Polymorphisms of the Interleukin 6 gene contribute to cervical cancer susceptibility in Eastern Chinese women

Human Genetics

Volumn 132, Issue 3, 2013, Pages 301-312

  Shi, Ting Yan ^a,b   Zhu, Mei Ling ^a,b   He, Jing ^a,b   Wang, Meng Yun ^a,b   Li, Qiao Xin ^a,b   Zhou, Xiao Yan ^a,b   Sun, Meng Hong ^a,b   Shao, Zhi Ming ^a,b   Yu, Ke Da ^a,b   Cheng, Xi ^a,b   Wu, Xiaohua ^a,b   Wei, Qingyi ^a,c  

^a FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

^b FUDAN UNIVERSITY   (China)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; IL6 PROTEIN, HUMAN;

ADULT; ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; CHINESE; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; MENOPAUSE; MULTIFACTOR DIMENSIONALITY REDUCTION; PAPILLOMAVIRUS INFECTION; PRIMIPARA; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; UTERINE CERVIX CANCER; AGE; AGED; ASIAN; CANCER STAGING; CARCINOMA; CASE CONTROL STUDY; CHINA; COMPUTER SIMULATION; EPIDEMIOLOGY; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; MIDDLE AGED; PARITY; PATHOLOGY; RISK FACTOR; STATISTICAL MODEL; STATISTICS; UTERINE CERVIX TUMOR;

HUMAN PAPILLOMAVIRUS;

ADULT; AGE FACTORS; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CARCINOMA; CASE-CONTROL STUDIES; CHINA; COMPUTER SIMULATION; CONFOUNDING FACTORS (EPIDEMIOLOGY); FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTERLEUKIN-6; LOGISTIC MODELS; MENOPAUSE; MIDDLE AGED; NEOPLASM STAGING; PARITY; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; UTERINE CERVICAL NEOPLASMS;

MLCS; MLOWN;

EID: 84875604023     PISSN: 03406717     EISSN: 14321203     Source Type: Journal    
DOI: 10.1007/s00439-012-1245-4     Document Type: Article

References (35)

