Knockdown of orexin type 2 receptor in the lateral pontomesencephalic tegmentum of rats increases REM sleep

European Journal of Neuroscience

Volumn 37, Issue 6, 2013, Pages 957-963

  Chen, Lichao ^a,b   Mckenna, James T ^a,b   Bolortuya, Yunren ^a,b   Brown, Ritchie E ^a,b   Mccarley, Robert W ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Diurnal; Hypocretin; Narcolepsy; RNA interference; SiRNA

Indexed keywords

MESSENGER RNA; OREXIN 2 RECEPTOR; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; LATERAL PONTOMESENCEPHALIC TEGMENTUM; MALE; NONHUMAN; NONREM SLEEP; PRIORITY JOURNAL; RAT; REM SLEEP; TEGMENTUM; WAKEFULNESS;

ANIMALS; GENE SILENCING; MALE; PHOTOPERIOD; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; RNA, MESSENGER; RNA, SMALL INTERFERING; SLEEP, REM; TEGMENTUM MESENCEPHALI; TRANSCRIPTION, GENETIC; WAKEFULNESS;

EID: 84875371150     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/ejn.12101     Document Type: Article

References (37)

1. Boissard, R., Fort, P., Gervasoni, D., Barbagli, B. & Luppi, P.H. (2003) Localization of the GABAergic and non-GABAergic neurons projecting to the sublaterodorsal nucleus and potentially gating paradoxical sleep onset. Eur. J. Neurosci., 18, 1627-1639.
2. Brischoux, F., Mainville, L. & Jones, B.E. (2008) Muscarinic-2 and orexin-2 receptors on GABAergic and other neurons in the rat mesopontine tegmentum and their potential role in sleep-wake state control. J. Comp. Neurol., 510, 607-630.
3. Brown, R.E. (2003) Involvement of hypocretins/orexins in sleep disorders and narcolepsy. Drug News Perspect., 16, 75-79.
4. Brown, R.E., Basheer, R., McKenna, J.T., Strecker, R.E. & McCarley, R.W. (2012) Control of sleep and wakefulness. Physiol. Rev., 92, 1087-1187.
5. Chemelli, R.M., Willie, J.T., Sinton, C.M., Elmquist, J.K., Scammell, T., Lee, C., Richardson, J.A., Williams, S.C., Xiong, Y., Kisanuki, Y., Fitch, T.E., Nakazato, M., Hammer, R.E., Saper, C.B. & Yanagisawa, M. (1999) Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell, 98, 437-451.
6. Chen, L., Thakkar, M.M., Winston, S., Bolortuya, Y., Basheer, R. & McCarley, R.W. (2006) REM sleep changes in rats induced by siRNA-mediated orexin knockdown. Eur. J. Neurosci., 24, 2039-2048.
7. Chen, L., Brown, R.E., McKenna, J.T. & McCarley, R.W. (2009) Animal models of narcolepsy. CNS Neurol. Disord.-Dr., 8, 296-308.
8. Chen, L., McKenna, J.T., Bolortuya, Y., Winston, S., Thakkar, M.M., Basheer, R., Brown, R.E. & McCarley, R.W. (2010) Knockdown of orexin type 1 receptor in rat locus coeruleus increases REM sleep during the dark period. Eur. J. Neurosci., 32, 1528-1536.
9. Cluderay, J.E., Harrison, D.C. & Hervieu, G.J. (2002) Protein distribution of the orexin-2 receptor in the rat central nervous system. Regul. Pept., 104, 131-144.
10. Crochet, S., Onoe, H. & Sakai, K. (2006) A potent non-monoaminergic paradoxical sleep inhibitory system: a reverse microdialysis and single-unit recording study. Eur. J. Neurosci., 24, 1404-1412.
11. Datta, S. & Maclean, R.R. (2007) Neurobiological mechanisms for the regulation of mammalian sleep-wake behavior: reinterpretation of historical evidence and inclusion of contemporary cellular and molecular evidence. Neurosci. Biobehav. Rev., 31, 775-824.
12. De Lecea, L., Kilduff, T.S., Peyron, C., Gao, X., Foye, P.E., Danielson, P.E., Fukuhara, C., Battenberg, E.L., Gautvik, V.T., Bartlett, F.S., Frankel, W.N., Van den Pol, A.N., Bloom, F.E., Gautvik, K.M. & Sutcliffe, J.G. (1998) The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl. Acad. Sci. USA, 95, 322-327.
13. Dillon, C.P., Sandy, P., Nencioni, A., Kissler, S., Rubinson, D.A. & Van Parijs, L. (2005) Rnai as an experimental and therapeutic tool to study and regulate physiological and disease processes. Annu. Rev. Physiol., 67, 147-173.
14. Greco, M.A. & Shiromani, P.J. (2001) Hypocretin receptor protein and mRNA expression in the dorsolateral pons of rats. Brain Res. Mol. Brain Res., 88, 176-182.
15. Johnson, P.L., Truitt, W., Fitz, S.D., Minick, P.E., Dietrich, A., Sanghani, S., Traskman-Bendz, L., Goddard, A.W., Brundin, L. & Shekhar, A. (2010) A key role for orexin in panic anxiety. Nat. Med., 16, 111-115.
16. Kaur, S., Thankachan, S., Begum, S., Liu, M., Blanco-Centurion, C. & Shiromani, P.J. (2009) Hypocretin-2 saporin lesions of the ventrolateral periaquaductal gray (vlPAG) increase REM sleep in hypocretin knockout mice. PLoS ONE, 4, e6346.
