Type 2 diabetes: The genetic conflict hypothesis

Medical Hypotheses

Volumn 80, Issue 4, 2013, Pages 436-440

  Denic, S ^a   Emerald, S ^a   Nicholls, M G ^b  

^a UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

SOMATOMEDIN B;

ALLELE; ARAB; ARTICLE; BIRTH WEIGHT; CONSANGUINEOUS MARRIAGE; DEVELOPMENTAL GENE; EPIGENETICS; FATHER; FETUS GROWTH; GENE EXPRESSION; GENE REPRESSION; GENETIC ASSOCIATION; GENETIC CONFLICT; GENETIC RISK; GENOME IMPRINTING; GENOTYPE; HEREDITY; HUMAN; HYPERGLYCEMIA; INSULIN RESISTANCE; LOW BIRTH WEIGHT; MATE CHOICE; MOTHER; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PLEIOTROPY; POLYANDRY; PREVALENCE; PROGENY; RISK ASSESSMENT; SPOUSE; UNDERWEIGHT;

DIABETES MELLITUS, TYPE 2; GENETIC PREDISPOSITION TO DISEASE; GENOMIC IMPRINTING; HETEROZYGOTE; HUMANS; MODELS, GENETIC;

EID: 84875387154     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2012.12.036     Document Type: Article

References (49)

