Cerebral blood flow and glucose metabolism in healthy volunteers measured using a high-resolution PET scanner

EJNMMI Research

Volumn 2, Issue 1, 2012, Pages 1-9

  Huisman, Marc C ^a   van Golen, Larissa W ^a   Hoetjes, Nikie J ^a   Greuter, Henri N ^a   Schober, Patrick ^a   Ijzerman, Richard G ^a   Diamant, Michaela ^a   Lammertsma, Adriaan A ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cerebral blood flow; Cerebral metabolic rate of glucose consumption; Full kinetic analysis; High resolution research tomograph; Image derived input function; Parametric images

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GLUCOSE; WATER O 15;

ADULT; ARTICLE; BLOOD SAMPLING; BRAIN BLOOD FLOW; BRAIN METABOLISM; BRAIN REGION; CAROTID ARTERY; CEREBRAL METABOLIC RATE; DIAGNOSTIC IMAGING EQUIPMENT; GLUCOSE METABOLISM; GLUCOSE UTILIZATION; GRAY MATTER; HIGH RESOLUTION POSITRON EMISSION TOMOGRAPHY SCANNER; HUMAN; HUMAN EXPERIMENT; MALE; METABOLIC PARAMETERS; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RELIABILITY; WHITE MATTER;

EID: 84875350349     PISSN: None     EISSN: 2191219X     Source Type: Journal    
DOI: 10.1186/2191-219X-2-63     Document Type: Article

References (36)

