Metabolic engineering of Bacillus subtilis for the efficient biosynthesis of uniform hyaluronic acid with controlled molecular weights

Bioresource Technology

Volumn 132, Issue , 2013, Pages 427-431

  Jia, Yuning ^a   Zhu, Jing ^a   Chen, Xiaofei ^a   Tang, Dongyang ^a   Su, Ding ^a   Yao, Wenbing ^a   Gao, Xiangdong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Hyaluronic acid; Metabolic engineering; Recombinant Bacillus subtilis; Two stage induction strategy; Uniform molecular weight

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; ENZYMES; GENE ENCODING; METABOLIC ENGINEERING; MOLECULAR WEIGHT; MOLECULES; ORGANIC ACIDS;

ARTIFICIAL OPERONS; BACILLUS SUBTILIS; CONTROLLED MOLECULAR WEIGHT; GENES ENCODING ENZYMES; INDUCTION STRATEGIES; PASTEURELLA MULTOCIDA; RECOMBINANT BACILLI; UDP-GLUCURONIC ACID;

HYALURONIC ACID;

HYALURONIC ACID; URIDINE DIPHOSPHATE GLUCURONIC ACID;

BACTERIUM; BIOENGINEERING; BIOLOGICAL PRODUCTION; ENZYME ACTIVITY; FUNCTIONAL ROLE; GENE EXPRESSION; INDUSTRIAL PRODUCTION; METABOLISM; POLYSACCHARIDE; SIZE DISTRIBUTION;

ARTICLE; BACILLUS SUBTILIS; BACTERIAL CELL; BACTERIAL GROWTH; BACTERIUM CULTURE; CARBOHYDRATE SYNTHESIS; CHEMICAL STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; INFRARED SPECTROSCOPY; METABOLIC ENGINEERING; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL;

BACILLUS SUBTILIS; PASTEURELLA MULTOCIDA;

EID: 84875251441     PISSN: 09608524     EISSN: 18732976     Source Type: Journal    
DOI: 10.1016/j.biortech.2012.12.150     Document Type: Article

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