1. Von Bonsdorff M.B., Muller M., Aspelund T., et al. Persistence of the effect of birth size on dysglycaemia and type 2 diabetes in old age: AGES-Reykjavik Study. Age (Dordr) 2012, May 16. [Epub ahead of print].
2. Vaag A., Jensen C.B., Poulsen P., et al. Metabolic aspects of insulin resistance in individuals born small for gestational age. Horm Res 2006, 65(Suppl. 3):137-143.
3. Wannamethee S.G., Lawlor D.A., Whincup P.H., Walker M., Ebrahim S., Davey-Smith G. Birthweight of offspring and paternal insulin resistance and paternal diabetes in late adulthood: cross sectional survey. Diabetologia 2004, 47:12-18.
4. Lindsay R.S., Dabelea D., Roumain J., Hanson R.L., Bennett P.H., Knowler W.C. Type 2 diabetes and low birth weight: the role of paternal inheritance in the association of low birth weight and diabetes. Diabetes 2000, 49:445-449.
5. Ng S.W., Zaghloul S., Ali H.I., Harrison G., Popkin B.M. The prevalence and trends of overweight, obesity and nutrition-related non-communicable diseases in the Arabian Gulf States. Obes Rev 2011, 12:1-13.
6. Saadi H., Carruthers S.G., Nagelkerke N., et al. Prevalence of diabetes mellitus and its complications in a population-based sample in Al Ain, United Arab Emirates. Diabetes Res Clin Pract 2007, 78:369-377.
7. Khamaisi M., Raz I. Diabetes epidemic and the thrifty gene. Isr Med Assoc J 2002, 4:720-721.
8. Dedoussis G.V., Kaliora A.C., Panagiotakos D.B. Genes, diet and type 2 diabetes mellitus: a review. Rev Diabet Stud 2007, 4:13-24.
9. O'Rahilly S., Barroso I., Wareham N.J. Genetic factors in type 2 diabetes: the end of the beginning?. Science 2005, 307:370-373.
10. Neel J.V. Diabetes mellitus: a " thrifty" genotype rendered detrimental by " progress" ? 1962. Bull World Health Organ 1999, 77:694-703. discussion.
11. Hattersley A.T., Tooke J.E. The fetal insulin hypothesis: an alternative explanation of the association of low birthweight with diabetes and vascular disease. Lancet 1999, 353:1789-1792.
12. Frayling T.M., Hattersley A.T. The role of genetic susceptibility in the association of low birth weight with type 2 diabetes. Br Med Bull 2001, 60:89-101.
13. Barker D.J. Adult consequences of fetal growth restriction. Clin Obstet Gynecol 2006, 49:270-283.
14. Ornoy A. Prenatal origin of obesity and their complications: Gestational diabetes, maternal overweight and the paradoxical effects of fetal growth restriction and macrosomia. Reprod Toxicol 2011, 32:205-212.
15. Mitchell B.D., Pollin T.I. Genomic imprinting in diabetes. Genome Med 2010, 2:55.
16. Zaitoun I., Downs K.M., Rosa G.J., Khatib H. Upregulation of imprinted genes in mice. an insight into the intensity of gene expression and the evolution of genomic imprinting. Epigenetics 2010, 5:149-158.
17. Burt A., Trivers R. Genes in conflict: the biology of selfish genetic elements 2006, Belknap Press of Harvard University Press, Cambridge.
18. Lim D.H., Maher E.R. Human imprinting syndromes. Epigenomics 2009, 1:347-369.
19. Piedrahita J.A. The role of imprinted genes in fetal growth abnormalities. Birth Defects Res, Part A 2011, 91:682-692.
20. Giddings S.J., King C.D., Harman K.W., Flood J.F., Carnaghi L.R. Allele specific inactivation of insulin 1 and 2, in the mouse yolk sac, indicates imprinting. Nat Genet 1994, 6:310-313.
21. Gluckman P.D., Hanson M.A. The consequences of being born small - an adaptive perspective. Horm Res 2006, 65(Suppl. 3):5-14.
22. Ng S.F., Lin R.C., Laybutt D.R., Barres R., Owens J.A., Morris M.J. Chronic high-fat diet in fathers programs beta-cell dysfunction in female rat offspring. Nature 2010, 467:963-966.
23. Seckl J.R. Prenatal glucocorticoids and long-term programming. Eur J Endocrinol 2004, 151(Suppl. 3):U49-62.
24. Harris A., Seckl J. Glucocorticoids, prenatal stress and the programming of disease. Horm Behav 2011, 59:279-289.
25. Drake A.J., Liu L. Intergenerational transmission of programmed effects: public health consequences. Trends Endocrinol Metab 2010, 21:206-213.
26. Skinner M.K. Metabolic disorders: Fathers' nutritional legacy. Nature 2010, 467:922-923.
27. Aro S.O., Adejumo D.O. The effect of social groups on reproductive performance of Wistar rats. J Anim Plant Sci 2010, 6:637-644.
28. Haig D. Genetic conflicts in human pregnancy. Q Rev Biol 1993, 68:495-532.
29. Burt A., Trivers R. Genetic conflicts in genomic imprinting. Proc Biol Sci 1998, 265:2393-2397.
30. Kanazawa S., Still C.M. Why monogamy?. Soc Forces 1999, 78:25-50.
31. Starkweather K. A preliminary survey of lesser-known polyandrous societies. Nebraska Antrhopologist 2009;17-35.
32. Haig D. Genomic imprinting and kinship: how good is the evidence?. Annu Rev Genet 2004, 38:553-585.
33. Vrana P.B., Guan X.J., Ingram R.S., Tilghman S.M. Genomic imprinting is disrupted in interspecific Peromyscus hybrids. Nat Genet 1998, 20:362-365.
34. Geary D.C., Vigil J., Byrd-Craven J. Evolution of human mate choice. J Sex Res 2004, 41:27-42.
35. Schmitt D.P. Sociosexuality from Argentina to Zimbabwe: a 48-nation study of sex, culture, and strategies of human mating. Behav Brain Sci 2005, 28:247-311. discussion.
36. Wilkins J.F., Haig D. Inbreeding, maternal care and genomic imprinting. J Theor Biol 2003, 221:559-564.
37. Wilkins J.F., Haig D. What good is genomic imprinting: the function of parent-specific gene expression. Nat Rev Genet 2003, 4:359-368.
38. Bittles A.H., Black M.L. Evolution in health and medicine Sackler colloquium: Consanguinity, human evolution, and complex diseases. Proc Natl Acad Sci USA 2010, 107(Suppl. 1):1779-1786.
39. Mumtaz G., Tamim H., Kanaan M., et al. Effect of consanguinity on birth weight for gestational age in a developing country. Am J Epidemiol 2007, 165:742-752.
40. [40] Bellad M.B., Goudar S.S., Edlavitch S.A., et al. Consanguinity, prematurity, birth weight and pregnancy loss: a prospective cohort study at four primary health center areas of Karnataka, India. Journal of Perinatology: official journal of the California Perinatal Association 2011, 32:431-437.
41. Magnus P., Berg K., Bjerkedal T. Association of parental consanguinity with decreased birth weight and increased rate of early death and congenital malformations. Clin Genet 1985, 28:335-342.
42. Chamie J. Polygyny among Arabs. Popul Stud 1986, 40:55-66.
43. Denic S., Nagelkerke N., Agarwal M.M. Choice of kin in consanguineous marriages: effects of altruism and ecological factors. Ann Hum Biol 2010, 37:738-753.
44. Al-Gazali L.I., Bener A., Abdulrazzaq Y.M., Micallef R., Al-Khayat A.I., Gaber T. Consanguineous marriages in the United Arab Emirates. J Biosoc Sci 1997, 29:491-497.
45. Khlat M. Endogamy in the Arab World. Genetic disorders among Arab populations 1997, 63-79. Oxford University Press, New York. A.S. Teebi, T.I. Farag (Eds.).
46. Abou-Rbiah Y., Weitzman S. Diabetes among Bedouins in the Negev: the transition from a rare to a highly prevalent condition. Isr Med Assoc J 2002, 4:687-689.
47. Kalter-Leibovici O., Chetrit A., Lubin F., et al. Adult-onset diabetes among Arabs and Jews in Israel: a population-based study. Diabet Med 2012, 29:748-754.
48. Khongsdier R., Mukherjee N. Effects of heterosis on growth in height and its segments: a cross-sectional study of the Khasi girls in Northeast India. Ann Hum Biol 2003, 30:605-621.
49. Khongsdier R., Mukherjee N. Growth and nutritional status of Khasi boys in Northeast India relating to exogamous marriages and socioeconomic classes. Am J Phys Anthropol 2003, 122:162-170.