VEGF -634G>C polymorphism and diabetic retinopathy risk: A meta-analysis

Gene

Volumn 518, Issue 2, 2013, Pages 310-315

  Qiu, Min ^a   Xiong, Wei ^a   Liao, Hui ^a   Li, Feng ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Diabetic retinopathy; Meta analysis; Single nucleotide polymorphism; VEGF

Indexed keywords

VASCULOTROPIN;

ALLELE; ARTICLE; COMPARATIVE STUDY; DIABETIC PATIENT; DIABETIC RETINOPATHY; GENETIC ASSOCIATION; GENETIC MODEL; GENETIC POLYMORPHISM; HUMAN; META ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR; SENSITIVITY ANALYSIS;

DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 2; DIABETIC RETINOPATHY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK; TRANSCRIPTION, GENETIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84875377887     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2013.01.018     Document Type: Article

References (53)

1. Abhary S., Hewitt A.W., Burdon K.P., Craig J.E. A systematic meta-analysis of genetic association studies for diabetic retinopathy. Diabetes 2009, 58:2137-2147.
2. Adamis A.P., et al. Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am. J. Ophthalmol. 1994, 118:445-450.
3. Aiello L.P., et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N. Engl. J. Med. 1994, 331:1480-1487.
4. Al-Kateb H., et al. Multiple variants in vascular endothelial growth factor (VEGFA) are risk factors for time to severe retinopathy in type 1 diabetes: the DCCT/EDIC genetics study. Diabetes 2007, 56:2161-2168.
5. Awata T., et al. A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes. Diabetes 2002, 51:1635-1639.
6. Awata T., et al. Functional VEGF C-634G polymorphism is associated with development of diabetic macular edema and correlated with macular retinal thickness in type 2 diabetes. Biochem. Biophys. Res. Commun. 2005, 333:679-685.
7. Buraczynska M., Ksiazek P., Baranowicz-Gaszczyk I., Jozwiak L. Association of the VEGF gene polymorphism with diabetic retinopathy in type 2 diabetes patients. Nephrol. Dial. Transplant. 2007, 22:827-832.
8. Cheung N., Mitchell P., Wong T.Y. Diabetic retinopathy. Lancet 2010, 376:124-136.
9. Chun M.Y., et al. Association of vascular endothelial growth factor polymorphisms with nonproliferative and proliferative diabetic retinopathy. J. Clin. Endocrinol. Metab. 2010, 95:3547-3551.
10. Churchill A.J., et al. VEGF polymorphisms are associated with severity of diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 2008, 49:3611-3616.
11. Congdon N.G., Friedman D.S., Lietman T. Important causes of visual impairment in the world today. JAMA 2003, 290:2057-2060.
12. Crawford T.N., Alfaro D.V., Kerrison J.B., Jablon E.P. Diabetic retinopathy and angiogenesis. Curr. Diabetes Rev. 2009, 5:8-13.
13. dos Santos K.G., Canani L.H., Gross J.L., Tschiedel B., Souto K.E., Roisenberg I. The -106CC genotype of the aldose reductase gene is associated with an increased risk of proliferative diabetic retinopathy in Caucasian-Brazilians with type 2 diabetes. Mol. Genet. Metab. 2006, 88:280-284.
14. Duh E., Aiello L.P. Vascular endothelial growth factor and diabetes: the agonist versus antagonist paradox. Diabetes 1999, 48:1899-1906.
15. Errera F.I., et al. Functional vascular endothelial growth factor -634G>C SNP is associated with proliferative diabetic retinopathy: a case-control study in a Brazilian population of European ancestry. Diabetes Care 2007, 30:275-279.
16. Feghhi M., Nikzamir A., Esteghamati A., Mahmoudi T., Yekaninejad M.S. Relationship of vascular endothelial growth factor (VEGF) +405G/C polymorphism and proliferative retinopathy in patients with type 2 diabetes. Transl. Res. 2011, 158:85-91.
17. Ferrara N., Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr. Rev. 1997, 18:4-25.
18. Frank R.N. Vascular endothelial growth factor-its role in retinal vascular proliferation. N. Engl. J. Med. 1994, 331:1519-1520.
19. Funatsu H., Yamashita H., Nakanishi Y., Hori S. Angiotensin II and vascular endothelial growth factor in the vitreous fluid of patients with proliferative diabetic retinopathy. Br. J. Ophthalmol. 2002, 86:311-315.
20. Hallman D.M., Huber J.C., Gonzalez V.H., Klein B.E., Klein R., Hanis C.L. Familial aggregation of severity of diabetic retinopathy in Mexican Americans from Starr County, Texas. Diabetes Care 2005, 28:1163-1168.
21. Hietala K., Forsblom C., Summanen P., Groop P.H. Heritability of proliferative diabetic retinopathy. Diabetes 2008, 57:2176-2180.
22. Jeganathan V.S., Wang J.J., Wong T.Y. Ocular associations of diabetes other than diabetic retinopathy. Diabetes Care 2008, 31:1905-1912.
23. Kang P., Tian C., Jia C. Association of RAGE gene polymorphisms with type 2 diabetes mellitus, diabetic retinopathy and diabetic nephropathy. Gene 2012, 500:1-9.
24. Kangas-Kontio T., et al. Polymorphism of the manganese superoxide dismutase gene but not of vascular endothelial growth factor gene is a risk factor for diabetic retinopathy. Br. J. Ophthalmol. 2009, 93:1401-1406.
25. Kempen J.H., et al. The prevalence of diabetic retinopathy among adults in the United States. Arch. Ophthalmol. 2004, 122:552-563.
