Withdrawal syndrome in the pediatric intensive care unit. incidence and risk factors;Síndrome de abstinencia en Cuidados Intensivos Pediátricos. Incidencia y factores de riesgo

Medicina Intensiva

Volumn 37, Issue 2, 2013, Pages 67-74

  Fernandez Carrion F ^a   Gaboli, M ^a   Gonzalez Celador R ^a   Gomez de Quero Masia P ^a   Fernandez de Miguel S ^a   Murga Herrera, V ^a   Serrano Ayestaran O ^a   Sanchez Granados J M ^a   Payo Perez R ^a  

^a HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

Author keywords

Benzodiazepines; Fentanyl; Iatrogenic withdrawal syndrome; Intensive Care Units; Midazolam; Opioids; Pediatric

Indexed keywords

FENTANYL; METHADONE; MIDAZOLAM;

ANALGESIA; ARTICLE; CLINICAL ARTICLE; CLINICAL FEATURE; COHORT ANALYSIS; CONTINUOUS INFUSION; CONTROLLED STUDY; DEMOGRAPHY; DISEASE SEVERITY; HUMAN; INTENSIVE CARE UNIT; MORBIDITY; RETROSPECTIVE STUDY; RISK FACTOR; SEDATION; TREATMENT DURATION; WITHDRAWAL SYNDROME;

ADOLESCENT; ANALGESICS, OPIOID; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; FEMALE; FENTANYL; HUMANS; HYPNOTICS AND SEDATIVES; INCIDENCE; INFANT; INFANT, NEWBORN; INTENSIVE CARE UNITS, PEDIATRIC; MALE; MIDAZOLAM; RETROSPECTIVE STUDIES; RISK FACTORS; SUBSTANCE WITHDRAWAL SYNDROME; TIME FACTORS;

EID: 84875377125     PISSN: 02105691     EISSN: 15786749     Source Type: Journal    
DOI: 10.1016/j.medin.2012.02.009     Document Type: Article

References (32)

