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Volumn 24, Issue 6, 2013, Pages 573-585

Dynamin 2 Potentiates Invasive Migration of Pancreatic Tumor Cells through Stabilization of the Rac1 GEF Vav1

Author keywords

[No Author keywords available]

Indexed keywords

DYNAMIN II; GUANINE NUCLEOTIDE EXCHANGE FACTOR; HEAT SHOCK COGNATE PROTEIN 70; PROTEIN SH3; PROTEIN VAV1; RAC1 PROTEIN; UNCLASSIFIED DRUG;

EID: 84875629080     PISSN: 15345807     EISSN: 18781551     Source Type: Journal    
DOI: 10.1016/j.devcel.2013.02.010     Document Type: Article
Times cited : (68)

References (52)
  • 3
    • 31544478789 scopus 로고    scopus 로고
    • Activation of Vav/Rho GTPase signaling by CXCL12 controls membrane-type matrix metalloproteinase-dependent melanoma cell invasion
    • Bartolomé R.A., Molina-Ortiz I., Samaniego R., Sánchez-Mateos P., Bustelo X.R., Teixidó J. Activation of Vav/Rho GTPase signaling by CXCL12 controls membrane-type matrix metalloproteinase-dependent melanoma cell invasion. Cancer Res. 2006, 66:248-258.
    • (2006) Cancer Res. , vol.66 , pp. 248-258
    • Bartolomé, R.A.1    Molina-Ortiz, I.2    Samaniego, R.3    Sánchez-Mateos, P.4    Bustelo, X.R.5    Teixidó, J.6
  • 4
    • 0035473464 scopus 로고    scopus 로고
    • Vav proteins, adaptors and cell signaling
    • Bustelo X.R. Vav proteins, adaptors and cell signaling. Oncogene 2001, 20:6372-6381.
    • (2001) Oncogene , vol.20 , pp. 6372-6381
    • Bustelo, X.R.1
  • 5
    • 0030713407 scopus 로고    scopus 로고
    • Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation
    • Bustelo X.R., Crespo P., López-Barahona M., Gutkind J.S., Barbacid M. Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation. Oncogene 1997, 15:2511-2520.
    • (1997) Oncogene , vol.15 , pp. 2511-2520
    • Bustelo, X.R.1    Crespo, P.2    López-Barahona, M.3    Gutkind, J.S.4    Barbacid, M.5
  • 6
    • 0034640526 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation
    • De Sepulveda P., Ilangumaran S., Rottapel R. Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation. J. Biol. Chem. 2000, 275:14005-14008.
    • (2000) J. Biol. Chem. , vol.275 , pp. 14005-14008
    • De Sepulveda, P.1    Ilangumaran, S.2    Rottapel, R.3
  • 7
    • 0037220769 scopus 로고    scopus 로고
    • Guanine exchange-dependent and -independent effects of Vav1 on integrin-induced T cell spreading
    • del Pozo M.A., Schwartz M.A., Hu J., Kiosses W.B., Altman A., Villalba M. Guanine exchange-dependent and -independent effects of Vav1 on integrin-induced T cell spreading. J. Immunol. 2003, 170:41-47.
    • (2003) J. Immunol. , vol.170 , pp. 41-47
    • del Pozo, M.A.1    Schwartz, M.A.2    Hu, J.3    Kiosses, W.B.4    Altman, A.5    Villalba, M.6
  • 9
    • 84858004951 scopus 로고    scopus 로고
    • Increased expression of the large GTPase dynamin 2 potentiates metastatic migration and invasion of pancreatic ductal carcinoma
    • Eppinga R.D., Krueger E.W., Weller S.G., Zhang L., Cao H., McNiven M.A. Increased expression of the large GTPase dynamin 2 potentiates metastatic migration and invasion of pancreatic ductal carcinoma. Oncogene 2012, 31:1228-1241.
    • (2012) Oncogene , vol.31 , pp. 1228-1241
    • Eppinga, R.D.1    Krueger, E.W.2    Weller, S.G.3    Zhang, L.4    Cao, H.5    McNiven, M.A.6
  • 10
    • 20444370219 scopus 로고    scopus 로고
    • Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase
    • Ezratty E.J., Partridge M.A., Gundersen G.G. Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase. Nat. Cell Biol. 2005, 7:581-590.
    • (2005) Nat. Cell Biol. , vol.7 , pp. 581-590
    • Ezratty, E.J.1    Partridge, M.A.2    Gundersen, G.G.3
  • 15
    • 0034526495 scopus 로고    scopus 로고
    • Dynamin and its role in membrane fission
