Age ≥60years was an independent risk factor for diabetes-related complications despite good control of cardiovascular risk factors in patients with type 2 diabetes mellitus

Experimental Gerontology

Volumn 48, Issue 5, 2013, Pages 485-491

  Chew, Boon How ^a   Shariff Ghazali, Sazlina ^a   Ismail, Mastura ^b   Haniff, Jamaiyah ^c   Bujang, Mohd Adam ^c  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b Klinik Kesihatan Seremban   (Malaysia)

^c HOSPITAL KUALA LUMPUR   (Malaysia)

Author keywords

Aged; Blood pressure; Diabetes complications; HbA1; LDL cholesterol; Type 2 diabetes mellitus

Indexed keywords

HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; GLYCOSYLATED HEMOGLOBIN; LIPID;

ADULT; AGE; AGED; ARTICLE; BLOOD PRESSURE MEASUREMENT; BODY MASS; CARDIOVASCULAR RISK; CEREBROVASCULAR ACCIDENT; DIABETES CONTROL; DIABETIC ANGIOPATHY; DIABETIC FOOT; DIABETIC MICROANGIOPATHY; DIABETIC NEPHROPATHY; DIABETIC RETINOPATHY; DISEASE DURATION; DYSLIPIDEMIA; ETHNICITY; FEMALE; HUMAN; HYPERTENSION; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RISK ASSESSMENT; BLOOD; CARDIOVASCULAR DISEASE; CROSS-SECTIONAL STUDY; DIABETES MELLITUS; MALAYSIA; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; RISK FACTOR;

ADULT; AGE FACTORS; AGED; BODY MASS INDEX; CARDIOVASCULAR DISEASES; CROSS-SECTIONAL STUDIES; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 2; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; LIPIDS; MALAYSIA; MALE; MIDDLE AGED; RISK FACTORS;

EID: 84875637964     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2013.02.017     Document Type: Article

References (55)

