메뉴 건너뛰기




Volumn 13, Issue 1, 2007, Pages 268-274

Inhibition of breast cancer cell growth in vitro and in vivo: Effect of restoration of Wwox expression

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CASPASE; COMPLEMENTARY DNA; DNA METHYLTRANSFERASE INHIBITOR; OXIDOREDUCTASE; PROTEIN WWOX; UNCLASSIFIED DRUG;

EID: 33846274591     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-06-2038     Document Type: Article
Times cited : (80)

References (37)
  • 1
    • 0003619249 scopus 로고    scopus 로고
    • American Cancer Society, Atlanta GA, American Cancer Society;
    • American Cancer Society. Breast cancer facts and figures. Atlanta (GA): American Cancer Society; 2006.
    • (2006) Breast cancer facts and figures
  • 2
    • 0034655131 scopus 로고    scopus 로고
    • Bednarek AK, Laflin KJ, Daniel RL, Liao Q, Hawkins KA, Aldaz CM. WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer. Cancer Res 2000;60:2140-5.
    • Bednarek AK, Laflin KJ, Daniel RL, Liao Q, Hawkins KA, Aldaz CM. WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer. Cancer Res 2000;60:2140-5.
  • 4
    • 12144289659 scopus 로고    scopus 로고
    • Functional association between Wwox tumor suppressor protein and p73, a p53 homolog
    • Aqeilan RI, Pekarsky Y, Herrero JJ, et al. Functional association between Wwox tumor suppressor protein and p73, a p53 homolog. Proc Natl Acad Sci U S A 2004;101:4401-6.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 4401-4406
    • Aqeilan, R.I.1    Pekarsky, Y.2    Herrero, J.J.3
  • 5
    • 8544283814 scopus 로고    scopus 로고
    • Physical and functional interactions between the Wwox tumor suppressor protein and the Ap-2γ transcription factor
    • Aqeilan RI, Palamarchuk A, Weigel RJ, Herrero JJ, Pekarsky Y, Croce CM. Physical and functional interactions between the Wwox tumor suppressor protein and the Ap-2γ transcription factor. Cancer Res 2004; 64:8256-61.
    • (2004) Cancer Res , vol.64 , pp. 8256-8261
    • Aqeilan, R.I.1    Palamarchuk, A.2    Weigel, R.J.3    Herrero, J.J.4    Pekarsky, Y.5    Croce, C.M.6
  • 6
    • 23044492008 scopus 로고    scopus 로고
    • WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function
    • Aqeilan RI, Donati V, Palamarchuk A, et al. WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function. Cancer Res 2005;65:6764-72.
    • (2005) Cancer Res , vol.65 , pp. 6764-6772
    • Aqeilan, R.I.1    Donati, V.2    Palamarchuk, A.3
  • 7
    • 30044438229 scopus 로고    scopus 로고
    • WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53
    • Chang NS, Doherty J, Ensign A, Schultz L, Hsu LJ, Hong Q. WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53. J Biol Chem 2005;280:43100-8.
    • (2005) J Biol Chem , vol.280 , pp. 43100-43108
    • Chang, N.S.1    Doherty, J.2    Ensign, A.3    Schultz, L.4    Hsu, L.J.5    Hong, Q.6
  • 8
    • 1842581808 scopus 로고    scopus 로고
    • The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma
    • Guler G, Uner A, Guler N, et al. The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma. Cancer 2004;8:1605-14.
    • (2004) Cancer , vol.8 , pp. 1605-1614
    • Guler, G.1    Uner, A.2    Guler, N.3
  • 9
    • 13844281272 scopus 로고    scopus 로고
    • Frequent loss of WWOX expression in breast cancer: Correlation with estrogen receptor status
    • Nunez MI, Ludes-Meyers J, Abba MC, et al. Frequent loss of WWOX expression in breast cancer: correlation with estrogen receptor status. Breast Cancer Res Treat 2005;89:99-105.
    • (2005) Breast Cancer Res Treat , vol.89 , pp. 99-105
    • Nunez, M.I.1    Ludes-Meyers, J.2    Abba, M.C.3
  • 10
  • 11
    • 0344874589 scopus 로고    scopus 로고
    • Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies
    • Ishii H, Vecchione A, Furukawa Y, et al. Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies. Mol Cancer Res 2003;1:940-7.