1. Abdelwahab SI, Abdul AB, Zain ZN, Hadi AH (2012) Zerumbone inhibits interleukin-6 and induces apoptosis and cell cycle arrest in ovarian and cervical cancer cells. Int Immunopharmacol 12:594-602
2. Bedoya AM, Jaramillo R, Baena A, Castano J, Olaya N, Zea AH, Herrero R, Sanchez GI (2012) Location and density of immune cells in precursor lesions and cervical cancer. Cancer Microenviron. doi: 10.1007/s12307-012-0097-8
3. Castro FA, Haimila K, Sareneva I, Schmitt M, Lorenzo J, Kunkel N, Kumar R, Forsti A, Kjellberg L, Hallmans G, Lehtinen M, Hemminki K, Pawlita M (2009) Association of HLA-DRB1, interleukin-6 and cyclin D1 polymorphisms with cervical cancer in the Swedish population-a candidate gene approach. Int J Cancer 125:1851-1858
4. Chen M, Kamat AM, Huang M, Grossman HB, Dinney CP, Lerner SP, Wu X, Gu J (2007) High-order interactions among genetic polymorphisms in nucleotide excision repair pathway genes and smoking in modulating bladder cancer risk. Carcinogenesis 28:2160-2165
5. Cheng X, Yang G, Schmeler KM, Coleman RL, Tu X, Liu J, Kavanagh JJ (2011) Recurrence patterns and prognosis of endometrial stromal sarcoma and the potential of tyrosine kinase-inhibiting therapy. Gynecol Oncol 121:323-327
6. Combarros O, van Duijn CM, Hammond N, Belbin O, Arias-Vasquez A, Cortina-Borja M, Lehmann MG, Aulchenko YS, Schuur M, Kolsch H, Heun R, Wilcock GK, Brown K, Kehoe PG, Harrison R, Coto E, Alvarez V, Deloukas P, Mateo I, Gwilliam R, Morgan K, Warden DR, Smith AD, Lehmann DJ (2009) Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease. J Neuroinflamm 6:22
7. Galvan A, Ioannidis JP, Dragani TA (2010) Beyond genome-wide association studies: genetic heterogeneity and individual predisposition to cancer. Trends Genet 26:132-141
8. Gangwar R, Mittal B, Mittal RD (2009) Association of interleukin-6 -174G>C promoter polymorphism with risk of cervical cancer. Int J Biol Markers 24:11-16
9. Gruol DL, Nelson TE (1997) Physiological and pathological roles of interleukin-6 in the central nervous system. Mol Neurobiol 15:307-339
10. Guan P, Howell-Jones R, Li N, Bruni L, de Sanjose S, Franceschi S, Clifford GM (2012) Human papillomavirus types in 115,789 HPV-positive women: a meta-analysis from cervical infection to cancer. Int J Cancer 131:2349-2359
11. He BZ, Holloway AK, Maerkl SJ, Kreitman M (2011) Does positive selection drive transcription factor binding site turnover? A test with Drosophila cis-regulatory modules. PLoS Genet 7:e1002053
12. He J, Qiu LX, Wang MY, Hua RX, Zhang RX, Yu HP, Wang YN, Sun MH, Zhou XY, Yang YJ, Wang JC, Jin L, Wei QY, Li J (2012) Polymorphisms in the XPG gene and risk of gastric cancer in Chinese populations. Hum Genet 131:1235-1244
13. International Collaboration of Epidemiological Studies of Cervical Cancer (2007) Comparison of risk factors for invasive squamous cell carcinoma and adenocarcinoma of the cervix: collaborative reanalysis of individual data on 8,097 women with squamous cell carcinoma and 1,374 women with adenocarcinoma from 12 epidemiological studies. Int J Cancer 120:885-891
14. Iyori M, Zhang T, Pantel H, Gagne BA, Sentman CL (2011) TRAIL/DR5 plays a critical role in NK cell-mediated negative regulation of dendritic cell cross-priming of T cells. J Immunol 187:3087-3095
15. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61:69-90
16. Kishimoto T, Akira S, Narazaki M, Taga T (1995) Interleukin-6 family of cytokines and gp130. Blood 86:1243-1254
17. Kwon EM, Salinas CA, Kolb S, Fu R, Feng Z, Stanford JL, Ostrander EA (2011) Genetic polymorphisms in inflammation pathway genes and prostate cancer risk. Cancer Epidemiol Biomarkers Prev 20:923-933
18. Lim WY, Chen Y, Ali SM, Chuah KL, Eng P, Leong SS, Lim E, Lim TK, Ng AW, Poh WT, Tee A, Teh M, Salim A, Seow A (2011) Polymorphisms in inflammatory pathway genes, host factors and lung cancer risk in Chinese female never-smokers. Carcinogenesis 32:522-529
19. Macintyre DA, Sykes L, Teoh TG, Bennett PR (2012) Prevention of preterm labour via the modulation of inflammatory pathways. J Matern Fetal Neonatal Med. doi: 10.3109/14767058.2012.666114
20. MacQuarrie KL, Fong AP, Morse RH, Tapscott SJ (2011) Genome-wide transcription factor binding: beyond direct target regulation. Trends Genet 27:141-148
21. Nogueira de Souza NC, Brenna SM, Campos F, Syrjanen KJ, Baracat EC, Silva ID (2006) Interleukin-6 polymorphisms and the risk of cervical cancer. Int J Gynecol Cancer 16:1278-1282
22. Pecorelli S (2009) Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet 2:103-104
23. Ritchie MD, Hahn LW, Roodi N, Bailey LR, Dupont WD, Parl FF, Moore JH (2001) Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. Am J Hum Genet 69:138-147
24. Sepkovic DW, Bradlow HL, Ho G, Hankinson SE, Gong L, Osborne MP, Fishman J (1995) Estrogen metabolite ratios and risk assessment of hormone-related cancers. Assay validation and prediction of cervical cancer risk. Ann NY Acad Sci 768:312-316
25. Therneau TM, Atkinson EJ, Foundation M (1997) An introduction to recursive partitioning using the RPART routines. In: Technical Report 61. Mayo Foundation, Rochester, Minnesota. Available at http://www.mayo.edu/hsr/techrpt/ 61.pdf
26. Tjiong MY, van der Vange N, ten Kate FJ, Tjong AHSP, ter Schegget J, Burger MP, Out TA (1999) Increased IL-6 and IL-8 levels in cervicovaginal secretions of patients with cervical cancer. Gynecol Oncol 73:285-291
27. Vazquez-Ortiz G, Ciudad CJ, Pina P, Vazquez K, Hidalgo A, Alatorre B, Garcia JA, Salamanca F, Peralta-Rodriguez R, Rangel A, Salcedo M (2005) Gene identification by cDNA arrays in HPV-positive cervical cancer. Arch Med Res 36:448-458
28. Veerapaneni P, Kirma N, Nair HB, Hammes LS, Hall KL, Tekmal RR (2009) Elevated aromatase expression correlates with cervical carcinoma progression. Gynecol Oncol 114:496-500
29. Verhoog NJ, Du Toit A, Avenant C, Hapgood JP (2011) Glucocorticoid- independent repression of tumor necrosis factor (TNF) alpha-stimulated interleukin (IL)-6 expression by the glucocorticoid receptor: a potential mechanism for protection against an excessive inflammatory response. J Biol Chem 286:19297-19310
30. Wacholder S, Chanock S, Garcia-Closas M, El Ghormli L, Rothman N (2004) Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. J Natl Cancer Inst 96:434-442
31. Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, Snijders PJ, Peto J, Meijer CJ, Munoz N (1999) Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 189:12-19
32. Wang X, Lu M, Qian J, Yang Y, Li S, Lu D, Yu S, Meng W, Ye W, Jin L (2009) Rationales, design and recruitment of the Taizhou Longitudinal Study. BMC Public Health 9:223
33. Wei LH, Kuo ML, Chen CA, Cheng WF, Cheng SP, Hsieh FJ, Hsieh CY (2001) Interleukin-6 in cervical cancer: the relationship with vascular endothelial growth factor. Gynecol Oncol 82:49-56
34. WHO (2010) World Health Organization. International histological classification of tumours. Available at http://www.who.int/classifications/icd/ en/
35. Zhang H, Bonney G (2000) Use of classification trees for association studies. Genet Epidemiol 19:323-332