1. Al-Qazaz H.K., Hassali M.A., Shafie A.A., Syed Sulaiman S.A., Sundram S. Perception and knowledge of patients with type 2 diabetes in Malaysia about their disease and medication: a qualitative study. Res. Social Adm. Pharm. 2011, 7:180-191.
2. Awin N. A Review of Primary Health Care in Malaysia - A Report for the World Health Organization Western Pacific Region 2001, Ministry of Health, Malaysia.
3. Bachschmid, M.M., Schildknecht, S., Matsui, R., Zee, R., Haeussler, D., A. Cohen, R., Pimental, D., Loo, B.v.d., in press. Vascular aging: Chronic oxidative stress and impairment of redox signaling-consequences for vascular homeostasis and disease. Ann. Med. 45, 17-36.
4. Best J.D., Drury P.L., Davis T.M.E., Taskinen M.-R., Kesäniemi Y.A., Scott R., Pardy C., Voysey M., Keech A.C. Glycemic Control Over 5Years in 4,900 People with Type 2 Diabetes. Diabetes Care 2012, 35:1165-1170. on behalf of the Fenofibrate Intervention and Event Lowering in Diabetes Study, I.
5. Browning C., Chapman A., Cowlishaw S., Li Z., Thomas S., Yang H., Zhang T. The Happy Life ClubTM study protocol: a cluster randomised controlled trial of a type 2 diabetes health coach intervention. BMC Publ. Health 2011, 11:90.
6. Chamnan P., Simmons R., Sharp S., Griffin S., Wareham N. Cardiovascular risk assessment scores for people with diabetes: a systematic review. Diabetologia 2009, 52:2001-2014.
7. Chan J.C.N., Malik V., Jia W., Kadowaki T., Yajnik C.S., Yoon K.-H., Hu F.B. Diabetes in Asia. JAMA 2009, 301:2129-2140.
8. Chew B.H., Ismail M., Lee P.Y., Taher S.W., Haniff J., Mustapha F.I., Bujang M.A. Determinants of uncontrolled dyslipidaemia among adult type 2 diabetes in Malaysia: the Malaysian Diabetes Registry 2009. Diabetes Res. Clin. Pract. 2012, 96:339-347.
9. Chew B.H., Ismail M., Shariff-Ghazali S., Lee P.Y., Cheong A.T., Ahmad Z., Taher S.W., Haniff J., Mustapha F.I., Bujang M.A. Determinants of uncontrolled hypertension in adult type 2 diabetes mellitus: an analysis of the Malaysian diabetes registry 2009. Cardiovasc. Diabetol. 2012, 11:54.
10. Chew B.H., Cheong A.T., Ahmad Z., Ismail M. Men were suffering more complications of diabetes despite similar glycaemic control and better cardiovascular risk profile: the ADCM study 2008. J. Mens Health 2012, 9:190-197.
11. Cigolle C.T., Lee P.G., Langa K.M., Lee Y.Y., Tian Z., Blaum C.S. Geriatric conditions develop in middle-aged adults with diabetes. J. Gen. Intern. Med. 2011, 26:272-279.
12. Cochran J., Conn V.S. Meta-analysis of quality of life outcomes following diabetes self-management training. Diabetes Educ. 2008, 34:815-823.
13. Cooney M.T., Cooney H.C., Dudina A., Graham I.M. Total cardiovascular disease risk assessment: a review. Curr. Opin. Cardiol. 2011, 26:429-437.
14. de Craen A.J., Oleksik A.M., Maier A.B., Westendorp R.G. Causes of health and disease in old age: new insights from the Leiden Research Program on Ageing. Tijdschr. Gerontol. Geriatr. 2009, 40:237-243.
15. Department of Statistics Population Distribution and Basic Demographic Characteristics 2010 2010, Department of Statistics, Malaysia, (http://www.statistics.gov.my/portal/download_Population/files/census2010/Taburan_Penduduk_dan_Ciri-ciri_Asas_Demografi.pdf).
16. Edelman D., Olsen M.K., Dudley T.K., Harris A.C., Oddone E.Z. Quality of care for patients diagnosed with diabetes at screening. Diabetes Care 2003, 26:367-371.
17. Fernando O. Cardiovascular implications of antihyperglycemic therapies for type 2 diabetes. Clin. Ther. 2011, 33:393-407.
18. Franco O.H., Steyerberg E.W., Hu F.B., Mackenbach J., Nusselder W. Associations of diabetes mellitus with total life expectancy and life expectancy with and without cardiovascular disease. Arch. Intern. Med. 2007, 167:1145-1151.
19. George D. Early and intensive therapy for management of hyperglycemia and cardiovascular risk factors in patients with type 2 diabetes. Clin. Ter. 2011, 33:665-678.
20. Girndt M., Seibert E. Premature cardiovascular disease in chronic renal failure (CRF): a model for an advanced ageing process. Exp. Gerontol. 2010, 45:797-800.
