Repression of telomerase activity during in vitro differentiation of osteosarcoma cells

Cancer Investigation

Volumn 20, Issue 1, 2002, Pages 38-45

  Wen, Jianming ^a   Wang, Lin ^a   Zhang, Meng ^a   Xie, Dan ^a   Sun, Laibao ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; DEXAMETHASONE; RETINOIC ACID; TELOMERASE;

ARTICLE; BONE DEVELOPMENT; CELL CYCLE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CELL GROWTH; CELL POPULATION; CELL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM;

ALKALINE PHOSPHATASE; BLOTTING, NORTHERN; BONE NEOPLASMS; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; HUMANS; OSTEOSARCOMA; RNA, MESSENGER; TELOMERASE; TRETINOIN; TUMOR CELLS, CULTURED;

EID: 0036172705     PISSN: 07357907     EISSN: None     Source Type: Journal    
DOI: 10.1081/CNV-120000364     Document Type: Article

References (22)

1. Dexamethasone induction of osteoblast mRNAs in rat marrow stromal cell cultures
2. 3 stimulates both alkaline phosphatase gene transcription and mRNA stability in human bone cells
3. 3-induced osteocalcin synthesis in human osteosarcoma cells by other steroid hormones
4. Effects of retinoic acid and dexamethasone on proliferation, differentiation, and glucocorticoid receptor expression in cultured human osteosarcoma cells
5. Differentiation of immortal cells inhibits telomerase activity
6. Down-regulation of telomerase activity is an early event in the differentiation of HL60 cells
7. Selective inhibition of telomerase activity during terminal differentiation of immortal cell lines
8. Specific association of human telomerase activity with immortal cells and cancer
9. Modifications of a Telomeric Repeat Amplification Protocol (TRAP) result in increased reliability, linearity and sensitivity
10. Telomeres, telomerase and cancer
11. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization
12. The RNA component of human telomerase
13. Expression of telomerase RNA, telomerase activity, and telomere length in human gliomas
14. Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues
15. Telomerase activity is repressed during differentiation of maturation-sensitive but not resistant human tumor cell lines
16. 3 and phorbol ester mediate the expression of alkaline phosphatase in NB4 acute promyelocytic leukemia cells
17. A non-isotopic method for the detection of telomerase activity in tumour tissues: TRAP-silver staining assay
18. Telomerase activation in malignant bone tumors
19. Immunomagnetic isolation of osteoprogenitors from human bone marrow stroma
20. Cell cycle-dependent modulation of telomerase activity in tumor cells
21. Lack of cell cycle regulation of telomerase activity in human cells
22. Telomerase activity is elevated in early S phase