Hiv-1 integrase variability and relationship with drug resistance in antiretroviral-naive and -experienced patients with different hiv-1 subtypes

Journal of Antimicrobial Chemotherapy

Volumn 68, Issue 4, 2013, Pages 969-972

  Reigadas, S ^a,b,c   Marcelin, A G ^d,e,f   Houssaini A ^e,f   Yerly, S ^g   Descamps, D ^h   Plantier, J C ⁱ   Ruffault, A ^j   Amiel, C ^f   Trabaud, M A ^k   Flandre, Philippe ^d,e,f   Fleury, H ^a,b,c   Masquelier, B ^a,b,c   Roussel, C ^l   Alloui, C ^l   Leguillou Guillemette, H ^l   Bettinger, D ^l   Pallier, C ^l   Brun Vezinet, F ^l   Peytavin, G ^l   Pinson, P ^l   Vallet, S ^l   Poveda, J D ^l   Mirand, A ^l   Krivine, A ^l   Auvray, C ^l   De Rougemont, A ^l   Signori Schmuck, A ^l   Bocket, L ^l   Rogez, S ^l   Tamalet, C ^l   Schneider, V ^l   Bouvier Alias, M ^l   Montes, B ^l   Schvoerer, E ^l   Ferre V ^l   Chaix, M L ^l   Guinard, J ^l   Haim Boukobza, S ^l   Soulie C ^l   Assoumou, L ^l   Calvez, V ^l   Maillard, A ^l   Morand Joubert, L ^l   Chaplain, C ^l   Delaugerre, C ^l   Bourlet, T ^l   Bertsch, S ^l   Raymond, S ^l   Marque Juillet, S ^l   more..

^a UNIVERSITÉ DE BORDEAUX   (France)

^b CNRS   (France)

^c BORDEAUX UNIVERSITY HOSPITAL   (France)

^d Service de Virologie   (France)

^e INSERM   (France)

^f HÔPITAL TENON   (France)

^g GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^h UNIVERSITÉ PARIS DESCARTES   (France)

ⁱ HÔPITAL CHARLES NICOLLE   (France)

^j RENNES UNIVERSITY HOSPITAL   (France)

^k HOSPICES CIVILS DE LYON   (France)

^l NONE

more..

Author keywords

Human; Nucleotides; Sequences; Viruses

Indexed keywords

DOLUTEGRAVIR; ELVITEGRAVIR; INTEGRASE; INTEGRASE INHIBITOR; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROTEINASE INHIBITOR; RALTEGRAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; TRANSCRIPTASE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIVIRAL RESISTANCE; CATALYSIS; CD4 LYMPHOCYTE COUNT; CODON; CONTROLLED STUDY; DRUG EXPOSURE; GENE MUTATION; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; LETTER; MAJOR CLINICAL STUDY; MULTICENTER STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; TREATMENT RESPONSE; VIRUS LOAD;

ANTI-HIV AGENTS; DRUG RESISTANCE, VIRAL; GENETIC VARIATION; HIV INFECTIONS; HIV INTEGRASE; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; SEQUENCE ANALYSIS, DNA;

EID: 84875278977     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dks474     Document Type: Letter

References (11)

1. Lataillade M, Chiarella J, Kozal MJ. Natural polymorphism of the HIV-1 integrase gene and mutations associated with integrase inhibitor resistance. Antivir Ther 2007; 12: 563-70.
2. Myers RE, Pillay D. Analysis of natural sequence variation and covariation in human immunodeficiency virus type 1 integrase. J Virol 2008; 82: 9228-35.
3. Ceccherini-Silberstein F, Malet I, D'Arrigo R et al. Characterization and structural analysis of HIV-1 integrase conservation. AIDS Rev 2009; 11: 17-29.
4. Rhee SY, Liu TF, Kiuchi M et al. Natural variation of HIV-1 group M integrase: implications for a new class of antiretroviral inhibitors. Retrovirology 2008; 5: 74.
5. Low A, Prada N, Topper M et al. Natural polymorphisms of human immunodeficiency virus type 1 integrase and inherent susceptibilities to a panel of integrase inhibitors. Antimicrob Agents Chemother 2009; 53: 4275-82.
6. Sierra S, Lubke N, Walter H et al. The SnoB study: frequency of baseline raltegravir resistance mutations prevalence in different non-B subtypes. Med Microbiol Immunol 2011; 200: 225-32.
7. Garrido C, Soriano V, Geretti AM et al. Resistance associated mutations to dolutegravir in HIV-infected patients-impact of HIV subtypes and prior raltegravir experience. Antiviral Res 2011; 90: 164-7.
8. Kobayashi M, Yoshinaga T, Seki T et al. In vitro antiretroviral properties of S/GSK1349572, a next-generation HIV integrase inhibitor. Antimicrob Agents Chemother 2011; 55: 813-21.
9. Sato A, Seki T, Kobayashi M et al. In vitro passage of drug resistant HIV-1 against a next generation integrase inhibitor (INI), S/GSK1349572. In: Abstracts of the Forty-ninth Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA, 2009. Abstract H-932. American Society for Microbiology, Washington, DC, USA.
10. Nouhin J, Donchai T, Hoang KT et al. Natural polymorphisms of HIV-1 CRF01_AE integrase coding region in ARV-naive individuals in Cambodia, Thailand and Vietnam: an ANRS AC12 working group study. Infect Genet Evol 2011; 11: 38-43.
11. Wainberg MA, Brenner BG. Role of HIV subtype diversity in the development of resistance to antiviral drugs. Viruses 2010; 2: 2493-508.