New potent calcimimetics: I. Discovery of a series of novel trisubstituted ureas

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 8, 2013, Pages 2451-2454

  Temal, Taoues ^a   Jary, Hélène ^a   Auberval, Marielle ^a   Lively, Sarah ^b   Guédin, Denis ^c   Vevert, Jean Paul ^d   Deprez, Pierre ^a  

^a Galapagos SASU   (France)

^b AMGEN INC   (United States)

^c INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^d NONE   (France)

Author keywords

Calcimimetics; Calcium sensing receptor; Positive allosteric modulators; Trisubstituted ureas

Indexed keywords

CALCIMIMETIC AGENT; CALCIUM SENSING RECEPTOR; FENDILINE; TECALCET; UREA DERIVATIVE;

ALLOSTERISM; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; RAT; SECONDARY HYPERPARATHYROIDISM;

BIOMIMETIC MATERIALS; CALCIUM; RECEPTORS, CALCIUM-SENSING; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 84875443231     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.01.078     Document Type: Article

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