Ultra-small NLC for improved dermal delivery of coenyzme Q10

International Journal of Pharmaceutics

Volumn 447, Issue 1-2, 2013, Pages 213-217

  Schwarz, Julia C ^a   Baisaeng, Nuttakorn ^b   Hoppel, Magdalena ^a   Löw, Monika ^a   Keck, Cornelia M ^c   Valenta, Claudia ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c UNIVERSITY OF APPLIED SCIENCES KAISERSLAUTERN   (Germany)

Author keywords

Coenzyme Q10; Nanoemulsion; NLC; Skin permeation; Stability

Indexed keywords

ANTIOXIDANT; COENYZME Q10; NANOCARRIER; ULTRA SMALL NANOSTRUCTURED LIPID CARRIER; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG PENETRATION; DRUG STABILITY; IN VITRO STUDY; NANOEMULSION; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SKIN PENETRATION; SKIN PERMEABILITY; ZETA POTENTIAL;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTIOXIDANTS; DRUG CARRIERS; LIPIDS; NANOPARTICLES; PARTICLE SIZE; SKIN; SKIN ABSORPTION; SWINE; UBIQUINONE;

EID: 84875281084     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.02.037     Document Type: Article

References (26)

1. N. Baisaeng, Shegokar, R.H. Müller, and C.M. Keck Development of ultra-small nanostructured lipid carriers (NLC) T3185, AAPS Annual Meeting Chicaco, Illinois Washington, DC, 23-27 October 2011 2011
2. N. Baisaeng, P. Sinambela, S. Okonogi, R.H. Müller, and C.M. Keck The physicochemical characterization of CoQ10-loaded ultra-small lipid nanocarriers T3254, AAPS Annual Meeting Washington, DC, 14-18 October 2012 2012
3. Baisaeng, N. Ultra-small lipid nanocarriers loaded with coenzyme Q10. PhD Thesis. Freie Universität Berlin, 2013.
4. R.E. Beyer Inhibition by coenzyme Q of ethanol- and carbon tetrachloride-stimulated lipid peroxidation in vivo and catalyzed by microsomal and mitochondrial systems Free Radic. Biol. Med. 5 1988 297 303
5. R.E. Beyer, B.A. Burnett, K.J. Cartwright, D.W. Edington, M.J. Falzon, K.R. Kreitman, T.W. Kuhn, B.J. Ramp, S.Y. Rhee, and M.J. Rosenwasser Tissue coenzyme Q (ubiquinone) and protein concentrations over the life span of the laboratory rat Mech. Aging Dev. 32 1985 267 281
6. A. Dingler, R.P. Blum, H. Niehus, R.H. Müller, and S. Gohla Solid lipid nanoparticles (SLN/Lipopearls)-a pharmaceutical and cosmetic carrier for the application of vitamin E in dermal products J. Microencapsul. 16 1999 751 767
7. L. Ernster, and G. Dallner Biochemical, physiological and medical aspects of ubiquinone function Biochim. Biophys. Acta 1271 1995 195 204
8. P. Forsmark-Andree, and L. Ernster Evidence for a protective effect of endogenous ubiquinol against oxidative damage to mitochondrial protein and DNA during lipid peroxidation Mol. Aspects Med. 15 Suppl. 1994 s73 s81
9. J. Hatanaka, Y. Kimura, Z. Lai-Fu, S. Onoue, and S. Yamada Physicochemical and pharmacokinetic characterization of water-soluble coenzyme Q(10) formulations Int. J. Pharm. 363 2008 112 127
10. V.B. Junyaprasert, V. Teeranachaideekul, E.B. Souto, P. Boonme, and R.H. Müller Q10-loaded NLC versus nanoemulsions: stability, rheology and in vitro skin permeation Int. J. Pharm. 377 2009 207 214
11. V. Klang, J.C. Schwarz, A. Hartl, and C. Valenta Facilitating in vitro tape stripping: application of infrared densitometry for quantification of porcine stratum corneum proteins Skin Pharmacol. Physiol. 24 2011 256 268
12. V. Klang, J.C. Schwarz, B. Lenobel, M. Nadj, A. Hartl, J. Auböck, M. Wolzt, and C. Valenta In vitro vs in vivo tape stripping: validation of the porcine ear model and penetration assessment of novel sucrose stearate emulsions Eur. J. Pharm. Biopharm. 80 2012 604 614
13. Malvern Instruments Ltd.; Zetasizer Nano technical note MRK693-01.
14. A. Maroz, R.F. Anderson, R.A. Smith, and M.P. Murphy Reactivity of ubiquinone and ubiquinol with superoxide and the hydroperoxyl radical: implications for in vivo antioxidant activity Free Radic. Biol. Med. 46 2009 105 109
15. R.H. Müller, R.D.P. Petersen, A.A. Hommoss, and J. Pardeike Nanostructured lipid carriers (NLC) in cosmetic dermal products Adv. Drug Deliv. Rev. 59 2007 522 530
16. R.H. Müller, R. Shegokar, and C.M. Keck 20 years of lipid nanoparticles (SLN and NLC): present state of development and industrial applications Curr. Drug Discov. Technol. 8 2011 207 227
17. Pardeike, J.; 2008. Nanosuspensions and nanostructured lipid carriers for dermal application. PhD Thesis. Freie Universität Berlin.
18. Pardeike, J.; Müller, R.H.; 2007. Coenzyme Q10-loaded NLCs: preparation, occlusive properties and penetration enhancement. Pharm. Technol. Eur.; 01 July.
19. J. Pardeike, K.H. Schulz, T. Miller, and R.H. Müller Coenzyme Q10 loaded NLC: in vitro release and in vivo skin penetration AAPS Annual Meeting & Exposition San Diego CA 2007
20. J. Pardeike, K. Schwabe, and R.H. Müller Influence of nanostructured lipid carriers (NLC) on the physical properties of the Cutanova Nanorepair Q10 cream and the in vivo skin hydration effect Int. J. Pharm. 396 2010 166 173
21. J.H. Rabe, A.J. Mamelak, P.J. McElgunn, W.L. Morison, and D.N. Sauder Photoaging: mechanisms and repair J. Am. Acad. Dermatol. 55 2006 1 19
22. P. Schlupp, T. Blaschke, K.D. Kramer, H.D. Höltje, W. Mehnert, and M. Schäfer-Korting Drug release and skin penetration from solid lipid nanoparticles and a base cream: a systematic approach from a comparison of three glucocorticoids Skin Pharmacol. Physiol. 24 2011 199 209
23. J.C. Schwarz, V. Klang, S. Karall, D. Mahrhauser, G.P. Resch, and C. Valenta Optimisation of W/O/W nanoemulsions for the dermal delivery of aciclovir Int. J. Pharm. 453 2012 69 75
24. Y. Shindo, E. Witt, D. Han, W. Epstein, and L. Packer Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin J. Invest. Dermatol. 102 1994 122 124
25. F. Stracke, B. Weiss, C.M. Lehr, K. Konig, U.F. Schäfer, and M. Schneider Multiphoton microscopy for the investigation of dermal penetration of nanoparticle-borne drugs J. Invest. Dermatol. 126 2006 2224 2233
26. V. Teeranachaideekul, E.B. Souto, B. Junyaprasert, and R.H. Müller Cetyl palmitate-based NLC for topical delivery of coenzyme Q10-development, physicochemical characterization and in vitro release studies Eur. J. Pharm. Biopharm. 67 2007 141 148