Expression of Rap1 during germ cell development in the rat and its functional implications in 2-methoxyacetic acid-induced spermatocyte apoptosis

Urology

Volumn 81, Issue 3, 2013, Pages 696.e1-696.e8

  Yang, Bo ^a   Sun, Hang ^a   Li, Wei ^a   Zhu, Chuchao ^a   Jian, Bailu ^a   Hou, Wugang ^a   Wang, He ^a   Yuan, Jianlin ^a   Yao, Bing ^b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; METHOXYACETIC ACID; RAP1 PROTEIN;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DIAGNOSTIC VALUE; EARLY DIAGNOSIS; GERM CELL; GOLGI COMPLEX; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MALE; MALE INFERTILITY; NEWBORN; NICK END LABELING; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPERMATID; SPERMATOCYTE; SPERMATOGENESIS; SPERMATOGONIUM; TESTIS; TESTIS DEVELOPMENT;

EID: 84875373059     PISSN: 00904295     EISSN: 15279995     Source Type: Journal    
DOI: 10.1016/j.urology.2012.11.005     Document Type: Article

References (21)

1. S. Weikert, F. Christoph, and W. Schulze Testicular expression of survivin and human telomerase reverse transcriptase (hTERT) associated with spermatogenic function in infertile patients Asian J Androl 8 2006 95 100
2. S. Laurentino, J. Goncalves, and J.E. Cavaco Apoptosis-inhibitor Aven is downregulated in defective spermatogenesis and a novel estrogen target gene in mammalian testis Fertil Steril 96 2011 745 750
3. J.J. Gu, C.P. Lavau, and E. Pugacheva Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1 Sci Signal 5 2012 ra51
4. E.S. Wittchen, and M.E. Hartnett The small GTPase Rap1 is a novel regulator of RPE cell barrier function Invest Ophthalmol Vis Sci 52 2011 7455 7463
5. X. Li, R. Zhang, and K.M. Draheim Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1) J Biol Chem 287 2012 22317 22327
6. E. Aivatiadou, E. Mattei, and M. Ceriani Impaired fertility and spermiogenetic disorders with loss of cell adhesion in male mice expressing an interfering Rap1 mutant Mol Biol Cell 18 2007 1530 1542
7. E. Aivatiadou, M. Ripolone, and F. Brunetti cAMP-Epac2-mediated activation of Rap1 in developing male germ cells: RA-RhoGAP as a possible direct down-stream effector Mol Reprod Dev 76 2009 407 416
8. B. Yang, H. Wang, and X.K. Gao Expression and significance of Rap1A in testes of azoospermic subjects Asian J Androl 6 2004 35 40
9. M. Oguro, M. Koike, and T. Ueno Dissociation and dispersion of claudin-3 from the tight junction could be one of the most sensitive indicators of reflux esophagitis in a rat model of the disease J Gastroenterol 46 2011 629 638
10. W. Li, J. Zhang, and X. Liu Correlation of appearance of metastasis-associated protein1 (Mta1) with spermatogenesis in developing mouse testis Cell Tissue Res 329 2007 351 362
11. R.J. Rasoulpour, and K. Boekelheide NF-kappaB activation elicited by ionizing radiation is proapoptotic in testis Biol Reprod 76 2007 279 285
12. J. Lee, and T. Shinohara Epigenetic modifications and self-renewal regulation of mouse germline stem cells Cell Res 21 2011 1164 1171
13. F. Niola, X. Zhao, and D. Singh Id proteins synchronize stemness and anchorage to the niche of neural stem cells Nat Cell Biol 14 2012 477 487
14. V. Pizon, M. Desjardins, and C. Bucci Association of Rap1a and Rap1b proteins with late endocytic/phagocytic compartments and Rap2a with the Golgi complex J Cell Sci 107 1994 1661 1670
15. F. Beranger, B. Goud, and A. Tavitian Association of the Ras-antagonistic Rap1/Krev-1 proteins with the Golgi complex Proc Natl Acad Sci U S A 88 1991 1606 1610
16. I. Maridonneau-Parini, and J. de Gunzburg Association of Rap1 and Rap2 proteins with the specific granules of human neutrophils: translocation to the plasma membrane during cell activation J Biol Chem 267 1992 6396 6402
17. N. Mochizuki, S. Yamashita, and K. Kurokawa Spatio-temporal images of growth factor-induced activation of Ras and Rap1 Nature 411 2001 1065 1068
18. A.V. Rao, and C. Shaha N-acetylcysteine prevents MAA induced male germ cell apoptosis: role of glutathione and cytochrome c FEBS Lett 527 2002 133 137
19. P.H. Remans, S.I. Gringhuis, and J.M. van Laar Rap1 signaling is required for suppression of Ras-generated reactive oxygen species and protection against oxidative stress in T lymphocytes J Immunol 173 2004 920 931
20. K. Mizuno, Y. Hayashi, and Y. Kojima Activation of NF-kappaB associated with germ cell apoptosis in testes of experimentally induced cryptorchid rat model Urology 73 2009 389 393
21. T.T. Turner, and J.J. Lysiak Oxidative stress: a common factor in testicular dysfunction J Androl 29 2008 488 498