Differential expression of chlamydial signal transduction genes in normal and interferon gamma-induced persistent Chlamydophila pneumoniae infections

Microbes and Infection

Volumn 8, Issue 1, 2006, Pages 61-72

  Polkinghorne, Adam ^a,b   Hogan, Richard J ^a   Vaughan, Lloyd ^b   Summersgill, James T ^c   Timms, Peter ^a  

^a QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c University of Louisville School of Medicine   (United States)

Author keywords

Chlamydophila pneumoniae; Interferon gamma; Reverse transcriptase polymerase chain reaction; Signal transduction

Indexed keywords

GAMMA INTERFERON; GUANOSINE TRIPHOSPHATASE; MESSENGER RNA;

ARTICLE; BACTERIAL CELL; BACTERIAL GENOME; BACTERIAL INFECTION; BACTERIUM CULTURE; BIOINFORMATICS; CELL CYCLE REGULATION; CHLAMYDOPHILA PNEUMONIAE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSDUCTION; GENOME ANALYSIS; HEP 2 CELL; INFECTION; NONHUMAN; PERSISTENT INFECTION; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RIBOSOME; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY;

CELL LINE; CHLAMYDOPHILA INFECTIONS; CHLAMYDOPHILA PNEUMONIAE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; INTERFERON TYPE II; RNA, MESSENGER; SIGNAL TRANSDUCTION;

ANIMALIA; BACTERIA (MICROORGANISMS); CHLAMYDOPHILA PNEUMONIAE;

EID: 31344431834     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2005.05.018     Document Type: Article

References (60)

