.J.2    David, M.3    Fabra, R.4    Trullenque, R.5    Heinrich, P.C.6
  • 21
    • 0030000589 scopus 로고    scopus 로고
    • STAT3 participates in transcriptional activation of the C-reactive protein gene by interleukin-6
    • 8621622 10.1074/jbc.271.16.9503 1:CAS:528:DyaK28XisFSmu70%3D
    • Zhang D, Sun M, Samols D, Kushner I (1996) STAT3 participates in transcriptional activation of the C-reactive protein gene by interleukin-6. J Biol Chem 271:9503-9509
    • (1996) J Biol Chem , vol.271 , pp. 9503-9509
    • Zhang, D.1    Sun, M.2    Samols, D.3    Kushner, I.4
  • 22
    • 49149095841 scopus 로고    scopus 로고
    • Transcriptional complex formation of c-Fos, STAT3, and hepatocyte NF-1 alpha is essential for cytokine-driven C-reactive protein gene expression
    • 18292576 1:CAS:528:DC%2BD1cXit1Okt7g%3D
    • Nishikawa T, Hagihara K, Serada S, Isobe T, Matsumura A, Song J, Tanaka T, Kawase I, Naka T, Yoshizaki K (2008) Transcriptional complex formation of c-Fos, STAT3, and hepatocyte NF-1 alpha is essential for cytokine-driven C-reactive protein gene expression. J Immunol 180:3492-3501
    • (2008) J Immunol , vol.180 , pp. 3492-3501
    • Nishikawa, T.1    Hagihara, K.2    Serada, S.3    Isobe, T.4    Matsumura, A.5    Song, J.6    Tanaka, T.7    Kawase, I.8    Naka, T.9    Yoshizaki, K.10
  • 23
    • 0027217386 scopus 로고
    • The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBP delta/NF-IL6 beta, are induced by IL-6 to promote acute phase gene transcription via different mechanisms
    • 7680115 10.1093/nar/21.2.289 1:CAS:528:DyaK3sXhsVGkurw%3D
    • Ramji DP, Vitelli A, Tronche F, Cortese R, Ciliberto G (1993) The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBP delta/NF-IL6 beta, are induced by IL-6 to promote acute phase gene transcription via different mechanisms. Nucleic Acids Res 21:289-294
    • (1993) Nucleic Acids Res , vol.21 , pp. 289-294
    • Ramji, D.P.1    Vitelli, A.2    Tronche, F.3    Cortese, R.4    Ciliberto, G.5
  • 24
    • 0029903287 scopus 로고    scopus 로고
    • Regulation of human C-reactive protein gene expression by two synergistic IL-6 responsive elements
    • 8703909 10.1021/bi953033d 1:CAS:528:DyaK28XjslOhs7c%3D
    • Li SP, Goldman ND (1996) Regulation of human C-reactive protein gene expression by two synergistic IL-6 responsive elements. Biochemistry 35:9060-9068
    • (1996) Biochemistry , vol.35 , pp. 9060-9068
    • Li, S.P.1    Goldman, N.D.2
  • 25
    • 34848836414 scopus 로고    scopus 로고
    • Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-κB and C/EBPβ activation
    • 17652082 10.1074/jbc.M703250200 1:CAS:528:DC%2BD2sXhtVWjsLfP
    • Patel DN, King CA, Bailey SR, Holt JW, Venkatachalam K, Agrawal A, Valente AJ, Chandrasekar B (2007) Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-κB and C/EBPβ activation. J Biol Chem 282:27229-27238
    • (2007) J Biol Chem , vol.282 , pp. 27229-27238
    • Patel, D.N.1    King, C.A.2    Bailey, S.R.3    Holt, J.W.4    Venkatachalam, K.5    Agrawal, A.6    Valente, A.J.7    Chandrasekar, B.8
  • 26
    • 0025233653 scopus 로고
    • Cis-acting elements responsible for interleukin-6 inducible C-reactive protein gene expression