1. Lammertsma AA, Brooks DJ, Frackowiak RS, Beaney RP, Herold S, Heather JD, Palmer AJ, Jones T: Measurement of glucose utilization with [18 F]2-fluoro-2-deoxy-D-glucose: a comparison of different analytical methods. J Cereb Blood Flow Metab 1987, 7:161-172.
2. Schmidt KC, Lucignani G, Sokoloff L: Fluorine-18-fluorodeoxyglucose PET to determine regional cerebral glucose utilization: a re-examination. J Nucl Med 1996, 37:394-399.
3. Huang SC, Phelps ME, Hoffman EJ, Sideris K, Selin CJ, Kuhl DE: Noninvasive determination of local cerebral metabolic rate of glucose in man. Am J Physiol 1980, 238:E69-E82.
4. Phelps ME, Huang SC, Hoffman EJ, Selin C, Sokoloff L, Kuhl DE: Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-D-glucose: validation of method. Ann Neurol 1979, 6:371-388.
5. Reivich M, Kuhl D, Wolf A, Greenberg J, Phelps M, Ido T, Casella V, Fowler J, Hoffman E, Alavi A, Som P, Sokoloff L: The [18 F]fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man. Circ Res 1979, 44:127-137.
6. Sokoloff L, Reivich M, Kennedy C, Des Rosiers MH, Patlak CS, Pettigrew KD, Sakurada O, Shinohara M: The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem 1977, 28:897-916.
7. Wienhard K, Pawlik G, Herholz K, Wagner R, Heiss WD: Estimation of local cerebral glucose utilization by positron emission tomography of [18 F]2-fluoro-2-deoxy-D-glucose: a critical appraisal of optimization procedures. J Cereb Blood Flow Metab 1985, 5:115-125.
8. Yu AS, Lin HD, Huang SC, Phelps ME, Wu HM: Quantification of cerebral glucose metabolic rate in mice using 18 F-FDG and small-animal PET. J Nucl Med 2009, 50:966-973.
9. Frackowiak R, Lenzi G, Jones T, Heather J: Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: theory, procedure, and normal values. J Comput Assist Tomogr 1980, 6:727-736.
10. Herscovitch P, Raichle ME: Effect of tissue heterogeneity on the measurement of cerebral blood flow with the equilibrium C15O2 inhalation technique. J Cereb Blood Flow Metab 1983, 3:407-415.
11. Koeppe RA, Holden JE, Ip WR: Performance comparison of parameter estimation techniques for the quantitation of local cerebral blood flow by dynamic positron computed tomography. J Cereb Blood Flow Metab 1985, 5:224-234.
12. Lammertsma AA, Cunningham VJ, Deiber MP, Heather JD, Bloomfield PM, Nutt J, Frackowiak RS, Jones T: Combination of dynamic and integral methods for generating reproducible functional CBF images. J Cereb Blood Flow Metab 1990, 10:675-686.
13. Silverman DH, Phelps ME: Application of positron emission tomography for evaluation of metabolism and blood flow in human brain: normal development, aging, dementia, and stroke. Mol Genet Metab 2001, 74:128-138.
14. de Jong HW, van Velden FH, Kloet RW, Buijs FL, Boellaard R, Lammertsma AA: Performance evaluation of the ECAT HRRT: an LSO-LYSO double layer high resolution, high sensitivity scanner. Phys Med Biol 2007, 52:1505-1526.
15. Heiss WD, Habedank B, Klein JC, Herholz K, Wienhard K, Lenox M, Nutt R: Metabolic rates in small brain nuclei determined by high-resolution PET. J Nucl Med 2004, 45:1811-1815.
16. Borghammer P, Hansen SB, Eggers C, Chakravarty M, Vang K, Aanerud J, Hilker R, Heiss WD, Rodell A, Munk OL, Keator D, Gjedde A: Glucose metabolism in small subcortical structures in Parkinson's disease. Acta Neurol Scand 2012, 125:303-310.
17. Walker MD, Feldmann M, Matthews JC, Anton-Rodriguez JM, Wang S, Koepp MJ, Asselin MC: Optimization of methods for quantification of rCBF using high-resolution [(15)O]H(2)O PET images. Phys Med Biol 2012, 57:2251-2271.
18. Mourik JE, van Velden FH, Lubberink M, Kloet RW, van Berckel BN, Lammertsma AA, Boellaard R: Image derived input functions for dynamic High Resolution Research Tomograph PET brain studies. Neuroimage 2008, 43:676-686.
19. Mourik JE, Lubberink M, Klumpers UM, Comans EF, Lammertsma AA, Boellaard R: Partial volume corrected image derived input functions for dynamic PET brain studies: methodology and validation for [11C] flumazenil. Neuroimage 2008, 39:1041-1050.
20. Zanotti-Fregonara P, Chen K, Liow JS, Fujita M, Innis RB: Image-derived input function for brain PET studies: many challenges and few opportunities. J Cereb Blood Flow Metab 2011, 31:1986-1998.
21. Mourik JE, Lubberink M, Lammertsma AA, Boellaard R: Image derived input functions: effects of motion on tracer kinetic analyses. Mol Imaging Biol 2011, 13:25-31.
22. Boellaard R, Van LA, Van-Balen SC, Hoving BG, Lammertsma AA: Characteristics of a new fully programmable blood sampling device for monitoring blood radioactivity during PET. Eur J Nucl Med 2001, 28:81-89.
23. Hong IK, Chung ST, Kim HK, Kim YB, Son YD, Cho ZH: Ultra fast symmetry and SIMD-based projection-backprojection (SSP) algorithm for 3-D PET image reconstruction. IEEE Trans Med Imaging 2007, 26:789-803.
24. van Velden FH, Kloet RW, van Berckel BN, Lammertsma AA, Boellaard R: Accuracy of 3-dimensional reconstruction algorithms for the high-resolution research tomograph. J Nucl Med 2009, 50:72-80.
25. Cizek J, Herholz K, Vollmar S, Schrader R, Klein J, Heiss WD: Fast and robust registration of PET and MR images of human brain. Neuroimage 2004, 22:434-442.
26. Svarer C, Madsen K, Hasselbalch SG, Pinborg LH, Haugbol S, Frokjaer VG, Holm S, Paulson OB, Knudsen GM: MR-based automatic delineation of volumes of interest in human brain PET images using probability maps. Neuroimage 2005, 24:969-979.
27. Loening AM, Gambhir SS: AMIDE: a free software tool for multimodality medical image analysis. Mol Imaging 2003, 2:131-137.
28. Patlak CS, Blasberg RG, Fenstermacher JD: Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 1983, 3:1-7.
29. Reivich M, Alavi A, Wolf A, Fowler J, Russell J, Arnett C, MacGregor RR, Shiue CY, Atkins H, Anand A: Glucose metabolic rate kinetic model parameter determination in humans: the lumped constants and rate constants for [18 F]fluorodeoxyglucose and [11C]deoxyglucose. J Cereb Blood Flow Metab 1985, 5:179-192.
30. Boellaard R, Knaapen P, Rijbroek A, Luurtsema GJ, Lammertsma AA: Evaluation of basis function and linear least squares methods for generating parametric blood flow images using 15O-water and positron emission tomography. Mol Imaging Biol 2005, 7:273-285.
31. Brooks DJ, Gibbs JS, Sharp P, Herold S, Turton DR, Luthra SK, Kohner EM, Bloom SR, Jones T: Regional cerebral glucose transport in insulindependent diabetic patients studied using [11C]3-O-methyl-D-glucose and positron emission tomography. J Cereb Blood Flow Metab 1986, 6:240-244.
32. Duckrow RB: Glucose transfer into rat brain during acute and chronic hyperglycemia. Metab Brain Dis 1988, 3:201-209.
33. Ziegler D, Langen KJ, Herzog H, Kuwert T, Muhlen H, Feinendegen LE, Gries FA: Cerebral glucose metabolism in type 1 diabetic patients. Diabet Med 1994, 11:205-209.
34. Wilson PD, Huang SC, Hawkins RA: Single-scan Bayes estimation of cerebral glucose metabolic rate: comparison with non-Bayes single-scan methods using FDG PET scans in stroke. J Cereb Blood Flow Metab 1988, 8:418-425.
35. Hasselbalch SG, Knudsen GM, Capaldo B, Postiglione A, Paulson OB: Blood-brain barrier transport and brain metabolism of glucose during acute hyperglycemia in humans. J Clin Endocrinol Metab 2001, 86:1986-1990.
36. Knudsen GM: Application of the double-indicator technique for measurement of blood-brain barrier permeability in humans. Cerebrovasc Brain Metab Rev 1994, 6:1-30.