1. A.C. Gerbase, J.T. Rowley, and T.E. Mertens Global epidemiology of sexually transmitted diseases Lancet 351 Suppl. 3 1998 2 4
2. J.T. Grayston Infections caused by Chlamydia pneumoniae strain TWAR Clin. Infect. Dis. 15 1992 757 763
3. J.P. Whitcher, M. Srinivasan, and M.P. Upadhyay Corneal blindness: a global perspective Bull. World Health Organ. 79 2001 214 221
4. C.-C. Kuo, A. Shor, L.A. Campbell, H. Fukushi, D.L. Patton, and J.T. Grayston Demonstration of Chlamydia pneumoniae in atherosclerotic lesions of coronary arteries J. Infect. Dis. 167 1993 841 849
5. P. Saikku, P.M. Leinonen, K. Mattila, M.-R. Ekman, M.S. Nieminen, P.H. Mäkelä, J.K. Huttunen, and V. Valtonen Serological evidence of an association of a novel Chlamydia, TWAR, with chronic coronary heart disease and acute myocardial infarction Lancet 2 1988 983 986
6. B.J. Balin, H.C. Ǵrard, E.J. Arking, D.M. Appelt, P.J. Branigan, J.T. Abrams, J.A. Whittum-Hudson, and A.P. Hudson Identification and localization of Chlamydia pneumoniae in the Alzheimer's brain Med. Microbiol. Immunol. (Berl.) 187 1998 23 42
7. W.L. Beatty, R.P. Morrison, and G.I. Byrne Reactivation of persistent Chlamydia trachomatis infection in cell culture Infect. Immun. 63 1995 199 205
8. L. Koehler, E. Nettelnbreker, A.P. Hudson, N. Ott, H.C. Ǵrard, P.J. Branigan, H.R. Schumacher, W. Drommer, and H. Zeidler Ultrastructural and molecular analyses of the persistence of Chlamydia trachomatis (serovar K) in human monocytes Microb. Pathog. 22 1997 133 142
9. A. Kutlin, C. Flegg, D. Stenzel, T. Reznik, P.M. Roblin, S. Mathews, P. Timms, and M.R. Hammerschlag Ultrastructural study of Chlamydia pneumoniae in a continuous-infection model J. Clin. Microbiol. 39 2001 3721 3723
10. A. Matsumoto, and G.P. Manire Electron microscopic observations on the effects of penicillin on the morphology of Chlamydia psittaci J. Bacteriol. 101 1970 278 285
11. H.M. Al-Younes, T. Rudel, V. Brinkmann, A.J. Szczepek, and T.F. Meyer Low iron availability modulates the course of Chlamydia pneumoniae infection Cell. Microbiol. 3 2001 427 437
12. R.E. Raulston Response of Chlamydia trachomatis serovar E to iron restriction in vitro and evidence for iron-regulated chlamydial proteins Infect. Immun. 65 1997 4539 4547
13. A. Harper, C.I. Pogson, M.L. Jones, and J.H. Pearce Chlamydial development is adversely affected by minor changes in amino acid supply, blood plasma amino acid levels and, glucose deprivation Infect. Immun. 68 2000 1457 1464
14. G.I. Byrne, L.K. Lehmann, and G.J. Landry Induction of tryptophan catabolism is the mechanism for gamma-interferon-mediated inhibition of intracellular Chlamydia psittaci replication in T24 cells Infect. Immun. 53 1996 347 351
15. R.J. Hogan, S.A. Mathews, A. Kutlin, M.R. Hammerschlag, and P. Timms Differential expression of genes encoding membrane proteins between acute and continuous Chlamydia pneumoniae infections Microb. Pathog. 34 2003 11 16
16. S.J. Mehta, R.D. Miller, J.A. Ramirez, and J.T. Summersgill Inhibition of Chlamydia pneumoniae replication in HEp-2 cells: role of tryptophan catabolism J. Infect. Dis. 177 1998 1326 1331
17. L.G. Pantoja, R.E. Molestina, R.D. Miller, J.A. Ramirez, and J.T. Summersgill Inhibition of Chlamydia pneumoniae replication in human aortic smooth muscle cells by interferon-gamma-induced indoleamine 2,3-dioxygenase activity Infect. Immun. 68 2000 6478 6481
18. L.G. Pantoja, R.E. Molestina, R.D. Miller, J.A. Ramirez, and J.T. Summersgill Characterization of Chlamydia pneumoniae persistence in HEp2 cells treated with gamma interferon Infect. Immun. 69 2001 7927 7932
19. J.T. Summersgill, C.A. Gaydos, N.N. Sahney, T.C. Quinn, and J.A. Ramirez Inhibition of Chlamydia pneumoniae growth in Hep2 cells pretreated with interferon gamma and tumor necrosis factor alpha Infect. Immun. 63 1995 2801 2803
20. R.J. Hogan, S.A. Mathews, S. Mukopadthay, J.T. Summersgill, and P. Timms Chlamydial persistence: beyond the biphasic paradigm Infect. Immun. 72 2004 1843 1855
21. R.J. Belland, D.E. Nelson, D. Virok, D.D. Crane, D. Hogan, D. Sturdevant, W.L. Beatty, and H.D. Caldwell Transcriptome analysis of chlamydial growth during IFN-γ-mediated persistence and reactivation Proc. Natl. Acad. Sci. USA 100 2003 15971 15976
