Effects of glucocorticoid receptor antagonist, RU486, on the proliferative and differentiation capabilities of bone marrow mesenchymal stromal cells in ovariectomized rats

Journal of Orthopaedic Research

Volumn 31, Issue 5, 2013, Pages 760-767

  Wei, Na ^a   Yu, Yang ^a   Schmidt, Thomas ^b   Stanford, Clark ^a   Hong, Liu ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

differentiation; glucocorticoid receptor antagonist (RU486); glucocorticoids; mesenchymal stem stromal cells; ovariectomy; proliferation

Indexed keywords

CORTICOSTERONE; ESTRADIOL; GLUCOCORTICOID; MIFEPRISTONE; SUPEROXIDE DISMUTASE;

ADIPOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; BONE DEVELOPMENT; BONE MARROW CELL; CELL AGING; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; MESENCHYMAL STROMA CELL; NONHUMAN; OVARIECTOMY; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; BODY WEIGHT; CELL DIFFERENTIATION; CELL PROLIFERATION; CORTICOSTERONE; ESTROGENS; FEMALE; HORMONE ANTAGONISTS; MESENCHYMAL STROMAL CELLS; MIFEPRISTONE; MODELS, ANIMAL; OVARIECTOMY; OXIDATIVE STRESS; PHENOLS; PLANT EXTRACTS; RATS; RATS, INBRED F344; RECEPTORS, GLUCOCORTICOID; SUPEROXIDE DISMUTASE;

EID: 84875229911     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.22298     Document Type: Article

References (29)

1. Dennis JE, Caplan AI., 1996. Differentiation potential of conditionally immortalized mesenchymal progenitor cells from adult marrow of a H-2Kb-tsA58 transgenic mouse. J Cell Physiol 167: 523-538.
2. Kim CH, Cheng SL, Kim GS., 1999. Effects of dexamethasone on proliferation, activity, and cytokine secretion of normal human bone marrow stromal cells: possible mechanisms of glucocorticoid-induced bone loss. J Endocrinol 162: 371-379.
3. Ichiyoshi H, Kiyozuka Y, Kishimoto Y, et al. 2003. Massive telomere loss and telomerase RNA expression in dexamethasone-induced apoptosis in mouse thymocytes. Exp Mol Pathol 75: 178-186.
4. Wen J, Wang L, Zhang M, et al. 2002. Repression of telomerase activity during in vitro differentiation of osteosarcoma cells. Cancer Invest 20: 38-45.
5. Wikgren M, Maripuu M, Karlsson T, et al. 2012. Short telomeres in depression and the general population are associated with a hypocortisolemic state. Biol Psychiatry 15: 294-300.
6. Costantini D, Marasco V, Møller AP., 2011. A meta-analysis of glucocorticoids as modulators of oxidative stress in vertebrates. J Comp Physiol B 181: 447-456 (review).
7. Kizaki T, Ookawara T, Iwabuchi K, et al. 2000. Age-associated increase of basal corticosterone levels decreases ED2high, NF-kappaBhigh activated macrophages. J Leukoc Biol 68: 21-30.
8. Mancini A, Festa R, Di Donna V, et al. 2010. Hormones and antioxidant systems: role of pituitary and pituitary-dependent axes. J Endocrinol Invest 33: 422-433 (review).
9. Hong L, Wei N, Joshi V, et al. 2012. Effects of glucocorticoid receptor siRNA delivered by poly lactic-co-glycolic acid microparticles on proliferation and differentiation capabilities of human mesenchymal stromal cells. Tissue Eng Part A 18: 775-784.
10. Yu Y, Wei N, Stanford C, et al. 2012. In vitro effects of RU486 on proliferation and differentiation capabilities of human bone marrow mesenchymal stromal cells. Steroids 77: 132-137.
11. Coutu DL, François M, Galipeau J., 2011. Inhibition of cellular senescence by developmentally regulated FGF-receptors in mesenchymal stem cells. Blood, 117: 6801-6812.
12. Ha BJ., 2004. Oxidative stress in ovariectomy menopause and role of chondroitin sulfate. Arch Pharm Res 27: 867-872.
13. Muthusami S, Ramachandran I, Muthusamy B, et al. 2005. Ovariectomy induces oxidative stress and impairs bone antioxidant system in adult rats. Clin Chim Acta 360: 81-86.
14. Carõn RW, Salicioni AM, Deis RP., 1994. Mifepristone treatment demonstrates the participation of adrenal glucocorticoids in the regulation of oestrogen-induced prolactin secretion in ovariectomized rats. J Steroid Biochem Mol Biol 48: 385-389.
15. Varkey M, Kucharski C, Doschak MR, et al. 2007. Osteogenic response of bone marrow stromal cells from normal and ovariectomized rats treated with a low dose of basic fibroblast growth factor. Tissue Eng 13: 809-817.
16. Pei W, Bellows CG, Elsubeihi ES, et al. 2003. Effect of ovariectomy on dexamethasone- and progesterone-dependent osteoprogenitors in vertebral and femoral rat bone cell populations. Bone 33: 822-830.
17. Hong L, Sultana H, Paulius K, et al. 2009. Steroid regulation of proliferation and osteogenic differentiation of bone marrow stromal cells: a gender difference. J Steroid Biochem Mol Biol 114: 180-185.
18. Hong L, Colpan A, Peptan IA., 2006. Modulations of 17-beta estradiol on osteogenic and adipogenic differentiations of human mesenchymal stem cells. Tissue Eng 12: 2747-2753.
19. Goodman Y, Bruce AJ, Cheng B, et al. 1996. Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid beta-peptide toxicity in hippocampal neurons. J Neurochem 66: 1836-1844.
20. White RE, Gerrity R, Barman SA, et al. 2010. Estrogen and oxidative stress: a novel mechanism that may increase the risk for cardiovascular disease in women. Steroids 75: 788-793.
21. Baltgalvis KA, Greising SM, Warren GL, et al. 2010. Estrogen regulates estrogen receptors and antioxidant gene expression in mouse skeletal muscle. PLoS ONE 5: e10164.
22. Numakawa T, Matsumoto T, Numakawa Y, et al. 2011. Protective action of neurotrophic factors and estrogen against oxidative stress-mediated neurodegeneration. J Toxicol 405: 194.
23. Chen TL., 2004. Inhibition of growth and differentiation of osteoprogenitors in mouse bone marrow stromal cell cultures by increased donor age and glucocorticoid treatment. Bone 35: 83-95.
24. Rodriguez JP, Garat S, Gajardo H, et al. 1999. Abnormal osteogenesis in osteoporotic patients is reflected by altered mesenchymal stem cells dynamics. J Cell Biochem 75: 414-423.
25. Rodríguez JP, Ríos S, Fernández M, et al. 2004. Differential activation of ERK1,2 MAP kinase signaling pathway in mesenchymal stem cell from control and osteoporotic postmenopausal women. J Cell Biochem 92: 745-754.
26. Muschler GF, Nitto H, Boehm CA, et al. 2001. Age- and gender-related changes in the cellularity of human bone marrow and the prevalence of osteoblastic progenitors. J Orthop Res 19: 117-125.
27. Manolagas SC., 2010. From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev 31: 266-300.
28. Ratka A, Simpkins JW., 1990. Dose-dependent effects of chronic treatment with estradiol or progesterone on LH secretion in ovariectomized rats. Endocr Res 16: 165-184.
29. Dang Z, Löwik CW., 2004. The balance between concurrent activation of ERs and PPARs determines daidzein-induced osteogenesis and adipogenesis. J Bone Miner Res 19: 853-861.