Fused thiophene derivatives as MEK inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 472-475

  Laing, Victoria E ^a   Brookings, Daniel C ^a   Carbery, Rachel J ^a   Simorte, Jose Gascon ^a   Hutchings, Martin C ^a   Langham, Barry J ^a   Lowe, Martin A ^a   Allen, Rodger A ^a   Fetterman, Joanne R ^a   Turner, James ^a   Meier, Christoph ^a   Kennedy, Jeff ^a   Merriman, Mark ^a  

^a UCB PHARMA   (Belgium)

Author keywords

Allosteric MEK inhibitor; MEK; Non ATP competitive MEK inhibitor

Indexed keywords

2 (2 FLUORO 4 IODO PHENYLAMINO) 7,7 DIMETHYL 5,6,7,8 TETRAHYDRO THIAZOLO[5,4 C]AZEPIN 4 ONE; 2 METHYL PROPANE 1,2 DIAMINE; ANTINEOPLASTIC AGENT; HYDROXAMIC ACID; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PIPERIDINE 3 YLAMINE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CELL STRAIN HT29; CHEMICAL REACTION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG POTENCY; DRUG SOLUBILITY; DRUG SYNTHESIS; FEMALE; IN VIVO STUDY; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; MAP KINASE KINASE KINASES; MICE; MODELS, CHEMICAL; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; STATIC ELECTRICITY; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES; TIME FACTORS;

EID: 84655164863     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.10.105     Document Type: Article

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