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Volumn 110, Issue 12, 2013, Pages 4774-4779

Serotonin spillover onto the axon initial segment of motoneurons induces central fatigue by inhibiting action potential initiation

Author keywords

Input output gain; Movement; Movement control; Spike genesis

Indexed keywords

SEROTONIN; SEROTONIN 1A RECEPTOR;

EID: 84875234468     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1216150110     Document Type: Article
Times cited : (122)

References (50)
  • 1
    • 34547642304 scopus 로고    scopus 로고
    • Sustained contraction at very low forces produces prominent supraspinal fatigue in human elbow flexor muscles
    • Smith JL, Martin PG, Gandevia SC, Taylor JL (2007) Sustained contraction at very low forces produces prominent supraspinal fatigue in human elbow flexor muscles. J Appl Physiol 103(2):560-568.
    • (2007) J Appl Physiol , vol.103 , Issue.2 , pp. 560-568
    • Smith, J.L.1    Martin, P.G.2    Gandevia, S.C.3    Taylor, J.L.4
  • 2
    • 38949093238 scopus 로고    scopus 로고
    • A comparison of central aspects of fatigue in submaximal and maximal voluntary contractions
    • Taylor JL, Gandevia SC (2008) A comparison of central aspects of fatigue in submaximal and maximal voluntary contractions. J Appl Physiol 104(2):542-550.
    • (2008) J Appl Physiol , vol.104 , Issue.2 , pp. 542-550
    • Taylor, J.L.1    Gandevia, S.C.2
  • 4
    • 0015266124 scopus 로고
    • Fatigue of maintained voluntary muscle contraction in man
    • Stephens JA, Taylor A (1972) Fatigue of maintained voluntary muscle contraction in man. J Physiol 220(1):1-18.
    • (1972) J Physiol , vol.220 , Issue.1 , pp. 1-18
    • Stephens, J.A.1    Taylor, A.2
  • 5
    • 0344393058 scopus 로고    scopus 로고
    • Responses of human motoneurons to corticospinal stimulation during maximal voluntary contractions and ischemia
    • Butler JE, Taylor JL, Gandevia SC (2003) Responses of human motoneurons to corticospinal stimulation during maximal voluntary contractions and ischemia. J Neurosci 23(32):10224-10230.
    • (2003) J Neurosci , vol.23 , Issue.32 , pp. 10224-10230
    • Butler, J.E.1    Taylor, J.L.2    Gandevia, S.C.3
  • 6
    • 0034783773 scopus 로고    scopus 로고
    • Spinal and supraspinal factors in human muscle fatigue
    • Gandevia SC (2001) Spinal and supraspinal factors in human muscle fatigue. Physiol Rev 81(4):1725-1789.
    • (2001) Physiol Rev , vol.81 , Issue.4 , pp. 1725-1789
    • Gandevia, S.C.1
  • 7
    • 84875249633 scopus 로고
    • The mechanism of voluntary muscular fatigue
    • Reid C (1927) The mechanism of voluntary muscular fatigue. BMJ 2(3481):545-546.
    • (1927) BMJ , vol.2 , Issue.3481 , pp. 545-546
    • Reid, C.1
  • 8
    • 1442286474 scopus 로고    scopus 로고
    • Properties of human motor units after prolonged activity at a constant firing rate
    • Johnson KV, Edwards SC, Van Tongeren C, Bawa P (2004) Properties of human motor units after prolonged activity at a constant firing rate. Exp Brain Res 154(4):479-487.
    • (2004) Exp Brain Res , vol.154 , Issue.4 , pp. 479-487
    • Johnson, K.V.1    Edwards, S.C.2    Van Tongeren, C.3    Bawa, P.4
  • 9
    • 13344276576 scopus 로고    scopus 로고
    • Supraspinal factors in human muscle fatigue: Evidence for suboptimal output from the motor cortex
    • Gandevia SC, Allen GM, Butler JE, Taylor JL (1996) Supraspinal factors in human muscle fatigue: Evidence for suboptimal output from the motor cortex. J Physiol 490(Pt 2):529-536.
