Simvastatin downregulates HER2 via upregulation of PEA3 to induce cell death in HER2-positive breast cancer cells

Oncology Research

Volumn 20, Issue 5-6, 2013, Pages 187-195

  Zhao, Zhen ^a   Cao, Xiangming ^a   Pan, Yukai ^a   Sha, Sha ^a   Zhao, Tao ^a   Zhang, Tingrong ^a  

^a JIANGYIN PEOPLE S HOSPITAL   (China)

Author keywords

Breast cancer cells; Cell death; HER2; PEA3; Simvastatin

Indexed keywords

ARGINASE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; MEVALONIC ACID; SIMVASTATIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR PEA3;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; GENE OVEREXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN STABILITY; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION;

EID: 84875635820     PISSN: 09650407     EISSN: 15553906     Source Type: Journal    
DOI: 10.3727/096504013X13589503482699     Document Type: Article

References (29)

1. Shimada, T.; Takeshita, Y.; Murohara, T.; Sasaki, K.; Egami, K.; Shintani, S.; Katsuda, Y.; Ikeda, H.; Nabeshima, Y.; Imaizumi, T. Angiogenesis and vasculogenesis are impaired in the precocious-aging klotho mouse. Circulation 110: 1148-1155; 2004.
2. Seeger, H.; Wallwiener, D.; Mueck, A. O. Statins can inhibit proliferation of human breast cancer cells in vitro. Exp. Clin. Endocrinol. Diabetes 111: 47-48; 2003.
3. Mandal, C. C.; Ghosh-Choudhury, N.; Yoneda, T.; Choudhury, G. G. Simvastatin prevents skeletal metastasis of breast cancer by an antagonistic interplay between p53 and CD44. J. Biol. Chem. 286: 11314-11327; 2011.
4. Hwang, K. E.; Na, K. S.; Park, D. S.; Choi, K. H.; Kim, B. R.; Shim, H.; Jeong, E. T.; Kim, H. R. Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin. Invest. New Drugs 29: 945-952; 2011.
5. Hussain, B.; Saleh, G. M.; Sivaprasad, S.; Hammond, C. J. Changing from Snellen to LogMAR: Debate or delay? Clin. Exp. Ophthalmol. 34: 6-8; 2006.
6. Campbell, M. J.; Esserman, L. J.; Zhou, Y.; Shoemaker, M.; Lobo, M.; Borman, E.; Baehner, F.; Kumar, A. S.; Adduci, K.; Marx, C.; Petricoin, E. F.; Liotta, L. A.; Winters, M.; Benz, S.; Benz, C. C. Breast cancer growth prevention by statins. Cancer Res. 66: 8707-8714; 2006.
7. Aberg, M.; Wickstrom, M.; Siegbahn, A. Simvastatin induces apoptosis in human breast cancer cells in a NFkappaB-dependent manner and abolishes the anti-apoptotic signaling of TF/FVIIa and TF/FVIIa/FXa. Thromb. Res. 122: 191-202; 2008.
8. Kotamraju, S.; Williams, C. L.; Kalyanaraman, B. Statin-induced breast cancer cell death: Role of inducible nitric oxide and arginase-dependent pathways. Cancer Res. 67: 7386-7394; 2007.
9. Nahta, R.; Esteva, F. J. Herceptin: Mechanisms of action and resistance. Cancer Lett. 232: 123-138; 2006.
10. Sieuwerts, A. M.; Mostert, B.; Bolt-de Vries, J.; Peeters, D.; de Jongh, F. E.; Stouthard, J. M.; Dirix, L. Y.; van Dam, P. A.; Van Galen, A.; de Weerd, V.; Kraan, J.; van der Spoel, P.; Ramirez-Moreno, R.; van Deurzen, C. H.; Smid, M.; Yu, J. X.; Jiang, J.; Wang, Y.; Gratama, J. W.; Sleijfer, S.; Foekens, J. A.; Martens, J. W. mRNA and microRNA expression profiles in circulating tumor cells and primary tumors of metastatic breast cancer patients. Clin. Cancer Res. 17: 3600-3618; 2011.
11. Brown, M. S.; Goldstein, J. L. Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth. J. Lipid Res. 21: 505-517; 1980.
