Cytokine profiles, signalling pathways and effects of fluticasone propionate in respiratory syncytial virus-infected human foetal lung fibroblasts

Cell Biology International

Volumn 37, Issue 4, 2013, Pages 326-339

  Seki, Erina ^a   Yoshizumi, Masakazu ^b   Tanaka, Ryota ^a   Ryo, Akihide ^c   Ishioka, Taisei ^b   Tsukagoshi, Hiroyuki ^b   Kozawa, Kunihisa ^b   Okayama, Yoshimichi ^d   Okabe Kado, Junko ^e   Goya, Tomoyuki ^a   Kimura, Hirokazu ^b,f  

^a KYORIN UNIVERSITY   (Japan)

^b GUNMA PREFECTURAL INSTITUTE OF PUBLIC HEALTH AND ENVIRONMENTAL SCIENCES   (Japan)

^c YOKOHAMA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d NIHON UNIVERSITY   (Japan)

^e SAITAMA CANCER CENTER   (Japan)

^f NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

Cytokine; Fluticasone propionate; Human foetal lung fibroblast; Respiratory syncytial virus; Signalling pathway

Indexed keywords

4 (2 AMINOETHYLAMINO) 1,8 DIMETHYLIMIDAZO[1,2 A]QUINOXALINE; CYTOKINE; EOTAXIN; FLUTICASONE PROPIONATE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; I KAPPA B ALPHA; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; PEGINTERFERON LAMBDA; PROTEIN KINASE B; RANTES; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG; ANDROSTANE DERIVATIVE; ANTIINFLAMMATORY AGENT; FLUTICASONE; SIGNAL PEPTIDE; TOLL LIKE RECEPTOR;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG EFFECT; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; EOSINOPHIL; FETUS; GRANULOPOIESIS; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; LUNG FIBROBLAST; NEUTROPHIL; PROTEIN EXPRESSION; RESPIRATORY SYNCYTIAL VIRUS INFECTION; SIGNAL TRANSDUCTION; TH1 CELL; TH2 CELL; CELL LINE; CYTOLOGY; DRUG EFFECTS; DRUG SCREENING; FIBROBLAST; HOST PATHOGEN INTERACTION; HUMAN RESPIRATORY SYNCYTIAL VIRUS; IMMUNOLOGY; LUNG; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING; SECRETION (PROCESS); VIROLOGY;

ANDROSTADIENES; ANTI-INFLAMMATORY AGENTS; CELL LINE; CYTOKINES; DRUG EVALUATION, PRECLINICAL; FIBROBLASTS; HOST-PATHOGEN INTERACTIONS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RESPIRATORY SYNCYTIAL VIRUSES; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 84875298088     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1002/cbin.10044     Document Type: Article

References (55)