    • (1996) J Physiol , vol.490 , Issue.PART. 2 , pp. 529-536
    • Gandevia, S.C.1    Allen, G.M.2    Butler, J.E.3    Taylor, J.L.4
  • 10
    • 0032575675 scopus 로고    scopus 로고
    • Influence of a voluntary fatigue test on the contralateral homologous muscle in humans?
    • Zijdewind I, Zwarts MJ, Kernell D (1998) Influence of a voluntary fatigue test on the contralateral homologous muscle in humans? Neurosci Lett 253(1):41-44.
    • (1998) Neurosci Lett , vol.253 , Issue.1 , pp. 41-44
    • Zijdewind, I.1    Zwarts, M.J.2    Kernell, D.3
  • 11
    • 34548044483 scopus 로고    scopus 로고
    • Central fatigue of the first dorsal interosseous muscle during low-force and high-force sustained submaximal contractions
    • Eichelberger TD, Bilodeau M (2007) Central fatigue of the first dorsal interosseous muscle during low-force and high-force sustained submaximal contractions. Clin Physiol Funct Imaging 27(5):298-304.
    • (2007) Clin Physiol Funct Imaging , vol.27 , Issue.5 , pp. 298-304
    • Eichelberger, T.D.1    Bilodeau, M.2
  • 12
    • 33745038764 scopus 로고    scopus 로고
    • The effect of sustained low-intensity contractions on supraspinal fatigue in human elbow flexor muscles
    • Søgaard K, Gandevia SC, Todd G, Petersen NT, Taylor JL (2006) The effect of sustained low-intensity contractions on supraspinal fatigue in human elbow flexor muscles. J Physiol 573(Pt 2):511-523.
    • (2006) J Physiol , vol.573 , Issue.PART. 2 , pp. 511-523
    • Søgaard, K.1    Gandevia, S.C.2    Todd, G.3    Petersen, N.T.4    Taylor, J.L.5
  • 13
    • 33748544255 scopus 로고    scopus 로고
    • Rotation of motoneurons during prolonged isometric contractions in humans
    • Bawa P, Pang MY, Olesen KA, Calancie B (2006) Rotation of motoneurons during prolonged isometric contractions in humans. J Neurophysiol 96(3):1135-1140.
    • (2006) J Neurophysiol , vol.96 , Issue.3 , pp. 1135-1140
    • Bawa, P.1    Pang, M.Y.2    Olesen, K.A.3    Calancie, B.4
  • 14
    • 0030812631 scopus 로고    scopus 로고
    • The effects of buspirone on perceived exertion and time to fatigue in man
    • Marvin G, et al. (1997) The effects of buspirone on perceived exertion and time to fatigue in man. Exp Physiol 82(6):1057-1060.
    • (1997) Exp Physiol , vol.82 , Issue.6 , pp. 1057-1060
    • Marvin, G.1
  • 15
    • 0026489149 scopus 로고
    • Evidence for a possible role of 5-hydroxytryptamine in the genesis of fatigue in man: Administration of paroxetine, a 5-HT re-uptake inhibitor, reduces the capacity to perform prolonged exercise
    • Wilson WM, Maughan RJ (1992) Evidence for a possible role of 5-hydroxytryptamine in the genesis of fatigue in man: Administration of paroxetine, a 5-HT re-uptake inhibitor, reduces the capacity to perform prolonged exercise. Exp Physiol 77(6): 921-924.
    • (1992) Exp Physiol , vol.77 , Issue.6 , pp. 921-924
    • Wilson, W.M.1    Maughan, R.J.2
  • 17
    • 0037212858 scopus 로고    scopus 로고
    • Evidence that tryptophan reduces mechanical efficiency and running performance in rats
    • Soares DD, Lima NR, Coimbra CC, Marubayashi U (2003) Evidence that tryptophan reduces mechanical efficiency and running performance in rats. Pharmacol Biochem Behav 74(2):357-362.