12. Konstantinopoulos, P. A.; Karamouzis, M. V.; Papavassil-iou, A. G. Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets. Nat. Rev. Drug Discov. 6: 541-555; 2007.
13. von Tresckow, B.; von Strandmann, E. P.; Sasse, S.; Tawadros, S.; Engert, A.; Hansen, H. P. Simvastatin-dependent apoptosis in Hodgkin's lymphoma cells and growth impairment of human Hodgkin's tumors in vivo. Haematologica 92: 682-685; 2007.
14. Xin, J. H.; Cowie, A.; Lachance, P.; Hassell, J. A. Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells. Genes Dev. 6: 481-496; 1992.
15. Xing, X.; Wang, S. C.; Xia, W.; Zou, Y.; Shao, R.; Kwong, K. Y.; Yu, Z.; Zhang, S.; Miller, S.; Huang, L.; Hung, M. C. The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis. Nat. Med. 6: 189-195; 2000.
16. Wang, S. C.; Hung, M. C. Transcriptional targeting of the HER-2/neu oncogene. Drugs Today (Barc). 36: 835-843; 2000.
17. Sumi, S.; Beauchamp, R. D.; Townsend, Jr., C. M.; Uchida, T.; Murakami, M.; Rajaraman, S.; Ishizuka, J.; Thompson, J. C. Inhibition of pancreatic adenocarcinoma cell growth by lovastatin. Gastroenterology 103: 982-989; 1992.
18. Liao, J. K. Isoprenoids as mediators of the biological effects of statins. J. Clin. Invest. 110: 285-288; 2002.
19. Lichtenstein, A.; Berenson, J.; Gera, J. F.; Waldburger, K.; Martinez-Maza, O.; Berek, J. S. Resistance of human ovarian cancer cells to tumor necrosis factor and lympho-kine-activated killer cells: Correlation with expression of HER2/neu oncogenes. Cancer Res. 50: 7364-7370; 1990.
20. Amodio, R.; Zarcone, M.; Cusimano, R.; Campisi, I.; Dolcemascolo, C.; Traina, A.; Agostara, B.; Romano, N. Target therapy in HER2-overexpressing breast cancer patients. OMICS 15: 363-367; 2011.
21. Yu, D.; Wolf, J. K.; Scanlon, M.; Price, J. E.; Hung, M. C. Enhanced c-erbB-2/neu expression in human ovarian cancer cells correlates with more severe malignancy that can be suppressed by E1A. Cancer Res. 53: 891-898; 1993.
22. Yu, D.; Wang, S. S.; Dulski, K. M.; Tsai, C. M.; Nicolson, G. L.; Hung, M. C. c-erbB-2/neu overexpression enhances metastatic potential of human lung cancer cells by induction of metastasis-associated properties. Cancer Res. 54: 3260-3266; 1994.
23. Tsai, C. M.; Yu, D.; Chang, K. T.; Wu, L. H.; Perng, R. P.; Ibrahim, N. K.; Hung, M. C. Enhanced chemoresis-tance by elevation of p185neu levels in HER-2/neu-trans-fected human lung cancer cells. J. Natl. Cancer Inst. 87: 682-684; 1995.
24. Goldstein, J. L.; Brown, M. S. Regulation of the mevalo-nate pathway. Nature 343: 425-430; 1990.
25. Pruitt, K.; Der, C. J. Ras and Rho regulation of the cell cycle and oncogenesis. Cancer Lett. 171: 1-10; 2001.
26. Seabra, M. C.; Mules, E. H.; Hume, A. N. Rab GTPases, intracellular traffic and disease. Trends Mol. Med. 8: 23-30; 2002.
27. Benz, C. C.; O'Hagan, R. C.; Richter, B.; Scott, G. K.; Chang, C. H.; Xiong, X.; Chew, K.; Ljung, B. M.; Edgerton, S.; Thor, A.; Hassell, J. A. HER2/Neu and the Ets transcription activator PEA3 are coordinately upregulated in human breast cancer. Oncogene 15: 1513-1525; 1997.
28. Baert, J. L.; Monte, D.; Musgrove, E. A.; Albagli, O.; Sutherland, R. L.; de Launoit, Y. Expression of the PEA3 group of ETS-related transcription factors in human breast-cancer cells. Int. J. Cancer 70: 590-597; 1997.
29. Baker, R.; Kent, C. V.; Silbermann, R. A.; Hassell, J. A.; Young, L. J.; Howe, L. R. Pea3 transcription factors and wnt1-induced mouse mammary neoplasia. PLoS One 5: e8854; 2010.