    • Hinshaw J.E. Dynamin and its role in membrane fission. Annu. Rev. Cell Dev. Biol. 2000, 16:483-519.
    • (2000) Annu. Rev. Cell Dev. Biol. , vol.16 , pp. 483-519
    • Hinshaw, J.E.1
  • 16
    • 0034708085 scopus 로고    scopus 로고
    • Caspase-dependent cleavage and inactivation of the Vav1 proto-oncogene product during apoptosis prevents IL-2 transcription
    • Hofmann T.G., Hehner S.P., Dröge W., Schmitz M.L. Caspase-dependent cleavage and inactivation of the Vav1 proto-oncogene product during apoptosis prevents IL-2 transcription. Oncogene 2000, 19:1153-1163.
    • (2000) Oncogene , vol.19 , pp. 1153-1163
    • Hofmann, T.G.1    Hehner, S.P.2    Dröge, W.3    Schmitz, M.L.4
  • 17
    • 0344406838 scopus 로고    scopus 로고
    • The haematopoietic specific signal transducer Vav1 is expressed in a subset of human neuroblastomas
    • Hornstein I., Pikarsky E., Groysman M., Amir G., Peylan-Ramu N., Katzav S. The haematopoietic specific signal transducer Vav1 is expressed in a subset of human neuroblastomas. J. Pathol. 2003, 199:526-533.
    • (2003) J. Pathol. , vol.199 , pp. 526-533
    • Hornstein, I.1    Pikarsky, E.2    Groysman, M.3    Amir, G.4    Peylan-Ramu, N.5    Katzav, S.6
  • 19
    • 0032559342 scopus 로고    scopus 로고
    • Role of dynamin in the formation of transport vesicles from the trans-Golgi network
    • Jones S.M., Howell K.E., Henley J.R., Cao H., McNiven M.A. Role of dynamin in the formation of transport vesicles from the trans-Golgi network. Science 1998, 279:573-577.
    • (1998) Science , vol.279 , pp. 573-577
    • Jones, S.M.1    Howell, K.E.2    Henley, J.R.3    Cao, H.4    McNiven, M.A.5
  • 20
    • 60349115007 scopus 로고    scopus 로고
    • Vav1: a hematopoietic signal transduction molecule involved in human malignancies
    • Katzav S. Vav1: a hematopoietic signal transduction molecule involved in human malignancies. Int. J. Biochem. Cell Biol. 2009, 41:1245-1248.
    • (2009) Int. J. Biochem. Cell Biol. , vol.41 , pp. 1245-1248
    • Katzav, S.1
  • 21
    • 0024433697 scopus 로고
    • Vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells
    • Katzav S., Martin-Zanca D., Barbacid M. vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. EMBO J. 1989, 8:2283-2290.
    • (1989) EMBO J. , vol.8 , pp. 2283-2290
    • Katzav, S.1    Martin-Zanca, D.2    Barbacid, M.3
  • 22
    • 84864318195 scopus 로고    scopus 로고
    • Chaperone-mediated autophagy: a unique way to enter the lysosome world
    • Kaushik S., Cuervo A.M. Chaperone-mediated autophagy: a unique way to enter the lysosome world. Trends Cell Biol. 2012, 22:407-417.
    • (2012) Trends Cell Biol. , vol.22 , pp. 407-417
    • Kaushik, S.1    Cuervo, A.M.2
  • 25
    • 33744508200 scopus 로고    scopus 로고
    • Dynamin as a mover and pincher during cell migration and invasion
    • Kruchten A.E., McNiven M.A. Dynamin as a mover and pincher during cell migration and invasion. J. Cell Sci. 2006, 119:1683-1690.
    • (2006) J. Cell Sci. , vol.119 , pp. 1683-1690
    • Kruchten, A.E.1    McNiven, M.A.2
  • 26
    • 68849084686 scopus 로고    scopus 로고
    • The haematopoietic specific signal transducer Vav1 is aberrantly expressed in lung cancer and plays a role in tumourigenesis
    • Lazer G., Idelchuk Y., Schapira V., Pikarsky E., Katzav S. The haematopoietic specific signal transducer Vav1 is aberrantly expressed in lung cancer and plays a role in tumourigenesis. J. Pathol. 2009, 219:25-34.
    • (2009) J. Pathol. , vol.219 , pp. 25-34
    • Lazer, G.1    Idelchuk, Y.2    Schapira, V.3    Pikarsky, E.4    Katzav, S.5
  • 27
    • 77954934945 scopus 로고    scopus 로고
    • Tyrosine residues at the carboxyl terminus of Vav1 play an important role in regulation of its biological activity