    • (2003) Pharmacol Biochem Behav , vol.74 , Issue.2 , pp. 357-362
    • Soares, D.D.1    Lima, N.R.2    Coimbra, C.C.3    Marubayashi, U.4
  • 18
    • 0027295429 scopus 로고
    • Serotonergic agonists and antagonists affect endurance performance in the rat
    • Bailey SP, Davis JM, Ahlborn EN (1993) Serotonergic agonists and antagonists affect endurance performance in the rat. Int J Sports Med 14(6):330-333.
    • (1993) Int J Sports Med , vol.14 , Issue.6 , pp. 330-333
    • Bailey, S.P.1    Davis, J.M.2    Ahlborn, E.N.3
  • 19
    • 0032844030 scopus 로고    scopus 로고
    • Activity of serotonergic neurons in behaving animals
    • Jacobs BL, Fornal CA (1999) Activity of serotonergic neurons in behaving animals. Neuropsychopharmacology 21(2, Suppl):9S-15S.
    • (1999) Neuropsychopharmacology , vol.21 , Issue.2 SUPPL.
    • Jacobs, B.L.1    Fornal, C.A.2
  • 20
    • 0029051506 scopus 로고
    • Response of serotonergic caudal raphe neurons in relation to specific motor activities in freely moving cats
    • Veasey SC, Fornal CA, Metzler CW, Jacobs BL (1995) Response of serotonergic caudal raphe neurons in relation to specific motor activities in freely moving cats. J Neurosci 15(7 Pt 2):5346-5359.
    • (1995) J Neurosci , vol.15 , Issue.7 PART. 2 , pp. 5346-5359
    • Veasey, S.C.1    Fornal, C.A.2    Metzler, C.W.3    Jacobs, B.L.4
  • 21
    • 0032579782 scopus 로고    scopus 로고
    • Distribution of 5-hydroxytryptamine-immunoreactive boutons on alpha-motoneurons in the lumbar spinal cord of adult cats
    • Alvarez FJ, et al. (1998) Distribution of 5-hydroxytryptamine- immunoreactive boutons on alpha-motoneurons in the lumbar spinal cord of adult cats. J Comp Neurol 393(1): 69-83.
    • (1998) J Comp Neurol , vol.393 , Issue.1 , pp. 69-83
    • Alvarez, F.J.1
  • 22
    • 0026479966 scopus 로고
    • Monoaminergic systems in the brainstem and spinal cord of the turtle Pseudemys scripta elegans as revealed by antibodies against serotonin and tyrosine hydroxylase
    • Kiehn O, Rostrup E, Møller M (1992) Monoaminergic systems in the brainstem and spinal cord of the turtle Pseudemys scripta elegans as revealed by antibodies against serotonin and tyrosine hydroxylase. J Comp Neurol 325(4):527-547.
    • (1992) J Comp Neurol , vol.325 , Issue.4 , pp. 527-547
    • Kiehn, O.1    Rostrup, E.2    Møller, M.3
  • 23
    • 0038069071 scopus 로고    scopus 로고
    • 5-HT1A receptors increase excitability of spinal motoneurons by inhibiting a TASK-1-like K+ current in the adult turtle
    • Perrier JF, Alaburda A, Hounsgaard J (2003) 5-HT1A receptors increase excitability of spinal motoneurons by inhibiting a TASK-1-like K+ current in the adult turtle. J Physiol 548(Pt 2):485-492.
    • (2003) J Physiol , vol.548 , Issue.PART. 2 , pp. 485-492
    • Perrier, J.F.1    Alaburda, A.2    Hounsgaard, J.3
  • 24
    • 0025059607 scopus 로고
    • 5-Hydroxytryptamine responses in neonate rat motoneurones in vitro
    • Wang MY, Dun NJ (1990) 5-Hydroxytryptamine responses in neonate rat motoneurones in vitro. J Physiol 430:87-103.
    • (1990) J Physiol , vol.430 , pp. 87-103
    • Wang, M.Y.1    Dun, N.J.2
  • 25
    • 10644294647 scopus 로고    scopus 로고
    • 5-HT1A receptors modulate small-conductance Ca2+-activated K+ channels
    • Grunnet M, Jespersen T, Perrier JF (2004) 5-HT1A receptors modulate small-conductance Ca2+-activated K+ channels. J Neurosci Res 78(6):845-854.