    • (2003) Mol Cancer Res , vol.1 , pp. 940-947
    • Ishii, H.1    Vecchione, A.2    Furukawa, Y.3
  • 12
    • 11144354718 scopus 로고    scopus 로고
    • The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis
    • Kuroki T, Yendamuri S, Trapasso F, et al. The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis. Clin Cancer Res 2004;10: 2459-65.
    • (2004) Clin Cancer Res , vol.10 , pp. 2459-2465
    • Kuroki, T.1    Yendamuri, S.2    Trapasso, F.3
  • 13
    • 20144372911 scopus 로고    scopus 로고
    • Fragile genes as biomarkers: Epigenetic control of WWOX and FHIT in lung, breast and bladder cancer
    • Iliopoulos D, Guler G, Han SY, et al. Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer. Oncogene 2005;24: 1625-33.
    • (2005) Oncogene , vol.24 , pp. 1625-1633
    • Iliopoulos, D.1    Guler, G.2    Han, S.Y.3
  • 14
    • 13144262880 scopus 로고    scopus 로고
    • Replacement of Fhit in cancer cells suppresses tumorigenicity
    • Siprashvili Z, Sozzi G, Barnes LD, et al. Replacement of Fhit in cancer cells suppresses tumorigenicity. Proc Natl Acad Sci U S A 1997;94:13771-6.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 13771-13776
    • Siprashvili, Z.1    Sozzi, G.2    Barnes, L.D.3
  • 15
    • 0033565920 scopus 로고    scopus 로고
    • Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression
    • Ji L, Fang B, Yen N, Fong K, Minna JD, Roth JA. Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression. Cancer Res 1999;59:3333-9.
    • (1999) Cancer Res , vol.59 , pp. 3333-3339
    • Ji, L.1    Fang, B.2    Yen, N.3    Fong, K.4    Minna, J.D.5    Roth, J.A.6
  • 16
    • 0035853128 scopus 로고    scopus 로고
    • FHIT gene therapy prevents tumor development in Fhit-deficient mice
    • Dumon KR, Ishii H, Fong LY, et al. FHIT gene therapy prevents tumor development in Fhit-deficient mice. Proc Natl Acad Sci U S A 2001;98:3346-51.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 3346-3351
    • Dumon, K.R.1    Ishii, H.2    Fong, L.Y.3
  • 17
    • 1442291697 scopus 로고    scopus 로고
    • Restoration of p53 tumor-suppressor activity in human tumor cells in vitro and in their xenografts in vivo by recombinant avian adenovirus CELO-p53
    • Logunov DY, Ilyinskaya GV, Cherenova LV, et al. Restoration of p53 tumor-suppressor activity in human tumor cells in vitro and in their xenografts in vivo by recombinant avian adenovirus CELO-p53. Gene Ther 2004;11:79-84.
    • (2004) Gene Ther , vol.11 , pp. 79-84
    • Logunov, D.Y.1    Ilyinskaya, G.V.2    Cherenova, L.V.3
  • 18
    • 0034115372 scopus 로고    scopus 로고
    • Adenovirus-mediated p53 gene therapy inhibits human sarcoma tumorigenicity
    • Milas M, Yu D, Lang A, et al. Adenovirus-mediated p53 gene therapy inhibits human sarcoma tumorigenicity. Cancer Gene Ther 2000;7:422-9.
    • (2000) Cancer Gene Ther , vol.7 , pp. 422-429
    • Milas, M.1    Yu, D.2    Lang, A.3
  • 19
    • 27344455410 scopus 로고    scopus 로고
    • WWOX gene restoration prevents lung cancer growth in vitro and in vivo
    • Fabbri M, Iliopoulos D, Trapasso F, et al. WWOX gene restoration prevents lung cancer growth in vitro and in vivo. Proc Natl Acad Sci U S A 2005;102:15611-6.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 15611-15616
    • Fabbri, M.1    Iliopoulos, D.2    Trapasso, F.3
  • 20
    • 33845391172 scopus 로고    scopus 로고
    • Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity
    • Cantor JP, Iliopoulos D, Rao AS, et al. Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity. Int J Cancer 2007;120:24-31.
