Strategies of clopidogrel load and atorvastatin reload to prevent ischemic cerebral events in patients undergoing protected carotid stenting: Results of the randomized ARMYDA-9 CAROTID (clopidogrel and atorvastatin treatment during carotid artery stenting) study

Journal of the American College of Cardiology

Volumn 61, Issue 13, 2013, Pages 1379-1387

  Patti, Giuseppe ^a   Tomai, Fabrizio ^b   Melfi, Rosetta ^a   Ricottini, Elisabetta ^a   Macrì, Michele ^a   Sedati, Pietro ^a   Giardina, Arianna ^b   Aurigemma, Cristina ^b   Leporace, Mario ^b   D'Ambrosio, Andrea ^a   Di Sciascio, Germano ^a  

^a UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^b EUROPEAN HOSPITAL   (Italy)

Author keywords

atorvastatin reload; carotid stenting; clopidogrel; magnetic resonance imaging; outcome

Indexed keywords

ACETYLSALICYLIC ACID; ATORVASTATIN; CLOPIDOGREL; HEPARIN;

ADULT; ARTICLE; BLEEDING; CAROTID ARTERY STENTING; CEREBROVASCULAR ACCIDENT; CLINICAL EVALUATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MEGADOSE; FEMALE; HUMAN; INCIDENCE; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; NEUROPROTECTION; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; TRANSIENT ISCHEMIC ATTACK; TREATMENT RESPONSE;

AGED; ANGIOPLASTY, BALLOON; ANTICHOLESTEREMIC AGENTS; BRAIN ISCHEMIA; CAROTID ARTERY DISEASES; CAROTID STENOSIS; DIFFUSION MAGNETIC RESONANCE IMAGING; DRUG THERAPY, COMBINATION; FEMALE; HEPTANOIC ACIDS; HUMANS; MALE; PLATELET AGGREGATION INHIBITORS; PYRROLES; RESEARCH DESIGN; STENTS; TICLOPIDINE; TREATMENT OUTCOME;

EID: 84875459737     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2013.01.015     Document Type: Article

References (27)