    • (2004) J Neurosci Res , vol.78 , Issue.6 , pp. 845-854
    • Grunnet, M.1    Jespersen, T.2    Perrier, J.F.3
  • 26
    • 1842408933 scopus 로고    scopus 로고
    • Metabotropic synaptic regulation of intrinsic response properties of turtle spinal motoneurones
    • Delgado-Lezama R, Perrier JF, Nedergaard S, Svirskis G, Hounsgaard J (1997) Metabotropic synaptic regulation of intrinsic response properties of turtle spinal motoneurones. J Physiol 504(Pt 1):97-102.
    • (1997) J Physiol , vol.504 , Issue.PART. 1 , pp. 97-102
    • Delgado-Lezama, R.1    Perrier, J.F.2    Nedergaard, S.3    Svirskis, G.4    Hounsgaard, J.5
  • 27
    • 33748523450 scopus 로고    scopus 로고
    • 5-HT2 receptor activation facilitates a persistent sodium current and repetitive firing in spinal motoneurons of rats with and without chronic spinal cord injury
    • Harvey PJ, Li X, Li Y, Bennett DJ (2006) 5-HT2 receptor activation facilitates a persistent sodium current and repetitive firing in spinal motoneurons of rats with and without chronic spinal cord injury. J Neurophysiol 96(3):1158-1170.
    • (2006) J Neurophysiol , vol.96 , Issue.3 , pp. 1158-1170
    • Harvey, P.J.1    Li, X.2    Li, Y.3    Bennett, D.J.4
  • 28
    • 0024319735 scopus 로고
    • Serotonin-induced bistability of turtle motoneurones caused by a nifedipine-sensitive calcium plateau potential
    • Hounsgaard J, Kiehn O (1989) Serotonin-induced bistability of turtle motoneurones caused by a nifedipine-sensitive calcium plateau potential. J Physiol 414:265-282.
    • (1989) J Physiol , vol.414 , pp. 265-282
    • Hounsgaard, J.1    Kiehn, O.2
  • 29
    • 0023856933 scopus 로고
    • Calcium conductance and firing properties of spinal motoneurones in the turtle
    • Hounsgaard J, Mintz I (1988) Calcium conductance and firing properties of spinal motoneurones in the turtle. J Physiol 398:591-603.
    • (1988) J Physiol , vol.398 , pp. 591-603
    • Hounsgaard, J.1    Mintz, I.2
  • 30
    • 0036824827 scopus 로고    scopus 로고
    • Spinal plasticity mediated by postsynaptic L-type Ca2+ channels
    • Perrier JF, Alaburda A, Hounsgaard J (2002) Spinal plasticity mediated by postsynaptic L-type Ca2+ channels. Brain Res Brain Res Rev 40(1-3):223-229.
    • (2002) Brain Res Brain Res Rev , vol.40 , Issue.1-3 , pp. 223-229
    • Perrier, J.F.1    Alaburda, A.2    Hounsgaard, J.3
  • 31
    • 24344508169 scopus 로고    scopus 로고
    • Synaptic release of serotonin induced by stimulation of the raphe nucleus promotes plateau potentials in spinal motoneurons of the adult turtle
    • Perrier JF, Delgado-Lezama R (2005) Synaptic release of serotonin induced by stimulation of the raphe nucleus promotes plateau potentials in spinal motoneurons of the adult turtle. J Neurosci 25(35):7993-7999.
    • (2005) J Neurosci , vol.25 , Issue.35 , pp. 7993-7999
    • Perrier, J.F.1    Delgado-Lezama, R.2
  • 32
    • 12744262877 scopus 로고    scopus 로고
    • Recruitment of motor neuronal persistent inward currents shapes withdrawal reflexes in the frog
    • Perrier JF, Tresch MC (2005) Recruitment of motor neuronal persistent inward currents shapes withdrawal reflexes in the frog. J Physiol 562(Pt 2):507-520.
