Q10-loaded NLC versus nanoemulsions: Stability, rheology and in vitro skin permeation

International Journal of Pharmaceutics

Volumn 377, Issue 1-2, 2009, Pages 207-214

  Junyaprasert, Varaporn B ^a   Teeranachaideekul, Veerawat ^a,b   Souto, Eliana B ^c   Boonme, Prapaporn ^d   Müller, Rainer H ^b  

^a MAHIDOL UNIVERSITY   (Thailand)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c UNIVERSIDADE FERNANDO PESSOA   (Portugal)

^d PRINCE OF SONGKLA UNIVERSITY   (Thailand)

Author keywords

Chemical stability; In vitro skin permeation; Nanostructured lipid carriers; NLC; Q10

Indexed keywords

LIPID; MEDIUM CHAIN TRIACYLGLYCEROL; NANOMATERIAL; NANOPARTICLE; NANOSTRUCTURED LIPID CARRIER; UBIDECARENONE; UNCLASSIFIED DRUG; XANTHAN; DRUG CARRIER; DRUG DERIVATIVE; TRIACYLGLYCEROL; UBIQUINONE;

ARTICLE; CONTROLLED STUDY; DISPERSION; DRUG PENETRATION; DRUG STABILITY; DRUG STORAGE; ELASTICITY; FLOW KINETICS; HUMAN; HUMAN TISSUE; HYDROGEL; IN VITRO STUDY; LIGHT EXPOSURE; NANOEMULSION; PRIORITY JOURNAL; SKIN PERMEABILITY; TEMPERATURE; VISCOSITY; ZETA POTENTIAL; ADULT; DRUG DELIVERY SYSTEM; DRUG EFFECT; EMULSION; FEMALE; METHODOLOGY; MIDDLE AGED; PARTICLE SIZE; SKIN ABSORPTION;

ADULT; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG STABILITY; EMULSIONS; FEMALE; HUMANS; HYDROGELS; LIPIDS; MIDDLE AGED; PARTICLE SIZE; RHEOLOGY; SKIN ABSORPTION; TRIGLYCERIDES; UBIQUINONE;

EID: 67649646737     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.05.020     Document Type: Article

References (36)