21. Health Technology Assessment U. Clinical practice guidelines - management of hypertension. Expert review of cardiovascular therapy 2008, Ministry of Health, Malaysia, Putrajaya.
22. Hsu, P.F., Sung, H.S., Cheng, H.M., Yeh, J.S., Liu,W.L., Chan,W.L., Chen, C.H., Chou, P., Chuang, S.Y., in press. Association of clinical symptomatic hypoglycemia with cardiovascular events and total mortality in type 2 diabetes mellitus: a nationwide population-based study. Diabetes Care (Electronic publication ahead of print).
23. Huang E.S., Shook M., Jin L., Chin M.H., Meltzer D.O. The impact of patient preferences on the cost-effectiveness of intensive glucose control in older patients with new-onset diabetes. Diabetes Care 2006, 29:259-264.
24. Huang E.S., Liu J.Y., Moffet H.H., John P.M., Karter A.J. Glycemic control, complications, and death in older diabetic patients. Diabetes Care 2011, 34:1329-1336.
25. Hubert K., Berthold S., Lutz H., Tim H., Volker L., Jacques K.T.T., Christian W., Werner A.S., Stephan M. Type 2 diabetes phenotype and progression is significantly different if diagnosed before versus after 65years of age. J. Diabetes Sci. Technol. 2008, 2:82-90.
26. Institute for Public Health The Third National Health and Morbidity Survey (NHMS III) 2006, Diabetes 2008, Ministry of Health, Malaysia, Malaysia.
27. Institute for Public Health (IPH) National health morbidity survey 2011 (NHMS 2011). Non-Communicable Diseases 2011, vol.II. (Putrajaya).
28. Inzucchi S.E., Bergenstal R.M., Buse J.B., Diamant M., Ferrannini E., Nauck M., Peters A.L., Tsapas A., Wender R., Matthews D.R., American Diabetes Association (ADA), European Association for the Study of Diabetes (EASD) Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 2012, 35:1364-1379.
29. Ismail M., Chew B.H., Lee P.Y., Cheong A.T., Sazlina S.G., Jamaiyah H., Alwi S.A.R.S., Wahyu T.S., Zaiton A. Control and treatment profiles of 70,889 adult type 2 diabetes mellitus patients in Malaysia. Int. J. Collab. Res. Internal Med. Public Health 2011, 3:98-113.
30. Jaakko T. Impact of age on cardiovascular risk: implications for cardiovascular disease management. Atheroscler. Suppl. 2004, 5:9-17.
31. Janssen I. Influence of age on the relation between waist circumference and cardiometabolic risk markers. Nutr. Metab. Cardiovasc. Dis. 2009, 19:163-169.
32. Joy S.V. Clinical pearls and strategies to optimize patient outcomes. Diabetes Educ. 2008, 34:54S-59S.
33. Katakura M., Naka M., Kondo T., Komatsu M., Yamauchi K., Hashizume K., Aizawa T. Normal mortality in the elderly with diabetes under strict glycemic and blood pressure control: outcome of 6-year prospective study. Diabetes Res. Clin. Pract. 2007, 78:108-114.
34. Kokkinos P., Myers J., Faselis C., Doumas M., Kheirbek R., Nylen E. BMI-mortality paradox and fitness in African American and Caucasian men with type 2 diabetes. Diabetes Care 2012, 35:1021-1027.
35. Lee, P.Y., Cheong, A.T., Zaiton, A., Mastura, I., Chew, B.H., Sazlina, S.G., Adam, B.M., Syed Alwi, S.A.R., Jamaiyah, H., SriWahyu, T., in press. Does ethnicity contribute to the control of cardiovascular risk factors among patients with type 2 diabetes? Asia Pac. J. Public Health (Electronic publication ahead of print).
36. Liu J., Wang W., Wang M., Sun J., Liu J., Li Y., Qi Y., Wu Z., Zhao D. Impact of diabetes, high triglycerides and low HDL cholesterol on risk for ischemic cardiovascular disease varies by LDL cholesterol level: a 15-year follow-up of the Chinese multi-provincial cohort study. Diabetes Res. Clin. Pract. 2012, 96:217-224.
37. Lu K.-Y., Lin P.-L., Tzeng L.-C., Huang K.-Y., Chang L.-C. Effectiveness of case management for community elderly with hypertension, diabetes mellitus, and hypercholesterolemia in Taiwan: a record review. Int. J. Nurs. Stud. 2006, 43:1001-1010.
38. Mazza A., Ramazzina E., Cuppini S., Armigliato M., Schiavon L., Rossetti C., Marzolo M., Santoro G., Ravenni R., Zuin M., Zorzan S., Rubello D., Casiglia E. Antihypertensive treatment in the elderly and very elderly: "always the lower, the better?". Int. J. Hypertens. 2012, 590683.
