Respiratory, metabolic and hemodynamic effects of clonidine in ventilated patients presenting with withdrawal syndrome

Intensive Care Medicine

Volumn 35, Issue 2, 2009, Pages 275-281

  Liatsi, Domniki ^a   Tsapas, Basilis ^a   Pampori, Smaro ^a   Tsagourias, Matthew ^a   Pneumatikos, Ioannis ^b   Matamis, Dimitrios ^a  

^a PAPAGEORGIOU GENERAL HOSPITAL   (Greece)

^b Alexandroupolis University Hospital   (Greece)

Author keywords

Clonidine; Hemodynamic effects; Metabolic effects; Respiratory effects; Sedation; Weaning from mechanical ventilation; Withdrawal syndrome

Indexed keywords

CARBON DIOXIDE; CLONIDINE; FENTANYL; MIDAZOLAM; PROPOFOL; REMIFENTANIL;

ADULT; AGITATION; ARTICLE; ARTIFICIAL VENTILATION; BRADYCARDIA; BREATHING; BREATHING RATE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTINUOUS INFUSION; DRUG EFFECT; DRUG SUBSTITUTION; DRUG WITHDRAWAL; ENERGY CONSUMPTION; FEMALE; HEART ARRHYTHMIA; HEART RATE; HEMODYNAMICS; HUMAN; HYPERHIDROSIS; HYPERTENSION; HYPERVENTILATION; HYPOTENSION; INTENSIVE CARE; MALE; MEAN ARTERIAL PRESSURE; METABOLIC PARAMETERS; OXYGEN CONSUMPTION; PROSPECTIVE STUDY; REPEATED DRUG DOSE; RESPIRATORY TRACT PARAMETERS; SEDATION; SIDE EFFECT; TACHYCARDIA; TIDAL VOLUME; TREATMENT RESPONSE; VENTILATED PATIENT; VENTILATOR; WITHDRAWAL SYNDROME;

ADRENERGIC ALPHA-AGONISTS; ADULT; CALORIMETRY, INDIRECT; CARBON DIOXIDE; CLONIDINE; ELECTROCARDIOGRAPHY; ENERGY METABOLISM; FEMALE; HEMODYNAMICS; HUMANS; HYPERTENSION; HYPNOTICS AND SEDATIVES; MALE; OXYGEN CONSUMPTION; PIPERIDINES; PROPOFOL; PROSPECTIVE STUDIES; RESPIRATION, ARTIFICIAL; RESPIRATORY INSUFFICIENCY; REST; SUBSTANCE WITHDRAWAL SYNDROME; TACHYCARDIA; VENTILATOR WEANING;

EID: 59849111661     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-008-1251-0     Document Type: Article

References (31)

