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Volumn 20, Issue 3, 2013, Pages 287-295

Oral antithrombotic effects of acylhydrazone derivatives

Author keywords

Acylhydrazones; Antiplatelet drugs; PAR; Platelet; Pulmonary thromboembolism; Venous thrombosis

Indexed keywords

ANTICOAGULANT AGENT; COLLAGEN; FIBRINOGEN; HEPARIN; INDOMETACIN; NORADRENALIN; PROTEINASE ACTIVATED RECEPTOR 1; THROMBIN;

EID: 84875391920     PISSN: 13403478     EISSN: 18803873     Source Type: Journal    
DOI: 10.5551/jat.14886     Document Type: Article
Times cited : (6)

References (33)
  • 1
    • 77950635286 scopus 로고    scopus 로고
    • Basic Principles of Platelet Biology and Clinical Implications
    • Dominick JA, Masafumi U, Shinya G: Basic Principles of Platelet Biology and Clinical Implications. Circ J, 2010; 74: 597-607
    • (2010) Circ J , vol.74 , pp. 597-607
    • Dominick, J.A.1    Masafumi, U.2    Shinya, G.3
  • 2
    • 75949128633 scopus 로고    scopus 로고
    • Antiplatelet therapies for the treatment of cardiovascular disease
    • Michelson AD: Antiplatelet therapies for the treatment of cardiovascular disease. Nat Rev Drug Discov, 2010; 9: 154-169
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 154-169
    • Michelson, A.D.1
  • 3
    • 0026035523 scopus 로고
    • Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
    • Vu T-KH, Hung DT, Wheaton VI, Coughlin SR: Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell, 1991; 64: 1057-1068
    • (1991) Cell , vol.64 , pp. 1057-1068
    • Vu, T.-K.H.1    Hung, D.T.2    Wheaton, V.I.3    Coughlin, S.R.4
  • 4
    • 0026577704 scopus 로고
    • Characterization of the cloned platelet thrombin receptor: Issues and opportunities
    • Coughlin SR, Vu TK-H, Hung DT, Wheaton VI: Characterization of the cloned platelet thrombin receptor: issues and opportunities. J Clin Invest, 1992; 89: 351-355
    • (1992) J Clin Invest , vol.89 , pp. 351-355
    • Coughlin, S.R.1    Vu, T.K.-H.2    Hung, D.T.3    Wheaton, V.I.4
  • 5
    • 0034733558 scopus 로고    scopus 로고
    • Structure-Function Analysis of Protease-activated Receptor 4 Tethered Ligand Peptides
    • Coughlin SR, Faruqi TR, Weiss EJ, Shapiro MJ, Huang W: Structure-Function Analysis of Protease-activated Receptor 4 Tethered Ligand Peptides. J Biol Chem, 2000; 275: 19728-19734
    • (2000) J Biol Chem , vol.275 , pp. 19728-19734
    • Coughlin, S.R.1    Faruqi, T.R.2    Weiss, E.J.3    Shapiro, M.J.4    Huang, W.5
  • 8
    • 34547466613 scopus 로고    scopus 로고
    • Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4
    • Bah A, Chen Z, Bush-Pelc LA, Mathews FS, Di Cera E: Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4. Proc Natl Acad Sci USA, 2007; 104: 11603-11608
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 11603-11608
    • Bah, A.1    Chen, Z.2    Bush-Pelc, L.A.3    Mathews, F.S.4    Di Cera, E.5
  • 9
    • 0036838525 scopus 로고    scopus 로고
    • Protection against thrombosis in mice lacking PAR3
    • Weiss EJ, Hamilton JR, Lease KE, Coughlin SR: Protection against thrombosis in mice lacking PAR3. Blood, 2002; 100: 3240-3244
    • (2002) Blood , vol.100 , pp. 3240-3244
    • Weiss, E.J.1    Hamilton, J.R.2    Lease, K.E.3    Coughlin, S.R.4
  • 10
    • 0036165065 scopus 로고    scopus 로고
    • Novel approaches to the treatment of thrombosis
    • Gresele P, Agnelli G: Novel approaches to the treatment of thrombosis TRENDS in Pharm Scienc, 2002; 23: 25-32
    • (2002) TRENDS in Pharm Scienc , vol.23 , pp. 25-32
    • Gresele, P.1    Agnelli, G.2
  • 12
    • 39749109478 scopus 로고    scopus 로고
    • Triggers, targets and treatments for thrombosis
    • Mackman N: Triggers, targets and treatments for thrombosis. Nature, 2008; 451: 914-918
    • (2008) Nature , vol.451 , pp. 914-918
    • Mackman, N.1
