The origins of a concept: The protease-antiprotease imbalance hypothesis

Chest

Volumn 122, Issue 3, 2002, Pages 1058-1060

  Turino, Gerard M ^a  

^a St Luke’s Roosevelt Hospital ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; CHONDROITIN SULFATE; ELASTASE; HYALURONIC ACID; PAPAIN; PROTEINASE; PROTEINASE INHIBITOR; SERINE;

ARTICLE; BRONCHUS; CARTILAGE DEGENERATION; CATTLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLOSTRIDIUM; CONNECTIVE TISSUE; EAR; ENZYME ANALYSIS; ENZYME DEFICIENCY; ENZYME MECHANISM; ENZYME STRUCTURE; FAMILY; HUMAN; HYPOTHESIS; IN VIVO STUDY; LUNG BLOOD VESSEL; LUNG DISEASE; LUNG EMPHYSEMA; LUNG PARENCHYMA; MAMMAL; MEDICAL SOCIETY; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DEGRADATION; RABBIT; SWINE; TRACHEA; UNITED STATES; URINE LEVEL;

EID: 0036384262     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.122.3.1058     Document Type: Article

References (16)

1. McCluskey RT. The in vivo removal of cartilage matrix by crystalline papain protease, and the prevention of recovery by a direct action of cortisone on cartilage. Trans Assoc Am Phys 1958; 71:297-305
2. Thomas L. Reversible collapse of rabbit ears after intravenous papain, and prevention of recovery by cortisone. J Exp Med 1956; 104:245-251
3. Turino GM, Goldring RM, Katz LM. The effect of experimental bronchomalaria on pulmonary mechanics [abstract]. J Clin Invest 1961; 40:1086
4. Turino GM, Lourenco RV, McCracken GH. The role of connective tissue elements in the function of large pulmonary airways [abstract]. Fed Proc 1962; 21:446
5. Turino GM, Lourenso RV, McCracken GH. The role of connective tissues in large pulmonary airways. J Appl Physiol 1968; 25:645-653
6. Laurell CB, Eriksson S. The electrophoretic α1-globulin pattern of serum in α1-antitrypsin deficiency. Scand J Clin Invest 1963; 15:132-140
7. Gross P, Pfitzer EA, Toker E, et al. Experimental emphysema: its production with papain in normal and silicotic rats. Arch Environ Health 1965; 11:50-58
8. Lewis UJ, Williams DE, Brink NG. Pancreatic elastase: purification, properties and function. J Biol Chem 1956; 222:705-720
9. Janoff A, Scherer J. Mediators of inflammation in leukocyte lysosomes: IX. Elastinolytic activity in granules of human polymorphonuclear leukocytes. J Exp Med 1968; 128:1137-1155
10. Turino GM, Senior RM, Garg GD, et al. Serum elastase inhibitor deficiency and α1-antitrypsin deficiency in patients with obstructive emphysema. Science 1969; 165:709-711
11. Snider GL, Hayes JA, Franzblau C, et al. Relationship between elastolytic activity and experimental emphysema inducing properties of papain preparations. Am Rev Respir Dis 1974; 110:254-262
12. Senior RM, Tegner H, Kuhn C, et al. The induction of pulmonary emphysema with leukocyte elastasel. Am Rev Respir Dis 1977; 116:469-475
13. Janoff A. Elastases and emphysema: current assessment of the protease-antiprotease hypothesis. Am Rev Respir Dis 1985; 132:417-433
14. National Heart, Lung, and Blood Institute Task Force report on problems, research approaches, and needs. Washington, DC: Department of Health, Education, and Welfare, 1972; publication no. 73; 432
15. Barnes PJ. Chronic obstructive pulmonary disease: new opportunities for drug development. Trends Pharmacol Sci 1998; 19:415-423
16. Cantor JO, Shteyngart B, Cerreta JM, et al. The effect of hyaluronan on elastic fiber injury in vitro and elastase-induced airspace enlargement in vivo. Proc Soc Exp Biol Med 2000; 225:65-71