Synthesis of 4-quinolones derivatives for their antihistaminic activity

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 5, Issue SUPPL.1, 2013, Pages 223-227

  Gajbhiye, Asmita ^a   Chaturvedi, Lavlesh ^a  

^a DR H S GOUR UNIVERSITY   (India)

Author keywords

Aminopyridine; Anti histaminic; Azelastine; Quinolnoes

Indexed keywords

4 QUINOLONE DERIVATIVE; ANTIHISTAMINIC AGENT; AZELASTINE; HISTAMINE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; GUINEA PIG; INFRARED SPECTROMETRY; NONHUMAN;

EID: 84875427257     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Neugebauer U, Szeghalmi A, Schmitt M, Kiefer W, Popp J, Holzgrabe U, Molecular and Biomolecular Spectroscopy. Spectrochimica Acta part A 2004; 61(7): 819-821.
2. Koga H, Itoh A, Murayama S, Suzue S, Irikwa T. Structure-activity relationships of antibacterial 6, 7-and 7, 8-disubstituted 1-alkyl-1, 4-dihydro-4-oxoquinoline-3-carboxylic acids. J Med Chem 1980; 23: 1358-1363.
3. Ares JJ, Outt PE, Randall JL, Johnston JN, Murray PD, O'Brien LM, Weisshar PM, Ems BL. Synthesis and biological evaluation of flavonoids and related compounds as gastroprotective agents. Bioorg Med Chem Letter 1996; 6(8): 995-998.
4. Ukrainets IV, Taran SG, Evtifeeva OA, Turov AV. 4-Hydroxy-2-quinolines. 15. Synthesis of N-(2-pyridyl)amides of 1-R-4-hydroxy-2-quinolone-3-carboxylic acids as possible new nonsteroidal anti-inflammatory agents. Khim Geterotsikl Soedin 1993; 8: 1101-1104.
5. Joseph IB, Vukanovic J, Isaacs JT. Antiangiogenic treatment with linomide as chemoprevention for prostate, seminal vesicle, and breast carcinogenesis in rodents. Cancer Res 1996; 56(15): 3404-3408.
6. Edmont D, Rocher R, Plisson C, Chennault J. Synthesis and evaluation of quinoline carboxyguanidines as antidiabetic agents. Bioorg Med Chem Lett 2000; 10(16): 1831-1834.
7. Yu D, Chen CH, Brossi A, Lee KH. Anti-AIDS agents. 60. Substituted 3'R, 4'R-di-O-(-)-camphanoyl-2', 2'-dimethyldihydropyrano[2, 3-f]chromone (DCP) analogues as potent anti-HIV agents. J Med Chem 2004; 47(16): 4072-4082.
8. Hall CM, Johnson HG, Wright JB. Quinoline Derivatives as Antiallergy Agents. J Med Chem 1974; 17: 685-690.
9. Buckle DR, Cantello BCC, Smith H, Spicer BA. 4-Hydroxy-3-nitro-2-quinolones and related compounds as inhibitors of allergic reactions. J Med Chem 1975; 18: 726-732.
10. Cairns H, Cox D, Gould KJ, Ingall AH, Susceritzky JL. New antiallergic pyrano [3, 2-g]quinoline-2, 8-dicarboxylic acids with potential for the topical treatment of asthma. J Med Chem 1985; 28(12): 1832-1842.
11. Beasley SC, Cooper N, Gowere L, Gugary JP, Haughan AF, Hellewell PG, Miotla J, Montana JG, Morgan T, Naylor R, Runcie KA, Tuladhar B, Warneck BH. Synthesis and evaluation of a novel series of phosphodiesterase IV inhibitors. A potential treatment for asthma. Bioorg Med Chem Lett 1998; 8(19): 2629-2634.
12. Crespo MI, Gracia J, Puig C, Veiga A, Bou J, Beleta J, Domenach T, Ryder H, Sequanch V, Paacios JM. Synthesis and biological evaluation of 2, 5-dihydropyrazol. Bioorg Med Chem Lett 2000; 10(23): 2661-2664.
13. Ko TC, Hour MJ, Lien JC, Teng CM, Lee KH, Kuo SC, Huang LJ. Synthesis of 4-alkoxy-2-phenylquinoline derivatives as potent antiplatelet agents. Biorg Med Chem lett 2001; 11(3): 279-282.
14. Reuse JJ. Comparisons of various histamine antagonists. Br J Pharmacol Chemother 1948; 3(2): 174-180.
15. Grossland J. In: Lewis Pharmacology, 5th ed. Churchill Livingstone, Edinburgh, 1980; 138.
16. Sehgal RC. hauhan A, Gilhotra UK. Effect of various plant extracts on histamine aerosol induced bronchospasm in guinea pigs. Int J Pharm Pharm Sci 2013; 5(1): 191-192.
17. Swaroop KKSLVVSN, Anbu J, Anjana A, Sumithra M, Sathish R. Influence of ethanolic leaf extract of Sargassum wightii and Adiantum capillus on histamine induced asthma in animal model. Int J Pharm Pharm Sci 2012; 4(4): 121-123.
18. Wolff ME. Burger's Medicinal Chemistry and Drug Discovery, Vol. 5,-Therapeutic Agents, 5th ed., John Wiley and Sons, New York, 1996; 543.