New potent calcimimetics: II. Discovery of benzothiazole trisubstituted ureas

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 8, 2013, Pages 2455-2459

  Deprez, Pierre ^a   Temal, Taoues ^a   Jary, Hélène ^a   Auberval, Marielle ^a   Lively, Sarah ^b   Guédin, Denis ^c   Vevert, Jean Paul ^d  

^a Galapagos SASU   (France)

^b AMGEN INC   (United States)

^c INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^d NONE   (France)

Author keywords

Benzothiazole urea; Calcium sensing receptor; Positive allosteric modulators

Indexed keywords

BENZOTHIAZOLE TRISUBSTITUTED UREA DERIVATIVE; CALCIMIMETIC AGENT; CALCIUM; CALCIUM SENSING RECEPTOR; PARATHYROID HORMONE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM BLOOD LEVEL; CELL ASSAY; CHRONIC KIDNEY FAILURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG IDENTIFICATION; DRUG POTENCY; IN VIVO CULTURE; NEPHRECTOMY; NONHUMAN; PARATHYROID HORMONE BLOOD LEVEL; RAT; SECONDARY HYPERPARATHYROIDISM; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

BENZOTHIAZOLES; CALCIUM; RECEPTORS, CALCIUM-SENSING; UREA;

RATTUS;

EID: 84875459745     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.01.077     Document Type: Article

References (16)

1. E.F. Nemeth J.P. Bilezikian, L.G. Raisz, G.A. Rodan, Principles of Bone Biology 2nd ed. 2002 Academic Press San Diego 1339
2. R.P. Wuthrich, D. Martin, and J.P. Bilezikian Eur. J. Clin. Invest. 37 2007 915
3. E.M. Brown, G. Gamba, D. Riccardi, M. Lombardi, R. Butters, O. Kifor, A. Sun, M.A. Hediger, J. Lytton, and S.C. Herbert Nature 366 1993 575
4. M. Rodriguez, E.F. Nemeth, and D. Martin Am. J. Physiol. 288 2005 F253
5. Nemeth, E. F. Van Wagenen, B. C.; Balandrin, M. F.; Delmar, E. G.; Moe, S. T. U.S. Patent 6,031,003, 2002.
6. E.F. Nemeth Endocrine 10 1999 97
7. L.A. Sorbera, R.M. Castaner, and M. Bayes Drugs Future 27 2002 831
8. E.F. Nemeth, W.H. Heaton, M. Miller, J. Fox, M.F. Balandrin, B.C. Van Wagenen, M. Colloton, W. Karbon, J. Scherrer, E. Shatzen, G. Rishton, S. Scully, M. Qi, R. Harris, D. Lacey, and D. Martin J. Pharmacol. Exp. Ther. 308 2004 627
9. Cohen, J. H.; Combs, D. W.; Rybczynski, P. J. U.S. Patent 6,172,091, 2001.
10. A. Kessler, H. Faure, C. Petrel, M. Ruat, and R.H. Dodd Bioorg. Med. Chem. Lett. 2000 2001 10
11. Miyazaki, H.; Tsubakimoto, J.; Yasuda, K.; Takamuro, I.; Sakurai, O.; Yanagida, T.; Hisada, Y. W.O. Patent 115,975, 2005.
12. Temal, T.; Jary, H.; Auberval, M.; Lively, S.; Guédin, D.; Vevert, J.-P.; Deprez, P. Bioorg. Med. Chem. Lett. 2013, http://dx.doi.org/10.1016/j. bmcl.2013.01.078.
13. Deprez, P.; Patek, M. W.O. Patent 059,102, 2002.
14. Deprez, P.; Jary, H.; Temal, T. W.O. Patent 117,211, 2006.
15. G.R. Pettit, M.F. Baumann, and K.N. Rangammal J. Med. Pharm. Chem. 5 1962 800
16. J. Fox, S.H. Lowe, B.A. Petty, and E.F. Nemeth J. Pharmacol. Exp. Ther. 290 1999 473