1. Adcock IM, Chung KF, Caramori G, Ito K (2006) Kinase inhibitors and airway inflammation. Eur J Pharmacol 533: 118-32.
2. Allen IC, Scull MA, Moore CB, Holl EK, McElvania-TeKippe E, Taxman DJ, Guthrie EH, Pickles RJ, Ting JP (2009) The NLRP3 inflammasomemediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity 30: 556-65.
3. Auphan N, DiDonato JA, Rossette C, Helmberg A, Karin M (1995) Immunosuppression by glucocorticoids: inhibition of NF-kB activity through induction of IkB synthesis. Science 270: 286-90.
4. Barnes PJ (1996) Mechanisms of action of glucocorticoids in asthma. Am J Respir Crit Care Med 154: S21-6.
5. Barnes PJ (1998) Transcription factors and asthma. Eur Respir J 12: 221-34.
6. Barnes PJ (2006) How corticosteroids control inflammation: quintiles prize lecture 2005. Br J Pharmacol 148: 245-54.
7. Barnes PJ (2008) The cytokine network in asthma and chronic obstructive pulmonary disease. J Clin Invest 118: 3546-56.
8. Bartz H, Büning-Pfaue F, Türkel O, Schauer U (2002) Respiratory syncytial virus induces prostaglandin E2, IL-10 and IL-11 generation in antigen presenting cells. Clin Exp Immunol 129: 438-45.
9. Blackwell TS, Christman JW (1997) The role of nuclear factor-kB in cytokine gene regulation. Am J Respir Cell Mol Biol 17: 3-9.
10. Bousse T, Chambers RL, Scroggs RA, Portner A, Takimoto T (2006) Human parainfluenza virus type 1 but not Sendai virus replicates in human respiratory cells despite IFN treatment. Virus Res 121: 23-32.
11. Centers for Disease Control and Prevention (2000) Respiratory syncytial virus activity: United States 1999-2000 season. MMWR Morb Mortal Wkly Rep 49: 1091-3.
12. Cheng HM, Hsiang CY, Chen GW, Wu SL, Chen JC, Huang CY, Bau DT, Ho TY (2008) Inhibition of lipopolysaccharideinduced interleukin-1beta and tumor necrosis factor-alpha production by menthone through nuclear factor-kappaB signaling pathway in HaCat cells. Chin J Physiol 51: 160-6.
13. Chou FP, Tsen TH, Chen JH, Wang HC, Wang CJ (2002) Induced proliferation of human MRC-5 cells by nitrogen oxides via direct and indirect activation of MEKK1, JNK, and p38 signals. Toxicol Appl Pharmacol 181: 203-8.
14. de Oña M Melón S, de la Iglesia P, Hidalgo F, Verdugo AF, (1995) Isolation of influenza virus in human lung embryonated fibroblast cells (MRC-5) from clinical samples. J Clin Microbiol 33: 1948-9.
15. Domachowske JB, Rosenberg HF (1999) Respiratory syncytial virus infection: immune response, immunopathogenesis, and treatment. Clin Microbiol Rev 12: 298-309.
16. Elkington PTG, O'Kane CM, Friedland JS (2005) The paradox of matrix metalloproteinases in infectious disease. Clin Exp Immunol 142: 12-20.
17. Erin EM, Zacharasiewicz AS, Nicholson GC, Tan AJ, Higgins LA, Williams TJ, Murdoch RD, Durham SR, Barnes PJ, Hansel TT (2005) Topical corticosteroid inhibits interloikin-4, -5 and -13 in nasal secretions following allergen challenge. Clin Exp Allergy 35: 1608-14.
18. Evans MJ, Van Winkle L, Fanucchi MV, Plopper CG (1999) The attenuated fibroblast sheath of the respiratory tract epithelialmesenchymal trophic unit. Am J Respir CellMol Biol 21: 655-7.
19. Gern JE (2009) Rhinovirus and the initiation of asthma. Curr Opin Allergy Clin Immunol 9: 73-8.
20. Haeberle HA, Takizawa R, Casola A, Brasier AR, Dieterich HJ, Van Rooijen N, Gatalica Z, Garofalo RP (2002) Respiratory syncytial virus-induced activation of nuclear factor-kappaB in the lung involves alveolar macrophages and toll-like receptor 4-dependent pathways. J Infect Dis 186: 1199-206.
21. Haynes L, Moore DD, Kurt-Jones EA, Finberg RW, Anderson LJ, Tripp RA (2001) Involvement of toll-like receptor 4 in innate immunity to respiratory syncytial virus. J Virol 7: 10730-7.
22. Holgate ST, Davies DE, Rorke S, Cakebread J, Murphy G, Poweel RM, Holloway JW (2004b) ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma. Clin Rev Allergy Immunol 27: 23-34.
23. Holgate ST, Holloway J, Wilson S, Bucchieri F, Puddicombe S, Davies DE (2004a) Epithelial-mesenchymal communication in the pathogenesis of chronic asthma. Proc Am Thorac Soc 1: 93-8.
24. Ishioka T, Kimura H, Kita H, Obuchi M, Hoshino H, Noda M, Nishina A, Kozawa K, Kato M (2010) Effects of respiratory syncytial virus infection and major basic protein derived from eosinophils in pulmonary alveolar epithelial cells (A549). Cell Biol Int 35: 467-74.
25. Kankkunen P, Teirilä L, Rintahaka J, Alenius H, Wolff H, Matikainen S (2010) (1,3)-b-glucans activate both dectin-1 and NLRP 3 inflammasome in human macrophages. J Immunol 184: 6335-42.
26. Kusel MM, de Klerk NH, Kebadze T, Vohma V, Holt PG, Johnston SL, Sly PD (2007) Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J Allergy Clin Immunol 119: 1105-10.
27. Lin XY, Choi MS, Poter AG (2000) Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP 5 gene by lipopolysaccharide and interferon-g. J Biol Chem 275: 33920-6.
28. Liu P, Jamaluddin M, Li K, Garofalo RP, Casola A, Brasier AR (2007) Retinoic acid-inducible gene I mediates early antiviral response and Toll-like receptor 3 expression in respiratory syncytial virus-infected airway epithelial cells. J Virol 81: 1401-11.
