Pathogenesis of Feline Diabetes

Veterinary Clinics of North America - Small Animal Practice

Volumn 43, Issue 2, 2013, Pages 221-231

  Rand, Jacquie S ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Diabetes mellitus; Feline; Pathogenesis; Type 2 diabetes

Indexed keywords

INSULIN;

ACROMEGALY; CAT; DISEASE PREDISPOSITION; HEREDITY; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PANCREATITIS; PATHOGENESIS; REVIEW; RISK FACTOR;

ANIMALS; CAT DISEASES; CATS; DIABETES MELLITUS; GLUCOSE; INSULIN; OBESITY;

FELIDAE;

EID: 84875581621     PISSN: 01955616     EISSN: 18781306     Source Type: Journal    
DOI: 10.1016/j.cvsm.2013.01.003     Document Type: Review

References (71)

1. Rand J.S. Feline diabetes mellitus. BSAVA Manual of Canine and Feline Endocrinology 2012, 133-147. British Small Animal Vet. Assoc, UK. 4th edition. C.T. Mooney, M.E. Peterson (Eds.).
2. Crenshaw K., Peterson M. Pretreatment clinical and laboratory evaluation of cats with diabetes mellitus: 104 cases (1992-1994). J Am Vet Med Assoc 1996, 209(5):943.
3. American Diabetes Association Diagnosis and classification of diabetes mellitus. Diabetes Care 2010, 33(Suppl 1):S62-S69.
4. Reeve-Johnson M., Rand J., Anderson S., et al. Determination of reference values for casual blood glucose concentration in clinically-healthy, aged cats measured with a portable glucose meter from an ear or paw sample. J Vet Int Med May 1, 2012, 26(3):755. [abstract].
5. Gottlieb S, Rand J, Marshall R. Diabetic cats in remission have mildly impaired glucose tolerance [abstract]. Paper presented at: Australian College of Veterinary Scientists Science Week June, 2012. Gold Coast, Australia.
6. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997, 20(7):1183-1197.
7. Nolan C.J., Damm P., Prentki M. Type 2 diabetes across generations: from pathophysiology to prevention and management. Lancet 2011, 378(9786):169-181.
8. Povel C., Boer J., Reiling E., et al. Genetic variants and the metabolic syndrome: a systematic review. Obes Rev 2011, 12(11):952-967.
9. Buchanan T.A., Xiang A., Kjos S.L., et al. What is gestational diabetes?. Diabetes Care 2007, 30(Suppl 2):S105-S111.
10. Rand J.S., Fleeman L.M., Farrow H.A., et al. Canine and feline diabetes mellitus: nature or nurture?. J Nutr 2004, 134(Suppl 8):2072S-2080S.
11. Niessen S.J.M., Petrie G., Gaudiano F., et al. Feline acromegaly: an underdiagnosed endocrinopathy?. J Vet Intern Med 2007, 21(5):899-905.
12. Goossens M.M., Nelson R.W., Feldman E.C., et al. Response to insulin treatment and survival in 104 cats with diabetes mellitus (1985-1995). J Vet Intern Med 1998, 12(1):1-6.
13. Zini E, Lunardi F, Zanetti R, et al. Histological investigation of endocrine and exocrine pancreas in cats with diabetes mellitus [abstract]. The European College of Veterinary Internal Medicine, Companion Animals Congress. Maastricht, September, 2012: EN-0-2.
14. Woods J., Panciera D., Snyder P., et al. Diabetes mellitus in a kitten. J AM Anim Hosp Assoc 1994, 30:177-180.
15. Wade C., Gething M., Rand J. Evidence of a genetic basis for diabetes mellitus in Burmese cats. J Vet Intern Med 1999, 13(3):269.
16. Rand J., Bobbermien L., Hendrikz J., et al. Over representation of Burmese cats with diabetes mellitus. Aust Vet J 1997, 75(6):402-404.
17. McCann T.M., Simpson K.E., Shaw D.J., et al. Feline diabetes mellitus in the UK: the prevalence within an insured cat population and a questionnaire-based putative risk factor analysis. J Feline Med Surg 2007, 9(4):289-299.
18. Lederer R., Rand J., Jonsson N., et al. Frequency of feline diabetes mellitus and breed predisposition in domestic cats in Australia. Vet J 2009, 179(2):254-258.
19. Meigs J.B., Cupples L.A., Wilson P. Parental transmission of type 2 diabetes: the Framingham Offspring Study. Diabetes 2000, 49(12):2201-2207.
20. Newman B., Selby J., King M.C., et al. Concordance for type 2 (non-insulin-dependent) diabetes mellitus in male twins. Diabetologia 1987, 30(10):763-768.
