Hypothesis: Increased consumption of emulsifiers as an explanation for the rising incidence of Crohn's disease

Journal of Crohn's and Colitis

Volumn 7, Issue 4, 2013, Pages 338-341

  Roberts, Carol L ^a   Rushworth, Sarah L ^a   Richman, Emile ^b   Rhodes, Jonathan M ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Bacterial translocation; Crohn's; Diet; Emulsifier; Incidence; Pathogenesis; Polysorbate

Indexed keywords

BILE ACID; CASPASE RECRUITMENT DOMAIN PROTEIN 15; COLECALCIFEROL; EMULSIFYING AGENT; FAT; MARGARINE; ORAL CONTRACEPTIVE AGENT; PHOSPHATIDYLCHOLINE; POLYSORBATE 60; POLYSORBATE 80; SORBIC ACID;

ARTICLE; ASTHMA; BACTERIAL TRANSLOCATION; CROHN DISEASE; DIETARY INTAKE; DRUG EFFICACY; ENTERIC FEEDING; ENVIRONMENTAL FACTOR; ESCHERICHIA COLI; FAT CONTENT; FOOD INTAKE; GENE LOCUS; GENETIC ASSOCIATION; GEOGRAPHIC DISTRIBUTION; HEREDITY; HUMAN; HYGIENE; HYPOTHESIS; INCIDENCE; INTESTINE EPITHELIUM; JAPAN; META ANALYSIS; PATHOGENESIS; PEYER PATCH; PREVALENCE; PRIORITY JOURNAL; REMISSION; RISK FACTOR; RISK REDUCTION; SMALL INTESTINE; SMOKING; SMOKING CESSATION; SUNLIGHT; VITAMIN SUPPLEMENTATION;

BACTERIAL TRANSLOCATION; CROHN DISEASE; DEVELOPED COUNTRIES; DIET; EMULSIFYING AGENTS; FOOD ADDITIVES; HUMANS; INCIDENCE; JAPAN; RISK FACTORS; SINGAPORE; WORLD HEALTH;

EID: 84875236506     PISSN: 18739946     EISSN: 18764479     Source Type: Journal    
DOI: 10.1016/j.crohns.2013.01.004     Document Type: Article

References (20)

1. Jostins L., Ripke S., Weersma R.K., Duerr R.H., McGovern D.P., Hui K.Y., et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 2012, 491:119-124.
2. Flanagan P., Campbell B.J., Rhodes J.M. Bacteria in the pathogenesis of inflammatory bowel disease. Biochem Soc Trans 2011, 39:1067-1072.
3. Logan R.F. Inflammatory bowel disease incidence: up, down or unchanged?. Gut 1998, 42:309-311.
4. Ahuja V., Tandon R.K. Inflammatory bowel disease in the Asia-Pacific area: a comparison with developed countries and regional differences. J Dig Dis 2010, 11:134-147.
5. Yao T., Matsui T., Hiwatashi N. Crohn's disease in Japan: diagnostic criteria and epidemiology. Dis Colon Rectum 2000, 43:S85-S93.
6. Armitage E.L., Aldhous M.C., Anderson N., Drummond H.E., Riemersma R.A., Ghosh S., et al. Incidence of juvenile-onset Crohn's disease in Scotland: association with northern latitude and affluence. Gastroenterology 2004, 127:1051-1057.
7. Yamamoto T., Nakahigashi M., Saniabadi A.R. Review article: diet and inflammatory bowel disease-epidemiology and treatment. Aliment Pharmacol Ther 2009, 30:99-112.
8. Raouf A.H., Hildrey V., Daniel J., Walker R.J., Krasner N., Elias E., et al. Enteral feeding as sole therapy for Crohn's disease: a controlled trial of whole protein versus amino-acid based feed and a case study of dietary challenge. Gut 1991, 32:702-707.
9. Shoda R., Matsueda K., Yamato S., Umeda N. Epidemiologic analysis of Crohn disease in Japan: increased dietary intake of n-6 polyunsaturated fatty acids and animal protein relates to the increased incidence of Crohn disease in Japan. Am J Clin Nutr 1996, 63:741-745.
10. Sakamoto N., Kono S., Wakai K., Fukuda Y., Satomi M., Shimoyama T., et al. Dietary risk factors for inflammatory bowel disease: a multicenter case-control study in Japan. Inflamm Bowel Dis 2005, 11:154-163.
11. Zachos M., Tondeur M., Griffiths A.M. Enteral nutritional therapy for induction of remission in Crohn's disease. Cochrane Database Syst Rev 2007, 1:CD000542.
12. Global Industry Analysts, Inc., USA Emulsifiers - a global strategic business report 06/07 2007.
13. Persson P.G., Ahlbom A., Hellers G. Diet and inflammatory bowel disease: a case-control study. Epidemiology 1992, 3:47-52.
14. Cashman K.D., Shanahan F. Is nutrition an aetiological factor for inflammatory bowel disease?. Eur J Gastroenterol Hepatol 2003, 15:607-613.
15. Dimitrijevic D., Shaw A.J., Florence A.T. Effects of some non-ionic surfactants on transepithelial permeability in Caco-2 cells. J Pharm Pharmacol 2000, 52:157-162.
16. Roberts C.L., Keita A.V., Duncan S.H., O'Kennedy N., Söderholm J.D., Rhodes J.M., et al. Translocation of Crohn's disease E. coli across M-cells: contrasting effects of soluble plant fibres and emulsifiers. Gut 2010, 59:1331-1339.
17. Keita A.V., Salim S.Y., Jiang T., Yang P.C., Franzén L., Söderkvist P., et al. Increased uptake of non-pathogenic E. coli via the follicle-associated epithelium in longstanding ileal Crohn's disease. J Pathol 2008, 215:135-144.
18. Lakatos P.L. Recent trends in the epidemiology of inflammatory bowel diseases: up or down?. World J Gastroenterol 2006, 12:6102-6108.
19. Hilmi I., Tan Y., Goh K. Crohn's disease in adults: observations in a multi-racial Asian population. World J Gastroenterol 2006, 12:6102-6108.
20. Ouyang Q., Tandon R., Goh K., Guo-Zong P., Fock K., Fiocchi C., et al. Management consensus of inflammatory bowel disease for the Asia Pacific region. J Gastroenterol Hepatol 2006, 21:1772-1782.