1. Tobias J.D. Tolerance, withdrawal, and physical dependency after long-term sedation and analgesia of children in the pediatric intensive care unit. Crit Care Med 2000, 28:2122-2132.
2. Valdivieso-Serna A. Analgesia, sedación y relajación en el niño con ventilación mecánica. Med Intensiva 2008, 32(Suppl 1):115-124. Grupo de Trabajo de Analgesia y Sedación de la SEMICYUC.
3. Estébanez-Montiel M.B., Alonso-Fernández M.A., Sandiumenge A., Jiménez-Martín M.J. Sedación prolongada en Unidades de Cuidados Intensivos. Med Intensiva 2008, 32(Suppl 1):19-30. Grupo de Trabajo de Analgesia y Sedación de la SEMICYUC.
4. Jenkins I.A., Playfor S.D., Bevan C., Davies G., Wolf A. Current United Kingdom sedation practice in pediatric intensive care. Paediatr Anaesth 2007, 17:675-683.
5. Mencía S., Botrán M., López-Herce J., del Castillo J. Sedative, analgesic and muscle relaxant management in Spanish paediatric intensive care units. An Pediatr (Barc) 2011, 74:396-404. Grupo de Estudio de Sedoanalgesia de la SECIP.
6. Birchley G. Opioid and benzodiazepine withdrawal síndromes in the paediatric intensive care unit: a review of recent literature. Nurs Crit Care 2009, 14:26-37.
7. Finnegan L.P., Connaughton J.F, Kron R.E., Emich J.P. Neonatal abstinence syndrome: Assessment and management. Addict Dis 1975, 2:141-158.
8. Bicudo J.N., De Souza N., Mangia C.M., De Carvalho W.B. Withdrawal syndrome associated with cessation of fentanyl and midazolam in pediatrics. Rev Assoc Med Bras 1999, 45:15-18.
9. Franck L.S., Naughton I., Winter I. Opioid and benzodiazepine withdrawal symptoms in paediatric intensive care patients. Intensive Crit Care Nurs 2004, 20:344-351.
10. Sfoggia A., Fontela P.S., Moraes A., Da Silva F., Sober R.B., Noer R.B., et al. Sedation and analgesia in children submitted to mechanical ventilation could be overestimated?. J Pediatr (Rio J) 2003, 79:343-348.
11. Sury M.R., Billingham I., Russell G.N., Hopkins C.S., Thornington R., Vivori E. Acute benzodiazepine withdrawal syndrome after midazolam infusions in children. Crit Care Med 1989, 17:301-302.
12. Bergman I., Steeves M., Burckart G., Thompson A. Reversible neurologic abnormalities associated with prolonged intravenous midazolam and fentanyl administration. J Pediatr 1991, 119:644-649.
13. Hughes J., Gill A., Leach H.J., Nunn A.J., Billingham I., Ratcliffe J., et al. A prospective study of the adverse effects of midazolam on withdrawal in critically ill children. Acta Paediatr 1994, 10:1194-1199.
14. Lugo R.A., McLaren R., Cash J., Pribble C.G., Vernon D.D. Enteral methadone to expedite fentanyl discontinuation and prevent opioid abstinence syndrome in the PICU. Pharmacotherapy 2001, 21:1566-1573.
15. Arnold J.H., Truog R.D., Orav E.J., Scavone J.M., Hershenson M.B. Tolerance and dependence in neonates sedated with fentanyl during extracorporeal membrane oxygenation. Anesthesiology 1990, 73:1136-1140.
16. Franck L.S., Vilardi J., Durand D., Powers R. Opioid withdrawal in neonates after continuous infusions of morphine or fentanyl during extracorporeal membrane oxygenation. Am J Crit Care 1998, 7:364-369.
17. Dominguez K.D., Lomako D.M., Katz R.W., Kelly H.W. Opioid withdrawal in critically ill neonates. Ann Pharmacother 2003, 37:473-477.
18. Katz R., Kelly H.W., Hsi A. Prospective study on the occurrence of withdrawal in critically ill children who receive fentanyl by continuous infusion. Crit Care Med 1994 May, 22:763-767.
19. Fonsmark L., Rasmussen Y.H., Carl P. Occurrence of withdrawal in critically ill sedated children. Crit Care Med 1999, 27:196-199.
20. Cammarano W.B., Pittet J.F., Weitz S., Schlobohm R., Marks J. Acute withdrawal syndrome related to the administration of analgesic and sedative medications in adult intensive care unit patients. Crit Care Med 1998, 26:676-684.
21. Siddappa R., Fletcher J.E., Heard A.M., Kielma D., Cimino M., Heard C.M. Methadone dosage for prevention of opioid withdrawal in children. Paediatr Anaesth 2003, 13:805-810.
22. Twite M.D., Rashid A., Zuk J., Friesen R.H. Sedation, analgesia and neuromuscular blockade in the pediatric intensive care unit: Survey of fellowship training programs. Pediatr Crit Care Med 2004, 5:521-532.
23. Cunliffe M., McArthur L., Dooley F. Managing sedation withdrawal in children who undergo prolonged PICU admission after discharge to the ward. Paediatr Anaesth 2004, 14:293-298.
24. Franck L.S., Harris S.K., Soetenga D.J., Amling J.K., Curley M.A. The Withdrawal Assessment Tool-1 (WAT-1): An assessment instrument for monitoring opioid and benzodiazepine withdrawal symptoms in pediatric patients. Pediatr Crit Care Med 2008, 9:573-580.
25. Ista E., Van Dijk M., De Hoog M., Tibboel D., Duivenvoorden H.J. Construction of the Sophia Observation withdrawal Symptoms-scale (SOS) for critically ill children. Intensive Care Med 2009, 35:1075-1081.
26. Robertson R.C., Darsey E., Fortenberry J.D., Pettignano R., Hartley G. Evaluation of an opiate-weaning protocol using methadone in pediatric intensive care unit patients. Pediatr Crit Care Med 2000, 1:119-123.
27. Meyer M.M., Berens R.J. Efficacy of an enteral 10-day methadone wean to prevent opioid withdrawal in fentanyl-tolerant pediatric intensive care unit patients. Pediatr Crit Care Med 2001, 2:329-333.
28. Berens R.J., Meyer M.T., Mikhailov T.A., Colpaert K.D., Czarnecki M.L., Ghanayem N.S., et al. A prospective evaluation of opioid weaning in opioid-dependent pediatric critical care patients. Anesth Analg 2006, 102:1045-1050.
29. Agthe A.G., Kim G.R., Mathias K.B., Hendrix C.W., Chavez-Valdez R., Jansson L., et al. Clonidine as an adjunct therapy to opioids for neonatal abstinence syndrome: a randomised, controlled trial. Pediatrics 2009, 123:849-856.
30. Esmaeili A., Keinhorst A.K., Schuster T., Beske F., Schlosser R., Bastanier C. Treatment of neonatal abstinence syndrome with clonidine and chloral hydrate. Acta Paediatr 2010, 99:209-214.
31. Liatsi D., Tsapas B., Pampori S., Tsagourias M., Pneumatikos I., Matamis D. Respiratory, metabolic and hemodynamic effects of clonidine in ventilated patients presenting with withdrawal syndrome. Intensive Care Med 2009, 35:275-281.
32. French J.P., Nocera M. Drug withdrawal symptoms in children after continuous infusions of fentanyl. J Pediatr Nurs 1994, 9:107-113.