Intra-Tumoral Heterogeneity in Metastatic Potential and Survival Signaling between Iso-Clonal HCT116 and HCT116b Human Colon Carcinoma Cell Lines

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Chowdhury, Sanjib ^a   Ongchin, Melanie ^b   Sharratt, Elizabeth ^c   Dominguez, Ivan ^b   Wang, Jing ^a   Brattain, Michael G ^a   Rajput, Ashwani ^d  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c ROSWELL PARK CANCER INSTITUTE   (United States)

^d UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INVASION; CELL LINE; CELL MOTILITY; CELL STRAIN HCT116; CELL STRAIN HCT116B; CELL SURVIVAL; CLONAL VARIATION; COLON CARCINOMA; CONTROLLED STUDY; HISTOPATHOLOGY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIVER METASTASIS; LUNG METASTASIS; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PERITONEUM METASTASIS; SIGNAL TRANSDUCTION; TUMOR GENE; TUMOR XENOGRAFT;

ANIMALS; CARCINOMA; CELL SURVIVAL; CLONE CELLS; COLONIC NEOPLASMS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC HETEROGENEITY; HCT116 CELLS; HUMANS; LIVER NEOPLASMS; LUNG NEOPLASMS; MALE; MICE; MICE, NUDE; NEOPLASM PROTEINS; NEOPLASM TRANSPLANTATION; ORGAN SPECIFICITY; SIGNAL TRANSDUCTION;

ANIMALIA; MUS; MUS MUSCULUS;

EID: 84875648026     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060299     Document Type: Article

References (25)

1. Chowdhury S, Howell GM, Rajput A, Teggart CA, Brattain LE, et al. (2011) Identification of a novel TGFbeta/PKA signaling transduceome in mediating control of cell survival and metastasis in colon cancer. PLoS One 6: e19335.
2. Markowitz SD, Bertagnolli MM, (2009) Molecular origins of cancer: Molecular basis of colorectal cancer. N Engl J Med 361: 2449-2460.
3. TCGA (2012) Comprehensive molecular characterization of human colon and rectal cancer. Nature 487: 330-337.
4. Marusyk A, Almendro V, Polyak K, (2012) Intra-tumour heterogeneity: a looking glass for cancer? Nat Rev Cancer 12: 323-334.
5. Guo XN, Rajput A, Rose R, Hauser J, Beko A, et al. (2007) Mutant PIK3CA-bearing colon cancer cells display increased metastasis in an orthotopic model. Cancer Res 67: 5851-5858.
6. Rajput A, Dominguez San Martin I, Rose R, Beko A, Levea C, et al. (2008) Characterization of HCT116 human colon cancer cells in an orthotopic model. J Surg Res 147: 276-281.
7. Rajput A, Koterba AP, Kreisberg JI, Foster JM, Willson JK, et al. (2007) A novel mechanism of resistance to epidermal growth factor receptor antagonism in vivo. Cancer Res 67: 665-673.
8. Wang J, Kuropatwinski K, Hauser J, Rossi MR, Zhou Y, et al. (2007) Colon carcinoma cells harboring PIK3CA mutations display resistance to growth factor deprivation induced apoptosis. Mol Cancer Ther 6: 1143-1150.
9. Wang J, Rajput A, Kan JL, Rose R, Liu XQ, et al. (2009) Knockdown of Ron kinase inhibits mutant phosphatidylinositol 3-kinase and reduces metastasis in human colon carcinoma. J Biol Chem 284: 10912-10922.
10. Ongchin M, Sharratt E, Dominguez I, Simms N, Wang J, et al. (2009) The effects of epidermal growth factor receptor activation and attenuation of the TGFbeta pathway in an orthotopic model of colon cancer. J Surg Res 156: 250-256.
11. Brattain MG, Marks ME, McCombs J, Finely W, Brattain DE, (1983) Characterization of human colon carcinoma cell lines isolated from a single primary tumour. Br J Cancer 47: 373-381.
12. Awwad RA, Sergina N, Yang H, Ziober B, Willson JK, et al. (2003) The role of transforming growth factor alpha in determining growth factor independence. Cancer Res 63: 4731-4738.
13. Boyd DD, Levine AE, Brattain DE, McKnight MK, Brattain MG, (1988) Comparison of growth requirements of two human intratumoral colon carcinoma cell lines in monolayer and soft agarose. Cancer Res 48: 2469-2474.
14. Brattain MG, Levine AE, Chakrabarty S, Yeoman LC, Willson JK, et al. (1984) Heterogeneity of human colon carcinoma. Cancer Metastasis Rev 3: 177-191.
15. Chowdhury S, Howell GM, Teggart CA, Chowdhury A, Person JJ, et al. (2011) Histone deacetylase inhibitor belinostat represses survivin expression through reactivation of transforming growth factor beta (TGFbeta) receptor II leading to cancer cell death. J Biol Chem 286: 30937-30948.
16. Wang J, Yang L, Yang J, Kuropatwinski K, Wang W, et al. (2008) Transforming growth factor beta induces apoptosis through repressing the phosphoinositide 3-kinase/AKT/survivin pathway in colon cancer cells. Cancer Res 68: 3152-3160.
17. Fang JY, Richardson BC, (2005) The MAPK signalling pathways and colorectal cancer. Lancet Oncol 6: 322-327.
18. Noh DY, Lee YH, Kim SS, Kim YI, Ryu SH, et al. (1994) Elevated content of phospholipase C-gamma 1 in colorectal cancer tissues. Cancer 73: 36-41.
19. Gulhati P, Bowen KA, Liu J, Stevens PD, Rychahou PG, et al. (2011) mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. Cancer Res 71: 3246-3256.
20. Crowe DL, Ohannessian A, (2004) Recruitment of focal adhesion kinase and paxillin to beta1 integrin promotes cancer cell migration via mitogen activated protein kinase activation. BMC Cancer 4: 18.
21. Mehlen P, Puisieux A, (2006) Metastasis: a question of life or death. Nat Rev Cancer 6: 449-458.
22. Wang D, Patil S, Li W, Humphrey LE, Brattain MG, et al. (2002) Activation of the TGFalpha autocrine loop is downstream of IGF-I receptor activation during mitogenesis in growth factor dependent human colon carcinoma cells. Oncogene 21: 2785-2796.
23. Jiang D, Yang H, Willson JK, Liang J, Humphrey LE, et al. (1998) Autocrine transforming growth factor alpha provides a growth advantage to malignant cells by facilitating re-entry into the cell cycle from suboptimal growth states. J Biol Chem 273: 31471-31479.
24. Maley CC, Galipeau PC, Finley JC, Wongsurawat VJ, Li X, et al. (2006) Genetic clonal diversity predicts progression to esophageal adenocarcinoma. Nat Genet 38: 468-473.
25. Park SY, Gonen M, Kim HJ, Michor F, Polyak K, (2010) Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype. J Clin Invest 120: 636-644.