Synthesis of substituted 6-amino-4-(2,4-dimethoxyphenyl)-[1,2]dithiolo[ 4,3-b]pyrrol-5-ones and their raising leukocyte count activities

Chemical and Pharmaceutical Bulletin

Volumn 61, Issue 3, 2013, Pages 351-357

  Tan, Xiangduan ^a   Li, Chungang ^a   Yu, Zhenpeng ^a   Wang, Panfeng ^a   Nian, Siyun ^a   Deng, Yifang ^a   Wu, Wei ^a   Wang, Guoping ^a  

^a Shanghai Institute of Pharmaceutical Industry   (China)

Author keywords

Antileukopenia; Dithiolopyrrolone; Raising leukocyte count; RhG CSF

Indexed keywords

[4 (2,4 DIMETHOXYPHENYL) 5 OXO 4,5 DIHYDRO[1,2]DITHIOLO[4,3 B]PYRROL 6 YL]CARBAMIC ACID; [4 (2,4 DIMETHOXYPHENYL) 5 OXO 4,5 DIHYDRO[1,2]DITHIOLO[4,3 B]PYRROL 6 YL]CARBAMIC ACID 2 PHENYLETHYL ESTER; [4 (2,4 DIMETHOXYPHENYL) 5 OXO 4,5 DIHYDRO[1,2]DITHIOLO[4,3 B]PYRROL 6 YL]CARBAMIC ACID 4 CHLOROPHENYL ESTER; [4 (2,4 DIMETHOXYPHENYL) 5 OXO 4,5 DIHYDRO[1,2]DITHIOLO[4,3 B]PYRROL 6 YL]CARBAMIC ACID 4 METHOXYPHENYL ESTER; [4 (2,4 DIMETHOXYPHENYL) 5 OXO 4,5 DIHYDRO[1,2]DITHIOLO[4,3 B]PYRROL 6 YL]CARBAMIC ACID ALLYL ESTER; [4 (2,4 DIMETHOXYPHENYL) 5 OXO 4,5 DIHYDRO[1,2]DITHIOLO[4,3 B]PYRROL 6 YL]CARBAMIC ACID BENZYL ESTER; [4 (2,4 DIMETHOXYPHENYL) 5 OXO 4,5 DIHYDRO[1,2]DITHIOLO[4,3 B]PYRROL 6 YL]CARBAMIC ACID CYCLOPENTYL ESTER; [4 (2,4 DIMETHOXYPHENYL) 5 OXO 4,5 DIHYDRO[1,2]DITHIOLO[4,3 B]PYRROL 6 YL]CARBAMIC ACID FURAN 2 YLMETHYL ESTER; [4 (2,4 DIMETHOXYPHENYL) 5 OXO 4,5 DIHYDRO[1,2]DITHIOLO[4,3 B]PYRROL 6 YL]CARBAMIC ACID HEPTYL ESTER; [4 (2,4 DIMETHOXYPHENYL) 5 OXO 4,5 DIHYDRO[1,2]DITHIOLO[4,3 B]PYRROL 6 YL]CARBAMIC ACID ISOBUTYL ESTER; [4 (2,4 DIMETHOXYPHENYL) 5 OXO 4,5 DIHYDRO[1,2]DITHIOLO[4,3 B]PYRROL 6 YL]CARBAMIC ACID ISOPROPYL ESTER; [4 (2,4 DIMETHOXYPHENYL) 5 OXO 4,5 DIHYDRO[1,2]DITHIOLO[4,3 B]PYRROL 6 YL]CARBAMIC ACID METHYL ESTER; [4 (2,4 DIMETHOXYPHENYL) 5 OXO 4,5 DIHYDRO[1,2]DITHIOLO[4,3 B]PYRROL 6 YL]CARBAMIC ACID N BUTYL ESTER; [4 (2,4 DIMETHOXYPHENYL) 5 OXO 4,5 DIHYDRO[1,2]DITHIOLO[4,3 B]PYRROL 6 YL]CARBAMIC ACID N PENTYL ESTER; [4 (2,4 DIMETHOXYPHENYL) 5 OXO 4,5 DIHYDRO[1,2]DITHIOLO[4,3 B]PYRROL 6 YL]CARBAMIC ACID PHENYL ESTER; [4 (2,4 DIMETHOXYPHENYL) 5 OXO 4,5 DIHYDRO[1,2]DITHIOLO[4,3 B]PYRROL 6 YL]CARBAMIC ACID TETRAHYDROFURAN 2 YLMETHYL ESTER; [4 (2,4 DIMETHOXYPHENYL) 5 OXO 4,5 DIHYDRO[1,2]DITHIOLO[4,3 B]PYRROL 6 YL]CARBAMIC ACID THIOPHEN 2 YLMETHYL ESTER; CYCLOPHOSPHAMIDE; PYRROLE DERIVATIVE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; UNCLASSIFIED DRUG;

ANTILEUKOPENIA ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; LEUKOCYTE COUNT; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; CYCLOPHOSPHAMIDE; GRANULOCYTE COLONY-STIMULATING FACTOR; LEUKOCYTE COUNT; LEUKOCYTES; LEUKOPENIA; MICE; MICE, INBRED BALB C; PYRROLES; RECOMBINANT PROTEINS;

EID: 84875474699     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.c12-00791     Document Type: Article

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