    • 2154496 1:CAS:528:DyaK3cXhsFaqsb0%3D
    • Li SP, Liu TY, Goldman ND (1990) cis-acting elements responsible for interleukin-6 inducible C-reactive protein gene expression. J Biol Chem 265:4136-4142
    • (1990) J Biol Chem , vol.265 , pp. 4136-4142
    • Li, S.P.1    Liu, T.Y.2    Goldman, N.D.3
  • 27
    • 0027499295 scopus 로고
    • Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6
    • 8384717 10.1073/pnas.90.6.2207 1:CAS:528:DyaK3sXitVKrtrY%3D
    • Nakajima T, Kinoshita S, Sasagawa T, Sasaki K, Naruto M, Kishimoto T, Akira S (1993) Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc Natl Acad Sci USA 90:2207-2211
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 2207-2211
    • Nakajima, T.1    Kinoshita, S.2    Sasagawa, T.3    Sasaki, K.4    Naruto, M.5    Kishimoto, T.6    Akira, S.7
  • 28
    • 0035914307 scopus 로고    scopus 로고
    • ERK2- and p90 (Rsk2)-dependent pathways regulate the CCAAT/enhancer- binding protein-beta interaction with serum response factor
    • 11500490 10.1074/jbc.M102165200 1:CAS:528:DC%2BD3MXnvVensLg%3D
    • Hanlon M, Sturgill TW, Sealy L (2001) ERK2- and p90 (Rsk2)-dependent pathways regulate the CCAAT/enhancer-binding protein-beta interaction with serum response factor. J Biol Chem 276:38449-38456
    • (2001) J Biol Chem , vol.276 , pp. 38449-38456
    • Hanlon, M.1    Sturgill, T.W.2    Sealy, L.3
  • 29
    • 0041677606 scopus 로고    scopus 로고
    • Principles of interleukin (IL)-6-type cytokine signalling and its regulation
    • 12773095 10.1042/BJ20030407 1:CAS:528:DC%2BD3sXmtF2hurs%3D
    • Heinrich PC, Behrmann I, Haan S, Hermanns HM, Müller-Newen G, Schaper F (2003) Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 374:1-20
    • (2003) Biochem J , vol.374 , pp. 1-20
    • Heinrich, P.C.1    Behrmann, I.2    Haan, S.3    Hermanns, H.M.4    Müller-Newen, G.5    Schaper, F.6
  • 30
    • 0033492399 scopus 로고    scopus 로고
    • STATs as mediators of cytokine induced responses
    • 9917912 10.1016/S0065-2776(08)60401-0 1:CAS:528:DyaK1MXotVOrtQ%3D%3D
    • Hoey T, Grusby MJ (1999) STATs as mediators of cytokine induced responses. Adv Immunol 71:145-160
    • (1999) Adv Immunol , vol.71 , pp. 145-160
    • Hoey, T.1    Grusby, M.J.2
  • 31
    • 78651315300 scopus 로고    scopus 로고
    • Adiponectin reduces C-reactive protein expression and downregulates STAT3 phosphorylation induced by IL-6 in HepG2 cells
    • 20978825 10.1007/s11010-010-0627-y 1:CAS:528:DC%2BC3cXhsFKmt7zF
    • Sun H, Zhang Y, Gao P, Li Q, Sun Y, Zhang J, Xu C (2011) Adiponectin reduces C-reactive protein expression and downregulates STAT3 phosphorylation induced by IL-6 in HepG2 cells. Mol Cell Biochem 347:183-189
    • (2011) Mol Cell Biochem , vol.347 , pp. 183-189
    • Sun, H.1    Zhang, Y.2    Gao, P.3    Li, Q.4    Sun, Y.5    Zhang, J.6    Xu, C.7
  • 32
    • 80053189960 scopus 로고    scopus 로고
    • N-3 Fatty acids uniquely affect anti-microbial resistance and immune cell plasma membrane organization
    • 21798252 10.1016/j.chemphyslip.2011.07.003 1:CAS:528:DC%2BC3MXht1anurzE