1. G. Patti, A. Nusca, F. Mangiacapra, L. Gatto, A. D'Ambrosio, G. Di Sciascio Point-of-care measurement of clopidogrel responsiveness predicts clinical outcome in patients undergoing percutaneous coronary intervention results of the ARMYDA-PRO (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty-Platelet Reactivity Predicts Outcome) study J Am Coll Cardiol 52 2008 1128 1133
2. G. Patti, G. Colonna, V. Pasceri, L.L. Pepe, A. Montinaro, G. Di Sciascio Randomized trial of high loading dose of clopidogrel for reduction of periprocedural myocardial infarction in patients undergoing coronary intervention: results from the ARMYDA-2 (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty) study Circulation 111 2005 2099 2106
3. T.G. Brott, J.L. Halperin, S. Abbara 2011 ASA/ACCF/AHA/AANN/AANS/ACR/ ASNR/CNS/SAIP/SCAI/SIR/SNIS/SVM/SVS guideline on the management of patients with extracranial carotid and vertebral artery disease J Am Coll Cardiol 57 2011 1002 1044
4. K. Gröschel, U. Ernemann, J.B. Schulz, T. Nägele, C. Terborg, A. Kastrup Statin therapy at carotid angioplasty and stent placement: effect on procedure-related stroke, myocardial infarction, and death Radiology 240 2006 145 151
5. G. Di Sciascio, G. Patti, V. Pasceri, A. Gaspardone, G. Colonna, A. Montinaro Efficacy of atorvastatin reload in patients on chronic statin therapy undergoing percutaneous coronary intervention: results of the ARMYDA-RECAPTURE (Atorvastatin for Reduction of Myocardial Damage During Angioplasty) Randomized Trial J Am Coll Cardiol 54 2009 558 565
6. K. Mensah, M.M. Mocanu, D.M. Yellon Failure to protect the myocardium against ischemia/reperfusion injury after chronic atorvastatin treatment is recaptured by acute atorvastatin treatment: a potential role for phosphatase and tensin homolog deleted on chromosome ten? J Am Coll Cardiol 45 2005 1287 1291
7. T.G. Brott, R.W. Hobson, G. Howard Stenting versus endarterectomy for treatment of carotid-artery stenosis N Engl J Med 363 2010 11 23
8. A.K. Rao, C. Pratt, A. Berke Thrombolysis in Myocardial Infarction (TIMI) Trial-phase I: hemorrhagic manifestations and changes in plasma fibrinogen and the fibrinolytic system in patients treated with recombinant tissue plasminogen activator and streptokinase J Am Coll Cardiol 11 1988 1 11
9. P. Montorsi, L. Caputi, S. Galli Microembolization during carotid artery stenting in patients with high-risk, lipid-rich plaque A randomized trial of proximal versus distal cerebral protection J Am Coll Cardiol 58 2011 1656 1663
10. A. Kastrup, T. Nägele, K. Gröschel Incidence of new brain lesions after carotid stenting with and without cerebral protection Stroke 37 2006 2312 2316
11. P. Piñero, A. González, A. Mayol Silent ischemia after neuroprotected percutaneous carotid stenting: a diffusion-weighted MRI study AJNR Am J Neuroradiol 27 2006 1338 1345
12. M. Schlüter, T. Tübler, J.C. Steffens, D.G. Mathey, J. Schofer Focal ischemia of the brain after neuroprotected carotid artery stenting J Am Coll Cardiol 42 2003 1007 1013
13. S.E. Vermeer, N.D. Prins, T. den Heijer, A. Hofman, P.J. Koudstaal, M.M. Breteler Silent brain infarcts and the risk of dementia and cognitive decline N Engl J Med 348 2003 1215 1222
14. F. Crawley, J. Stygall, S. Lunn, M. Harrison, M.M. Brown, S. Newman Comparison of microembolism detected by transcranial Doppler and neuropsychological sequelae of carotid surgery and percutaneous transluminal angioplasty Stroke 31 2000 1329 1334
15. R.A. Crisostomo, M.M. Garcia, D.C. Tong Detection of diffusion-weighted MRI abnormalities in patients with transient ischemic attack: correlation with clinical characteristics Stroke 34 2003 932 937
16. J. Schofer, M. Arendt, T. Tübler, J. Sandstede, M. Schlüter Late cerebral embolization after emboli-protected carotid artery stenting assessed by sequential diffusion-weighted magnetic resonance imaging J Am Coll Cardiol Intv 1 2008 571 577
17. I. Muller, M. Seyfarth, S. Rudiger Effect of a high loading dose of clopidogrel on platelet function in patients undergoing coronary stent placement Heart 85 2001 92 93
18. D.J. Angiolillo, A. Fernàndez-Ortiz, E. Bernardo High clopidogrel loading dose during coronary stenting: effects on drug response and inter-individual variability Eur Heart J 25 2004 1903 1910
19. R. Schulz Pleiotropic effects of statins: acutely good, but chronically bad? J Am Coll Cardiol 45 2005 1292 1294
20. G. Patti, C.P. Cannon, S.A. Murphy Clinical benefit of statin pretreatment in patients undergoing percutaneous coronary intervention: a collaborative patient-level meta-analysis of 13 randomized studies Circulation 123 2011 1622 1632
21. P.O. Bonetti, L.O. Lerman, C. Napoli, A. Lerman Statin effects beyond lipid lowering - are they clinically relevant? Eur Heart J 24 2003 225 248
22. S.G. Ellis, S. Anwaruddin Recapturing the magic: revisiting the pleiotropic effects of statins in percutaneous coronary revascularization J Am Coll Cardiol 54 2009 566 568
23. I. Ifergan, K. Wosik, R. Cayrol Statins reduce human blood-brain barrier permeability and restrict leukocyte migration: relevance to multiple sclerosis Ann Neurol 60 2006 45 55
24. D. Yang, R.A. Knight, Y. Han Vascular recovery promoted by atorvastatin and simvastatin after experimental intracerebral hemorrhage: magnetic resonance imaging and histological study J Neurosurg 114 2011 1135 1142
25. K.H. Jung, K. Chu, S.W. Jeong HMG-CoA reductase inhibitor, atorvastatin, promotes sensorimotor recovery, suppressing acute inflammatory reaction after experimental intracerebral hemorrhage Stroke 35 2004 1744 1749
26. M. Endres, U. Laufs, Z. Huang Stroke protection by 3-hydroxy-3- methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase Proc Natl Acad Sci U S A 95 1998 8880 8885
27. J.S. Yadav, M.H. Wholey, R.E. Kuntz Protected carotid-artery stenting versus endarterectomy in high-risk patients N Engl J Med 351 2004 1493 1501