    • Lazer G., Pe'er L., Farago M., Machida K., Mayer B.J., Katzav S. Tyrosine residues at the carboxyl terminus of Vav1 play an important role in regulation of its biological activity. J. Biol. Chem. 2010, 285:23075-23085.
    • (2010) J. Biol. Chem. , vol.285 , pp. 23075-23085
    • Lazer, G.1    Pe'er, L.2    Farago, M.3    Machida, K.4    Mayer, B.J.5    Katzav, S.6
  • 28
    • 0037894847 scopus 로고    scopus 로고
    • Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav
    • López-Lago M., Lee H., Cruz C., Movilla N., Bustelo X.R. Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav. Mol. Cell. Biol. 2000, 20:1678-1691.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 1678-1691
    • López-Lago, M.1    Lee, H.2    Cruz, C.3    Movilla, N.4    Bustelo, X.R.5
  • 29
    • 79952328610 scopus 로고    scopus 로고
    • Nestin is a novel target for suppressing pancreatic cancer cell migration, invasion and metastasis
    • Matsuda Y., Naito Z., Kawahara K., Nakazawa N., Korc M., Ishiwata T. Nestin is a novel target for suppressing pancreatic cancer cell migration, invasion and metastasis. Cancer Biol. Ther. 2011, 11:512-523.
    • (2011) Cancer Biol. Ther. , vol.11 , pp. 512-523
    • Matsuda, Y.1    Naito, Z.2    Kawahara, K.3    Nakazawa, N.4    Korc, M.5    Ishiwata, T.6
  • 30
    • 0034161330 scopus 로고    scopus 로고
    • The dynamin family of mechanoenzymes: pinching in new places
    • McNiven M.A., Cao H., Pitts K.R., Yoon Y. The dynamin family of mechanoenzymes: pinching in new places. Trends Biochem. Sci. 2000, 25:115-120.
    • (2000) Trends Biochem. Sci. , vol.25 , pp. 115-120
    • McNiven, M.A.1    Cao, H.2    Pitts, K.R.3    Yoon, Y.4
  • 31
    • 0034597062 scopus 로고    scopus 로고
    • Regulated interactions between dynamin and the actin-binding protein cortactin modulate cell shape
    • McNiven M.A., Kim L., Krueger E.W., Orth J.D., Cao H., Wong T.W. Regulated interactions between dynamin and the actin-binding protein cortactin modulate cell shape. J. Cell Biol. 2000, 151:187-198.
    • (2000) J. Cell Biol. , vol.151 , pp. 187-198
    • McNiven, M.A.1    Kim, L.2    Krueger, E.W.3    Orth, J.D.4    Cao, H.5    Wong, T.W.6
  • 32
    • 0032481142 scopus 로고    scopus 로고
    • Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1
    • Miranti C.K., Leng L., Maschberger P., Brugge J.S., Shattil S.J. Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1. Curr. Biol. 1998, 8:1289-1299.
    • (1998) Curr. Biol. , vol.8 , pp. 1289-1299
    • Miranti, C.K.1    Leng, L.2    Maschberger, P.3    Brugge, J.S.4    Shattil, S.J.5
  • 34
    • 0030945262 scopus 로고    scopus 로고
    • Thrombopoietin and thrombin induce tyrosine phosphorylation of Vav in human blood platelets
    • Miyakawa Y., Oda A., Druker B.J., Ozaki K., Handa M., Ohashi H., Ikeda Y. Thrombopoietin and thrombin induce tyrosine phosphorylation of Vav in human blood platelets. Blood 1997, 89:2789-2798.
    • (1997) Blood , vol.89 , pp. 2789-2798
    • Miyakawa, Y.1    Oda, A.2    Druker, B.J.3    Ozaki, K.4    Handa, M.5    Ohashi, H.6    Ikeda, Y.7
  • 35
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • Mizushima N., Levine B., Cuervo A.M., Klionsky D.J. Autophagy fights disease through cellular self-digestion. Nature 2008, 451:1069-1075.
    • (2008) Nature , vol.451 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 36
  • 37
    • 55049125773 scopus 로고    scopus 로고
    • The ubiquitin-proteasome pathway mediates gelsolin protein downregulation in pancreatic cancer
    • Ni X.G., Zhou L., Wang G.Q., Liu S.M., Bai X.F., Liu F., Peppelenbosch M.P., Zhao P. The ubiquitin-proteasome pathway mediates gelsolin protein downregulation in pancreatic cancer. Mol. Med. 2008, 14:582-589.
    • (2008) Mol. Med. , vol.14 , pp. 582-589
    • Ni, X.G.1    Zhou, L.2    Wang, G.Q.3    Liu, S.M.4    Bai, X.F.5    Liu, F.6    Peppelenbosch, M.P.7    Zhao, P.8