  • 14
    • 38949174253 scopus 로고    scopus 로고
    • Synthesis and anti-platelet activity of novel arylsulfonate--acylhydrazone derivatives, designed as antithrombotic candidates
    • Lima LM, Frattani FS, Dos Santos JL, Castro HC, Fraga CA, Zingali RB, Barreiro EJ: Synthesis and anti-platelet activity of novel arylsulfonate--acylhydrazone derivatives, designed as antithrombotic candidates. Eur J Med Chem, 2008; 43: 348-356
    • (2008) Eur J Med Chem , vol.43 , pp. 348-356
    • Lima, L.M.1    Frattani, F.S.2    Dos Santos, J.L.3    Castro, H.C.4    Fraga, C.A.5    Zingali, R.B.6    Barreiro, E.J.7
  • 15
    • 78651139188 scopus 로고
    • The Aggregation of Blood Platelets
    • Born GV, Cross MJ: The Aggregation of Blood Platelets. J Physiol, 1963; 168: 178-195
    • (1963) J Physiol , vol.168 , pp. 178-195
    • Born, G.V.1    Cross, M.J.2
  • 16
    • 0032005738 scopus 로고    scopus 로고
    • Activated human protein C prevents thrombin-induced thromboembolism in mice. Evidence that activated protein C reduces intravascular fibrin accumulation through the inhibition of additional thrombin generation
    • Gresele P, Momi S, Berrettini M: Activated human protein C prevents thrombin-induced thromboembolism in mice. Evidence that activated protein C reduces intravascular fibrin accumulation through the inhibition of additional thrombin generation. J Clin Invest, 1998; 101: 667-676
    • (1998) J Clin Invest , vol.101 , pp. 667-676
    • Gresele, P.1    Momi, S.2    Berrettini, M.3
  • 19
    • 0033398477 scopus 로고    scopus 로고
    • Studies on antiplatelet agents from natural safrole II. Synthesis and pharmacological properties of novel functionalized oxime O-benzylether derivatives
    • Reis AL, Ormelli CB, Miranda AL, Fraga CA, Barreiro EJ: Studies on antiplatelet agents from natural safrole II. Synthesis and pharmacological properties of novel functionalized oxime O-benzylether derivatives. Pharm Acta Helv, 1999; 74: 19-28
    • (1999) Pharm Acta Helv , vol.74 , pp. 19-28
    • Reis, A.L.1    Ormelli, C.B.2    Miranda, A.L.3    Fraga, C.A.4    Barreiro, E.J.5
  • 20
    • 0031958030 scopus 로고    scopus 로고
    • The mechanism of binding of low-molecular-weight active site inhibitors to human alpha-thrombin
    • Nilsson T, Sjöling-Ericksson A, Deinum J: The mechanism of binding of low-molecular-weight active site inhibitors to human alpha-thrombin. J Enzyme Inhib, 1998; 13: 11-29
    • (1998) J Enzyme Inhib , vol.13 , pp. 11-29
    • Nilsson, T.1    Sjöling-Ericksson, A.2    Deinum, J.3
  • 21
    • 33646025816 scopus 로고    scopus 로고
    • Ximelagatran: Direct thrombin inhibitor
    • Ho SJ, Brighton TA: Ximelagatran: direct thrombin inhibitor. Vasc Health Risk Manag, 2006; 2: 49-58
    • (2006) Vasc Health Risk Manag , vol.2 , pp. 49-58
    • Ho, S.J.1    Brighton, T.A.2
  • 22
    • 0034324766 scopus 로고    scopus 로고
    • In Vitro and in vivo Properties of Bicyclic Lactam Inhibitors: A Novel Class of Low Molecular Weight Peptidomimetic Thrombin Inhibitors
    • Leblond L, Grouix B, Boudreau C, Yang Q, Siddiqui MA, Winocour PD: In Vitro and in vivo Properties of Bicyclic Lactam Inhibitors: A Novel Class of Low Molecular Weight Peptidomimetic Thrombin Inhibitors. Thromb Res, 2000; 100: 195-209
    • (2000) Thromb Res , vol.100 , pp. 195-209
    • Leblond, L.1    Grouix, B.2    Boudreau, C.3    Yang, Q.4    Siddiqui, M.A.5    Winocour, P.D.6
  • 23
    • 1642279517 scopus 로고    scopus 로고
    • Protease-Activated Receptors: Contribution to Physiology and Disease
    • Ossovskaya VS, Bunnett NW: Protease-Activated Receptors: Contribution to Physiology and Disease. Am Physio Soc, 2004; 84: 579-621
    • (2004) Am Physio Soc , vol.84 , pp. 579-621
    • Ossovskaya, V.S.1    Bunnett, N.W.2
  • 24
