Kaempferol ameliorates aflatoxin B1 (AFB1) induced hepatocellular carcinoma through modifying metabolizing enzymes, membrane bound ATPases and mitochondrial TCA cycle enzymes

Asian Pacific Journal of Tropical Biomedicine

Volumn 2, Issue 3 SUPPL., 2012, Pages

  Langeswaran, Kulanthaivel ^a   Revathy, Rajendran ^b   Kumar, Subbaraj Gowtham ^c   Vijayaprakash, Shanmugam ^b   Balasubramanian, Maruthaiveeran Periyasamy ^b  

^a BHARATH UNIVERSITY   (India)

^b UNIVERSITY OF MADRAS   (India)

^c CHETTINAD HOSPITAL AND RESEARCH INSTITUTE   (India)

Author keywords

Aflatoxins; ATPase; Carbohydrate metabolism enzymes; Citric acid cycle enzymes; Kaempferol; Liver cancer; TCA cycle enzymes

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (MAGNESIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); FRUCTOSE BISPHOSPHATASE; FRUCTOSE BISPHOSPHATE ALDOLASE; GLUCOSE 6 PHOSPHATASE; GLUCOSE 6 PHOSPHATE ISOMERASE; HEXOKINASE; KAEMPFEROL; NUCLEIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG RESPONSE; ENZYME REGULATION; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 84875401729     PISSN: 22211691     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2221-1691(12)60471-7     Document Type: Article

References (62)