39. Ministry of Health Malaysia Health Facts 2010 2011, Ministry of Health Malaysia, Putrajaya.
40. Muradian K., Schachtschabel D.O. The role of apoptosis in aging and age-related disease: update. Z. Gerontol. Geriatr. 2001, 34:441-446.
41. Nagrebetsky A., Griffin S., Kinmonth A.L., Sutton S., Craven A., Farmer A. Predictors of suboptimal glycaemic control in type 2 diabetes patients: the role of medication adherence and body mass index in the relationship between glycaemia and age. Diabetes Res. Clin. Pract. 2012, 96:119-128.
42. Nakao Y.M., Teramukai S., Tanaka S., Yasuno S., Fujimoto A., Kasahara M., Ueshima K., Nakao K., Hinotsu S., Nakao K., Kawakami K. Effects of renin-angiotensin system blockades on cardiovascular outcomes in patients with diabetes mellitus: a systematic review and meta-analysis. Diabetes Res. Clin. Pract. 2012, 96:68-75.
43. Navarro A., Boveris A. The mitochondrial energy transduction system and the aging process. Am. J. Cell. Physiol. 2007, 292:C670-C686.
44. Ooi C.P., Loke S.C., Zaiton A., Tengku-Aizan H., Zaitun Y. Cross-sectional study of older adults with type 2 diabetes mellitus in two rural public primary healthcare facilities in Malaysia. Med. J. Malaysia 2011, 66:108-112.
45. Pornet C., Bourdel-Marchasson I., Lecomte P., Eschwege E., Romon I., Fosse S., Assogba F., Roudier C., Fagot-Campagna A., ENTRED Scientific Committee Trends in the quality of care for elderly people with type 2 diabetes: the need for improvements in safety and quality (the 2001 and 2007 ENTRED Surveys). Diabetes Metab. 2011, 37:152-161.
46. Punthakee Z., Miller M.E., Launer L.J., Williamson J.D., Lazar R.M., Cukierman-Yaffee T., Seaquist E.R., Ismail-Beigi F., Sullivan M.D., Lovato L.C., Bergenstal R.M., Gerstein H.C., for the, A.G.o.I.a.t.A.-M.I. Poor cognitive function and risk of severe hypoglycemia in type 2 diabetes. Diabetes Care 2012, 35:787-793.
47. Sheu W.H.H., Ji L.-N., Nitiyanant W., Baik S.H., Yin D., Mavros P., Chan S.-P. Hypoglycemia is associated with increased worry and lower quality of life among patients with type 2 diabetes treated with oral antihyperglycemic agents in the Asia-Pacific region. Diabetes Res. Clin. Pract. 2012, 96:141-148.
48. Sho-ichi Y. Role of Advanced Glycation End Products (AGEs) and Receptor for AGEs (RAGE) in Vascular Damage in Diabetes 2011, 46:217-224.
49. So W.-Y., Raboca J., Sobrepena L., Yoon K.-H., Deerochanawong C., Ho L.-T., Himathongkam T., Tong P., Lyubomirsky G., Ko G., Nan H., Chan J., for the, J.P.R.T. Comprehensive risk assessments of diabetic patients from seven Asian countries: the Joint Asia Diabetes Evaluation (JADE) program. J. Diabetes 2011, 3:109-118.
50. Soe K., Sacerdote A., Karam J., Bahtiyar G. Management of type 2 diabetes mellitus in the elderly. Maturitas 2011, 70:151-159.
51. Terry D.F., Evans J.C., Pencina M.J., Murabito J.M., Vasan R.S., Wolf P.A., Kelly-Hayes M., Levy D., D'Agostino R.B., Benjamin E.J. Characteristics of Framingham offspring participants with long-lived parents. Arch. Intern. Med. 2007, 167:438-444.
52. Turin T.C., Murakami Y., Miura K., Rumana N., Kadota A., Ohkubo T., Okamura T., Okayama A., Ueshima H. Diabetes and life expectancy among Japanese-NIPPON DATA80. Diabetes Res. Clin. Pract. 2012, 96:18-22.
53. Watkins K.W., Connell C.M., Fitzgerald J.T., Klem L., Hickey T., Ingersoll-Dayton B. Effect of adults' self-regulation of diabetes on quality-of-life outcomes. Diabetes Care 2000, 23:1511-1515.
54. Wexler D., Grant R., Wittenberg E., Bosch J., Cagliero E., Delahanty L., Blais M., Meigs J. Correlates of health-related quality of life in type 2 diabetes. Diabetologia 2006, 49:1489-1497.
55. Zoungas S., Patel A., Chalmers J., de Galan B.E., Li Q., Billot L., Woodward M., Ninomiya T., Neal B., MacMahon S., Grobbee D.E., Kengne A.P., Marre M., Heller S. Severe hypoglycemia and risks of vascular events and death. N Engl J Med 2010, 363:1410-1418. ADVANCE Collaborative Group.