Combinational effects of hexane insoluble fraction of Ficus septica Burm. F. and doxorubicin chemotherapy on T47D breast cancer cells

Asian Pacific Journal of Tropical Biomedicine

Volumn 3, Issue 4, 2013, Pages 297-302

  Nugroho, Agung Endro ^a   Hermawan, Adam ^a   Putri, Dyaningtyas Dewi Pamungkas ^a   Novika, Anindya ^a   Meiyanto, Edy ^a  

^a GADJAH MADA UNIVERSITY   (Indonesia)

Author keywords

Cancer; Cytotoxic; Ficus septica Burm. F.; T47D cells

Indexed keywords

DOXORUBICIN; FICUS SEPTICA EXTRACT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PLANT EXTRACT; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; HEXANE; N-HEXANE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER COMBINATION CHEMOTHERAPY; CELL CYCLE; CELL CYCLE G1 PHASE; CELL GROWTH; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; FICUS; FICUS SEPTICA; G2 PHASE CELL CYCLE CHECKPOINT; GROWTH INHIBITION; HUMAN; HUMAN CELL; PLANT LEAF; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; UPREGULATION; BREAST TUMOR; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; FEMALE; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; SOLUBILITY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; DOXORUBICIN; FEMALE; FICUS; FLOW CYTOMETRY; HEXANES; HUMANS; IMMUNOHISTOCHEMISTRY; SOLUBILITY;

EID: 84875505603     PISSN: 22211691     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2221-1691(13)60066-0     Document Type: Article

References (22)

1. Mikail CN, Hearney E, Nemesure B Increasing physician awareness of the common uses and contraindications of herbal medicines: utility of a case-based tutorial for residents. J Altern Complement Med 2003, 9(4):571-576.
2. Miroddi M, Calapai F, Calapai G Potential beneficial effects of garlic in oncohematology. Mini Rev Med Chem 2011, 11(6):461-472.
3. Nurcahya BM Efek antiproliferatif ekstrak etanolik daun awar-awar (Ficus septica Burm. f.) terhadap sel kanker payudaraT47D, skripsi 2007, Fakultas Farmasi UGM, Yogyakarta.
4. Pratama RH, Ikhtiarsyah YG, Fitriasari A, Anindyajati, Ikawati M, Meiyanto E Awar-awar leaves ehanolic extract sinergistically enhances cytotoxic of doxorubicin on T47D breast cancer cells. Ind J Pharm Sci 2011, 9(1):67-71.
5. Sekti DA, Mubarok MF, Armandani I, Junedy S, Meiyanto E Awar-awar (Ficus septica Burm. F.) leaves ethanolic extract induced apoptosis of MCF-7 cells by downregulation of Bcl-2. J Trad Med 2010, 15(3):100-104.
6. Septhea DB, Anindyajati, Darma A, Nurzijah I, Nugroho AE Ficus septica burm. F. leaves ethanolic extract induces apoptosis in 7,12-dimethylbenz[a]nthracene-induced rat liver cancer quantitatively. Indo J Cancer Chemoprev 2010, 2(2):242-248.
7. Nugroho AE, Ikawati M, Hermawan A, Putri DDP, Meiyanto E Cytotoxic effect of ethanolic extract fractions of Indonesia plant Ficus septica Burm. F. on human breast cancer T47D cell lines. Int J Phytomed 2011, 3:216-226.
8. Mosmann T Rapid colorimetric assay for cellular growth and survival: aplication to proliferation and citotoxicity assays. J Immunol Methods 1983, 65:55-63.
9. Prayong P, Barusrux S, Weerapreeyakul N Cytotoxic activity screening of some indigenous Thai plants. Fitoterapia 2008, 79:598-601.
10. Wu PL, Rao KV, Su CH, Kuoh CS, Wu TS Phenanthroindolizidine alkaloids and their cytotoxicity from the leaves of Ficus septica. Heterocycles 2002, 57:2401-2408.
11. Junedi S, Susidarti RA, Meiyanto E Naringenin meningkatkan efek sitotoksik doxorubicin pada sel kanker payudara T47D melalui induksi apoptosis. Ind J Pharm Sci 2010, 8(2):85-90.
12. Di Leo A, Tanner M, Desmed C, Paesman M, Cardoso F, Durbecq V, et al. p-53 gene mutations as a predictive marker in a population of advanced breast cancer patients randomly treated with doxorubicin or docetaxel in the context of a phase III clinical trial. Ann Oncol 2007, 18:997-1003.
13. Vayssade M, Haddada H, Faridoni-Laurens L, Tourpin S, Valent A, Benard J, et al. p73 functionally replaces p53 in adriamycin-treated, p53-deficient breast cancer cells. Int J Cancer 2005, 116(6):860-869.
14. Rudin CM, Thompson CB Regulation and clinical relevance of programmed cell death. Annu Rev Med 1997, 48:267-281.
15. Fan TJ, Han LH, Cong RS, Liang J Caspase family proteases and apoptosis. Acta Biochim Biophys Sin 2005, 37(11):719-727.
16. Sodhi RK, Singh N, Jaggi AS Poly (ADP-ribose) polymerase-1 (PARP-1) and its therapeutic implications. Vascul Pharmacol 2010, 53(3-4):77-87.
17. Peralta-Leal A, Rodríguez MI, Oliver FJ Poly(ADP-ribose)polymerase-1 (PARP-1) in carcinogenesis: potential role of PARP inhibitors in cancer treatment. Clin Transl Oncol 2008, 10(6):318-323.
18. Boulares AH, Yakovlev AG, Ivanova V, Stoica BA, Wang G, Iyer S, et al. Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells. J Biol Chem 1999, 274(33):22932-22940.
19. Rios J, Puhalla S PARP inhibitors in breast cancer: BRCA and beyond. Oncology 2011, 25(11):1014-1025.
20. Pellikainen MJ, Pekola TT, Kataja VV, Kellokoski JK, Eskelinen MJ, Kosma VM p21WAF1 expression in invasive breast cancer and its association with p53, AP-2, cell proliferation, and prognosis. J Clin Pathol 2003, 56:214-220.
21. Zhang Y, Fujita N, Tsuruo T Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis. Oncogene 1999, 18:1131-1138.
22. Kaneuchi M, Yamashita T, Shindoh M, Segawa K, Takahashi S, Furuta I, et al. Induction of apoptosis by the p53-273L (Arg3Leu) mutant in HSC3 cells without transactivation of p21Waf1/Cip1/Sdi1 and bax. Mol Carcinog 1999, 26:44-52.