Thiolutin, an inhibitor of huvec adhesion to vitronectin, reduces paxillin in huvecs and suppresses tumor cell-induced angiogenesis

International Journal of Cancer

Volumn 93, Issue 3, 2001, Pages 307-316

  Minamiguchi, Kazuhisa ^a   Kumagai, Hiroyuki ^a   Masuda, Tohru ^a   Kawada, Manabu ^a   Ishizuka, Masaaki ^a   Takeuchi, Tomio ^a  

^a Numazu Bio Medical Research Institute   (Japan)

Author keywords

HUVEC; Paxillin; Thiolutin; Tumor angiogenesis; Vitronectin

Indexed keywords

ANGIOGENESIS INHIBITOR; AUREOTHRICIN; FOCAL ADHESION KINASE; IRSOGLADINE MALEATE; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; NATURAL PRODUCT; PAXILLIN; PROTEINASE INHIBITOR; THIOAURIN; THIOLUTIN; UNCLASSIFIED DRUG; VINCULIN; VITRONECTIN;

ANIMAL EXPERIMENT; ARTICLE; CANCER INHIBITION; CELL ADHESION; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; IC 50; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; TUMOR CELL; UMBILICAL VEIN;

ANIMALS; ANTIBIOTICS, ANTIFUNGAL; BLOTTING, WESTERN; CELL ADHESION; CELL ADHESION MOLECULES; CYTOSKELETAL PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; IMMUNOBLOTTING; MICE; MICE, INBRED ICR; NEOVASCULARIZATION, PATHOLOGIC; PAXILLIN; PEPTIDES; PHOSPHOPROTEINS; PLATELET AGGREGATION INHIBITORS; PRECIPITIN TESTS; PYRROLIDINONES; RECEPTORS, VITRONECTIN; TUMOR CELLS, CULTURED; UMBILICAL VEINS; VITRONECTIN;

EID: 0035427064     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.1321     Document Type: Article

References (36)

1. Inhibition of angiogenesis
2. Tumor interactions with the vasculature: Angiogenesis and tumor metastasis
3. Capillary growth: A two-cell system
4. Macrophages and angiogenesis
5. Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
6. Requirement of vascular integrin αvβ3 for angiogenesis
7. Definition of two angiogenic pathways by distinct αv integrins
8. Antiintegrin αvβ3 blocks human breast cancer growth and angiogenesis in human skin
9. Integrins: Emerging paradigms of signal transduction
10. Cellular functions regulated by Src family kinases
11. Mitosis specific serine phosphorylation and downregulation of one of the focal adhesion protein, paxillin
12. Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2A
13. The structure of thiolutin and aureothricin, antibiotics containing a unique pyrrolinodithiol nucleus
14. Evidence for the involvement of endothelial cell integrin αvβ3 in the disruption of the tumor vasculature induced by TNF and IFN-γ
15. Delaminomycins, novel nonpeptide extracellular matrix receptor antagonist and a new class of potent immunomodulator
16. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
17. Effect of Cytogenin, a novel microbial product, on embryonic and tumor cell-induced angiogenic response in vivo
18. Inhibition of tumor growth and neovascularization by an anti-gastric ulcer agent, irsogladine
19. Inhibition of angiogenesis by interferons: Effects on tumor- and lymphocyte-induced vascular responses
20. Calcium alginate beads as a slow-release system for delivering angiogenic molecules in vivo and in vitro
21. Synergistic effect of retinoids and interferon α on tumor-induced angiogenesis: Anti-angiogenic effect on HPV-harboring tumor cell lines
22. Structure, function and biological properties at integrin αvβ3 on human melanoma cells
23. Integrins: Versatility, modulation, and signaling in cell adhesion
24. Soluble ligands of the αvβ3 integrin mediate enhanced tyrosine phosphorylation of multiple proteins in adherent bovine pulmonary artery endothelial cells
25. Quantification of angiogenesis and anti-angiogenesis in the chick embryo chorioallantonic membrane
26. Site-directed neovessel formation in vivo
27. Quantification of angiogenesis assays: Progress and problems
28. Angiogenic factors
29. Echistatin induces decrease of pp125FAK phosphorylation, disassembly of actin cytoskeleton and focal adhesions, and detachment of fibronectin-adherent melanoma cells
30. Inhibition of yeast ribonucleic acid polymerases by thiolutin
31. Integrins and signal transduction pathways, the road taken
32. Integrin function, molecular hierarchies of cytoskeletal and signal molecules
33. The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton
34. Efficient synthetic method for ethyl (+)-(2S,3S)-3-[(S)-3-methyl-1-(3-methylbutylcarbamoyl) butylcarbamoyl]-2-oxiranecarb oxylate (EST), a new inhibitor of cysteine proteinases
35. Degradation process of ligand-stimulated platelet-derived growth factor β-receptor involves ubiquitin-proteasome proteolytic pathway
36. Angiogenesis inhibition: A review