17. Krenzer, M., Anaclet, C., Vetrivelan, R., Wang, N., Vong, L., Lowell, B.B., Fuller, P.M. & Lu, J. (2011) Brainstem and spinal cord circuitry regulating REM sleep and muscle atonia. PLoS ONE, 6, e24998.
18. Liao, F., Taishi, P., Churchill, L., Urza, M.J. & Krueger, J.M. (2010) Localized suppression of cortical growth hormone-releasing hormone receptors state-specifically attenuates electroencephalographic delta waves. J. Neurosci., 30, 4151-4159.
19. Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X., Qiu, X., de Jong, P.J., Nishino, S. & Mignot, E. (1999) The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell, 98, 365-376.
20. Livak, K.J. & Schmittgen, T.D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods, 25, 402-408.
21. Lu, J., Sherman, D., Devor, M. & Saper, C.B. (2006) A putative flip-flop switch for control of REM sleep. Nature, 441, 589-594.
22. Luppi, P.H., Clement, O., Sapin, E., Gervasoni, D., Peyron, C., Leger, L., Salvert, D. & Fort, P. (2011) The neuronal network responsible for paradoxical sleep and its dysfunctions causing narcolepsy and rapid eye movement (REM) behavior disorder. Sleep Med. Rev., 15, 153-163.
23. Manrique, C., Compan, V., Rosselet, C. & Duflo, S.G. (2009) Specific knock-down of GAD67 in the striatum using naked small interfering RNAs. J. Biotechnol., 142, 185-192.
24. Marcus, J.N., Aschkenasi, C.J., Lee, C.E., Chemelli, R.M., Saper, C.B., Yanagisawa, M. & Elmquist, J.K. (2001) Differential expression of orexin receptors 1 and 2 in the rat brain. J. Comp. Neurol., 435, 6-25.
25. Mieda, M., Hasegawa, E., Kisanuki, Y.Y., Sinton, C.M., Yanagisawa, M. & Sakurai, T. (2011) Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep. J. Neurosci., 31, 6518-6526.
26. Paxinos, G. & Watson, C. (1998) The Rat Brain in Stereotaxic Coordinates. Academic Press, San Diego, CA.
27. Peyron, C., Tighe, D.K., van den Pol, A.N., de Lecea, L., Heller, H.C., Sutcliffe, J.G. & Kilduff, T.S. (1998) Neurons containing hypocretin (orexin) project to multiple neuronal systems. J. Neurosci., 18, 9996-10015.
28. Port, M., Schmelz, H.U., Stassen, T., Müeller, K., Stockinger, M., Obermair, R. & Abend, M. (2007) Correcting false gene expression measurements from degraded RNA using RTQ-PCR. Diagn. Mol. Pathol., 16, 38-49.
29. Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R.M., Tanaka, H., Williams, S.C., Richardson, J.A., Kozlowski, G.P., Wilson, S., Arch, J.R., Buckingham, R.E., Haynes, A.C., Carr, S.A., Annan, R.S., McNulty, D.E., Liu, W.S., Terrett, J.A., Elshourbagy, N.A., Bergsma, D.J. & Yanagisawa, M. (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell, 92, 573-585.
30. Sapin, E., Lapray, D., Berod, A., Goutagny, R., Leger, L., Ravassard, P., Clement, O., Hanriot, L., Fort, P. & Luppi, P.H. (2009) Localization of the brainstem GABAergic neurons controlling paradoxical (REM) sleep. PLoS ONE, 4, e4272.
31. Sastre, J.P., Buda, C., Kitahama, K. & Jouvet, M. (1996) Importance of the ventrolateral region of the periaqueductal gray and adjacent tegmentum in the control of paradoxical sleep as studied by muscimol microinjections in the cat. Neuroscience, 74, 415-426.
32. Taheri, S., Zeitzer, J.M. & Mignot, E. (2002) The role of hypocretins (orexins) in sleep regulation and narcolepsy. Annu. Rev. Neurosci., 25, 283-313.
33. Thakkar, M.M., Strecker, R.E. & McCarley, R.W. (2002) Phasic but not tonic REM-selective discharge of periaqueductal gray neurons in freely behaving animals: relevance to postulates of GABAergic inhibition of monoaminergic neurons. Brain Res., 945, 276-280.
34. Thankachan, S., Kaur, S. & Shiromani, P.J. (2009) Activity of pontine neurons during sleep and cataplexy in hypocretin knock-out mice. J. Neurosci., 29, 1580-1585.
35. Trivedi, P., Yu, H., MacNeil, D.J., Van der Ploeg, L.H. & Guan, X.M. (1998) Distribution of orexin receptor mRNA in the rat brain. FEBS Lett., 438, 71-75.
36. Vanini, G., Torterolo, P., McGregor, R., Chase, M.H. & Morales, F.R. (2007) GABAergic processes in the mesencephalic tegmentum modulate the occurrence of active (rapid eye movement) sleep in guinea pigs. Neuroscience, 145, 1157-1167.
37. Willie, J.T., Chemelli, R.M., Sinton, C.M., Tokita, S., Williams, S.C., Kisanuki, Y.Y., Marcus, J.N., Lee, C., Elmquist, J.K., Kohlmeier, K.A., Leonard, C.S., Richardson, J.A., Hammer, R.E. & Yanagisawa, M. (2003) Distinct narcolepsy syndromes in orexin receptor-2 and orexin null mice: molecular genetic dissection of non-REM and REM sleep regulatory processes. Neuron, 38, 715-730.