Genome-wide association study of serum albumin:globulin ratio in Korean populations

Journal of Human Genetics

Volumn 58, Issue 3, 2013, Pages 174-177

  Hong, Kyung Won ^a   Jin, Hyun Seok ^b   Song, Daesub ^a   Kwak, Hye Kyoung ^a   Kim, Sung Soo ^a   Kim, Yeonjung ^a  

^a Korea Centers for Disease Control and Prevention   (South Korea)

^b Ajou University School of Medicine   (South Korea)

Author keywords

albumin:globulin ratio; FADS1; GWAS; TNFRSF13B; total protein

Indexed keywords

ACYL COENZYME A DESATURASE 1; ALBUMIN; GLOBULIN; HLA ANTIGEN; HLA DBP1; INTERFERON REGULATORY FACTOR 4; PROTEIN; PROTEIN GALNT2; TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR; UNCLASSIFIED DRUG;

ADULT; AGED; ALBUMIN BLOOD LEVEL; ALCOHOL CONSUMPTION; ARTICLE; BODY MASS; CHROMOSOME 11Q; DRINKING BEHAVIOR; FEMALE; GENE FREQUENCY; GENE LOCUS; GENE REPLICATION; GENETIC ASSOCIATION; GENOTYPE; HEREDITY; HUMAN; KOREA; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; POPULATION; PROTEIN BLOOD LEVEL; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING;

ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 17; COHORT STUDIES; FATTY ACID DESATURASES; FEMALE; GENE FREQUENCY; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LINEAR MODELS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; REPUBLIC OF KOREA; SERUM ALBUMIN; SERUM GLOBULINS; TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN;

EID: 84875427508     PISSN: 14345161     EISSN: 1435232X     Source Type: Journal    
DOI: 10.1038/jhg.2012.130     Document Type: Article

References (22)

1. Al-Joudi, F. S. & Wahab, N. A. The utilization of an index for serum globulin compensation in diseases associated with decreased serum albumin. Med. J. Malaysia 59, 495-501 (2004).
2. Henry, J. B. Clinical Diagnosis and Management by Laboratory Methods. (W B Saunder Co., Philadelphia, 1996).
3. Dufour, D. R., Lott, J. A., Nolte, F. S., Gretch, D. R., Koff, R. S. & Seeff, L. B. Diagnosis and monitoring of hepatic injury. II. Recommendations for use of laboratory tests in screening, diagnosis, and monitoring. Clin. Chem. 46, 2050-2068 (2000).
4. Azab, B., Bibawy, J., Harris, K., Khoueiry, G., Akeman, M., Selim, J. et al. Value of albumin-globulin ratio as a predictor of all-cause mortality after non-ST elevation myocardial infarction. Angiology (in press) (2012).
5. Giles, H. M., Pugh, R. C. B., Darmady, E. M., Stranack, F. & Woolf, L. I. The neprotic syndrome in early infancy: a report of three cases. Arch. Dis. Child. 32, 167-180 (1957).
6. Al-Joudi, F. S. Prognostic value of an index for serum globulin compensation in colon and breast cancers. Singapore Med. J. 46, 710-713 (2005).
7. Ku, C. S., Loy, E. Y., Pawitan, Y. & Cha, K. S. The pursuit of genomewide association studies: where are we now? J. Hum. Genet. 55, 195-206 (2010).
8. Visscher, P. M., Brown, M. A., McCarthy, M. I. & Yang, J. Five years of GWAS discovery. Am. J. Hum. Genet. 90, 7-24 (2012).
9. Kim, Y. J., Go, M. J., Hu, C., Hong, C. B., Kim, Y. K., Lee, J. Y. et al. Large-scale genomewide association studies in east Asians identify new genetic loci influencing metabolic traits. Nat. Genet. 43, 990-995 (2011).
10. Kamatani, Y., Matsuda, K., Okada, Y., Kubo, M., Hosono, N., Daigo, Y. et al. Genomewide association study of hematological and biochemical traits in a Japanese population. Nat. Genet. 42, 210-215 (2010).
11. Osman, W., Okada, Y., Kamatani, Y., Kubo, M., Matsuda, K. & Nakamura, Y. Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in japanese. PLOS one 7, e32683 (2012).
12. Cho, Y. S., Go, M. J., Kim, Y. J., Heo, J. Y., Oh, J. H., Ban, H. J. et al. A large-scale genomewide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat. Genet. 41, 527-534 (2009).
13. Hong, K. W., Lim, J. E., Kim, Y. J., Cho, N. H., Shin, C. & Oh, B. K. A. R. E. Genomewide association study of blood pressure using imputed SNPs. Genomics Inform. 8, 103-107 (2010).
14. Howie, B. N., Donnelly, P. & Marchini, J. A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet. 5, e1000529 (2009).
15. Chan, Y. C., Suzuki, M. & Yamamoto, S. A comparison of anthropometry, biochemical variables and plasma amino acids among centenarians, elderly and young subjects. J. Am. Coll. Nutr. 18, 358-365 (1999).
16. Castigli, E., Wilson, S. A., Garibyan, L., Rachid, R., Bonilla, F., Schneider, L. et al. TACI is mutant in common variable immunodeficiency and IgA deficiency. Nat. Genet. 37, 829-834 (2005).
17. Salzer, U., Chapel, H. M., Webster, A. D., Pan-Hammarstrom, Q., Schmitt-Graeff, A., Schlesier, M. et al. Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans. Nat. Genet. 37, 820-828 (2005).
18. Barile, M., Passarella, S., Bertoldi, A. & Quagliariello, E. Flavin adenine dinucleotide synthesis in isolated rat liver mitochondria caused by imported flavin mononucleotide. Arch. Biochem. Biophys. 350, 442-447 (1993).
19. Deluca, C. & Kaplan, N. O. Flavin adenine dinucleotide synthesis in animal tissues. Biochem. Biophys. Acta 30, 6-11 (1958).
20. Lin, J., Diamanduros, A., Chowdhury, S. A., Scelsa, S., Latov, N. & Sadiq, S. A. Specific electron transport chain abnormalities in amyotrophic lateral sclerosis. J. Nurol. 256, 774-782 (2009).
21. Gieger, C., Geistlinger, L., Altmaier, E., Hrabe de Angelis, M., Kronenberg, F. et al. Genetics meets metabolomics: a genomewide association study of metabolite profiles in human serum. PLoS Genet. 4, e1000282 (2008).
22. Waterworth, D. M., Ricketts, S. L., Song, K., Chen, L., Zhao, J. H., Ripatti, S. et al. Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler. Thromb. Vasc. Biol. 30, 2264-2276 (2010).