22. R. Hengge-Aronis Interplay of global regulators and cell physiology in the general stress response of Escherichia coli Curr. Opin. Microbiol. 2 1999 148 152
23. A.L. Sonenshein Control of sporulation initiation in Bacillus subtilis Curr. Opin. Microbiol. 3 2000 561 566
24. E.M. Quardokus, and Y.V. Brun Cell cycle timing and developmental checkpoints in Caulobacter crescentus Curr. Opin. Microbiol. 6 2003 541 549
25. S. Kalman, W. Mitchell, R. Marathe, C. Lammel, J. Fan, R.W. Hyman, L. Olinger, J. Grimwood, R.W. Davis, and R.S. Stephens Comparative genomes of Chlamydia pneumoniae and C. trachomatis Nat. Genet. 21 1999 385 389
26. T.D. Read, R.C. Brunham, C. Shen, S.R. Gill, J.F. Heidelberg, O. White, E.K. Hickey, J. Peterson, T. Utterback, K. Berry, S. Bass, K. Linher, J. Weidman, H. Khouri, B. Craven, C. Bowman, R. Dodson, M. Gwinn, W. Nelson, R. DeBoy, J. Kolonay, G. McClarty, S.L. Salzberg, J. Eisen, and C.M. Fraser Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39 Nucleic Acids Res. 28 2000 1397 1406
27. T.D. Read, G.S.A. Myers, R.C. Brunham, W.C. Nelson, I.T. Paulsen, J. Heidelberg, E. Holtzapple, H. Khouri, N.B. Federova, H.A. Carty, L.A. Umayam, D.H. Haft, J. Peterson, M.J. Beanan, O. White, S.L. Salzberg, R.-C. Hsia, G. McClarty, R.G. Rank, P.M. Bavoil, and C.M. Fraser Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae Nucleic Acids Res. 31 2003 2134 2147
28. R.S. Stephens, S. Kalman, C. Lammel, J. Fan, R. Marathe, L. Aravind, W. Mitchell, L. Olinger, R.L. Tatusov, Q. Zhao, E.V. Koonin, and R.W. Davis Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis Science 282 1998 754 759
29. I. Cases, V. de Lorenzo, and C. Ouzounis Transcription regulation and environmental adaptation in bacteria Trends Microbiol. 11 2003 248 253
30. L. Falquet, M. Pagni, P. Bucher, N. Hulo, C.J. Sigrist, K. Hofmann, and A. Bairoch The PROSITE database, its status in 2002 Nucleic Acids Res. 30 2002 235 238
31. S.F. Altschul, T.L. Madden, A.A. Schäffer, J. Zhang, Z. Zhang, W. Miller, and D.J. Lipman Gapped BLAST and PSI-BLAST: a new generation of protein database search programs Nucleic Acids Res. 25 1997 3389 3402
32. L. Shi, M. Potts, and P.J. Kennelly The serine, threonine, and/or tyrosine-specific protein kinases and protein phosphatases of prokaryotic organisms: a family portrait FEMS Microbiol. Rev. 22 1998 229 253
33. J.A. Ramirez, S. Ahkee, J.T. Summersgill, B.L. Ganzel, L.L. Odgen, T.C. Quinn, C.A. Gaydos, L.L. Bobo, M.R. Hammerschlag, P.M. Roblin, W. Le Bar, J.T. Grayston, C. Kuo, L.A. Campbell, D.L. Patton, D. Dean, and J. Schachter Isolation of Chlamydia pneumoniae from the coronary artery of a patient with coronary atherosclerosis Ann. Intern. Med. 125 1996 979 982
34. R.E. Molestina, D. Dean, R.D. Miller, J.A. Ramirez, and J.T. Summersgill Characterization of a strain of Chlamydia pneumoniae isolated from a coronary atheroma by analysis of the omp1 gene and biological activity in human endothelial cells Infect. Immun. 66 1998 1370 1376
35. D.C. Caldwell, J. Kromhout, and J. Schachter Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatis Infect. Immun. 31 1981 1161 1176
36. S.A. Mathews, K.M. Volp, and P. Timms Development of a quantitative gene expression assay for Chlamydia trachomatis identified temporal expression of sigma factors FEBS Lett. 458 1999 354 358
37. M. Goebl, and M. Yanagida The TPR snap helix: a novel protein repeat motif from mitosis to transcription Trends Biochem. Sci. 16 1991 173 177
38. R.J. Belland, G. Zhong, D.D. Crane, D. Hogan, D. Sturdevant, J. Sharma, W.L. Beatty, and H.D. Caldwell Genomic transcriptional profiling of the developmental cycle of Chlamydia trachomatis Proc. Natl. Acad. Sci. USA 100 2003 8478 8483
39. T.L. Nicholson, L. Olinger, K. Chong, G. Schoolnik, and R.S. Stephens Global stage-specific gene regulation during the developmental cycle of Chlamydia trachomatis J. Bacteriol. 185 2003 3179 3189
40. A. Slepenkin, V. Motin, L.M. de la Maza, and E.M. Peterson Temporal expression of Type III secretion genes of Chlamydia pneumoniae Infect. Immun. 71 2003 2555 2562
41. G.I. Byrne, S.P. Ouellette, Z. Wang, J.P. Rao, L. Lu, W.L. Beatty, and A.P. Hudson Chlamydia pneumoniae expresses genes required for DNA replication but not cytokinesis during persistent infection of HEp-2 cells Infect. Immun. 69 2001 5423 5429