  • 39
    • 48749086577 scopus 로고    scopus 로고
    • Targeted cleavage of signaling proteins by caspase 3 inhibits T cell receptor signaling in anergic T cells
    • Puga I., Rao A., Macian F. Targeted cleavage of signaling proteins by caspase 3 inhibits T cell receptor signaling in anergic T cells. Immunity 2008, 29:193-204.
    • (2008) Immunity , vol.29 , pp. 193-204
    • Puga, I.1    Rao, A.2    Macian, F.3
  • 40
    • 79959677602 scopus 로고    scopus 로고
    • Life at the leading edge
    • Ridley A.J. Life at the leading edge. Cell 2011, 145:1012-1022.
    • (2011) Cell , vol.145 , pp. 1012-1022
    • Ridley, A.J.1
  • 42
    • 3142707203 scopus 로고    scopus 로고
    • Regulating actin dynamics at membranes: a focus on dynamin
    • Schafer D.A. Regulating actin dynamics at membranes: a focus on dynamin. Traffic 2004, 5:463-469.
    • (2004) Traffic , vol.5 , pp. 463-469
    • Schafer, D.A.1
  • 44
    • 77956880594 scopus 로고    scopus 로고
    • A Dyn2-CIN85 complex mediates degradative traffic of the EGFR by regulation of late endosomal budding
    • Schroeder B., Weller S.G., Chen J., Billadeau D., McNiven M.A. A Dyn2-CIN85 complex mediates degradative traffic of the EGFR by regulation of late endosomal budding. EMBO J. 2010, 29:3039-3053.
    • (2010) EMBO J. , vol.29 , pp. 3039-3053
    • Schroeder, B.1    Weller, S.G.2    Chen, J.3    Billadeau, D.4    McNiven, M.A.5
  • 45
    • 35648962884 scopus 로고    scopus 로고
    • CD44 regulates hepatocyte growth factor-mediated vascular integrity. Role of c-Met, Tiam1/Rac1, dynamin 2, and cortactin
    • Singleton P.A., Salgia R., Moreno-Vinasco L., Moitra J., Sammani S., Mirzapoiazova T., Garcia J.G. CD44 regulates hepatocyte growth factor-mediated vascular integrity. Role of c-Met, Tiam1/Rac1, dynamin 2, and cortactin. J. Biol. Chem. 2007, 282:30643-30657.
    • (2007) J. Biol. Chem. , vol.282 , pp. 30643-30657
    • Singleton, P.A.1    Salgia, R.2    Moreno-Vinasco, L.3    Moitra, J.4    Sammani, S.5    Mirzapoiazova, T.6    Garcia, J.G.7
  • 46
    • 0036631548 scopus 로고    scopus 로고
    • VAV proteins as signal integrators for multi-subunit immune-recognition receptors
    • Turner M., Billadeau D.D. VAV proteins as signal integrators for multi-subunit immune-recognition receptors. Nat. Rev. Immunol. 2002, 2:476-486.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 476-486
    • Turner, M.1    Billadeau, D.D.2
  • 47
    • 18844449626 scopus 로고    scopus 로고
    • Vav-family proteins in T-cell signalling
    • Tybulewicz V.L. Vav-family proteins in T-cell signalling. Curr. Opin. Immunol. 2005, 17:267-274.
    • (2005) Curr. Opin. Immunol. , vol.17 , pp. 267-274
    • Tybulewicz, V.L.1
  • 49
    • 79955520123 scopus 로고    scopus 로고
    • A direct interaction between the large GTPase dynamin-2 and FAK regulates focal adhesion dynamics in response to active Src
    • Wang Y., Cao H., Chen J., McNiven M.A. A direct interaction between the large GTPase dynamin-2 and FAK regulates focal adhesion dynamics in response to active Src. Mol. Biol. Cell 2011, 22:1529-1538.
    • (2011) Mol. Biol. Cell , vol.22 , pp. 1529-1538
    • Wang, Y.1    Cao, H.2    Chen, J.3    McNiven, M.A.4
  • 50
    • 34547937489 scopus 로고    scopus 로고
    • Eps8 is increased in pancreatic cancer and required for dynamic actin-based cell protrusions and intercellular cytoskeletal organization
    • Welsch T., Endlich K., Giese T., Büchler M.W., Schmidt J. Eps8 is increased in pancreatic cancer and required for dynamic actin-based cell protrusions and intercellular cytoskeletal organization. Cancer Lett. 2007, 255:205-218.
    • (2007) Cancer Lett. , vol.255 , pp. 205-218
    • Welsch, T.1    Endlich, K.2    Giese, T.3    Büchler, M.W.4    Schmidt, J.5


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