21. Feero W.G., Guttmacher A.E., McCarthy M.I. Genomics, type 2 diabetes, and obesity. N Engl J Med 2010, 363(24):2339-2350.
22. Hochberg I., Hochberg Z. Expanding the definition of hypothalamic obesity. Obes Rev 2010, 11(10):709-721.
23. Lee P., Mori A., Coradini M., et al. Potential predictive biomarkers of obesity in Burmese cats. Vet J 2012, [Epub ahead of print].
24. Ahrén B., Pacini G. Islet adaptation to insulin resistance: mechanisms and implications for intervention. Diabetes Obes Metab 2005, 7(1):2-8.
25. Appleton D.J., Rand J.S., Sunvold G.D. Insulin sensitivity decreases with obesity, and lean cats with low insulin sensitivity are at greatest risk of glucose intolerance with weight gain. J Feline Med Surg 2001, 3(4):211-228.
26. Browning L.M. n-3 Polyunsaturated fatty acids, inflammation and obesity-related disease. Proc Nutr Soc 2003, 62(2):447-453.
27. Legro R.S., Finegood D., Dunaif A. A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome. J Clin Endocrinol Metab 1998, 83(8):2694-2698.
28. Biering H., Knappe G., Gerl H., et al. Acta Med Austriaca 2000, 27(1):27-31. [in German].
29. Blüher M., Windgassen M., Paschke R. Improvement of insulin sensitivity after adrenalectomy in patients with pheochromocytoma. Diabetes Care 2000, 23(10):1591.
30. Stenstrom G., Sjostrom L., Smith U. Diabetes mellitus in phaeochromocytoma. Fasting blood glucose levels before and after surgery in 60 patients with phaeochromocytoma. Acta Endocrinol (Copenh) 1984, 106(4):511-515.
31. Elias A.N., Hofflich H. Abnormalities in glucose metabolism in patients with schizophrenia treated with atypical antipsychotic medications. Am J Med 2008, 121(2):98-104. [see comment].
32. Qi D., Pulinilkunnil T., An D., et al. Single-dose dexamethasone induces whole-body insulin resistance and alters both cardiac fatty acid and carbohydrate metabolism. Diabetes 2004, 53(7):1790-1797.
33. Hutley L., Prins J.B. Fat as an endocrine organ: relationship to the metabolic syndrome. Am J Med Sci 2005, 330(6):280-289.
34. Dandona P., Aljada A., Bandyopadhyay A. Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol 2004, 25(1):4-7.
35. Neiger R., Witt A.L., Noble A., et al. Trilostane therapy for treatment of pituitary-dependent hyperadrenocorticism in 5 cats. J Vet Intern Med 2004, 18(2):160-164.
36. Li S., Shin H.J., Ding E.L., et al. Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA 2009, 302(2):179-188.
37. Richards A.A., Stephens T., Charlton H.K., et al. Adiponectin multimerization is dependent on conserved lysines in the collagenous domain: evidence for regulation of multimerization by alterations in posttranslational modifications. Mol Endocrinol 2006, 20(7):1673-1687.
38. Lara-Castro C., Luo N., Wallace P., et al. Adiponectin multimeric complexes and the metabolic syndrome trait cluster. Diabetes 2006, 55(1):249-259.
39. Tan H.Y., Rand J.S., Morton J.M., et al. Adiponectin profiles are affected by chronic and acute changes in carbohydrate intake in healthy cats. Gen Comp Endocrinol 2011, 172(3):468-474.
40. Hoenig M., Thomaseth K., Waldron M., et al. Insulin sensitivity, fat distribution, and adipocytokine response to different diets in lean and obese cats before and after weight loss. Am J Physiol Regul Integr Comp Physiol 2007, 292(1):R227-R234.
41. Appleton D.J., Rand J.S., Sunvold G.D. Plasma leptin concentrations are independently associated with insulin sensitivity in lean and overweight cats. J Feline Med Surg 2002, 4:83-93.
42. Appleton D.J., Rand J.S., Sunvold G.D. Plasma leptin concentrations in cats: reference range, effects of weight gain and relationship with adiposity a measured by dual energy X-ray absorptiometry. J Feline Med Surg 2000, 2:191-199.
43. Tilg H., Moschen A.R. Inflammatory mechanisms in the regulation of insulin resistance. Mol Med 2008, 14(3-4):222.
44. Ahren B., Pacini G. Importance of quantifying insulin secretion in relation to insulin sensitivity to accurately assess beta cell function in clinical studies. Eur J Endocrinol 2004, 150(2):97-104.
