Purification and characterization of a novel small-molecule polysaccharide from the maitake medicinal mushroom grifola frondosa (higher basidiomycetes)

International Journal of Medicinal Mushrooms

Volumn 15, Issue 2, 2013, Pages 145-152

  Zhou, Changyan ^a,b   Qiao, Yanru ^b,c   Tang, Qingjiu ^b   Jia, Wei ^b   Liu, Yanfang ^b   Wu, Aizhong ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b INSTITUTE OF EDIBLE FUNGI   (China)

^c SOUTHWEST UNIVERSITY   (China)

Author keywords

Grifola frondosa; Immune activity; Macrophages; Maitake mushroom; Medicinal mushrooms; Purification; Small molecule polysaccharide

Indexed keywords

ENDOTOXIN; GRIFOLA FRONDOSA POLYSACCHARIDE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; NITRIC OXIDE; PLANT EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; GAS CHROMATOGRAPHY; GRIFOLA FRONDOSA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; IMMUNITY; INFRARED SPECTROSCOPY; ION EXCHANGE CHROMATOGRAPHY; MACROPHAGE; METHYLATION; NONHUMAN; QUALITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CARBOHYDRATE CONFORMATION; CELL LINE; FUNGAL POLYSACCHARIDES; GENE EXPRESSION REGULATION; GRIFOLA; INTERLEUKIN-1BETA; INTERLEUKIN-6; MACROPHAGES; MICE; NITRIC OXIDE; TUMOR NECROSIS FACTOR-ALPHA;

BASIDIOMYCOTA; GRIFOLA FRONDOSA;

EID: 84875470603     PISSN: 15219437     EISSN: 19404344     Source Type: Journal    
DOI: 10.1615/IntJMedMushr.v15.i2.30     Document Type: Article

References (23)

1. Kodama N, Mizuno S, Nanba H, Saito N. Potential antitumor activity of a low-molecular-weight protein fraction from Grifola frondosa through enhancement of cytokine production. J Med Food. 2010;13:20-30.
2. Shomori K, Yamamoto M, Arifuku I, Teramachi K, Ito H. Antitumor effects of a water-soluble extract from Maitake (Grifola frondosa) on human gastric cancer cell lines. Oncol Rep. 2009;22:615-20.
3. Griessmayr PC, Gauthier M, Barber LG, Cotter SM. Mushroom-derived maitake PETfraction as single agent for the treatment of lymphoma in dogs. J Veterinary Intern Med. 2007;21:1409-12.
4. Kurashig S, Akuzaw Y, Endo F. Effects of Lentinus edodes, Grifola frondosa and Pleurotus ostreatus administration on cancer outbreak, and activities of macrophages and lymphocytes in mice treated with a carcinogen, N-butyl-N-butanolnitrosoamine. Immunopharmacol Immunotoxicol. 1997;19:175-83.
5. Hishida I, Nanba H, Kuroda H. Antitumor activity exhibited by orally administered extract from fruit body of Grifola frondosa (maitake). Chem Pharmaceut Bull. 1988;36:1819-27.
6. Ohno N, Suzuki I, Oikawa, S, Sato K, Miyazaki T, Yado-mae T. Antitumor activity and structural characterization of glucans extracted from cultured fruit bodies of Grifola frondosa. Chem Pharm Bull (Tokyo). 1984;32:1142-51.
7. Preuss HG, Echard B, Bagchi D, Perricone NV. Maitake mushroom extracts ameliorate progressive hypertension and other chronic metabolic perturbations in aging female rats. Int J Med Sci. 2010;7:169-80.
8. Talpur NA, Echard BW, Fan AY, Jaffari O, Bagchi D, Preuss HG. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol Cellular Biochem. 2002;237:129-36
9. Adachi K, Nanba H, Otsuka M, Kuroda H. Blood pressure-lowering activity present in the fruit body of Grifola frondosa (maitake). I. Chem Pharm Bull (Tokyo). 1988;36:1000-6.
10. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutrit Sci Vitaminol. 1987;33:341-46.
11. Hong L, Xun M, Wutong W. Anti-diabetic effect of an alpha-glucan from fruit body of maitake (Grifola frondosa) on KK-Ay mice. J Pharmacy Pharmacol. 2007;59:575-82.
12. Horio H, Ohtsuru M. Maitake (Grifola frondosa) improve glucose tolerance of experimental diabetic rats. J Nutr Sci Vitaminol. 2001:47:57-63.
13. Kubo K, Aoki H, Nanba H. Anti-diabetic activity present in the fruit body of Grifola frondosa (Maitake). I. Biol Pharmaceut Bull. 1994;17:1106-10.
14. Suzuki I, Itani T, Ohno N, Oikawa S, Sato K, Miyazaki T, Yadomae T. Effect of a polysaccharide fraction from Grifola frondosa on immune response in mice. J Pharmacobiodyn. 1985;8:217-26.
15. Masuda Y, Murata Y, Hayashi M, Nanba H. Inhibitory effect of MD-Fraction on tumor metastasis: involvement of NK cell activation and suppression of intercellular adhesion molecule (ICAM)-1 expression in lung vascular endothelial cells. Biol Pharm Bull. 2008;31:1104-8.
16. Kodama N, Asakawa A, Inui A, Masuda Y, Nanba H. Enhancement of cytotoxicity of NK cells by D-Fraction, a polysaccharide from Grifola frondosa. Oncol Rep. 2005;13:497-502.
17. Kodama N, Komuta K, Nanba H. Effect of Maitake (Grifola frondosa) D-Fraction on the activation of NK cells in cancer patients. J Med Food. 2003;6:371-77.
18. Harada N, Kodama N, Nanba H. Relationship between dendritic cells and the D-fraction-induced Th-1 dominant response in BALB/c tumor-bearing mice. Cancer Lett. 2003;192:181-87.
19. Kodama N, Komuta K, Sakai N, Nanba H. Effects of D-Fraction, a polysaccharide from Grifola frondosa, on tumor growth involve activation of NK cells. Biol Pharm Bull. 2002;25:1647-50.
20. Inoue A, Kodama N, Nanba H. Effect of maitake (Grifola frondosa) D-fraction on the control of the T lymph node Th-1/Th-2 proportion. Biol Pharm Bull. 2002;25:536-40.
21. Anumula KR, Taylor PB. A comprehensive procedure for preparation of partially methylated alditol acetates from glycoprotein carbohydrates. Anal Biochem. 1992;203:101-8.
22. Alleva DG, Burger CJ, Elgert KD. Tumor-induced regulation of suppressor macrophage nitric oxide and TNF-alpha production. Role of tumor-derived IL-10, TGF-beta, and prostaglandin E2. J Immunol. 1994;153:1674-86.
23. Ji Z, Tang Q, Zhang J, Yang Y, Jia W, Pan Y. Immuno-modulation of RAW264.7 macrophages by GLIS, a proteopolysaccharide from Ganoderma lucidum. J Ethnopharmacol. 2007;112:445-50.