1. Natasa J.Strelic, Zvonko M.Magic, Natasa V.Trutic, Koviljka V.Krtolica Influence of aflatoxin B1 on mRNA levels of acute-phase proteins and oncoproteins in albino rat liver. Arch Oncol 2009, 17(1-2):3-6.
2. Kobayashi T, Abe K, Asai K, Gomi K, Juvvadi PR Genomics of Aspergillus oryzae. Biosci Biotechnol. Biochem 2007, 71:646-670.
3. Nierman WC, Pain A, Anderson MJ, Wortman JR, Kim HS Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature 2005, 438:1151-1156.
4. Bennet JW, Klich M Mycotoxins. Clin Microbiol Rev 2003, 16:497-516.
5. Wild CP, Hall AJ Primary prevention of hepatocellular carcinoma in developing countries. Mutat Res 2000, 462:381-393.
6. Reddy KRN, Reddy CS, Muralidharan K Characterization of aflatoxin B1produced by Aspergillus flavus isolated from discolored rice grains. J Mycol Plant Pathol 2005, 35(3):470-474.
7. Speijers GJA, Speijers MHM Combined toxic effects of mycotoxins. Toxicol Lett 2004, 153(1):91-98.
8. Aflatoxins IARC Monograph on the Evaluation of Carcinogenic. Risks to Humans. 1993, 56:245-395.
9. Jaeschke H, Gores GJ, Cederbaum AI, Hinson JA, Pessayre D, Lemasters JJ Mechanisms of hepatotoxicity. Toxicol Sci 2002, 65:166-176.
10. Gbenga A Adenuga. The Ca2+-Transporting Activity of Rat Liver Microsomes in Response to Protein Undernutrition: Implications for Liver Tumor Promotion. Bioscience Reports 2000, 20(2):93-98.
11. Chuang Shu-Chun, Vecchia Carlo La, Boffetta Paolo Liver cancer: Descriptive epidemiology and risk factors other than HBV and HCV infection. Cancer Letters 2009, 286:9-14.
12. Zhang Yu-Jing, Li Haiyang, Wu Hui-Chen, Shen Jing, Wang Lin, Yu Ming-Whei, Lee Po- Huang, Bernard Weinstein I, Santella Regina M. Silencing of Hint1, a novel tumor suppressor gene, by promoter hypermethylation in hepatocellular carcinoma. Cancer Letters 2009, 175:277-284.
13. El-Serag HB, Mason AC Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med 1999, 340:745-750.
14. Bosch FX, Ribes J, Cleries R, Diaz M Epidemiology of hepatocellular carcinoma. Clin Liver Dis 2005, 9:191-211.
15. Kondoh N, Wakatsuki T, Hada A, Shuda M, Tanaka K, Arai M Genetic and epigenetic events in human hepatocarcinogenesis. Int J Oncol 2001, 16:1271-1278.
16. Premalatha B, Sachdanandam P Potency of semecarpus anacardium linn. nut milk extract against aflatoxin b1-induced hepatocarcinogenesis: reflection on microsomal biotransformation enzymes. Pharmacological Research 2000, 42(2):161-166.
17. Mittal A, Pathania V, Agarwal PK, Prasad J, Singh S, Goel HC Influence of Podophyllum hexandrum on endogenous antioxidant defense system in mice: possible role in radio protection. J Ethanopharmacol 2001, 76:53-262.
18. Vijayavel K, Anbuselvam C, Balasubramanian MP Free radical scavenging activity of the marine mangrove Rhizophora apiculata bark extract with reference to naphthalene induced mitochondrial dysfunction. Chem Biol Interact 2006, 163:170-175.
19. Jovanovic SV, Steeden S, Tosic M, Marjanovic B, Simic MG Flavonoids as antioxidants. J Am Chem Soc 1994, 116:4846-4851.
20. Chen Guifang, Xiang Ma, Fanben Meng, Genxi Li The electron transfer reactivity of kaempferol and its interaction with amino acid residues. Bioelectrochemistry 2008, 72:169-173.
21. Premalatha B, Muthulakshmi V, Vijayalakshmi T, Sachdanandam P Semecarpus anacardium nut extract induced changes in enzymic antioxidants studied in aflatoxin B1 caused hepatocellular carcinoma bearing Wistar rats. International Journal of Pharmacognosy 1997, 35:1-6.
22. Burton K A study of the conditions and mechanisms of diphenylamine reaction for colorimetric estimation of deoxyribonucleic acid. J Biochem 1956, 62:315-323.
23. Rawal VM, Patel VS, Rao GN, Desai RR Chemical and biochemical studies on cataractous human lenses-III- Quantitative study of protein. RNA and DNA. Arogya J Health Sci 1977, 3:69-75.
24. Bonting SL. Sodium-potassium activated adenosine triphosphatase and cation transport. In: Membranes and ion transport, Eds by Bittar EE, Wiley-Interscience, London, Vol. 1, pp. 257-363.
25. Hjerten S, Pan H Purification and characterization of two forms of a low affinity calcium ion ATPase from erythrocyte membranes. Biochem Biophys Acta 1983, 728:281-288.
26. Ohnishi T, Suzuki T, Suzuki Y, Ozawa KA Comparative study of plasma membrane Mg2+ ATPase activities in normal, regenerating and malignant cells. Biochem Biophys Acta 1962, 684:67-74.
27. Brandstrup N, Kirk JE, Bruni C Determination of hexokinase and phosphoglucoisomerase activities of arotic and pulmonary artery tissue in individuals of various ages. J Gerentol 1957, 12:166-171.
28. Horrrocks JE, Ward J, King J A routine method for the determination of phosphoglucose isomerise activity in body fluid. J Clin Pathol 1963, 16:248-251.
29. King J The phosphohydrolysases-acid and alkaline transaminase. Practical Clinical Enzymology 1965, 191-208. Van Nostrand Co. Ltd, London.
30. Gancedo JM, Gancedo C Fructose-1,6-disphosphatase, phosphofrucokinase and glucose-6-phosphate dehydrogenase from fermenting and non-fermenting yeasts. Arch Microbiol 1971, 76:132-136.
31. King J The transferases-alanine ans aspartate transaminases. Practical Clinical Enzymology 1965, 191-208. Nostrand Company Limitied, London. D. Van (Ed.).
