Synthesis and evaluation of cholecystokinin trimers: A multivalent approach to pancreatic cancer detection and treatment

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 8, 2013, Pages 2422-2425

  Brabez, Nabila ^a,b,c   Nguyen, Kevin L ^c   Saunders, Kara ^c   Lacy, Ryan ^c   Xu, Liping ^d   Gillies, Robert J ^d   Lynch, Ronald M ^e   Chassaing, Gerard ^a,b   Lavielle, Solange ^a,b   Hruby, Victor J ^c  

^a Centre National de la Recherche Scientifique   (France)

^b ECOLE NORMALE SUPÉRIEURE   (France)

^c University of Arizona   (United States)

^d H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^e UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

CCK; Early detection; Multimers; Multivalent interactions; Pancreatic cancer

Indexed keywords

CHOLECYSTOKININ B RECEPTOR; CHOLECYSTOKININ DERIVATIVE; NB 306; NB 308; NB 309; NB 310; NB 311; NB 312; TETRAGASTRIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER DIAGNOSIS; CELL SURFACE; DRUG SYNTHESIS; EARLY DIAGNOSIS; PANCREAS CANCER; PROTEIN EXPRESSION;

CHOLECYSTOKININ; HUMANS; PANCREATIC NEOPLASMS; RECEPTORS, CHOLECYSTOKININ; TUMOR MARKERS, BIOLOGICAL;

EID: 84875411840     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.02.022     Document Type: Article

References (19)

1. J.E. Gestwicki, C.W. Cairo, L.E. Strong, K.A. Oetjen, and L.L. Kiessling J. Am. Chem. Soc. 124 2002 14922
2. M. Mammen, S.-K. Choi, and G.M. Whitesides Angew. Chem., Int. Ed. 37 1998 2754
3. H.L. Handl, J. Vagner, H. Han, E. Mash, V.J. Hruby, and R.J. Gillies Expert Opin. Ther. Targets 8 2004 565
4. N. Brabez, R.M. Lynch, L. Xu, R.J. Gillies, G. Chassaing, S. Lavielle, and V.J. Hruby J. Med. Chem. 54 2011 7375
5. M. Hidalgo N. Engl. J. Med. 362 2010 1605
6. A. Maitra, and R.H. Hruban Annu. Rev. Pathol. Mech. Dis. 3 2008 157
7. R. Chandra, and R.A. Liddle Curr. Opin. Endocr. Diabetes Obes. 14 2007 63
8. M. Dufresne, C. Seva, and D. Fourmy Phys. Rev. 86 2006 805
9. F. Noble, S.A. Wank, J.N. Crawley, J. Bradwejn, K.B. Seroogy, M. Hamon, and B.P. Roques Pharmacol. Rev. 51 1999 745
10. S. Li, S. Huang, and S.B. Peng Int. J. Oncol. 27 2005 1329
11. F. Noble, and B.P. Roques Prog. Neurobiol. 58 1999 349
12. J.C. Reubi Endocr. Rev. 24 2003 389
13. S. Roosenburg, P. Laverman, F.L. van Delft, and O.C. Boerman Amino Acids 41 2011 1049
14. P.J. Corringer, J.H. Weng, B. Ducos, C. Durieux, P. Boudeau, A. Bohme, and B.P. Roques J. Med. Chem. 36 1993 166
15. M.-E. Million, I. Lena, S. Da Nascimento, F. Noble, V.r. Dauge, C. Garbay, and B. Roques Lett. Pept. Sci. 4 1997 407
16. H.L. Handl, and R.J. Gillies Life Sci. 77 2005 361
17. H.L. Handl, J. Vagner, H.I. Yamamura, V.J. Hruby, and R.J. Gillies Anal. Biochem. 330 2004 242
18. H.L. Handl, J. Vagner, H.I. Yamamura, V.J. Hruby, and R.J. Gillies Anal. Biochem. 343 2005 299
19. L. Xu, J. Vagner, J. Josan, R.M. Lynch, D.L. Morse, B. Baggett, H. Han, E.A. Mash, V.J. Hruby, and R.J. Gillies Mol. Cancer Ther. 8 2009 2356