    • 42549092982 scopus 로고    scopus 로고
    • Effect of low and high dose melagatran and other antithrombotic drugs on platelet aggregation
    • Soslau G, Ando A, Floyd L, Hong T, Mathew L, Yen Y: Effect of low and high dose melagatran and other antithrombotic drugs on platelet aggregation. J Thromb Thrombolysis, 2008; 25: 198-203
    • (2008) J Thromb Thrombolysis , vol.25 , pp. 198-203
    • Soslau, G.1    Ando, A.2    Floyd, L.3    Hong, T.4    Mathew, L.5    Yen, Y.6
  • 25
    • 37349053529 scopus 로고    scopus 로고
    • Characterization of a new peptide agonist of the protease-activated receptor-1. Biochem
    • Mao Y, Jin J, Kunapuli SP: Characterization of a new peptide agonist of the protease-activated receptor-1. Biochem. Pharmacol, 2008; 75: 438-447
    • (2008) Pharmacol , vol.75 , pp. 438-447
    • Mao, Y.1    Jin, J.2    Kunapuli, S.P.3
  • 27
    • 0036285450 scopus 로고    scopus 로고
    • Selective inhibition of protease-activated receptor 4-dependent platelet activation by YD-3
    • Wu CC, Hwang TL, Liao CH, Kuo SC, Lee FY, Lee CY, Teng CM: Selective inhibition of protease-activated receptor 4-dependent platelet activation by YD-3. Thromb Haemost, 2002; 87: 1026-1033
    • (2002) Thromb Haemost , vol.87 , pp. 1026-1033
    • Wu, C.C.1    Hwang, T.L.2    Liao, C.H.3    Kuo, S.C.4    Lee, F.Y.5    Lee, C.Y.6    Teng, C.M.7
  • 28
    • 0035076283 scopus 로고    scopus 로고
    • The optimal treatment of venous thrombosis: Current status and future perspectives
    • Prandoni P, Bernardi E, Bagatella P, Piccioli A, Marchiori A: The optimal treatment of venous thrombosis: current status and future perspectives. Clin Lab, 2001; 47: 151-154
    • (2001) Clin Lab , vol.47 , pp. 151-154
    • Prandoni, P.1    Bernardi, E.2    Bagatella, P.3    Piccioli, A.4    Marchiori, A.5
  • 29
    • 0142214926 scopus 로고    scopus 로고
    • Therapeutic indications for acute venous thromboembolism. Current status and future perspectives
    • Prandoni P, Simioni P, Pagnan A: Therapeutic indications for acute venous thromboembolism. Current status and future perspectives. Minerva Cardioangiol, 2003; 51: 361-371
    • (2003) Minerva Cardioangiol , vol.51 , pp. 361-371
    • Prandoni, P.1    Simioni, P.2    Pagnan, A.3
  • 30
    • 77749289263 scopus 로고    scopus 로고
    • Comparative efficacy and safety of the novel oral anticoagulants dabigatran, rivaroxaban and apixaban in preclinical and clinical development
    • Ufer M: Comparative efficacy and safety of the novel oral anticoagulants dabigatran, rivaroxaban and apixaban in preclinical and clinical development. Thromb Haemost, 2010; 103: 572-585
    • (2010) Thromb Haemost , vol.103 , pp. 572-585
    • Ufer, M.1
  • 31
    • 34547924093 scopus 로고    scopus 로고
    • Effects of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate, on thrombus formation and bleeding time in rats
    • Wienen W, Stassen JM, Priepke H, Ries UJ, Hauel N: Effects of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate, on thrombus formation and bleeding time in rats. Thromb Haemost, 2007; 98: 333-338
    • (2007) Thromb Haemost , vol.98 , pp. 333-338
    • Wienen, W.1    Stassen, J.M.2    Priepke, H.3    Ries, U.J.4    Hauel, N.5
  • 33
    • 67949112764 scopus 로고    scopus 로고
    • Favorable therapeutic index of the direct factor Xa inhibitors, apixaban and rivaroxaban, compared to the thrombin inhibitor dabigatran in rabbits
    • Wong PC, Crain EJ, Watson CA, Xin B: Favorable therapeutic index of the direct factor Xa inhibitors, apixaban and rivaroxaban, compared to the thrombin inhibitor dabigatran in rabbits. J Thromb Haemost, 2009; 7: 1313-1320
    • (2009) J Thromb Haemost , vol.7 , pp. 1313-1320
    • Wong, P.C.1    Crain, E.J.2    Watson, C.A.3    Xin, B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.