45. Kelishadi R., Cook S.R., Motlagh M.E., et al. Metabolically obese normal weight and phenotypically obese metabolically normal youths: the CASPIAN Study. J Am Diet Assoc 2008, 108(1):82-90.
46. Leahy J.L. Pathogenesis of type 2 diabetes mellitus. Arch Med Res 2005, 36(3):197-209.
47. Verkest K.R., Fleeman L.M., Rand J.S., et al. Evaluation of beta-cell sensitivity to glucose and first-phase insulin secretion in obese dogs. Am J Vet Res 2011, 72(3):357-366.
48. Wagner J.D., Kavanagh K., Ward G.M., et al. Old world nonhuman primate models of type 2 diabetes mellitus. ILAR J 2006, 47(3):259.
49. Rees D.A., Alcolado J.C. Animal models of diabetes mellitus. Diabet Med 2005, 22(4):359-370.
50. Kjos S.L., Buchanan T.A. Gestational diabetes mellitus. N Engl J Med 1999, 341(23):1749-1756.
51. Johnson K.H., O'Brien T.D., Betsholtz C., et al. Islet amyloid polypeptide: mechanisms of amyloidogenesis in the pancreatic islets and potential roles in diabetes mellitus. Lab Invest 1992, 66(5):522-535.
52. Yano B.L., Hayden D.W., Johnson K.H. Feline insular amyloid: association with diabetes mellitus. Vet Pathol 1981, 18:621-627.
53. Hoenig M., Hall G., Ferguson D., et al. A feline model of experimentally induced islet amyloidosis. Am J Pathol 2000, 157(6):2143.
54. Clark A., Wells C., Buley I., et al. Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes. Diabetes Res 1988, 9(4):151.
55. Guardado-Mendoza R., Davalli A.M., Chavez A.O., et al. Pancreatic islet amyloidosis, β-cell apoptosis, and α-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons. Proc Natl Acad Sci U S A 2009, 106(33):13992-13997.
56. Khemtemourian L., Antoinette Killian J., Hoppener J.W., et al. Recent insights in islet amyloid polypeptide-induced membrane disruption and its role in β-cell death in type 2 diabetes mellitus. Exp Diabetes Res 2008, 2008:421287.
57. Haataja L., Gurlo T., Huang C.J., et al. Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis. Endocr Rev 2008, 29(3):303-316.
58. Scheuner D., Kaufman R.J. The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr Rev 2008, 29(3):317-333.
59. Zraika S., Hull R., Verchere C., et al. Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?. Diabetologia 2010, 53(6):1046-1056.
60. Poitout V. Glucolipotoxicity of the pancreatic beta-cell: myth or reality?. Biochem Soc Trans 2008, 36(Pt 5):901-904.
61. Back S.H., Kaufman R.J. Endoplasmic reticulum stress and type 2 diabetes. Annu Rev Biochem 2012, 81(1):767-793.
62. Zini E., Osto M., Franchini M., et al. Hyperglycaemia but not hyperlipidaemia causes beta cell dysfunction and beta cell loss in the domestic cat. Diabetologia 2009, 52(2):336-346.
63. Tschuor F., Zini E., Schellenberg S., et al. Remission of diabetes mellitus in cats cannot be predicted by the arginine stimulation test. J Vet Intern Med 2011, 25(1):83-89.
64. Nolan C.J., Prentki M. The islet beta-cell: fuel responsive and vulnerable. Trends Endocrinol Metab 2008, 19(8):285-291.
65. Prentki M., Nolan C.J. Islet beta cell failure in type 2 diabetes. J Clin Invest 2006, 116(7):1802-1812.
66. Donath M.Y., Shoelson S.E. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 2011, 11(2):98-107.
67. Donath M.Y., Storling J., Berchtold L.A., et al. Cytokines and {beta}-cell biology: from concept to clinical translation. Endocr Rev 2008, 29(3):334-350.
68. Dinarello C.A., Donath M.Y., Mandrup-Poulsen T. Role of IL-1[beta] in type 2 diabetes. Curr Opin Endocrinol Diabetes Obes 2010, 17(4):314-321. 310.1097/MED.1090b1013e32833bf32836dc.
69. Peterson M.E., Taylor R.S., Greco D.S., et al. Acromegaly in 14 cats. J Vet Intern Med 1990, 4(4):192-201.
70. Zoran D.L. Pancreatitis in cats: diagnosis and management of a challenging disease. J Am Anim Hosp Assoc 2006, 42(1):1-9.
71. Xenoulis P.G., Steiner J.M. Current concepts in feline pancreatitis. Top Companion Anim Med 2008, 23(4):185-192.