    • (2005) J Physiol , vol.562 , Issue.PART. 2 , pp. 507-520
    • Perrier, J.F.1    Tresch, M.C.2
  • 33
    • 0037289839 scopus 로고    scopus 로고
    • 5-HT2 receptors promote plateau potentials in turtle spinal motoneurons by facilitating an L-type calcium current
    • Perrier JF, Hounsgaard J (2003) 5-HT2 receptors promote plateau potentials in turtle spinal motoneurons by facilitating an L-type calcium current. J Neurophysiol 89(2): 954-959.
    • (2003) J Neurophysiol , vol.89 , Issue.2 , pp. 954-959
    • Perrier, J.F.1    Hounsgaard, J.2
  • 34
    • 0032969754 scopus 로고    scopus 로고
    • Pharmacological characterisation of 5-HT receptors positively coupled to adenylyl cyclase in the rat hippocampus
    • Markstein R, et al. (1999) Pharmacological characterisation of 5-HT receptors positively coupled to adenylyl cyclase in the rat hippocampus. Naunyn Schmiedebergs Arch Pharmacol 359(6):454-459.
    • (1999) Naunyn Schmiedebergs Arch Pharmacol , vol.359 , Issue.6 , pp. 454-459
    • Markstein, R.1
  • 35
    • 0022444356 scopus 로고
    • Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine
    • Bradley PB, et al. (1986) Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine. Neuropharmacology 25(6):563-576.
    • (1986) Neuropharmacology , vol.25 , Issue.6 , pp. 563-576
    • Bradley, P.B.1
  • 36
    • 0013079380 scopus 로고
    • Response of single motoneurons to direct stimulation in toad's spinal cord
    • Araki T, Otani T (1955) Response of single motoneurons to direct stimulation in toad's spinal cord. J Neurophysiol 18(5):472-485.
    • (1955) J Neurophysiol , vol.18 , Issue.5 , pp. 472-485
    • Araki, T.1    Otani, T.2
  • 37
    • 77049185815 scopus 로고
    • Intracellular recording from antidromically activated motoneurones
    • Brock LG, Coombs JS, Eccles JC (1953) Intracellular recording from antidromically activated motoneurones. J Physiol 122(3):429-461.
    • (1953) J Physiol , vol.122 , Issue.3 , pp. 429-461
    • Brock, L.G.1    Coombs, J.S.2    Eccles, J.C.3
  • 38
    • 0002819192 scopus 로고
    • Sequence of events in synaptic activation of a motoneurone
    • Fatt P (1957) Sequence of events in synaptic activation of a motoneurone. J Neurophysiol 20(1):61-80.
    • (1957) J Neurophysiol , vol.20 , Issue.1 , pp. 61-80
    • Fatt, P.1
  • 39
    • 68149161179 scopus 로고    scopus 로고
    • Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation
    • Hu W, et al. (2009) Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation. Nat Neurosci 12(8):996-1002.
    • (2009) Nat Neurosci , vol.12 , Issue.8 , pp. 996-1002
    • Hu, W.1
  • 40
    • 0029132789 scopus 로고
    • A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635
    • Forster EA, et al. (1995) A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635. Eur J Pharmacol 281(1):81-88.
    • (1995) Eur J Pharmacol , vol.281 , Issue.1 , pp. 81-88
    • Forster, E.A.1
  • 41
    • 0035891886 scopus 로고    scopus 로고
    • Modern views on an ancient chemical: Serotonin effects on cell proliferation, maturation, and apoptosis
    • Azmitia EC (2001) Modern views on an ancient chemical: Serotonin effects on cell proliferation, maturation, and apoptosis. Brain Res Bull 56(5):413-424.
    • (2001) Brain Res Bull , vol.56 , Issue.5 , pp. 413-424
    • Azmitia, E.C.1
  • 42
    • 78049298614 scopus 로고    scopus 로고
    • Dopaminergic modulation of axon initial segment calcium channels regulates action potential initiation
    • Bender KJ, Ford CP, Trussell LO (2010) Dopaminergic modulation of axon initial segment calcium channels regulates action potential initiation. Neuron 68(3): 500-511.
