Analysis of HAX-1 gene expression in esophageal squamous cell carcinoma

Diagnostic Pathology

Volumn 8, Issue 1, 2013, Pages

  Li, Min ^a   Tang, Yue ^a   Zang, Wenqiao ^a   Xuan, Xiaoyan ^a   Wang, Na ^a   Ma, Yunyun ^b   Wang, Yuanyuan ^a   Dong, Ziming ^a   Zhao, Guoqiang ^a  

^a ZHENGZHOU UNIVERSITY   (China)

^b Department of Immunology and Microbiology   (China)

Author keywords

Esophageal squamous cell carcinoma; Gene expression; HAX 1; Prognosis

Indexed keywords

HAX1 PROTEIN, HUMAN; MESSENGER RNA; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TUMOR MARKER;

ADULT; AGED; ARTICLE; CHEMISTRY; CHI SQUARE DISTRIBUTION; ESOPHAGUS TUMOR; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; KAPLAN MEIER METHOD; LYMPH NODE METASTASIS; MALE; METASTASIS; MIDDLE AGED; MORTALITY; PATHOLOGY; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; REAL TIME POLYMERASE CHAIN REACTION; RISK FACTOR; SQUAMOUS CELL CARCINOMA; STATISTICAL MODEL; TIME; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AGED; CARCINOMA, SQUAMOUS CELL; CHI-SQUARE DISTRIBUTION; ESOPHAGEAL NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; LOGISTIC MODELS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; REAL-TIME POLYMERASE CHAIN REACTION; RISK FACTORS; RNA, MESSENGER; TIME FACTORS; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

MLCS; MLOWN;

EID: 84875303218     PISSN: None     EISSN: 17461596     Source Type: Journal    
DOI: 10.1186/1746-1596-8-47     Document Type: Article

References (23)