26. Klein R., Klein B.E., Moss S.E., Davis M.D., DeMets D.L. The Wisconsin epidemiologic study of diabetic retinopathy. III. Prevalence and risk of diabetic retinopathy when age at diagnosis is 30 or more years. Arch. Ophthalmol. 1984, 102:527-532.
27. Lambrechts D., et al. VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nat. Genet. 2003, 34:383-394.
28. Lambrechts D., et al. Low expression VEGF haplotype increases the risk for tetralogy of Fallot: a family based association study. J. Med. Genet. 2005, 42:519-522.
29. Mohamed Q., Gillies M.C., Wong T.Y. Management of diabetic retinopathy: a systematic review. JAMA 2007, 298:902-916.
30. Monti M.C., Lonsdale J.T., Montomoli C., Montross R., Schlag E., Greenberg D.A. Familial risk factors for microvascular complications and differential male-female risk in a large cohort of American families with type 1 diabetes. J. Clin. Endocrinol. Metab. 2007, 92:4650-4655.
31. Nakamura S., Iwasaki N., Funatsu H., Kitano S., Iwamoto Y. Impact of variants in the VEGF gene on progression of proliferative diabetic retinopathy. Graefes Arch. Clin. Exp. Ophthalmol. 2009, 247:21-26.
32. Nakanishi K., Watanabe C. Single nucleotide polymorphisms of vascular endothelial growth factor gene intron 2 are markers for early progression of diabetic retinopathy in Japanese with type 1 diabetes. Clin. Chim. Acta 2009, 402:171-175.
33. Ogata N., Nishikawa M., Nishimura T., Mitsuma Y., Matsumura M. Unbalanced vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in diabetic retinopathy. Am. J. Ophthalmol. 2002, 134:348-353.
34. Perrin R.M., Konopatskaya O., Qiu Y., Harper S., Bates D.O., Churchill A.J. Diabetic retinopathy is associated with a switch in splicing from anti- to pro-angiogenic isoforms of vascular endothelial growth factor. Diabetologia 2005, 48:2422-2427.
35. Petrovic M.G., et al. Local and genetic determinants of vascular endothelial growth factor expression in advanced proliferative diabetic retinopathy. Mol. Vis. 2008, 14:1382-1387.
36. Ray D., Mishra M., Ralph S., Read I., Davies R., Brenchley P. Association of the VEGF gene with proliferative diabetic retinopathy but not proteinuria in diabetes. Diabetes 2004, 53:861-864.
37. Sasongko M.B., Wong T.Y., Nguyen T.T., Shaw J.E., Jenkins A.J., Wang J.J. Novel versus traditional risk markers for diabetic retinopathy. Diabetologia 2012, 55:666-670.
38. Sato H., et al. Vitreous levels of vasohibin-1 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy. Diabetologia 2009, 52:359-361.
39. Schwartz S.G., Brantley M.A., Flynn H.W. Genetic associations with diabetic retinopathy. Curr. Diabetes Rev. 2012, 9:86-92.
40. Shen W.Y., et al. Long-term global retinal microvascular changes in a transgenic vascular endothelial growth factor mouse model. Diabetologia 2006, 49:1690-1701.
41. Simo R., Hernandez C. Intravitreous anti-VEGF for diabetic retinopathy: hopes and fears for a new therapeutic strategy. Diabetologia 2008, 51:1574-1580.
42. Stevens A., Soden J., Brenchley P.E., Ralph S., Ray D.W. Haplotype analysis of the polymorphic human vascular endothelial growth factor gene promoter. Cancer Res. 2003, 63:812-816.
43. Suganthalakshmi B., et al. Association of VEGF and eNOS gene polymorphisms in type 2 diabetic retinopathy. Mol. Vis. 2006, 12:336-341.
44. Szaflik J.P., et al. An association between vascular endothelial growth factor gene promoter polymorphisms and diabetic retinopathy. Graefes Arch. Clin. Exp. Ophthalmol. 2008, 246:39-43.
45. Uthra S., et al. Association of VEGF gene polymorphisms with diabetic retinopathy in a south Indian cohort. Ophthalmic Genet. 2008, 29:11-15.
46. Varma R. Diabetic retinopathy: challenges and future directions. Am. J. Ophthalmol. 2006, 141:539-541.
47. Waisbourd M., Goldstein M., Loewenstein A. Treatment of diabetic retinopathy with anti-VEGF drugs. Acta Ophthalmol. 2011, 89:203-207.
48. Watanabe D., et al. Vitreous levels of angiopoietin 2 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy. Am. J. Ophthalmol. 2005, 139:476-481.
49. Watson C.J., Webb N.J., Bottomley M.J., Brenchley P.E. Identification of polymorphisms within the vascular endothelial growth factor (VEGF) gene: correlation with variation in VEGF protein production. Cytokine 2000, 12:1232-1235.
50. Yang Y., Andresen B.T., Yang K., Zhang Y., Li X., Wang H. Association of vascular endothelial growth factor -634C/G polymorphism and diabetic retinopathy in type 2 diabetic Han Chinese. Exp. Biol. Med. (Maywood) 2010, 235:1204-1211.
51. Yang X., et al. Polymorphisms in the vascular endothelial growth factor gene and the risk of diabetic retinopathy in Chinese patients with type 2 diabetes. Mol. Vis. 2011, 17:3088-3096.
52. Yau J.W., et al. Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care 2012, 35:556-564.
53. Zhao T., Zhao J. Association between the -634C/G polymorphisms of the vascular endothelial growth factor and retinopathy in type 2 diabetes: a meta-analysis. Diabetes Res. Clin. Pract. 2010, 90:45-53.