    • (2010) Neuron , vol.68 , Issue.3 , pp. 500-511
    • Bender, K.J.1    Ford, C.P.2    Trussell, L.O.3
  • 43
    • 84855180863 scopus 로고    scopus 로고
    • Control of firing patterns through modulation of axon initial segment T-type calcium channels
    • Bender KJ, Uebele VN, Renger JJ, Trussell LO (2012) Control of firing patterns through modulation of axon initial segment T-type calcium channels. J Physiol 590(Pt 1): 109-118.
    • (2012) J Physiol , vol.590 , Issue.PART. 1 , pp. 109-118
    • Bender, K.J.1    Uebele, V.N.2    Renger, J.J.3    Trussell, L.O.4
  • 44
    • 0034711598 scopus 로고    scopus 로고
    • Serotonin inhibits voltage-gated sodium current by cyclic adenosine monophosphate-dependent mechanism in bullfrog taste receptor cells
    • Imendra KG, Fujiyama R, Miyamoto T, Okada Y, Sato T (2000) Serotonin inhibits voltage-gated sodium current by cyclic adenosine monophosphate- dependent mechanism in bullfrog taste receptor cells. Neurosci Lett 294(3):151-154.
    • (2000) Neurosci Lett , vol.294 , Issue.3 , pp. 151-154
    • Imendra, K.G.1    Fujiyama, R.2    Miyamoto, T.3    Okada, Y.4    Sato, T.5
  • 45
    • 0036460097 scopus 로고    scopus 로고
    • Serotonin differentially modulates the electrical properties of different subsets of taste receptor cells in bullfrog
    • Imendra KG, Miyamoto T, Okada Y, Toda K (2002) Serotonin differentially modulates the electrical properties of different subsets of taste receptor cells in bullfrog. Eur J Neurosci 16(4):629-640.
    • (2002) Eur J Neurosci , vol.16 , Issue.4 , pp. 629-640
    • Imendra, K.G.1    Miyamoto, T.2    Okada, Y.3    Toda, K.4
  • 47
    • 0033842330 scopus 로고    scopus 로고
    • Serotonin and central nervous system fatigue: Nutritional considerations
    • Davis JM, Alderson NL, Welsh RS (2000) Serotonin and central nervous system fatigue: Nutritional considerations. Am J Clin Nutr 72(2, Suppl):573S-578S.
    • (2000) Am J Clin Nutr , vol.72 , Issue.2 SUPPL.
    • Davis, J.M.1    Alderson, N.L.2    Welsh, R.S.3
  • 48
    • 34447307966 scopus 로고    scopus 로고
    • Role of endogenous release of norepinephrine in muscle spasms after chronic spinal cord injury
    • Rank MM, Li X, Bennett DJ, Gorassini MA (2007) Role of endogenous release of norepinephrine in muscle spasms after chronic spinal cord injury. J Neurophysiol 97(5):3166-3180.
    • (2007) J Neurophysiol , vol.97 , Issue.5 , pp. 3166-3180
    • Rank, M.M.1    Li, X.2    Bennett, D.J.3    Gorassini, M.A.4
  • 49
    • 0000018340 scopus 로고
    • The generation of impulses in motoneurones
    • Coombs JS, Curtis DR, Eccles JC (1957) The generation of impulses in motoneurones. J Physiol 139(2):232-249.
    • (1957) J Physiol , vol.139 , Issue.2 , pp. 232-249
    • Coombs, J.S.1    Curtis, D.R.2    Eccles, J.C.3
  • 50
    • 0035898264 scopus 로고    scopus 로고
    • Action potential threshold of hippocampal pyramidal cells in vivo is increased by recent spiking activity
    • Henze DA, Buzsáki G (2001) Action potential threshold of hippocampal pyramidal cells in vivo is increased by recent spiking activity. Neuroscience 105(1):121-130.
    • (2001) Neuroscience , vol.105 , Issue.1 , pp. 121-130
    • Henze, D.A.1    Buzsáki, G.2


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