42. T. Nicholson, R.S. Stephens, Chlamydial genomic transcriptional profile for penicillin-induced persistence, in: J. Schachter, G. Christiansen, I.N. Clarke, M.R. Hammerschlag, B. Kaltenboeck, C.-C. Kuo, R.G. Rank, G.L. Ridgway, P. Saikku, W.E. Stamm, R.S. Stephens, J.T. Summersgill, P. Timms, P.B. Wyrick (Eds.), International Chlamydia Symposium, San Francisco, Chlamydial Infections: Proceedings of the Tenth International Symposium on Human Chlamydial Infections, 2002, pp. 611-614.
43. H.C. Gérard, B. Krauße-Opatz, Z. Wang, D. Rudy, J.P. Rao, H. Zeidler, H.R. Schumacher, J.A. Whittum-Hudson, L. Köhler, A.P. Hudson, Expression of Chlamydia trachomatis genes encoding products required for DNA synthesis and cell division during active versus persistent infection, Mol. Microbiol. 41 (2001) 731-741.
44. S.B. Pandit, and N. Srinivasan Survey for g-proteins in the prokaryotic genomes: prediction of functional roles based on classification Proteins 52 2003 585 597
45. C.E. Caldon, P. Yoong, and P.E. March Evolution of a molecular switch: universal bacterial GTPases regulate ribosome function Mol. Microbiol. 41 2001 289 297
46. J.M. Scott, and W.G. Haldenwang Obg, an essential GTP binding protein of Bacillus subtilis, is necessary for stress activation of transcription factor sigma (B) J. Bacteriol. 181 1999 4653 4660
47. J.M. Scott, J. Ju, T. Mitchell, and W.G. Haldenwang The Bacillus subtilis GTP binding protein obg and regulators of the sigma(B) stress response transcription factor cofractionate with ribosomes J. Bacteriol. 182 2000 2771 2777
48. P. Wout, K. Pu, S.M. Sullivan, V. Reese, S. Zhou, B. Lin, and J.R. Maddock The Escherichia coli GTPase CgtAE cofractionates with the 50S ribosomal subunit and interacts with SpoT, a ppGpp synthetase/hydrolase J. Bacteriol. 186 2004 5249 5257
49. G. Kobayashi, S. Moriya, and C. Wada Deficiency of essential GTP-binding protein ObgE in Escherichia coli inhibits chromosome partition Mol. Microbiol. 41 2001 1037 1051
50. R. Dutkiewicz, M. Slominska, G. Wegrzyn, and A. Czyz Overexpression of the cgtA (yhbZ, obgE) gene, coding for an essential GTP-binding protein, impairs the regulation of chromosomal functions in Escherichia coli Curr. Microbiol. 45 2002 440 445
51. K. Datta, J.M. Skidmore, K. Pu, and J.R. Maddock The Caulobacter crescentus GTPase CgtA is required for progression through the cell cycle and for maintaining 50S ribosomal subunit levels Mol. Microbiol. 54 2004 1379 1392
52. J. Tan, U. Jakob, and J.C.A. Bardwell Overexpression of two different GTPases rescues a null mutation in a heat-induced rRNA methyltransferase J. Bacteriol. 184 2002 2692 2698
53. C. Li, J.K. Ichikawa, J.J. Ravetto, H.C. Kuo, J.C. Fu, and S. Clarke A new gene involved in stationary-phase survival located at 59:min on the Escherichia coli chromosome J. Bacteriol. 176 1994 6015 6022
54. C.E. Gustafson, S. Kaul, and E.E. Ishiguro Identification of the Escherichia coli lytB gene, which is involved in penicillin tolerance and control of the stringent response J. Bacteriol. 175 1993 1203 1205
55. T. Clausen, C. Southan, and M. Ehrmann The HtrA family of proteases: Implications for protein composition and cell fate Mol. Cell 10 2002 443 455
56. I.C. Koo, and R.S. Stephens A developmentally regulated two-component signal transduction system in Chlamydia J. Biol. Chem. 78 2003 17314 17319
57. E.R. Iliffe-Lee, and G. McClarty Regulation of carbon metabolism in Chlamydia trachomatis Mol. Microbiol. 38 2000 20 30
58. H. Wood, C. Fehlner-Gardner, J. Berry, E. Fischer, B. Graham, T. Hackstadt, C. Roshick, and G. McClarty Regulation of tryptophan synthase gene expression in Chlamydia trachomatis Mol. Microbiol. 49 2003 1347 1359
59. C. Fehlner-Gardiner, C. Roshick, J.H. Carlson, S. Hughes, R.J. Belland, H.D. Caldwell, and G. McClarty Molecular basis defining human Chlamydia trachomatis tissue tropism. A possible role for tryptophan synthase J. Biol. Chem. 277 2002 26893 26903
60. H.D. Caldwell, H. Wood, D. Crane, R. Bailey, R.B. Jones, D. Mabey, I. Maclean, Z. Mohammed, R. Peeling, C. Roschick, J. Schacter, A.W. Solomon, W.E. Stamm, R.J. Suchland, L. Taylor, S.K. West, T.C. Quinn, R.J. Belland, and G. McClarty Polymorphisms in Chlamydia trachomatis tryptophan synthase genes differentiate between genital and ocular isolates J. Clin. Invest. 111 2003 1647 1649