    • McMurray DN, Bonilla DL, Chapkin RS (2011) n-3 Fatty acids uniquely affect anti-microbial resistance and immune cell plasma membrane organization. Chem Phys Lipids 164:626-635
    • (2011) Chem Phys Lipids , vol.164 , pp. 626-635
    • McMurray, D.N.1    Bonilla, D.L.2    Chapkin, R.S.3
  • 33
    • 32844456005 scopus 로고    scopus 로고
    • Docosahexaenoic acid enhances the antioxidant response of human fibroblasts by upregulating gamma-glutamyl-cysteinyl ligase and glutathione reductase
    • 16441913 10.1079/BJN20051626 1:CAS:528:DC%2BD28XitFCjsbg%3D
    • Arab K, Rossary A, Flourié F, Tourneur Y, Steghens JP (2006) Docosahexaenoic acid enhances the antioxidant response of human fibroblasts by upregulating gamma-glutamyl-cysteinyl ligase and glutathione reductase. Br J Nutr 95:18-26
    • (2006) Br J Nutr , vol.95 , pp. 18-26
    • Arab, K.1    Rossary, A.2    Flourié, F.3    Tourneur, Y.4    Steghens, J.P.5
  • 34
    • 79960329364 scopus 로고    scopus 로고
    • Omega-3 fatty acids attenuate dendritic cell function via NF-κB independent of PPARγ
    • 21111596 10.1016/j.jnutbio.2010.06.009 1:CAS:528:DC%2BC3MXptVWrt7k%3D
    • Draper E, Reynolds CM, Canavan M, Mills KH, Loscher CE, Roche HM (2011) Omega-3 fatty acids attenuate dendritic cell function via NF-κB independent of PPARγ. J Nutr Biochem 22:784-790
    • (2011) J Nutr Biochem , vol.22 , pp. 784-790
    • Draper, E.1    Reynolds, C.M.2    Canavan, M.3    Mills, K.H.4    Loscher, C.E.5    Roche, H.M.6
  • 35
    • 84861846606 scopus 로고    scopus 로고
    • Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling
    • 22586114 10.1073/pnas.1200189109 1:CAS:528:DC%2BC38XoslKhtLc%3D
    • Norris PC, Dennis EA (2012) Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling. Proc Natl Acad Sci USA 109:8517-8522
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 8517-8522
    • Norris, P.C.1    Dennis, E.A.2
  • 36
    • 77957942833 scopus 로고    scopus 로고
    • Specialized pro-resolving lipid mediators in the inflammatory response: An update
    • 20708099 10.1016/j.bbalip.2010.08.002 1:CAS:528:DC%2BC3cXhtlShtLzP
    • Bannenberg G, Serhan CN (2010) Specialized pro-resolving lipid mediators in the inflammatory response: an update. Biochim Biophys Acta 1801:1260-1273
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 1260-1273
    • Bannenberg, G.1    Serhan, C.N.2
  • 37
    • 78651259229 scopus 로고    scopus 로고
    • Docosahexaenoic acid attenuates VCAM-1 expression and NF-κB activation in TNF-α-treated human aortic endothelial cells
    • 20573493 10.1016/j.jnutbio.2010.01.007 1:CAS:528:DC%2BC3MXntVaqtA%3D%3D
    • Wang TM, Chen CJ, Lee TS, Chao HY, Wu WH, Hsieh SC, Sheu HH, Chiang AN (2011) Docosahexaenoic acid attenuates VCAM-1 expression and NF-κB activation in TNF-α-treated human aortic endothelial cells. J Nutr Biochem 22:187-194
    • (2011) J Nutr Biochem , vol.22 , pp. 187-194
    • Wang, T.M.1    Chen, C.J.2    Lee, T.S.3    Chao, H.Y.4    Wu, W.H.5    Hsieh, S.C.6    Sheu, H.H.7    Chiang, A.N.8
  • 38
    • 82155164210 scopus 로고    scopus 로고
    • Docosahexaenoic acid inhibits UVB-induced activation of NF-κB and expression of COX-2 and NOX-4 in HR-1 hairless mouse skin by blocking MSK1 signaling