1. Chantasart D., Pongjanyakul T., Higuchi W.I., and Li S.K. Effects of oxygen-containing terpenes as skin permeation enhancers on the lipoidal pathways of human epidermal membrane. J. Pharm. Sci. (2009) 10.1002/jps.21666
2. Chantasart D., Sa-Nguandeekul P., Prakongpan S., Li S.K., and Higuchi W.I. Comparison of the effects of chemical permeation enhancers on the lipoidal pathways of human epidermal membrane and hairless mouse skin and the mechanism of enhancer action. J. Pharm. Sci. 96 (2007) 2310-2326
3. Chen H., Chang X., Du D., Liu W., Liu J., Weng T., Yang Y., Xu H., and Yang X. Podophyllotoxin-loaded solid lipid nanoparticles for epidermal targeting. J. Control. Release 110 (2006) 296-306
4. Choi M.J., and Maibach H.I. Liposomes and niosomes as topical drug delivery systems. Skin. Pharmacol. Physiol. 18 (2005) 209-219
5. Dingler A. Feste lipid-nanopartikel als kolloidale wirkstofftragersysteme zur dermalen applikation (1998), Free University of Berlin, Berlin
6. Dingler A., Blum R.P., Niehus H., Mller R.H., and Gohla S. Solid lipid nanoparticles (SLN/Lipopearls)-a pharmaceutical and cosmetic carrier for the application of vitamin E in dermal products. J. Microencapsul. 16 (1999) 751-767
7. Freitas C., and Müller R.H. Correlation between long-term stability of solid lipid nanoparticles (SLN) and crystallinity of the lipid phase. Eur. J. Pharm. Biopharm. 47 (1999) 125-132
8. Hu F.Q., Jiang S.P., Du Y.Z., Yuan H., Ye Y.Q., and Zeng S. Preparation and characterization of stearic acid nanostructured lipid carriers by solvent diffusion method in an aqueous system. Colloids Surf. B: Biointerfaces 45 (2005) 167-173
9. Hu F.Q., Jiang S.P., Du Y.Z., Yuan H., Ye Y.Q., and Zeng S. Preparation and characteristics of monostearin nanostructured lipid carriers. Int. J. Pharm. 314 (2006) 83-89
10. Jenning V., and Gohla S.H. Encapsulation of retinoids in solid lipid nanoparticles (SLN). J. Microencapsul. 18 (2001) 149-158
11. Jenning V., Schäfer-Korting M., and Gohla S. Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties. J. Control. Release 66 (2000) 115-126
12. Jores K., Mehnert W., Drechsler M., Bunjes H., Johann C., and Mader K. Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron microscopy. J. Control. Release 95 (2004) 217-227
13. Junyaprasert V.B., Boonme P., Songkro S., Krauel K., and Rades T. Transdermal delivery of hydrophobic and hydrophilic local anesthetics from o/w and w/o brij 97 based microemulsions. J. Pharm. Pharm. Sci. 10 (2007) 288-298
14. Kalariya M., Padhi B.K., Chougule M., and Misra A. Clobetasol propionate solid lipid nanoparticles cream for effective treatment of eczema: Formulation and clinical implications. Indian J. Exp. Biol. 43 (2005) 233-240
15. Kasting G.B., and Bowman L.A. DC electrical properties of frozen, excised human skin. Pharm. Res. 7 (1990) 134-143
16. Liu J., Hu W., Chen H., Ni Q., Xu H., and Yang X. Isotretinoin-loaded solid lipid nanoparticles with skin targeting for topical delivery. Int. J. Pharm. 328 (2007) 191-195
17. Müller R.H., Mäder K., and Gohla S. Solid lipid nanoparticles (SLN) for controlled drug delivery-a review of the state of the art. Eur. J. Pharm. Biopharm. 50 (2000) 161-177
18. Müller R.H., Radtke M., and Wissing S.A. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv. Drug Deliv. Rev. 54 (2002) S131-S155
19. Schüfer-Korting M., Mehnert W., and Korting H.C. Lipid nanoparticles for improved topical application of drugs for skin diseases. Adv. Drug Deliv. Rev. 59 (2007) 427-443
20. Schwarz C., and Mehnert W. Solid lipid nanoparticles (SLN) for controlled drug delivery. II. Drug incorporation and physicochemical characterization. J. Microencapsul. 16 (1999) 205-213
21. Songkro S., Purwo Y., Becket G., and Rades T. Investigation of newborn pig skin as an in vitro animal model for transdermal drug delivery. STP Pharma Sci. 13 (2003) 133-139
22. Souto E.B., and Müller R.H. SLN and NLC for topical delivery of ketoconazole. J. Microencapsul. 22 (2005) 501-510
23. Souto E.B., Wissing S.A., Barbosa C.M., and Müller R.H. Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery. Int. J. Pharm. 278 (2004) 71-77
24. Teeranachaideekul V., Boonme P., Souto E.B., Müller R.H., and Junyaprasert V.B. Influence of oil content on physicochemical properties and skin distribution of Nile red-loaded NLC. J. Control. Release 128 (2008) 134-141
25. 10-development, physicochemical characterization and in vitro release studies. Eur. J. Pharm. Biopharm. 67 (2007) 141-148
26. Üner M., Wissing S.A., Yener G., and Müller R.H. Influence of surfactants on the physical stability of solid lipid nanoparticle (SLN) formulations. Pharmazie 59 (2004) 331-332
27. Üner M., Wissing S.A., Yener G., and Müller R.H. Skin moisturizing effect and skin penetration of ascorbyl palmitate entrapped in solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) incorporated into hydrogel. Pharmazie 60 (2005) 751-755
28. Üner M., Wissing S.A., Yener G., and Müller R.H. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for application of ascorbyl palmitate. Pharmazie 60 (2005) 577-582
29. Williams A. Structure and function of human skin. In: Williams A. (Ed). Transdermal and Topical Drug Delivery (2003), Pharmaceutical Press, London 1-26
30. Wissing S., Lippacher A., and Müller R. Investigations on the occlusive properties of solid lipid nanoparticles (SLN). J. Cosmet. Sci. 52 (2001) 313-324
31. Wissing S.A., and Müller R.H. Solid lipid nanoparticles (SLN)-a novel carrier for UV blockers. Pharmazie 56 (2001) 783-786
32. Wissing S.A., and Müller R.H. Solid lipid nanoparticles as carrier for sunscreens: In vitro release and in vivo skin penetration. J. Control. Release 81 (2002) 225-233
33. Wissing S.A., and Müller R.H. Cosmetic applications for solid lipid nanoparticles (SLN). Int. J. Pharm. 254 (2003) 65-68
34. Wissing S.A., and Müller R.H. The influence of solid lipid nanoparticles on skin hydration and viscoelasticity-in vivo study. Eur. J. Pharm. Biopharm. 56 (2003) 67-72
35. 10-loaded solid lipid nanoparticles by NMR spectroscopy. Pharm. Res. 21 (2004) 400-405
36. 1H NMR. Pharmazie 60 (2005) 508-513