Strategy to target the substrate binding site of SET domain protein methyltransferases

Journal of Chemical Information and Modeling

Volumn 53, Issue 3, 2013, Pages 681-691

  Nguyen, Kong T ^a   Li, Fengling ^a   Poda, Gennadiy ^b   Smil, David ^a   Vedadi, Masoud ^a   Schapira, Matthieu ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b ONTARIO INSTITUTE FOR CANCER RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; AMINO ACIDS; LIBRARIES; PROTEINS;

BIOLOGICAL MECHANISMS; CHEMICAL FRAGMENTS; CHEMICAL INHIBITORS; CHEMICAL LIBRARIES; METHYLTRANSFERASES; NOVEL STRATEGIES; PROTEIN SUBSTRATE; SUBSTRATE-BINDING SITES;

BINDING SITES;

AMINO ACID; ION CHANNEL; LYSINE; PROTEIN METHYLTRANSFERASE;

ARTICLE; CHEMICAL STRUCTURE; CHROMATIN; DRUG DESIGN; ENZYME SPECIFICITY; HYDROGEN BOND; METABOLISM; MOLECULAR LIBRARY; PHYLOGENY; PHYSIOLOGY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

AMINO ACIDS; CHROMATIN; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HYDROGEN BONDING; ION CHANNELS; LYSINE; MODELS, MOLECULAR; PHYLOGENY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN METHYLTRANSFERASES; PROTEIN STRUCTURE, TERTIARY; SMALL MOLECULE LIBRARIES; SUBSTRATE SPECIFICITY;

EID: 84875468373     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci300596x     Document Type: Article

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