1. WB Cammarano JF Pittet S Weitz RM Schlobohm JD Marks 1998 Acute withdrawal syndrome related to the administration of analgesic and sedative medications in adult intensive care unit patients Crit Care Med 26 676 684
2. J Jacobi GL Fraser DB Coursin RR Riker D Fontaine ET Wittbrodt DB Chalfin MF Masica HS Bjerke WM Coplin DW Crippen BD Fuchs RM Kelleher PE Marik SA Nasraway Jr MJ Murray WT Peruzzi PD Lumb 2002 Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult Crit Care Med 30 119 141
3. CA Soderstrom PC Dischinger GS Smith DR McDuff JR Hebel DA Gorelick 1992 Psychoactive substance dependence among trauma center patients JAMA 267 2756 2759
4. JA Blackman PD Patrick ML Buck RS Rust Jr 2004 Paroxysmal autonomic instability with dystonia after brain injury Arch Neurol 61 321 328
5. TR Kosten PG O'Connor 2003 Management of drug and alcohol withdrawal N Engl J Med 348 1786 1795
6. JE Hall TD Uhrich TJ Ebert 2001 Sedative, analgesic and cognitive effects of clonidine infusions in humans Br J Anaesth 86 5 11
7. MS Gold DE Redmond Jr HD Kleber 1978 Clonidine blocks acute opiate-withdrawal symptoms Lancet 2 599 602
8. DR Jasinski RE Johnson TR Kocher 1985 Clonidine in morphine withdrawal Differential effects on signs and symptoms Arch Gen Psychiatry 42 1063 1066
9. JW Flacke BC Bloor WE Flacke D Wong S Dazza SW Stead H Laks 1987 Reduced narcotic requirement by clonidine with improved hemodynamic and adrenergic stability in patients undergoing coronary bypass surgery Anesthesiology 67 11 19
10. PL Bailey RJ Sperry GK Johnson SJ Eldredge KA East TD East NL Pace TH Stanley 1991 Respiratory effects of clonidine alone and combined with morphine, in humans Anesthesiology 74 43 48
11. DA Jarvis SR Duncan IS Segal M Maze 1992 Ventilatory effects of clonidine alone and in the presence of alfentanil, in human volunteers Anesthesiology 76 899 905
12. R Ooi J Pattison SA Feldman 1991 The effects of intravenous clonidine on ventilation Anaesthesia 46 632 633
13. JA Harris FG Benedict 1918 A biometric study of human basal metabolism Proc Natl Acad Sci USA 4 370 373
14. M Velasco H Bertoncini E Romero A Urbina-Quintana J Guevara O Hernandez-Pieretti 1978 Effect of clonidine on sympathetic nervous activity in hydralazine-treated hypertensive patients Eur J Clin Pharmacol 13 317 320
15. PC Ip Yam A Forbes WJ Kox 1992 Clonidine in the treatment of alcohol withdrawal in the intensive care unit Br J Anaesth 68 106 108
16. CD Spies N Dubisz T Neumann S Blum C Muller H Rommelspacher G Brummer M Specht C Sanft L Hannemann HW Striebel W Schaffartzik 1996 Therapy of alcohol withdrawal syndrome in intensive care unit patients following trauma: results of a prospective, randomized trial Crit Care Med 24 414 422
17. S Arenas-Lopez S Riphagen SM Tibby A Durward S Tomlin G Davies IA Murdoch 2004 Use of oral clonidine for sedation in ventilated paediatric intensive care patients Intensive Care Med 30 1625 1629
18. H Bohrer A Bach M Layer P Werning 1990 Clonidine as a sedative adjunct in intensive care Intensive Care Med 16 265 266
19. Schneemilch CE, Bachmann H, Ulrich A, Elwert R, Halloul Z, Hachenberg T (2006) Clonidine decreases stress response in patients undergoing carotid endarterectomy under regional anesthesia: a prospective, randomized, double-blinded, placebo-controlled study. Anesth Analg 103:297-302; table of contents
20. L Quintin F Roudot C Roux I Macquin A Basmaciogullari T Guyene M Vaubourdolle JP Viale F Bonnet M Ghignone 1991 Effect of clonidine on the circulation and vasoactive hormones after aortic surgery Br J Anaesth 66 108 115
21. DN Sutton MR Tremlett TE Woodcock MS Nielsen 1990 Management of autonomic dysfunction in severe tetanus: the use of magnesium sulphate and clonidine Intensive Care Med 16 75 80
22. S Naredi E Eden S Zall H Stephensen B Rydenhag 1998 A standardized neurosurgical neurointensive therapy directed toward vasogenic edema after severe traumatic brain injury: clinical results Intensive Care Med 24 446 451
23. LM Wing JL Reid CA Hamilton P Sever DS Davies CT Dollery 1977 Effects of clonidine on biochemical indices of sympathetic function and plasma renin activity in normotensive man Clin Sci Mol Med 53 45 53
24. D Payen L Quintin P Plaisance B Chiron F Lhoste 1990 Head injury: clonidine decreases plasma catecholamines Crit Care Med 18 392 395
25. L Delaunay F Bonnet P Duvaldestin 1991 Clonidine decreases postoperative oxygen consumption in patients recovering from general anaesthesia Br J Anaesth 67 397 401
26. MT Taittonen OA Kirvela R Aantaa JH Kanto 1997 Effect of clonidine and dexmedetomidine premedication on perioperative oxygen consumption and haemodynamic state Br J Anaesth 78 400 406
27. D Benhamou Y Veillette P Narchi C Ecoffey 1991 Ventilatory effects of premedication with clonidine Anesth Analg 73 799 803
28. M Younes 1993 Patient-ventilator interaction with pressure-assisted modalities of ventilatory support Semin Respir Med 14 299 322
29. MJ Tobin W Perez SM Guenther G D'Alonzo DR Dantzker 1986 Breathing pattern and metabolic behavior during anticipation of exercise J Appl Physiol 60 1306 1312
30. MJ Mador MJ Tobin 1991 Effect of alterations in mental activity on the breathing pattern in healthy subjects Am Rev Respir Dis 144 481 487
31. A Jubran MJ Tobin 1997 Pathophysiologic basis of acute respiratory distress in patients who fail a trial of weaning from mechanical ventilation Am J Respir Crit Care Med 155 906 915