Immunogenic and Invasive Properties of Brucella melitensis 16M Outer Membrane Protein Vaccine Candidates Identified via a Reverse Vaccinology Approach

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Gomez, Gabriel ^a   Pei, Jianwu ^a   Mwangi, Waithaka ^a   Adams, L Garry ^a   Rice Ficht, Allison ^a,b   Ficht, Thomas A ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; BRUCELLA VACCINE; CELL SURFACE PROTEIN HIA; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; METAL CHELATE RC PROTEIN; NITRIC OXIDE; OUTER MEMBRANE PROTEIN; OUTER MEMBRANE PROTEIN 22; OUTER MEMBRANE PROTEIN W; PROTEIN FLGK; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN DETECTION; ARTICLE; ARTIFICIAL SELECTION; BACTERIAL VIRULENCE; BRUCELLA MELITENSIS; COMPUTER MODEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FEMALE; GENE EXPRESSION; GOAT; HUMAN; HUMORAL IMMUNITY; IMMUNIZATION; IMMUNOGENICITY; IMMUNOREACTIVITY; IMMUNOSTIMULATION; IN VITRO STUDY; NONHUMAN; OPEN READING FRAME; PREDICTIVE VALUE; PROTEIN EXPRESSION; PROTEIN PURIFICATION; REVERSE VACCINOLOGY; SPLEEN CELL; TH1 CELL; TH2 CELL; VACCINE PRODUCTION; VALIDATION PROCESS;

ANIMALS; BACTERIAL OUTER MEMBRANE PROTEINS; BRUCELLA MELITENSIS; BRUCELLA VACCINE; CELLS, CULTURED; CHROMATOGRAPHY, GEL; GOATS; HUMANS; MICE; NITRIC OXIDE; SPLEEN;

EID: 84875319728     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0059751     Document Type: Article

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