Single nucleotide polymorphisms of vascular endothelial growth factor gene intron 2 are markers for early progression of diabetic retinopathy in Japanese with type 1 diabetes

Clinica Chimica Acta

Volumn 402, Issue 1-2, 2009, Pages 171-175

  Nakanishi, Koji ^a,b   Watanabe, Chizuru ^a  

^a TORANOMON HOSPITAL   (Japan)

^b Okinaka Memorial Institute for Medical Research   (Japan)

Author keywords

Diabetic retinopathy; Glycemic exposure; Single nucleotide polymorphism; Type 1 diabetes; Vascular endothelial growth factor gene

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C;

ADULT; ALLELE; ARTICLE; DIABETIC PATIENT; DIABETIC RETINOPATHY; DISEASE COURSE; DISEASE SEVERITY; EYE FUNDUS; FEMALE; GENE; GENE LINKAGE DISEQUILIBRIUM; GENOTYPE; GLUCOSE BLOOD LEVEL; HOMOZYGOTE; HUMAN; INCIDENCE; INSULIN DEPENDENT DIABETES MELLITUS; INTRON; JAPAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; VEGF GENE;

ADULT; ALLELES; DIABETES MELLITUS, TYPE 1; DIABETIC RETINOPATHY; FEMALE; GENE FREQUENCY; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INTRONS; JAPAN; LINKAGE DISEQUILIBRIUM; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 60649087113     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2009.01.004     Document Type: Article

References (22)

1. Ferrara N., and Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev 18 (1997) 4-25
2. Witmer A.N., Vrensen G.F.J.M., Van Noorden C.J.F., and Schlingemann R.O. Vascular endothelial growth factors and angiogenesis in eye disease. Prog Retin Eye Res 22 (2003) 1-29
3. Aiello L.M., Aiello L.P., and Cavallerano J.D. Ocular complications of diabetes mellitus. In: Kahn C.R., Weir G.C., King G.L., Jacobson A.M., Moses A.C., and Smith R.J. (Eds). Joslin's Diabetes Mellitus. 14th ed. (2005), Lippincott Williams & Wilkins, Philadelphia 901-924
4. Aiello L.P., Avery R.L., Arrigg P.G., et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 331 (1994) 1480-1487
5. Awata T., Inoue K., Kurihara S., et al. A common polymorphism in the 5′-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes. Diabetes 51 (2002) 1635-1639
6. Awata T., Kurihara S., Takata N., et al. Functional VEGF C-634G polymorphism is associated with development of diabetic macular edema and correlated with macular retinal thickness in type 2 diabetes. Biochem Biophys Res Commun 333 (2005) 679-685
7. Buraczynska M., Ksiazek P., Baranowicz-Gaszczyk I., and Jozwiak L. Association of the VEGF gene polymorphism with diabetic retinopathy in type 2 diabetes patients. Nephrol Dial Transplant 22 (2007) 827-832
8. Ray D., Mishra M., Ralph S., Read I., Davies R., and Brenchley P. Association of the VEGF gene with proliferative diabetic retinopathy but not proteinuria in diabetes. Diabetes 53 (2004) 861-864
9. Tischer E., Mitchell R., Hartman T., et al. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J Biol Chem 266 (1991) 11947-11954
10. Lachin J.M., Genuth S., Nathan D.M., Zinman B., and Rutledge B.N. Effect of glycemic exposure on the risk of microvascular complications in the Diabetes Control and Complications Trial-revisited. Diabetes 57 (2008) 995-1001
11. Al-Kateb H., Mirea L., Xie X., et al. Multiple variants in vascular endothelial growth factor (VEGFA) are risk factors for time to severe retinopathy in type 1 diabetes. The DCCT/EDIC Genetics Study. Diabetes 56 (2007) 2161-2168
12. Nakanishi K., and Watanabe C. Rate of β-cell destruction in type 1 diabetes influences the development of diabetic retinopathy: protective effect of residual β-cell function for more than 10 years. J Clin Endocrinol Metab 93 (2008) 4759-4766
13. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 28 Suppl. 1 (2005) S37-S42
14. Wilkinson C.P., Ferris III F.L., Klein R.E., et al. Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology 110 (2003) 1677-1682
15. Early Treatment Diabetic Retinopathy Study Research Group. Fundus photographic risk factors for progression of diabetic retinopathy. ETDRS report number 12. Ophthalmology 98 (1991) 823-833
16. Nakanishi K., Kobayashi T., Inoko H., Tsuji K., Murase T., and Kosaka K. Residual β-cell function and HLA-A24 in IDDM. Markers of glycemic control and subsequent development of diabetic retinopathy. Diabetes 44 (1995) 1334-1339
17. 1c: a rapid, automated precision-chromatography technique. Clin Chim Acta 92 (1979) 33-39
18. Shima K., Endo J., Oimomi M., et al. Interlaboratory difference in GHb measurement in Japan. The fifth report of the GHb standardization committee, the Japan Diabetes Society. J Jpn Diab Soc 41 (1998) 317-323
19. Barrett J.C., Fry B., Maller J., and Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21 (2005) 263-265
20. Cox D.R., and Oakes D. Analysis of Survival Data (1984), Chapman and Hall, London
21. Brogan I.J., Khan N., Isaac K., Hutchinson J.A., Pravica V., and Hutchinson I.V. Novel polymorphisms in the promoter and 5′ UTR regions of the human vascular endothelial growth factor gene. Hum Immunol 60 (1999) 1245-1249
22. Stevens A., Soden J., Brenchley P.E., Ralph S., and Ray D.W. Haplotype analysis of the polymorphic human vascular endothelial growth factor gene promoter. Cancer Res 63 (2003) 812-816