Effects of Tribulus terrestris on endocrine sensitive organs in male and female Wistar rats

Journal of Ethnopharmacology

Volumn 127, Issue 1, 2010, Pages 165-170

  Martino Andrade, Anderson J ^a   Morais, Rosana N ^a   Spercoski, Katherinne M ^a   Rossi, Stefani C ^a   Vechi, Marina F ^a   Golin, Munisa ^a   Lombardi, Natália F ^a   Greca, Cláudio S ^a   Dalsenter, Paulo R ^a  

^a FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

Author keywords

Androgenicity; Estrogenicity; Testosterone; Tribulus terrestris

Indexed keywords

ANDROGEN; ETHINYLESTRADIOL; METHYLTESTOSTERONE; PRASTERONE; TESTOSTERONE; TRIBULUS TERRESTRIS EXTRACT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CASTRATION; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFECT; ENDOCRINE GLAND; FEMALE; MALE; METABOLITE; NONHUMAN; POSTMENOPAUSE; PROSTATE; RAT; SEMINAL VESICLE; SPERMATID; TESTOSTERONE BLOOD LEVEL; UTERUS; VAGINA EPITHELIUM;

ANDROGENS; ANIMALS; CASTRATION; CELL COUNT; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIUM; FECES; FEMALE; MALE; MEDICINE, TRADITIONAL; ORGAN SIZE; ORGAN SPECIFICITY; PHYTOTHERAPY; PLANT EXTRACTS; PROSTATE; RATS; RATS, WISTAR; SEMINAL VESICLES; SPERMATIDS; TESTIS; TESTOSTERONE; TRIBULUS; UTERUS; VAGINA;

RATTUS; RATTUS NORVEGICUS; TRIBULUS TERRESTRIS;

EID: 72149125310     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.09.031     Document Type: Article

References (23)

1. Adaikan P.G., Gauthaman K., and Prasad R.N. History of herbal medicines with insight on the pharmacological properties of Tribulus terrestris. The Aging Male 4 (2001) 163-169
2. Amann R.P. Use of animal models for detecting specific alterations in reproduction. Fundamental and Applied Toxicology 2 (1982) 13-25
3. Andrade A.J., Araújo S., Santana G.M., Ohi M., and Dalsenter P.R. Screening for in vivo (anti)estrogenic and (anti)androgenic activities of technical and formulated deltamethrin. Regulatory Toxicology and Pharmacology 35 (2002) 379-382
4. Andrade A.J., Araújo S., Santana G.M., Ohi M., and Dalsenter P.R. Reproductive effects of deltamethrin on male offspring rats exposed during pregnancy and lactation. Regulatory Toxicology and Pharmacology 36 (2002) 310-317
5. Andrade A.J., Grande S.W., Talsness C.E., Grote K., and Chahoud I. A dose response study following in utero and lactational exposure to Di-(2-ethylhexyl) phthalate (DEHP): nonmonotonic dose response and low dose effects on rat brain aromatase activity. Toxicology 227 (2006) 185-192
6. Arsyad K.M. Effect of protodioscin on the quantity and quality of sperms from males with moderate idiopathic oligozoospermia. Medika 22 (1996) 614-618
7. Belz R.G. Stimulation versus inhibition-bioactivity of parthenin, a phytochemical from Parthenium hysterophorus L. Dose Response 30 (2007) 80-96
8. Brown G.A., Vukovich M.D., Reifenrath T.A., Uhl N.L., Parsons K.A., Sharp R.L., and King D.S. Effects of anabolic precursors on serum testosterone concentrations and adaptations to resistance training in young men. International Journal of Sport Nutrition and Exercise Metabolism 10 (2000) 340-359
9. Brown G.A., Vukovich M.D., Martini E.R., Kohut M.L., Franke W.D., Jackson D.A., and King D.S. Endocrine and lipid responses to chronic androstenediol-herbal supplementation in 30 to 58 year old men. Journal of the American College of Nutrition 20 (2001) 520-528
10. El-Tantawy W.H., Temraz A., and El-Gindi O.D. Free serum testosterone level in male rats treated with Tribulus alatus extracts. International Braz J Urol 33 (2007) 554-558
11. Gauthaman K., Adaikan P.G., and Prasad R.N. Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats. Life Sciences 71 (2002) 1385-1396
12. Gauthaman K., Ganesan A.P., and Prasad R.N. Sexual effects of puncturevine (Tribulus terrestris) extract (protodioscin): an evaluation using a rat model. Journal of Alternative and Complementary Medicine 9 (2003) 257-265
13. Gauthaman K., and Ganesan A.P. The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction-an evaluation using primates, rabbit and rat. Phytomedicine 15 (2008) 44-54
14. Munro C.J., Stabenfeldt G.H., Cragun J.R., Addiego L.A., Overstreet J.W., and Lasley B.L. Relationship of serum estradiol and progesterone concentrations to the excretion profiles of their major urinary metabolites as measured by enzyme immunoassay and radioimmunoassay. Clinical Chemistry 37 (1991) 838-844
15. Nevill A.M. The need to scale for differences in body size and mass: an explanation of Kleiber's 0.75 mass exponent. Journal of Applied Physiology 77 (1994) 2870-2873
16. Neychev V.K., and Mitev V.I. The aphrodisiac herb Tribulus terrestris does not influence the androgen production in young men. Journal of Ethnopharmacology 101 (2005) 319-323
17. Nian H., Qin L.P., Chen W.S., Zhang Q.Y., Zheng H.C., and Wang Y. Protective effect of steroidal saponins from rhizome of Anemarrhena asphodeloides on ovariectomy-induced bone loss in rats. Acta Pharmacologica Sinica 27 (2006) 728-734
18. Owens W., Zeiger E., Walker M., Ashby J., Onyon L., and Gray Jr. L.E. The OECD program to validate the rat Hershberger bioassay to screen compounds for in vivo androgen and antiandrogen responses. Phase 1: use of a potent agonist and a potent antagonist to test the standardized protocol. Environmental Health Perspectives 114 (2006) 1259-1265
19. Rhoden E.L., Gobbi D., Rhoden C.R., Menti E., Roehe A.N., Hartmann A., and Morgentaler A. Effects of chronic administration of dehydroepiandrosterone on serum testosterone levels and prostatic tissue in rats. Journal of Urology 170 (2003) 2101-2103
20. Rice S., and Whitehead S.A. Phytoestrogens and breast cancer--promoters or protectors?. Endocrine-Related Cancer 13 (2006) 995-1015
21. Touma C., and Palme R. Measuring fecal glucocorticoid metabolites in mammals and birds: the importance of validation. Annals of the New York Academy of Sciences 1046 (2005) 54-74
22. Welshons W.V., Thayer K.A., Judy B.M., Taylor J.A., Curran E.M., and vom Saal F.S. Large effects from small exposures I. Mechanisms for endocrine-disrupting chemicals with estrogenic activity. Environmental Health Perspectives 111 (2003) 994-1006
23. Wuttke W., Jarry H., and Seidlová-Wuttke D. Isoflavones-safe food additives or dangerous drugs?. Ageing Research Reviews 6 (2007) 150-188