Transplantation of porcine embryonic stem cells and their derived neuronal progenitors in a spinal cord injury rat model

Cytotherapy

Volumn 15, Issue 2, 2013, Pages 201-208

  Yang, Jenn Rong ^a   Liao, Chia Hsin ^b,c   Pang, Cheng Yoong ^b,c   Huang, Lynn Ling Huei ^d,e   Chen, Yi Ling ^f   Shiue, Yow Ling ^f   Chen, Lih Ren ^a,d,g  

^a FISHERIES RESEARCH INSTITUTE   (Taiwan)

^b Department of Medical Research ^*  (Taiwan)

^c TZU CHI UNIVERSITY   (Taiwan)

^d Institutes of Biotechnology   (Taiwan)

^e NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^f NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^g SOUTHERN TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

Embryonic stem cells; Porcine; Spinal cord injury; Xenotransplantation

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CONTROLLED STUDY; CONVALESCENCE; EMBRYO; EMBRYONIC STEM CELL; FLUORESCENCE IMAGING; HINDLIMB; IMMUNOHISTOCHEMISTRY; LONG EVANS RAT; MALE; NEURAL STEM CELL; NONHUMAN; PORCINE EMBRYONIC STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL CORD INJURY; STEM CELL TRANSPLANTATION;

EID: 84875442169     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.1016/j.jcyt.2012.09.001     Document Type: Article

References (27)

1. Bramlett HM, Dietrich WD. Progressive damage after brain and spinal cord injury: pathomechanisms and treatment strategies. Prog Brain Res. 2007;161:125-41.
2. McDonald JW, Becker D, Holekamp TF, Howard M, Liu S, Lu A, et al. Repair of the injured spinal cord and the potential of embryonic stem cell transplantation. J Neurotrauma. 2004; 21:383-93.
3. Yang CC, Shih YH, Ko MH, Hsu SY, Cheng H, Fu YS. Transplantation of human umbilical mesenchymal stem cells from Wharton's jelly after complete transection of the rat spinal cord. PLoS One. 2008;3:-3336.
4. Myckatyn TM,Mackinnon SE,McDonald JW. Stem cell transplantation and other novel techniques for promoting recovery from spinal cord injury. Transpl Immunol. 2004;12:343-58.
5. Cloutier F, Siegenthaler MM, Nistor G, Keirstead HS. Transplantation of human embryonic stem cell-derived oligodendrocyte progenitors into rat spinal cord injuries does not cause harm. Regen Med. 2006;1:469-79.
6. Keirstead HS, Nistor G, Bernal G, Totoiu M, Cloutier F, Sharp K, et al. Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. J Neurosci. 2005;25:4694-705.
7. Liu S, Qu Y, Stewart TJ, Howard MJ, Chakrabortty S, Holekamp TF, et al. Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation. Proc Natl Acad Sci U S A. 2000;97:6126-31.
8. Deshpande DM, Kim YS, Martinez T, Carmen J, Dike S, Shats I, et al. Recovery from paralysis in adult rats using embryonic stem cells. Ann Neurol. 2006;60:32-44.
9. Jendelová P, Herynek V, Urdzíková L, Glogarová K, Kroupová J, Andersson B, et al. Magnetic resonance tracking of transplanted bone marrow and embryonic stem cells labeled by iron oxide nanoparticles in rat brain and spinal cord. J Neurosci Res. 2004;76:232-43.
10. Kumagai G, Okada Y, Yamane J, Nagoshi N, Kitamura K, Mukaino M, et al. Roles of ES cell-derived gliogenic neural stem/progenitor cells in functional recovery after spinal cord injury. PLoS One. 2009;4:-7706.
11. Yang JR, Liao CH, Pang CY, Huang LL, Lin YT, Chen YL, et al. Directed differentiation into neural lineages and therapeutic potential of porcine embryonic stem cells in rat Parkinson's disease model. Cell Reprogram. 2010;12:447-61.
12. Yang JR, Shiue YL, Liao CH, Lin SZ, Chen LR. Establishment and characterization of novel porcine embryonic stem cell lines expressing hrGFP. Cloning Stem Cells. 2009;11:235-44.
13. Young W. Spinal cord contusion models. Prog Brain Res. 2002;137:231-55.
14. Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma. 1995;12:1-21.
15. Baptiste DC, Fehlings MG. Update on the treatment of spinal cord injury. Prog Brain Res. 2007;161:217-33.
16. Zhang N, Wimmer J, Qian SJ, Chen WS. Stem cells: current approach and future prospects in spinal cord injury repair. Anat Rec (Hoboken). 2010;293:519-30.
17. Sundberg M, Andersson PH, -Akesson E, Odeberg J, Holmberg L, Inzunza J, et al. Markers of pluripotency and differentiation in human neural precursor cells derived from embryonic stem cells and CNS tissue. Cell Transplant. 2011; 20:177-91.
18. Nandoe Tewarie RS, Hurtado A, Bartels RH, Grotenhuis A, Oudega M. Stem cell-based therapies for spinal cord injury. J Spinal Cord Med. 2009;32:105-14.
19. McDonald JW, Liu XZ, Qu Y, Liu S, Mickey SK, Turetsky D, et al. Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord. Nat Med. 1999;5:1410-2.
20. McDonald JW, Howard MJ. Repairing the damaged spinal cord: a summary of our early success with embryonic stem cell transplantation and remyelination. Prog Brain Res. 2002;137: 299-309.
21. Gruner JA. A monitored contusion model of spinal cord injury in the rat. J Neurotrauma. 1992;9:123-8.
22. Brüstle O, Jones KN, Learish RD, Karram K, Choudhary K, Wiestler OD, et al. Embryonic stem cell-derived glial precursors: a source of myelinating transplants. Science. 1999;285:754-6.
23. Totoiu MO, Keirstead HS. Spinal cord injury is accompanied by chronic progressive demyelination. J Comp Neurol. 2005; 486:373-83.
24. Illes S, Theiss S, Hartung HP, Siebler M, Dihn-e M. Nichedependent development of functional neuronal networks from embryonic stem cell-derived neural populations. BMC Neurosci. 2009;10:93.
25. Wewetzer K, Radtke C, Kocsis J, Baumgärtner W. Speciesspecific control of cellular proliferation and the impact of large animal models for the use of olfactory ensheathing cells and Schwann cells in spinal cord repair. Exp Neurol. 2011;229: 80-7.
26. Li JY, Christophersen NS, Hall V, Soulet D, Brundin P. Critical issues of clinical human embryonic stem cell therapy for brain repair. Trends Neurosci. 2008;31:146-53.
27. Ronaghi M, Erceg S, Moreno-Manzano V, Stojkovic M. Challenges of stem cell therapy for spinal cord injury: human embryonic stem cells, endogenous neural stem cells, or induced pluripotent stem cells? Stem Cells. 2010;28:93-9.