    • 22140508 10.1371/journal.pone.0028065 1:CAS:528:DC%2BC3MXhs1eqtb7L
    • Rahman M, Kundu JK, Shin JW, Na HK, Surh YJ (2011) Docosahexaenoic acid inhibits UVB-induced activation of NF-κB and expression of COX-2 and NOX-4 in HR-1 hairless mouse skin by blocking MSK1 signaling. PLoS ONE 6:e28065
    • (2011) PLoS ONE , vol.6 , pp. 28065
    • Rahman, M.1    Kundu, J.K.2    Shin, J.W.3    Na, H.K.4    Surh, Y.J.5
  • 40
    • 84867713403 scopus 로고    scopus 로고
    • Eicosapentaenoic acid and docosahexaenoic acid inhibit macrophage-induced gastric cancer cell migration by attenuating the expression of matrix metalloproteinase 10
    • doi: 10.1016/j.jnutbio.2011.09.004
    • Wu MH, Tsai YT, Hua KT, Chang KC, Kuo ML, Lin MT (2012) Eicosapentaenoic acid and docosahexaenoic acid inhibit macrophage-induced gastric cancer cell migration by attenuating the expression of matrix metalloproteinase 10. J Nutr Biochem. doi: 10.1016/j.jnutbio.2011.09.004
    • (2012) J Nutr Biochem
    • Wu, M.H.1    Tsai, Y.T.2    Hua, K.T.3    Chang, K.C.4    Kuo, M.L.5    Lin, M.T.6
  • 42
    • 73349102809 scopus 로고    scopus 로고
    • STAT3 revs up the powerhouse
    • Reich NC (2009) STAT3 revs up the powerhouse. Sci Signal 2:pe61
    • (2009) Sci Signal , vol.2
    • Reich, N.C.1
  • 43
    • 2942530310 scopus 로고    scopus 로고
    • ERK and p38 MAPK-activated protein kinases: A family of protein kinases with diverse biological functions
    • 15187187 10.1128/MMBR.68.2.320-344.2004 1:CAS:528:DC%2BD2cXlsl2hu7Y%3D
    • Roux PP, Blenis J (2004) ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev 68:320-344
    • (2004) Microbiol Mol Biol Rev , vol.68 , pp. 320-344
    • Roux, P.P.1    Blenis, J.2
  • 44
    • 73849127376 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase 1/2 activation, via downregulation of mitogen-activated protein kinase phosphatase 1, mediates sex differences in desoxycorticosterone acetate-salt hypertension vascular reactivity
    • 19901158 10.1161/HYPERTENSIONAHA.109.140459 1:CAS:528:DC%2BD1MXhsFaqt7bK
    • Giachini FR, Sullivan JC, Lima VV, Carneiro FS, Fortes ZB, Pollock DM, Carvalho MH, Webb RC, Tostes RC (2010) Extracellular signal-regulated kinase 1/2 activation, via downregulation of mitogen-activated protein kinase phosphatase 1, mediates sex differences in desoxycorticosterone acetate-salt hypertension vascular reactivity. Hypertension 55:172-179
    • (2010) Hypertension , vol.55 , pp. 172-179
    • Giachini, F.R.1    Sullivan, J.C.2    Lima, V.V.3    Carneiro, F.S.4    Fortes, Z.B.5    Pollock, D.M.6    Carvalho, M.H.7    Webb, R.C.8    Tostes, R.C.9
  • 45
    • 34250160235 scopus 로고    scopus 로고
    • Effect of wine phenolics on cytokine-induced C-reactive protein expression
    • 17388968 10.1111/j.1538-7836.2007.02527.x 1:CAS:528:DC%2BD2sXntl2ktLo%3D
    • Kaur G, Rao LV, Agrawal A, Pendurthi UR (2007) Effect of wine phenolics on cytokine-induced C-reactive protein expression. J Thromb Haemost 5:1309-1317
    • (2007) J Thromb Haemost , vol.5 , pp. 1309-1317
    • Kaur, G.1    Rao, L.V.2    Agrawal, A.3    Pendurthi, U.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.