1. Suzuki Y, Demoliere C, Kitamura D, Takeshita H, Deuschle U, Watanabe T. HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases. J Immunol 1997, 158:2736-2744.
2. Carlsson G, van't Hooft I, Melin M, Entesarian M, Laurencikas E, Nennesmo I, Trebińska A, Grzybowska E, Palmblad J, Dahl N, Nordenskjöld M, Fadeel B, Henter JI. Central nervous system involvement in severe congenital neutropenia: neurological and neuropsychological abnormalities associated with specific HAX1 mutations. J Intern Med 2008, 264:388-400. 10.1111/j.1365-2796.2008.01982.x, 18513342.
3. Fadeel B, Grzybowska E. HAX-1: a multifunctional protein with emerging roles in human disease [J]. Biochim Biophys Acta 2009, 1790:1139-1148. 10.1016/j.bbagen.2009.06.004, 19524642.
4. Chao JR, Parganas E, Boyd K, Hong CY, Opferman JT, Ihle JN. Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons. Nature 2008, 452:98-102. 10.1038/nature06604, 18288109.
5. Sharp TV, Wang HW, Koumi A, Hollyman D, Endo Y, Ye H, Du MQ, Boshoff C. K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic function. J Virol 2002, 76:802-816. 10.1128/JVI.76.2.802-816.2002, 136811, 11752170.
6. Han Y, Chen YS, Liu Z, Bodyak N, Rigor D, Bisping E, Pu WT, Kang PM. Overexpression of HAX-1 protects cardiac myocytes from apoptosis through caspase-9 inhibition. Circ Res 2006, 99:415-423. 10.1161/01.RES.0000237387.05259.a5, 16857965.
7. Cilenti L, Soundarapandian MM, Kyriazis GA, Stratico V, Singh S, Gupta S, Bonventre JV, Alnemri ES, Zervos AS. Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death. J Biol Chem 2004, 79:50295-50301.
8. Lee AY, Lee Y, Park YK, Bae KH, Cho S, Lee do H, Park BC, Kang S, Park SG. HS1-associated protein X-1 is cleaved by caspase-3 during apoptosis. Mol Cells 2008, 25:86-90.
9. Vafiadaki E, Arvanitis DA, Pagakis SN, Papalouka V, Sanoudou D, Kontrogianni-Konstantopoulos A, Kranias EG. The anti-apoptotic protein HAX-1 interacts with SERCA2 and regulates its protein levels to promote cell survival. Mol Biol Cell 2009, 20:306-318. 10.1091/mbc.E08-06-0587, 2613088, 18971376.
10. Yedavalli VS, Shih HM, Chiang YP, Lu CY, Chang LY, Chen MY, Chuang CY, Dayton AI, Jeang KT, Huang LM. Human immunodeficiency virus type 1 Vpr interacts with antiapoptotic mitochondrial protein HAX-1. J Virol 2005, 79:13735-13746. 10.1128/JVI.79.21.13735-13746.2005, 1262574, 16227293.
11. Shaw J, Kimheubaum LA. HAX-1 represses postmitochondrial caspase-9 activation and cell death during hypoxia-reoxygenation. Circ Res 2006, 99:336-338. 10.1161/01.RES.0000239408.03169.94, 16917098.
12. Ramsay AG, Keppler MD, Jazayeri M, Thomas GJ, Parsons M, Violette S, Weinreb P, Hart IR, Marshall JF. HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin alphavbeta6. Cancer Res 2007, 67:5275-5284. 10.1158/0008-5472.CAN-07-0318, 17545607.
13. Radhika V, Onesime D, Ha JH, Dhanasekaran N. Galpha13 stimulates cell migration through cortactin-interacting protein Hax-1. J Biol Chem 2004, 279:49406-49413. 10.1074/jbc.M408836200, 15339924.
14. Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A, Chinnaiyan AM. ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia 2004, 6:1-6. 1635162, 15068665.
15. Jiang Y, Zhang W, Kondo K, Klco JM, St Martin TB, Dufault MR, Madden SL, Kaelin WG, Nacht M. Gene expression profiling in a renal cell carcinoma cell line: Dissecting VHL and hypoxia-dependent pathways. Mol Cancer Res 2003, 1:453-462.
16. Mirmohammadsadegh A, Tartler U, Michel G, Baer A, Walz M, Wolf R, Ruzicka T, Hengge UR. HAX-1, identified by differential display reverse transcription polymerase chain reaction, is overexpressed in lesional psoriasis. J Invest Dermatol 2003, 120:1045-1051. 10.1046/j.1523-1747.2003.12247.x, 12787133.
17. Trebinska A, Rembiszewska A, Ciosek K, Ptaszynski K, Rowinski S, Kupryjanczyk J, Siedlecki JA, Grzybowska EA. HAX-1 overexpression, splicing and cellular localization in tumors. BMC Cancer 2010, 10:76. 10.1186/1471-2407-10-76, 2843675, 20196840.
18. Banerjee A, Saito K, Meyer K, Banerjee S, Ait-Goughoulte M, Ray RB, Ray R. Hepatitis C virus core protein and cellular protein HAX-1 promote 5-fluorouracil-mediated hepatocyte growth inhibition. J Virol 2009, 83:9663-9671. 10.1128/JVI.00872-09, 2748019, 19605487.
19. Simmen T. Hax-1: a regulator of calcium signaling and apoptosis progression with multiple roles in human disease. Expert Opin Ther Targets 2011, 15:741-751. 10.1517/14728222.2011.561787, 21391832.
20. Li WB, Feng J, Geng SM, Zhang PY, Yan XN, Hu G, Zhang CQ, Shi BJ. Induction of apoptosis by Hax-1 siRNA in melanoma cells. Cell Biol Int 2009, 33:548-554. 10.1016/j.cellbi.2009.02.005, 19254774.
21. Szwarc M, Sarnowska E, Grzybowska EA. HAX-1 protein: multifunctional factor involved in apoptosis, cell migration, endocytosis and mRNA transport. Postepy Biochem 2007, 53:218-227.
22. Huang L, Lu Q, Han Y, Li Z, Zhang Z, Li X. ABCG2/V-ATPase was associated with the drug resistance and tumor metastasis of esophageal squamous cancer cells. Diagnostic Pathology 2012, 7:180. 10.1186/1746-1596-7-180, 3542252, 23244569.
23. Sun SJ, Feng L, Zhao GQ, Dong ZM. HAX-1 promotes the chemoresistance, invasion, and tumorigenicity of esophageal squamous carcinoma cells. Dig Dis Sci 2012, 57:1838-1846. 10.1007/s10620-012-2108-5, 22451114.