    • (2007) Int J Cancer , vol.120 , pp. 24-31
    • Cantor, J.P.1    Iliopoulos, D.2    Rao, A.S.3
  • 21
    • 2342557977 scopus 로고    scopus 로고
    • A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements
    • Yang AS, Estecio MR, Doshi K, Kondo Y, Tajara EH, Issa JP. A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res 2004;32:e38.
    • (2004) Nucleic Acids Res , vol.32
    • Yang, A.S.1    Estecio, M.R.2    Doshi, K.3    Kondo, Y.4    Tajara, E.H.5    Issa, J.P.6
  • 22
    • 0035753424 scopus 로고    scopus 로고
    • FRA3B and other common fragile sites: The weakest links
    • Huebner K, Croce CM. FRA3B and other common fragile sites: the weakest links. Nat Rev Cancer 2001;1: 214-21.
    • (2001) Nat Rev Cancer , vol.1 , pp. 214-221
    • Huebner, K.1    Croce, C.M.2
  • 23
    • 0021690129 scopus 로고
    • Constitutive fragile sites and cancer
    • Yunis JJ, Soreng AL. Constitutive fragile sites and cancer. Science 1984;226:1199-204.
    • (1984) Science , vol.226 , pp. 1199-1204
    • Yunis, J.J.1    Soreng, A.L.2
  • 24
    • 25844465921 scopus 로고    scopus 로고
    • Epigenetic therapy of cancer with 5-aza-2′- deoxycytidine (decitabine)
    • Momparler RL. Epigenetic therapy of cancer with 5-aza-2′- deoxycytidine (decitabine). Semin Oncol 2005;32:443-51.
    • (2005) Semin Oncol , vol.32 , pp. 443-451
    • Momparler, R.L.1
  • 25
    • 27644582534 scopus 로고    scopus 로고
    • Antimitogenic and chemosensitizing effects of the methylation inhibitor zebularine in ovarian cancer
    • Balch C, Yan P, Craft T, et al. Antimitogenic and chemosensitizing effects of the methylation inhibitor zebularine in ovarian cancer. Mol Cancer Ther 2005; 4:1505-14.
    • (2005) Mol Cancer Ther , vol.4 , pp. 1505-1514
    • Balch, C.1    Yan, P.2    Craft, T.3
  • 26
    • 33746154619 scopus 로고    scopus 로고
    • A role for the WWOX gene in prostate cancer
    • Qin HR, Iliopoulos D, Semba S, et al. A role for the WWOX gene in prostate cancer. Cancer Res 2006;66: 6477-81.
    • (2006) Cancer Res , vol.66 , pp. 6477-6481
    • Qin, H.R.1    Iliopoulos, D.2    Semba, S.3
  • 27
    • 0037068379 scopus 로고    scopus 로고
    • 5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: Mechanistic studies and their implications for cancer therapy
    • Christman JK. 5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene 2002;21:5483-95.
    • (2002) Oncogene , vol.21 , pp. 5483-5495
    • Christman, J.K.1
  • 28
    • 0028151343 scopus 로고
    • Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation
    • Juttermann R, Li E, Jaenisch R. Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. Proc Natl Acad Sci U S A 1994;91:11797-801.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 11797-11801
    • Juttermann, R.1    Li, E.2    Jaenisch, R.3
  • 29
    • 21244449980 scopus 로고    scopus 로고
    • Evaluation of a 7-day continuous intravenous infusion of decitabine: Inhibition of promoter-specific and global genomic DNA methylation
    • Samlowski WE, Leachman SA, Wade M, et al. Evaluation of a 7-day continuous intravenous infusion of decitabine: inhibition of promoter-specific and global genomic DNA methylation. J Clin Oncol 2005;23: 3897-905.
    • (2005) J Clin Oncol , vol.23 , pp. 3897-3905
    • Samlowski, W.E.1    Leachman, S.A.2    Wade, M.3
  • 30
    • 10744233452 scopus 로고    scopus 로고
    • Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′- deoxycytidine (decitabine) in hematopoietic malignancies
    • Issa JP, Garcia-Manero G, Giles FJ, et al. Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′- deoxycytidine (decitabine) in hematopoietic malignancies. Blood 2004;103:1635-40.
