P73 participates in WWOX-mediated apoptosis in leukemia cells

International Journal of Molecular Medicine

Volumn 31, Issue 4, 2013, Pages 849-854

  Lin, Donghong ^a   Cui, Zhaolei ^a   Kong, Lingying ^b   Cheng, Feng ^b   Xu, Jianping ^a   Lan, Fenghua ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

^b FUJIAN NORMAL UNIVERSITY   (China)

Author keywords

Apoptosis; Leukemia; Mechanism; Overexpression; P73; WWOX

Indexed keywords

PROTEIN P53; PROTEIN P73; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; WW DOMAIN CONTAINING OXIDOREDUCTASE;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL ASSAY; CELL GROWTH; CELLULAR PARAMETERS; CONTROLLED STUDY; CYTOPLASM; FLOW CYTOMETRY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; LEUKEMIA CELL; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NUCLEAR CYTOPLASMIC TRANSLOCATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

APOPTOSIS; CELL SURVIVAL; DNA-BINDING PROTEINS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; JURKAT CELLS; K562 CELLS; LEUKEMIA; NUCLEAR PROTEINS; OXIDOREDUCTASES; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

EID: 84875259917     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2013.1289     Document Type: Article

References (27)

1. Bednarek AK, Laflin KJ, Daniel RL, Liao Q, Hawkins KA and Aldaz CM: WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer. Cancer Res 60: 2140-2145, 2000.
2. Ried K, Finnis M, Hobson L, et al: Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells. Hum Mol Genet 9: 1651-1663, 2000.
3. Del Mare S, Salah Z and Aqeilan RI: WWOX: its genomics, partners, and functions. J Cell Biochem 108: 737-745, 2009.
4. Macias MJ, Wiesner S and Sudol M: WW and SH3 domains, two different scaffolds to recognize proline-rich ligands. FEBS Lett 513: 30-37, 2002.
5. Nunez MI, Ludes-Meyers J and Aldaz CM: WWOX protein expression in normal human tissues. J Mol Hist 37: 115-125, 2006.
6. Wang X, Chao L, Jin G, Ma G, Zang Y and Sun J: Association between CpG island methylation of the WWOX gene and its expression in breast cancers. Tumour Biol 30: 8-14, 2009.
7. Guo W, Wang G, Dong Y, Guo Y, Kuang G and Dong Z: Decreased expression of WWOX in the development of esophageal squamous cell carcinoma. Mol Carcinog: Dec. 27, 2011 (Epub ahead of print).
8. Nakayama S, Semba S, Maeda N, Matsushita M, Kuroda Y and Yokozaki H: Hypermethylation-mediated reduction of WWOX expression in intraductal papillary mucinous neoplasms of the pancreas. Br J Cancer 100: 1438-1443, 2009.
9. Dias EP, Pimenta FJ, Sarquis MS, et al: Association between decreased WWOX protein expression and thyroid cancer development. Thyroid 17: 1055-1059, 2007.
10. Yang J, Cogdell D, Yang D, et al: Deletion of the WWOX gene and frequent loss of its protein expression in human osteosarcoma. Cancer Lett 291: 31-38, 2010.
11. Fabbri M, Iliopoulos D, Trapasso F, et al: WWOX gene restoration prevents lung cancer growth invitro and invivo. Proc Natl Acad Sci USA 102: 15611-15616, 2005.
12. Iliopoulos D, Fabbri M, Druck T, Qin HR, Han SY and Huebner K: Inhibition of breast cancer cell growth invitro and invivo: effect of restoration of Wwox expression. Clin Cancer Res 13: 268-274, 2007.
13. Aqeilan RI, Trapasso F, Hussain S, et al: Targeted deletion of Wwox reveals a tumor-suppressor function. Proc Natl Acad Sci USA 104: 3949-3954, 2007.
14. Aqeilan RI, Pekarsky Y, Herrero JJ, et al: Functional association between Wwox tumor suppressor protein and p73, a p53 homolog. Proc Natl Acad Sci USA 101: 4401-4406, 2004.
15. Hezova R, Ehrmann J and Kolar Z: WWOX, a new potential tumor suppressor gene. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 151: 11-15, 2007.
16. Yang JL and Zhang W: WWOX tumor suppressor gene. Histol Histopathol 23: 877-882, 2008.
17. Chang NS, Hsu LJ, Lin YS, Lai FJ and Sheu HM: WW domain-containing oxidoreductase: a candidate tumor suppressor. Trends Mol Med 13: 12-22, 2007.
18. Gomes CC, Diniz MG, Oliveira CS, Tavassoli M, Odell EW, Gomez RS and De Marco L: Impact of WWOX alterations on p73, ΔNp73, p53, cell proliferation and DNA ploidy in salivary gland neoplasms. Oral Dis 17: 564-571, 2011.
19. Aqeilan RI, Kuroki T, Pekarsky Y, et al: Loss of WWOX expression in gastric carcinoma. Clin Cancer Res 10: 3053-3058, 2004.
20. Alsop AE, Taylor K, Zhang J, Gabra H, Paige AJ and Edwards PA: Homozygous deletions may be markers of nearby heterozygous mutations: the complex deletion at FRA16D in the HCT116 colon cancer cell line removes exons of WWOX. Genes Chromosomes Cancer 47: 437-447, 2008.
21. Zelazowski MJ, Płuciennik E, Pasz-Walczak G, Potemski P, Kordek R and Bednarek AK: WWOX expression in colorectal cancer: a real-time quantitative RT-PCR study. Tumour Biol 32: 551-560, 2011.
22. Qin HR, Iliopoulos D, Semba S, et al: A role for the WWOX gene in prostate cancer. Cancer Res 66: 6477-6480, 2006.
23. Ishii H and Furukawa Y: Alterations of common chromosome fragile sites in hematopoietic malignancies. Int J Hematol 79: 238-242, 2004.
24. Ishii H, Vecchione A, Furukawa Y, et al: Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies. Mol Cancer Res 1: 940-947, 2003.
25. Watanabe A, Hippo Y, Taniguchi H, et al: An opposing view on WWOX protein function as a tumor suppressor. Cancer Res 63: 8629-8633, 2003.
26. Chang NS: A potential role of p53 and WOX1 in mitochondrial apoptosis (Review). Int J Mol Med 9: 19-24, 2002.
27. Aqeilan RI, Donati V, Palamarchuk A, et al: WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function. Cancer Res 65: 6764-6772, 2005.