Effects and mechanism of action of a Tribulus terrestris extract on penile erection

Korean Journal of Urology

Volumn 54, Issue 3, 2013, Pages 183-188

  Do, Jungmo ^a   Choi, Seemin ^a   Choi, Jaehwi ^a   Hyun, Jae Seog ^a  

^a Gyeongsang National University   (South Korea)

Author keywords

Penile erection; Smooth muscle; Tribulus

Indexed keywords

4 AMINOPYRIDINE; CYCLIC AMP; CYCLIC GMP; GLIBENCLAMIDE; INDOMETACIN; N (G) NITROARGININE METHYL ESTER; TRIBULUS TERRESTRIS EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DRUG EFFECT; DRUG MECHANISM; ELECTROSTIMULATION; ERECTILE DYSFUNCTION; IMMUNOASSAY; IN VIVO STUDY; INTERNATIONAL INDEX OF ERECTILE FUNCTION; LEISURE; MALE; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; PENIS ERECTION; RABBIT; RAT; SMOOTH MUSCLE RELAXATION; TRANSDUCER; TUNICA ALBUGINEA;

EID: 84875317709     PISSN: 20056737     EISSN: 20056745     Source Type: Journal    
DOI: 10.4111/kju.2013.54.3.183     Document Type: Article

References (13)

1. Gholamine B, Shafiei M, Motevallian M, Mahmoudian M. Effects of pioglitazone on erectile dysfunction in sildenafil poor-responders: a randomized, controlled study. J Pharm Pharm Sci 2008;11:22-31.
2. Gauthaman K, Ganesan AP. The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction: an evaluation using primates, rabbit and rat. Phytomedicine 2008;15:44-54.
3. Gauthaman K, Adaikan PG, Prasad RN. Aphrodisiac properties of Tribulus terrestris extract (Protodioscin) in normal and castrated rats. Life Sci 2002;71:1385-96.
4. Martino-Andrade AJ, Morais RN, Spercoski KM, Rossi SC, Vechi MF, Golin M, et al. Effects of Tribulus terrestris on endocrine sensitive organs in male and female Wistar rats. J Ethnopharmacol 2010;127:165-70.
5. Bagcivan I, Gokce G, Yildirim S, Sarioglu Y. Investigation of the mechanism of nicotine induced relaxation in rabbit corpus cavernosum in vitro. Urol Res 2004;32:209-12.
6. Utkan NZ, Utkan T, Sarioglu Y, Canturk NZ, Okay E. Investigation of the mechanism of nicotine-induced relaxation in guinea pig gallbladder. J Surg Res 2003;110:272-5.
7. Skiker M, Mekhfi H, Aziz M, Haloui B, Lahlou S, Legssyer A, et al. Artemisia herba-alba Asso relaxes the rat aorta through activation of NO/cGMP pathway and K(ATP) channels. J Smooth Muscle Res 2010;46:165-74.
8. Diederichs W, Stief CG, Lue TF, Tanagho EA. Norepinephrine involvement in penile detumescence. J Urol 1990;143:1264-6.
9. Gauthaman K, Ganesan AP, Prasad RN. Sexual effects of punctu-revine (Tribulus terrestris) extract (protodioscin): an evaluation using a rat model. J Altern Complement Med 2003;9:257-65.
10. Arsyad KM. Effect of protodioscin on the quantity and quality of sperms from males with moderate idiopathic oligozoospermia. Medika 1996;22:614-8.
11. El-Tantawy WH, Temraz A, El-Gindi OD. Free serum testosterone level in male rats treated with Tribulus alatus extracts. Int Braz J Urol 2007;33:554-8.
12. Burnett AL. Nitric oxide in the penis: physiology and pathology. J Urol 1997;157:320-4.
13. Hedlund P, Aszodi A, Pfeifer A, Alm P, Hofmann F, Ahmad M, et al. Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice. Proc Natl Acad Sci U S A 2000;97:2349-54.