5-HT1A receptors increase excitability of spinal motoneurons by inhibiting a TASK-1-like K+ current in the adult turtle

Journal of Physiology

Volumn 548, Issue 2, 2003, Pages 485-492

  Perrier, Jean François ^a   Alaburda, Aidas ^a   Hounsgaard, Jørn ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; ANANDAMIDE; CESIUM CHLORIDE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; POTASSIUM CHANNEL; SEROTONIN; SEROTONIN 1A RECEPTOR; TWIK RELATED ACID SENSITIVE POTASSIUM CHANNEL; UNCLASSIFIED DRUG; AMIDE; ARACHIDONIC ACID DERIVATIVE; NERVE PROTEIN; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL SUBFAMILY K MEMBER 3; SEROTONIN AGONIST; TANDEM PORE DOMAIN POTASSIUM CHANNEL;

ADULT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CURRENT CLAMP TECHNIQUE; DEPOLARIZATION; HYPERPOLARIZATION; INTRACELLULAR RECORDING; NERVE CELL EXCITABILITY; NONHUMAN; POTASSIUM CONDUCTANCE; POTASSIUM CURRENT; PRIORITY JOURNAL; SPINAL CORD MOTONEURON; TRACHEMYS SCRIPTA ELEGANS; TURTLE; VOLTAGE CLAMP TECHNIQUE; ANIMAL; CELL MEMBRANE POTENTIAL; CYTOLOGY; DRUG EFFECT; ELECTROPHYSIOLOGY; IN VITRO STUDY; MOTONEURON; PATCH CLAMP; PHYSIOLOGY; SPINAL CORD;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; ARACHIDONIC ACIDS; ELECTROPHYSIOLOGY; MEMBRANE POTENTIALS; MOTOR NEURONS; NERVE TISSUE PROTEINS; PATCH-CLAMP TECHNIQUES; POLYUNSATURATED ALKAMIDES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN; SEROTONIN AGONISTS; SPINAL CORD; TURTLES;

EID: 0038069071     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2002.037952     Document Type: Article

References (29)

1. Azmitia EC, Gannon PJ, Kheck NM & Whitaker-Azmitia PM (1996). Cellular localization of the 5-HT1A receptor in primate brain neurons and glial cells. Neuropsychopharmacology 14, 35-46.
2. + channel to sense external pH variations near physiological PH. EMBO J 16, 5464-5471.
3. Fletcher A, Forster EA, Bill DJ, Brown G, Cliffe IA, Hartley JE, Jones DE, McLenachan A, Stanhope KJ, Critchley DJ, Childs KJ, Middlefell VC, Lanfumey L, Corradetti R, Laporte AM, Gozlan H, Hamon M & Dourish CT (1996). Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist. Behav Brain Res 73, 337-353.
4. Hille B (2001). Ionic Channels of Excitable Membranes, 3rd edn. Sinauer, Sunderland, MA, USA.
5. + channels. Receptors Channels 6, 363-374.
6. Hochman S & Schmidt BJ (1998). Whole cell recordings of lumbar motoneurons during locomotor-like activity in the in vitro neonatal rat spinal cord. J Neurophysiol 79, 743-752.
7. Hounsgaard J, Hultborn H, Jespersen B & Kiehn O (1988). Bistability of α-motoneurones in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxytryptophan. J Physiol 405, 345-367.
8. Hounsgaard J & Kiehn O (1989). Serotonin- induced bistability of turtle motoneurones caused by a nifedipine-sensitive calcium plateau potential. J Physiol 414, 265-282.
9. Hoyer D & Martin G (1997). 5-HT receptor classification and nomenclature: towards a harmonization with the human genome. Neuropharmacology 36, 419-428.
10. Hsiao CF, Trueblood PR, Levine MS & Chandler SH (1997). Multiple effects of serotonin on membrane properties of trigeminal motoneurons in vitro. J Neurophysiol 77, 2910-2924.
11. Jacobs BL & Fornal CA (1997). Serotonin and motor activity. Curr Opin Neurobiol 7, 820-825.
12. Kheck NM, Gannon PJ & Azmitia EC (1995). 5-HT1A receptor localization on the axon hillock of cervical spinal motoneurons in primates. J Comp Neurol 355, 211-220.
13. Kiehn O, Rostrup E & Moller M (1992). Monoaminergic systems in the brainstem and spinal cord of the turtle Pseudemys scripta elegans as revealed by antibodies against serotonin and tyrosine hydroxylase. J Comp Neurol 325, 527-547.
14. Kjaerulff O & Kiehn O (2001). 5-HT modulation of multiple inward rectifiers in motoneurons in intact preparations of the neonatal rat spinal cord. J Neurophysiol 85, 580-593.
15. Kojima M & Sano Y (1983). The organization of serotonin fibers in the anterior column of the mammalian spinal cord. An immunohistochemical study. Anat Embryol (Berl) 167, 1-11.
16. Maingret F, Patel AJ, Lazdunski M & Honore E (2001). The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1. EMBO J 20, 47-54.
17. Markstein R, Matsumoto M, Kohler C, Togashi H, Yoshioka M & Hoyer D (1999). Pharmacological characterisation of 5-HT receptors positively coupled to adenylyl cyclase in the rat hippocampus. Naunyn Schmiedebergs Arch Pharmacol 359, 454-459.
18. Ong WY & Mackie K (1999). A light and electron microscopic study of the CB1 cannabinoid receptor in the primate spinal cord. J Neurocytol 28, 39-45.
19. + channels. Trends Neurosci 24, 339-346.
20. Perrier JF & Hounsgaard J (2000). Development and regulation of response properties in spinal cord motoneurons. Brain Res Bull 53, 529-535.
21. Rekling JC, Funk GD, Bayliss DA, Dong XW & Feldman JL (2000). Synaptic control of motoneuronal excitability. Physiol Rev 80, 767-852.
22. Roberts A & Kahn JA (1982). Intracellular recordings from spinal neurons during 'swimming' in paralysed amphibian embryos. Philos Trans R Soc Lond B Biol Sci 296, 213-228.
23. Shefchyk SJ & Jordan LM (1985). Motoneuron input-resistance changes during fictive locomotion produced by stimulation of the mesencephalic locomotor region. J Neurophysiol 54, 1101-1108.
24. Skydsgaard M & Hounsgaard J (1996). Multiple actions of iontophoretically applied serotonin on motorneurones in the turtle spinal cord in vitro. Acta Physiol Scand 158, 301-310.
25. Takahashi T & Berger AJ (1990). Direct excitation of rat spinal motoneurones by serotonin. J Physiol 423, 63-76.
26. + channel, is modulated by multiple neurotransmitters in motoneurons. Neuron 25, 399-410.
27. Talley EM, Sadr NN & Bayliss DA (1997). Postnatal development of serotonergic innervation, 5-HT1A receptor expression, and 5-HT responses in rat motoneurons. J Neurosci 17, 4473-4485.
28. Wang MY & Dun NJ (1990). 5-Hydroxytryptamine responses in neonate rat motoneurones in vitro. J Physiol 430, 87-103.
29. Ziskind-Conhaim L, Seebach BS & Gao BX (1993). Changes in serotonin-induced potentials during spinal cord development. J Neurophysiol 69, 1338-1349.