Peptide inhibitor of CXCL4-CCL5 heterodimer formation, MKEY, inhibits experimental aortic aneurysm initiation and progression

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 33, Issue 4, 2013, Pages 718-726

  Iida, Yasunori ^a   Xu, Baohui ^a   Xuan, Haojun ^a   Glover, Keith J ^a   Tanaka, Hiroki ^a   Hu, Xiaolei ^a   Fujimura, Naoki ^a   Wang, Wei ^a   Schultz, Joshua R ^b   Turner, Court R ^b   Dalman, Ronald L ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Therapeutics Inc   (United States)

Author keywords

abdominal aortic aneurysm; CCL5; chemokines; CXCL4; mice

Indexed keywords

ANGIOTENSIN II; APOLIPOPROTEIN E; CHEMOKINE; CHEMOKINE RECEPTOR CCR5; ELASTIN; GELATINASE A; HETERODIMER; MKEY; PANCREATIC ELASTASE; PROTEIN CXCL4; PROTEIN INHIBITOR; RANTES; UNCLASSIFIED DRUG;

ABDOMINAL AORTA ANEURYSM; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CELL INFILTRATION; CONTROLLED STUDY; DISEASE COURSE; EXPERIMENTAL MODEL; IMMUNOHISTOCHEMISTRY; LEUKOCYTE MIGRATION INHIBITION; MACROPHAGE; MALE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SMOOTH MUSCLE FIBER;

ANGIOTENSIN II; ANIMALS; AORTA, ABDOMINAL; AORTIC ANEURYSM, ABDOMINAL; APOLIPOPROTEINS E; CELLS, CULTURED; CHEMOKINE CCL5; CHEMOTAXIS, LEUKOCYTE; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; INJECTIONS, INTRAVENOUS; LEUKOCYTES; MACROPHAGES; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCYTES, SMOOTH MUSCLE; OLIGOPEPTIDES; PANCREATIC ELASTASE; PLATELET FACTOR 4; RECEPTORS, CCR5; TIME FACTORS;

EID: 84875304506     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.112.300329     Document Type: Article

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