29. Machida K, Cheng KT, Sung VM, Levine AM, Foung S, Lai MM (2006) Hepatitis C virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon and interleukin-6. J Virol 80: 866-74.
30. MacMaster JF, Dambach DM, Lee DB, Berry KK, Qiu Y, Zusi FC, Burke JR (2003) An inhibitor of IkB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice. Inflamm Res 52: 508-11.
31. Mallia P, Johnston SL (2006) How viral infections cause exacerbation of airway diseases. Chest 130: 1203-10.
32. Mukherjee S, Lindell DM, Berlin AA, Morris SB, Shanley TP, Hershenson MB, Lukacs NW (2011) IL-17-induced pulmonary pathogenesis during respiratory viral infection and exacerbation of allergic disease. Am J Pathol 179: 248-58.
33. Noah TL, Wortman IA, Becker S (1998) The effect of fluticasone propionate on respiratory syncytial virus-induced chemokine release by a human bronchial epithelial cell line. Immunopharmacology 39: 193-9.
34. Okazaki K, Kondo M, Kato M, Kakinuma R, Hishida A, Noda M, Taniguchi K, Kimura H (2008) Serum cytokine and chemokine profiles in neonates with meconium aspiration syndrome. Pediatrics 121: e748-53.
35. Pazdrak K, Olszewska-Pazdrak B, Liu T, Takizawa R, Brasier AR, Garofalo RP, Casola A (2002) MAPK activation is involved in posttranscriptional regulation of RSV-induced RANTES gene expression. Am J Physiol Lung Cell Mol Physiol 283: L364-72.
36. Pinto RA, Arredono SM, Bono MR, Gaggero AA, Díaz PV (2006) T helper 1/T helper 2 cytokine imbalance in respiratory syncytial virus infection is associated with increased endogenous plasma cortisol. Pediatrics 117: e878-86.
37. Puxeddu I, Bader R, Piliponsky AM, Reich R, Levi-Schaffer F, Berkman N (2006) The CC chemokine eotaxin/CCL11 has a selective profibrogenic effect on human lung fibroblasts. J Allergy Clin Immunol 117: 103-10.
38. Qin L, Hu CP, Feng JT, Xia Q (2011) Activation of lymphocytes induced by bronchial epithelial cells with prolonged RSV infection. PLoS ONE 6: e27113.
39. Román M, Calhoun WJ, Hinton KL, Avendaño LF, Simon V, Escobar AM, Gaggero A, Díaz PV (1997) Respiratory syncytial virus infection in infants is associated with predominant Th-2-like response. Am J Respir Crit Care Med 156: 190-5.
40. Roumestan C, Henriquet C, Bousquet J, Mathieu M (2003) Fluticasone propionate and mometasone furoate have equivalent transcriptional potencies. Clin Exp Allergy 33: 895-901.
41. Sampieri CL, Nuttall RK, Young DA, Goldspink D, Clark IM, Edwards DR (2008) Activation of p38 and JNKMAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes. Matrix Biol 27: 128-38.
42. Scheinman RI, Cogswell PC, Lofquist AK, Baldwin AS, Jr (1995) Role of transcriptional activation of IkBa in mediation of immunosuppression by glucocorticoids. Science 270: 283-6.
43. Sharma RK, Sodhi A, Batra HV (2005) Involvement of c-Jun Nterminal kinase in rF1 mediated activation of murine peritoneal macrophages in vitro. J Clin Immunol 25: 215-23.
44. Shirey KA, Pletneva LM, Puche AC, Keequan AD, Prince GA, Blanco JC, Voqel SN (2010) Control of RSV-induced lung injury by alternatively activated macrophages is IL-4R alpha-, TLR4-, and IFN-beta-dependent. Mucosal Immunol 3: 291- 300.
45. Sigurs N (2002) Clinical perspectives on the association between respiratory syncytial virus and reactive airway disease. Respir Res 3: S8-14.
46. Stein RT, Sherrill D, Morgan WJ, Holberg CJ, Halonen M, Taussig LM (1999) Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet 354: 541-5.
47. Ueba O (1978) Respiratory syncytial virus. I. Concentration and purification of the infectious virus. Acta Med Okayama 32: 265-72.
48. Vande Walle L, Lamkanfi M (2001) Inflammasomes: caspase-1-activating platforms with critical roles in host defense. Front Microbiol 2: 1-6.
49. Van LyD, King NJC, Moir LM, Burgess JK, Black JL, Oliver BG (2011) Effects of b2 agonists, corticosteroids, and novel therapies on Rhinovirus-induced cytokine release and Rhinovirus replication in primary airway fibroblast. J Allergy (Cairo) 2011: 457169.
50. Watanabe T, Yoshikawa H, Abe Y, Yamazaki S, Uehara Y, Abe T (2003) Renal involvement in children with influenza A virus infection. Pediatr Nephrol 18: 541-4.
51. Wong CK,Wang CB, IpWK, Tian YP, Lam CW (2005) Role of p38 MAPKand NF-kB for chemokine release in coculture of human eosinophils and bronchial epithelial cells. Clin Exp Immunol 139: 90-100.
52. Yoshizumi M, Kimura H, Okayama Y, Hishina A, Noda M, Tsukagoshi H, Kozawa K, Kurabayashi M (2010) Relationships between cytokine profiles and signaling pathways (IkB kinase and p38 MAPK) in parainfluenza virus-induced lung fibroblasts. Front Microbiol 1: 124-30.
53. You D, Becnel D, Wang K, Ripple M, Daly M, Cormier SA (2006) Exposure of neonates to respiratory syncytial virus is critical in determining airway response in adult. Respir Res 7: 107-17.
54. Zhen Y, An H, Yao M, Hou J, Yu Y, Feng G, Cao X (2010) Scaffolding adaptor protein Gab 1 is required for TLR 3/4- and RIG-1 mediated production of proinflammatory cytokines and type I IFN in macrophages. J Immunol 184: 6447-56.
55. Zhou X, KonkelME, Call DR (2009) Type III secretion system 1 of Vibrio parahaemolyticus induces oncosis in both epithelial and monocytic cell lines. Mycrobiology 155: 837-51.