    • (2004) Blood , vol.103 , pp. 1635-1640
    • Issa, J.P.1    Garcia-Manero, G.2    Giles, F.J.3
  • 31
    • 27144509196 scopus 로고    scopus 로고
    • Lyko F, Brown R. DNA Methyltransferase inhibitors and the development of epigenetic cancer therapies. J Natl Cancer Inst 2005;97:1498-506.
    • Lyko F, Brown R. DNA Methyltransferase inhibitors and the development of epigenetic cancer therapies. J Natl Cancer Inst 2005;97:1498-506.
  • 32
    • 29244477848 scopus 로고    scopus 로고
    • Inhibition of DNA methylation sensitizes glioblastoma for tumor necrosis factor-related apoptosis-inducing ligand-mediated destruction
    • Eramo A, Pallini R, Lotti F, et al. Inhibition of DNA methylation sensitizes glioblastoma for tumor necrosis factor-related apoptosis-inducing ligand-mediated destruction. Cancer Res 2005;65:11469-77.
    • (2005) Cancer Res , vol.65 , pp. 11469-11477
    • Eramo, A.1    Pallini, R.2    Lotti, F.3
  • 33
    • 0035988868 scopus 로고    scopus 로고
    • Review of the clinical experience with 5-aza-cytidine and 5-aza-2′-deoxycytidine in solid tumors
    • Aparicio A, Weber JS. Review of the clinical experience with 5-aza-cytidine and 5-aza-2′-deoxycytidine in solid tumors. Curr Opin Investig Drugs 2002;3:627-33.
    • (2002) Curr Opin Investig Drugs , vol.3 , pp. 627-633
    • Aparicio, A.1    Weber, J.S.2
  • 34
    • 0033452480 scopus 로고    scopus 로고
    • DNA methylation of retinoic acid receptor β in breast cancer and possible therapeutic role of 5-aza-2′-deoxycytidine
    • Bovenzi V, Le NL, Cote S, et al. DNA methylation of retinoic acid receptor β in breast cancer and possible therapeutic role of 5-aza-2′-deoxycytidine. Anticancer Drugs 1999;10:471-6.
    • (1999) Anticancer Drugs , vol.10 , pp. 471-476
    • Bovenzi, V.1    Le, N.L.2    Cote, S.3
  • 35
    • 1542299085 scopus 로고    scopus 로고
    • Evaluation of antineoplastic action of 5-aza-2′-deoxycytidine (Dacogen) and docetaxel (Taxotere) on human breast, lung, and prostate carcinoma cell lines
    • Hurtubise A, Momparler RL. Evaluation of antineoplastic action of 5-aza-2′-deoxycytidine (Dacogen) and docetaxel (Taxotere) on human breast, lung, and prostate carcinoma cell lines. Anticancer Drugs 2004; 15:161-7.
    • (2004) Anticancer Drugs , vol.15 , pp. 161-167
    • Hurtubise, A.1    Momparler, R.L.2
  • 36
    • 33846269978 scopus 로고    scopus 로고
    • 5-Aza-2′-deoxycytidine-2′-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation
    • Jun 26. Epub ahead of print
    • Wozniak RJ, Klimecki WT, Lau SS, Feinstein Y, Futscher BW. 5-Aza-2′-deoxycytidine-2′-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation. Oncogene 2006 Jun 26. Epub ahead of print.
    • (2006) Oncogene
    • Wozniak, R.J.1    Klimecki, W.T.2    Lau, S.S.3    Feinstein, Y.4    Futscher, B.W.5
  • 37
    • 0033624150 scopus 로고    scopus 로고
    • Induction of apoptosis in p16INK4A mutant cell lines by adenovirus-mediated overexpression of p16INK4A protein
    • Kim M, Katayose Y, Rojanala L, et al. Induction of apoptosis in p16INK4A mutant cell lines by adenovirus-mediated overexpression of p16INK4A protein. Cell Death Differ 2000;7:706-11.
    • (2000) Cell Death Differ , vol.7 , pp. 706-711
    • Kim, M.1    Katayose, Y.2    Rojanala, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.