32. Slater EC, Borner WD The effect of fluoride on the succinate oxidase system. Biochem J 1952, 52:185-196.
33. Mehler AH, Kornberg AM, Grisolia S, Ochoa S The enzymatic mechanisum of oxidation-reductions between malate or isocitrate and pyruvate. J Biol Chem 1948, 17:961-977.
34. Reed LJ, Mukherjee BB α-ketoglutarate dehydrogenase complex from E. coli. Methods is Enzymology 1969, Vol. 13:55-61. Academic Press, New York. J.M. Lowenstein (Ed.).
35. Ellis CN, Burnette JJ, Sedlack R, Dyas C, Blackmore WS Prognostic applications of DNA analysis in soild malignant lesions in humans. Surgery 1991, 173:329-342.
36. Keppler D, Lesch R, Reutter W, Decker K Experimental hepatitis induced by D-galactosamine. Exp Mol Pathol 1968, 2:279-290.
37. Gallagher RE Comprehensive textbook of oncology 1968, 36-45. Williams and Wilkins, Baltimore. A.R. Moosa, M.C. Robson, S.C. Schimpff (Eds.).
38. Bestwick CS, Milne L, Duthie SJ Kaempferol induced inhibition of HL-60 cell growth results from a heterogeneous response, dominated by cell cycle alterations. Chem Biol Interact 2007, 170:76-85.
39. Leung HW, Lin CJ, Hour HJ, Yang WH, Wang MY, Lee HZ Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes. Food Chem Toxicol 2007, 45:2005-2013.
40. Sharma V, Joseph C, Ghosh S, Agarwal A, Mishra NK, Sen E Kaempferol induces apoptosis in glioblastoma cells through oxidative stress. Mol Cancer Ther 2007, 6:2544-2553.
41. Balakrishnan A, Kokilavani R Biopotency of Cucumis trigonus Roxb. Fruit on membrane bound ATP ases and Marker enzymes in urolithic rats. South As J Biol Sci 2011, 1(2):58-70.
42. Stekhoren MA, Bonting SL Transport ATPases: Properties and functions. Physiological Rev 1981, 61:1-76.
43. Schuurmans-stekhoven FMAH, Bonting SL Transport of adenosine triphosphate, properties and functions. Physiol Rev 1981, 61:1-16.
44. Hebell Rb, Shalev O, Roker W, Bank BH Inhibition of erythrocyte Ca2+ ATPase by activated oxygen through thiol and lipid dependent mechanism. Biochem Biophy Acta 1986, 862:8-16.
45. Dechen C, Aadhitya A, Devaraja R, Sakthisekaran D Effect of Genistein on modulating lipid peroxidation and membrane bound enzymes in N-Nitrosodiethylamine induced and Phenobarbital promoted rat liver carcinogenesis. Journal of Health Science 2008, 54(2):137-142.
46. Veena K, Shanthi P, Sachdanandam P Protective effect of Kalpaamruthaa on altered glycoproteins component levels and membrane stability in mammary carcinoma. International Journal of cancer research. 2006, 2(4):315-329.
47. Ahn YS, Zerban H, Grobholz R, Bannasch P Sequential changes in glycogen content, expression of glucose transporters and enzymic patterns during development of clear/acidophillic cell tumors in rat kidney. Carcinogenesis 1992, 13:2329-2334.
48. Eigenbrodt E, Glossmann H Glycolysis one of the keys to cancer?. Trends Pharmacol Sci 1980, 1:240-245.
49. Bannasch P, Mayer D, Hacker HJ Hepatocellular glycogenesis and hepatocarcinogenesis. Biochim Biophys Acta 1980, 605:217-245.
50. Parry DM, Pedersen PL Intracellular localizat6ion and properties of particulate hexokinase in the Novikoff ascites tumour. Evidence for an outer mitochondrial membrane location. J BiolChem 1983, 258:10904-10912.
51. Fanciulli M, Paggi MG, Bruno T, Del Carlo C, Bonetto F, Gentile FP, Floridi A Glycolysis and growth rate in normal and in hexokinase transfected NIH-3T3 cells. Oncol Res 1994, 6:405-409.
52. Campbell DM, King EJ Serum phosphatases and glycolytic enzymes in cancer of the breast. Biochem J 1962, 82:23-28.
53. Ebrahim AS, Balakrishnan K, Sakthisekaran D Perchloroethylene induced alterations in glucose metabolism and their prevention by 2-deoxy-D-glucose and vitamin E in mice. J Appl Toxicol 1996, 16:339-348.
54. Mazurek S, Zwerschke W, Jansen-Duerr P, Eigenbrodt E Effects of the human papilloma virus HPV-16 E7 on- coprotein on glycolysis and glutaminolysis: role of pyruvate kinase type M2 and the glycolytic enzymes complex. Biochem J 2001, 356:247-256.
55. Schamhart DHJ, Van De Poll K, Van Wick R Comparative studies of glucose metabolism in HTC, RLC, MH1C1 and Reuber H35 rat hepatoma cells. Cancer Res 1979, 39:1051-1055.
56. Baggetto LG Deviant energetic metabolism of glycolytic cancer cells. Biochemie 1992, 74:959-974.
57. Neustadt John, Steve R Pieczenik. Medication-induced mitochondrial damage and disease. Mol Nutr & Food Res 2008, 52:780-788.
58. Shoffner JM, Wallace DC Oxidative phosphorylation diseases and mitochondrial DNA mutations: diagnosis and treatment. Annu Rev Nutr 1994, 14:535-568.
59. Padma, Setty OH Effect of administration of galactosamine hydrochloride on rat liver mitochondria. Ind J Biochem Biophy 1997, 34:296-301.
60. Sohal R, Dubey A Mitochondria oxidative damage: hydrogen peroxide release and ageing. Free Rad Biol Med 1994, 16:621-626.
61. Das, Mukherjee SC Chronic toxic effects of quinalphos on some biochemical parameters in Labeo rohita. Toxicol Lett 2000, 114:8-11.
62. Sree Priya M, Devaki T Effect of Indigofera tinctoria Linn on liver antoxidant defense system during D-galactosamine/endotoxin acute hepatitis in rodents. Ind J Exp Biol 2001, 23:181-184.